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J. P. Oettgen, MD

Publications

  • Wythe JD, Dang LT, Devine WP, Boudreau E, Artap ST, He D, Schachterle W, Stainier DY, Oettgen P, Black BL, Bruneau BG, Fish JE.ETS factors regulate Vegf-dependent arterial specification.Dev Cell. 2013 Jul 15;26(1):45-58.
    23830865
  • Kato M, Dang V, Wang M, Park JT, Deshpande S, Kadam S, Mardiros A, Zhan Y, Oettgen P, Putta S, Yuan H, Lanting L, Natarajan R.TGF-β induces acetylation of chromatin and of Ets-1 to alleviate repression of miR-192 in diabetic nephropathy.Sci Signal. 2013 Jun 4;6(278):ra43.
    23737551
  • Shirodkar AV, St Bernard R, Gavryushova A, Kop A, Knight BJ, Yan MS, Man HS, Sud M, Hebbel RP, Oettgen P, Aird WC, Marsden PA.A mechanistic role for DNA methylation in endothelial cell (EC)-enriched gene expression: relationship with DNA replication timing.Blood. 2013 Feb 28.
    23449636
  • Liu J, Yuan L, Molema G, Regan E, Janes L, Beeler D, Spokes KC, Okada Y, Minami T, Oettgen P, Aird WC.Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletal muscle.Blood. 2011 Jan 6;117(1):342-51.
    20980682
  • Zhan Y, Yuan L, Kondo M, Oettgen P.The Counter-Regulatory Effects of ESE-1 During Angiotensin II-Mediated Vascular Inflammation and Remodeling.Am J Hypertens. 2010 Dec;23(12):1312-7.
    20689519
  • Harris TA, Yamakuchi M, Kondo M, Oettgen P, Lowenstein CJ.Ets-1 and Ets-2 regulate the expression of microRNA-126 in endothelial cells.Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1990-7.
    20671229
  • Le Bras A, Vijayaraj P, Oettgen P.Molecular mechanisms of endothelial differentiation.Vasc Med. 2010 Aug;15(4):321-31.
    20621955
  • Bhasin M, Yuan L, Keskin DB, Otu HH, Libermann TA, Oettgen P.Bioinformatic identification and characterization of human endothelial cell-restricted genes.BMC Genomics. 2010;11:342.
    20509943
  • Oettgen P.The role of ets factors in tumor angiogenesis.J Oncol. 2010;2010:767384.
    20454645
  • Nikolova-Krstevski V, Yuan L, Le Bras A, Vijayaraj P, Kondo M, Gebauer I, Bhasin M, Carman CV, Oettgen P.ERG is required for the differentiation of embryonic stem cells along the endothelial lineage.BMC Dev Biol. 2009;9:72.
    20030844
  • Jin E, Liu J, Suehiro J, Yuan L, Okada Y, Nikolova-Krstevski V, Yano K, Janes L, Beeler D, Spokes KC, Li D, Regan E, Shih SC, Oettgen P, Minami T, Aird WC.Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo.Blood. 2009 Dec 24;114(27):5557-66.
    19822898
  • Song H, Suehiro J, Kanki Y, Kawai Y, Inoue K, Daida H, Yano K, Ohhashi T, Oettgen P, Aird WC, Kodama T, Minami T.Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells.J Biol Chem. 2009 Oct 16;284(42):29109-24.
    19674970
  • Oettgen P.Functional redundancy of Ets1 and Ets2.Blood. 2009 Jul 30;114(5):934-5.
    19643995
  • Melero-Martin JM,De Obaldia ME,Kang SY,Khan ZA,Yuan L,Oettgen P,Bischoff J.Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells.Circ Res. 2008 Jul 18;103(2):194-202.
    18556575
  • Nikolova-Krstevski V, Bhasin M, Otu HH, Libermann T, Oettgen P.Gene expression analysis of embryonic stem cells expressing VE-cadherin (CD144) during endothelial differentiation.BMC Genomics. 2008;9:240.
    18498633
  • Ni W, Zhan Y, He H, Maynard E, Balschi JA, Oettgen P.Ets-1 is a critical transcriptional regulator of reactive oxygen species and p47(phox) gene expression in response to angiotensin II.Circ Res. 2007 Nov 9;101(10):985-94.
    17872466
  • Okada Y, Yano K, Jin E, Funahashi N, Kitayama M, Doi T, Spokes K, Beeler DL, Shih SC, Okada H, Danilov TA, Maynard E, Minami T, Oettgen P, Aird WC.A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium.Circ Res. 2007 Jun 22;100(12):1712-22.
    17495228
  • Oettgen P.Regulation of vascular inflammation and remodeling by ETS factors.Circ Res. 2006 Nov 24;99(11):1159-66. Review.
    17122446
  • Oettgen P, Boyle AJ, Schulman SP, Hare JM.Cardiac Stem Cell Therapy. Need for Optimization of Efficacy and Safety Monitoring.Circulation. 2006 Jul 25;114(4):353-8. Review.
