• Home
  • News
  • Calendar
  • About DF/HCC
  • Membership
  • Visitor Center

Andrea I. McClatchey, PhD


  • Shapiro IM, Kolev VN, Vidal CM, Kadariya Y, Ring JE, Wright Q, Weaver DT, Menges C, Padval M, McClatchey AI, Xu Q, Testa JR, Pachter JA.Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship.Sci Transl Med. 2014 May 21;6(237):237ra68.
  • Widemann BC, Acosta MT, Ammoun S, Belzberg AJ, Bernards A, Blakeley J, Bretscher A, Cichowski K, Clapp DW, Dombi E, Evans GD, Ferner R, Fernandez-Valle C, Fisher MJ, Giovannini M, Gutmann DH, Hanemann CO, Hennigan R, Huson S, Ingram D, Kissil J, Korf BR, Legius E, Packer RJ, McClatchey AI, McCormick F, North K, Pehrsson M, Plotkin SR, Ramesh V, Ratner N, Schirmer S, Sherman L, Schorry E, Stevenson D, Stewart DR, Ullrich N, Bakker AC, Morrison H.CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies.Am J Med Genet A. 2014 Mar;164A(3):563-78.
  • Pore D, Parameswaran N, Matsui K, Stone MB, Saotome I, McClatchey AI, Veatch SL, Gupta N.Ezrin tunes the magnitude of humoral immunity.J Immunol. 2013 Oct 15;191(8):4048-58.
  • McClatchey AI, Yap AS.Contact inhibition (of proliferation) redux.Curr Opin Cell Biol. 2012 Oct;24(5):685-94.
  • McClatchey AI.ERM proteins.Curr Biol. 2012 Sep 25;22(18):R784-5.
  • McClatchey AI, Cichowski K.SPRED proteins provide a NF-ty link to Ras suppression.Genes Dev. 2012 Jul 15;26(14):1515-9.
  • Gladden AB, Hebert AM, Schneeberger EE, McClatchey AI.The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex.Dev Cell. 2010 Nov 16;19(5):727-39.
  • Shaffer MH, Huang Y, Corbo E, Wu GF, Velez M, Choi JK, Saotome I, Cannon JL, McClatchey AI, Sperling AI, Maltzman JS, Oliver PM, Bhandoola A, Laufer TM, Burkhardt JK.Ezrin is highly expressed in early thymocytes, but dispensable for T cell development in mice.PLoS ONE. 2010;5(8):e12404.
  • Benhamouche S, Curto M, Saotome I, Gladden AB, Liu CH, Giovannini M, McClatchey AI.Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver.Genes Dev. 2010 Aug 15;24(16):1718-30.
  • Wong HK, Lahdenranta J, Kamoun WS, Chan AW, McClatchey AI, Plotkin SR, Jain RK, di Tomaso E.Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors.Cancer Res. 2010 May 1;70(9):3483-93.
  • Fehon RG, McClatchey AI, Bretscher A.Organizing the cell cortex: the role of ERM proteins.Nat Rev Mol Cell Biol. 2010 Apr;11(4):276-87. Review.
  • Morris ZS,McClatchey AI.Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma.Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9767-72.
  • Morris ZS,McClatchey AI.The neurofibroma cell of origin: SKPs expand the playing field.Cell Stem Cell. 2009 May 8;4(5):371-2.
  • McClatchey AI,Fehon RG.Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex.Trends Cell Biol. 2009 May;19(5):198-206. Review.
  • Shaffer MH,Dupree RS,Zhu P,Saotome I,Schmidt RF,McClatchey AI,Freedman BD,Burkhardt JK.Ezrin and moesin function together to promote T cell activation.J Immunol. 2009 Jan 15;182(2):1021-32.
  • Larsson J,Ohishi M,Garrison B,Aspling M,Janzen V,Adams GB,Curto M,McClatchey AI,Schipani E,Scadden DT.Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture.Cell Stem Cell. 2008 Aug 7;3(2):221-7.