    16864740
  • Min JY, Huang X, Xiang M, Meissner A, Chen Y, Ke Q, Kaplan E, Rana JS, Oettgen P, Morgan JP.Homing of intravenously infused embryonic stem cell-derived cells to injured hearts after myocardial infarction.J Thorac Cardiovasc Surg. 2006 Apr;131(4):889-97.
    16580449
  • Brown C, Gaspar J, Pettit A, Lee R, Gu X, Wang H, Manning C, Voland C, Goldring SR, Goldring MB, Libermann TA, Gravalllese EM, Oettgen P.ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation.J Biol Chem. 2004 Mar 26;279(13):12794-803.
    14715662
  • Bates RC, Goldsmith JD, Bachelder RE, Brown C, Shibuya M, Oettgen P, Mercurio AM.Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids.Curr Biol. 2003 Sep 30;13(19):1721-7.
    14521839
  • Gaspar J, Thai S, Voland C, Dube A, Libermann TA, Iruela-Arispe ML, Oettgen P.Opposing functions of the Ets factors NERF and ELF-1 during chicken blood vessel development.Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1106-12.
    12117724
  • Christensen RA, Fujikawa K, Madore R, Oettgen P, Varticovski L.NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxia.J Cell Biochem. 2002;85(3):505-15.
    11967990
  • Oettgen P.Transcriptional regulation of vascular development.Circ Res. 2001 Aug 31;89(5):380-8.
    11532898
  • Dube A, Thai S, Gaspar J, Rudders S, Libermann TA, Iruela-Arispe L, Oettgen P.Elf-1 is a transcriptional regulator of the Tie2 gene during vascular development.Circ Res. 2001 Feb 2;88(2):237-44.
    11157678
  • Gu X, Shin BH, Akbarali Y, Weiss A, Boltax J, Oettgen P, Libermann TA.Tel-2 is a novel transcriptional repressor related to the Ets factor Tel/ETV-6.J Biol Chem. 2001 Mar 23;276(12):9421-36.
    11108721
  • Rudders S, Gaspar J, Madore R, Voland C, Grall F, Patel A, Pellacani A, Perrella MA, Libermann TA, Oettgen P.ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene.J Biol Chem. 2001 Feb 2;276(5):3302-9.
    11036073
  • Kas K, Finger E, Grall F, Gu X, Akbarali Y, Boltax J, Weiss A, Oettgen P, Kapeller R, Libermann TA.ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1.J Biol Chem. 2000 Jan 28;275(4):2986-98.
    10644770
  • Oettgen P, Finger E, Sun Z, Akbarali Y, Thamrongsak U, Boltax J, Grall F, Dube A, Weiss A, Brown L, Quinn G, Kas K, Endress G, Kunsch C, Libermann TA.PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression.J Biol Chem. 2000 Jan 14;275(2):1216-25.
    10625666
  • Oettgen P, Kas K, Dube A, Gu X, Grall F, Thamrongsak U, Akbarali Y, Finger E, Boltax J, Endress G, Munger K, Kunsch C, Libermann TA.Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes.J Biol Chem. 1999 Oct 8;274(41):29439-52.
    10506207
  • Dube A, Akbarali Y, Sato TN, Libermann TA, Oettgen P.Role of the Ets transcription factors in the regulation of the vascular-specific Tie2 gene.Circ Res. 1999 May 28;84(10):1177-85.
    10347092
  • Oettgen P, Barcinski M, Boltax J, Stolt P, Akbarali Y, Libermann TA.Genomic organization of the human ELF3 (ESE-1/ESX) gene, a member of the Ets transcription factor family, and identification of a functional promoter.Genomics. 1999 Feb 1;55(3):358-62.
    10049594
  • Iljin K, Dube A, Kontusaari S, Korhonen J, Lahtinen I, Oettgen P, Alitalo K.Role of ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter.FASEB J. 1999 Feb;13(2):377-86.
    9973326
  • Sata M, Perlman H, Muruve DA, Silver M, Ikebe M, Libermann TA, Oettgen P, Walsh K.Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response.Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1213-7.
    9448311
  • Oettgen P, Carter KC, Augustus M, Barcinski M, Boltax J, Kunsch C, Libermann TA.The novel epithelial-specific Ets transcription factor gene ESX maps to human chromosome 1q32.1.Genomics. 1997 Oct 15;45(2):456-7.
    9463090
  • Oettgen P, Alani RM, Barcinski MA, Brown L, Akbarali Y, Boltax J, Kunsch C, Munger K, Libermann TA.Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family.Mol Cell Biol. 1997 Aug;17(8):4419-33.
    9234700
  • Akbarali Y, Oettgen P, Boltax J, Libermann TA.ELF-1 interacts with and transactivates the IgH enhancer pi site.J Biol Chem. 1996 Oct 18;271(42):26007-12.
    8824239
  • Oettgen P, Akbarali Y, Boltax J, Best J, Kunsch C, Libermann TA.Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1.Mol Cell Biol. 1996 Sep;16(9):5091-106.
    8756667