  • Plotkin SR,Singh MA,O'Donnell CC,Harris GJ,McClatchey AI,Halpin C.Audiologic and radiographic response of NF2-related vestibular schwannoma to erlotinib therapy.Nat Clin Pract Oncol. 2008 Aug;5(8):487-91.
  • Kim WJ, Okimoto RA, Purton LE, Goodwin M, Haserlat SM, Dayyani F, Sweetser DA, McClatchey AI, Bernard OA, Look AT, Bell DW, Scadden DT, Haber DA.Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.Blood. 2008 May 1;111(9):4716-22.
  • Johannessen CM, Johnson BW, Williams SM, Chan AW, Reczek EE, Lynch RC, Rioth MJ, McClatchey A, Ryeom S, Cichowski K.TORC1 is essential for NF1-associated malignancies.Curr Biol. 2008 Jan 8;18(1):56-62.
  • Cole BK, Curto M, Chan AW, McClatchey AI.Localization to the cortical cytoskeleton is necessary for Nf2/merlin-dependent epidermal growth factor receptor silencing.Mol Cell Biol. 2008 Feb;28(4):1274-84.
  • Curto M, McClatchey AI.Nf2/Merlin: a coordinator of receptor signalling and intercellular contact.Br J Cancer. 2008 Jan 29;98(2):256-62. Review.
  • Curto M, Cole BK, Lallemand D, Liu CH, McClatchey AI.Contact-dependent inhibition of EGFR signaling by Nf2/Merlin.J Cell Biol. 2007 Jun 4;177(5):893-903.
  • Bonilha VL, Rayborn ME, Saotome I, McClatchey AI, Hollyfield JG.Microvilli defects in retinas of ezrin knockout mice.Exp Eye Res. 2006 Apr;82(4):720-9.
  • Yajnik V, Paulding C, Sordella R, McClatchey AI, Saito M, Wahrer DC, Reynolds P, Bell DW, Lake R, van den Heuvel S, Settleman J, Haber DA.DOCK4, a GTPase activator, is disrupted during tumorigenesis.Cell. 2003 Mar 7;112(5):673-84.
  • McClatchey AI, Saotome I, Mercer K, Crowley D, Gusella JF, Bronson RT, Jacks T.Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors.Genes Dev. 1998 Apr 15;12(8):1121-33.
  • McClatchey AI, Saotome I, Ramesh V, Gusella JF, Jacks T.The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation.Genes Dev. 1997 May 15;11(10):1253-65.
  • McClatchey AI, McKenna-Yasek D, Cros D, Worthen HG, Kuncl RW, DeSilva SM, Cornblath DR, Gusella JF, Brown RH.Novel mutations in families with unusual and variable disorders of the skeletal muscle sodium channel.Nat Genet. 1992 Oct;2(2):148-52.
  • McClatchey AI, Lin CS, Wang J, Hoffman EP, Rojas C, Gusella JF.The genomic structure of the human skeletal muscle sodium channel gene.Hum Mol Genet. 1992 Oct;1(7):521-7.
  • McClatchey AI, Trofatter J, McKenna-Yasek D, Raskind W, Bird T, Pericak-Vance M, Gilchrist J, Arahata K, Radosavljevic D, Worthen HG.Dinucleotide repeat polymorphisms at the SCN4A locus suggest allelic heterogeneity of hyperkalemic periodic paralysis and paramyotonia congenita.Am J Hum Genet. 1992 May;50(5):896-901.
  • McClatchey AI, Van den Bergh P, Pericak-Vance MA, Raskind W, Verellen C, McKenna-Yasek D, Rao K, Haines JL, Bird T, Brown RH.Temperature-sensitive mutations in the III-IV cytoplasmic loop region of the skeletal muscle sodium channel gene in paramyotonia congenita.Cell. 1992 Feb 21;68(4):769-74.