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Tayyaba Hasan, PhD


  • Spring BQ, Palanisami A, Hasan T.Microscale receiver operating characteristic analysis of micrometastasis recognition using activatable fluorescent probes indicates leukocyte imaging as a critical factor to enhance accuracy.J Biomed Opt. 2014 Jun 1;19(6):66006.
  • Anand S, Rollakanti KR, Horst RL, Hasan T, Maytin EV.Combination of Oral Vitamin D3 with Photodynamic Therapy Enhances Tumor Cell Death in a Murine Model of Cutaneous Squamous Cell Carcinoma.Photochem Photobiol. 2014 May 7.
  • Tichauer KM, Samkoe KS, Gunn JR, Kanick SC, Hoopes PJ, Barth RJ, Kaufman PA, Hasan T, Pogue BW.Microscopic lymph node tumor burden quantified by macroscopic dual-tracer molecular imaging.Nat Med..
  • Anbil S, Rizvi I, Celli JP, Alagic N, Pogue BW, Hasan T.Impact of treatment response metrics on photodynamic therapy planning and outcomes in a three-dimensional model of ovarian cancer.J Biomed Opt. 2013 Sep 1;18(9):98004.
  • Ghogare AA, Rizvi I, Hasan T, Greer A."Pointsource" Delivery of a Photosensitizer Drug and Singlet Oxygen: Eradication of Glioma Cells In Vitro.Photochem Photobiol. 2014 Mar 27.
  • Jermyn M, Davis SC, Dehghani H, Huggett MT, Hasan T, Pereira SP, Bown SG, Pogue BW.CT contrast predicts pancreatic cancer treatment response to verteporfin-based photodynamic therapy.Phys Med Biol. 2014 Apr 21;59(8):1911-21.
  • Spring BQ, Abu-Yousif AO, Palanisami A, Rizvi I, Zheng X, Mai Z, Anbil S, Sears RB, Mensah LB, Goldschmidt R, Erdem SS, Oliva E, Hasan T.Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates.Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):E933-42.
  • Mallidi S, Anbil S, Lee S, Manstein D, Elrington S, Kositratna G, Schoenfeld D, Pogue B, Davis SJ, Hasan T.Photosensitizer fluorescence and singlet oxygen luminescence as dosimetric predictors of topical 5-aminolevulinic acid photodynamic therapy nduced clinical erythema.J Biomed Opt. 2014 Feb 1;19(2):028001.
  • Celli JP, Rizvi I, Blanden AR, Massodi I, Glidden MD, Pogue BW, Hasan T.An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models.Sci Rep. 2014;4:3751.
  • Samkoe KS, Bryant A, Gunn JR, Pereira SP, Hasan T, Pogue BW.Contrast enhanced-magnetic resonance imaging as a surrogate to map verteporfin delivery in photodynamic therapy.J Biomed Opt. 2013 Dec;18(12):120504.
  • Tichauer KM, Deharvengt SJ, Samkoe KS, Gunn JR, Bosenberg MW, Turk MJ, Hasan T, Stan RV, Pogue BW.Tumor Endothelial Marker Imaging in Melanomas Using Dual-Tracer Fluorescence Molecular Imaging.Mol Imaging Biol. 2013 Nov 12.
  • Anand S, Hasan T, Maytin EV.Mechanism of differentiation-enhanced photodynamic therapy for cancer: upregulation of coproporphyrinogen oxidase by C/EBP transcription factors.Mol Cancer Ther. 2013 Aug;12(8):1638-50.
  • Davis SC, Samkoe KS, Tichauer KM, Sexton KJ, Gunn JR, Deharvengt SJ, Hasan T, Pogue BW.Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo.Proc Natl Acad Sci U S A. 2013 May 13.
  • Rizvi I, Gurkan UA, Tasoglu S, Alagic N, Celli JP, Mensah LB, Mai Z, Demirci U, Hasan T.Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules.Proc Natl Acad Sci U S A. 2013 May 3.
  • Rizvi I, Dinh TA, Yu W, Chang Y, Sherwood ME, Hasan T.Photoimmunotherapy and irradiance modulation reduce chemotherapy cycles and toxicity in a murine model for ovarian carcinomatosis: perspective and results.Isr. J. Chem. 2012 Sep;52(8-9):776-787.
  • Bartusik D, Aebisher D, Ghogare A, Ghosh G, Abramova I, Hasan T, Greer A.A Fiberoptic (Photodynamic Therapy Type) Device with a Photosensitizer and Singlet Oxygen Delivery Probe Tip for Ovarian Cancer Cell Killing.Photochem Photobiol. 2013 Mar 17.
  • Mir Y, Elrington SA, Hasan T.A new nanoconstruct for epidermal growth factor receptor-targeted photo-immunotherapy of ovarian cancer.Nanomedicine : Nanotechnology, Biology, And Medicine. 2013 Feb 26.
  • Rizvi I, Anbil S, Alagic N, Celli JP, Zheng LZ, Palanisami A, Glidden MD, Pogue BW, Hasan T.PDT Dose Parameters Impact Tumoricidal Durability and Cell Death Pathways in a 3D Ovarian Cancer Model.Photochem Photobiol. 2013 Feb 27.
  • Kimani S, Ghosh G, Ghogare A, Rudshteyn B, Bartusik D, Hasan T, Greer A.Synthesis and Characterization of Mono-, Di-, and Tri-Poly(ethylene glycol) Chlorin e(6) Conjugates for the Photokilling of Human Ovarian Cancer Cells.J Org Chem. 2012 Nov 14.
  • Glidden MD, Celli JP, Massodi I, Rizvi I, Pogue BW, Hasan T.Image-Based Quantification of Benzoporphyrin Derivative Uptake, Localization, and Photobleaching in 3D Tumor Models, for Optimization of PDT Parameters.Theranostics. 2012;2(9):827-39.
  • Hasan T.Using cellular mechanisms to develop effective combinations of photodynamic therapy and targeted therapies.J Natl Compr Canc Netw. 2012 Oct 1;10 Suppl 2:S23-6.
  • Torosean S, Flynn B, Axelsson J, Gunn J, Samkoe KS, Hasan T, Doyley MM, Pogue BW.Nanoparticle uptake in tumors is mediated by the interplay of vascular and collagen density with interstitial pressure.Nanomedicine : Nanotechnology, Biology, And Medicine. 2012 Jul 25.
  • Anand S, Ortel BJ, Pereira SP, Hasan T, Maytin EV.Biomodulatory approaches to photodynamic therapy for solid tumors.Cancer Lett. 2012 Dec 29;326(1):8-16.
  • Dhar DK, Damink SW, Brindley JH, Godfrey A, Chapman MH, Sandanayake NS, Andreola F, Mazurek S, Hasan T, Malago M, Pereira SP.Pyruvate kinase M2 is a novel diagnostic marker and predicts tumor progression in human biliary tract cancer.Cancer. 2012 Aug 1.
  • Tichauer KM, Samkoe KS, Sexton KJ, Gunn JR, Hasan T, Pogue BW.Improved tumor contrast achieved by single time point dual-reporter fluorescence imaging.J Biomed Opt. 2012 Jun;17(6):066001.
  • Abu-Yousif AO, Moor AC, Zheng X, Savellano MD, Yu W, Selbo PK, Hasan T.Epidermal growth factor receptor-targeted photosensitizer selectively inhibits EGFR signaling and induces targeted phototoxicity in ovarian cancer cells.Cancer Lett. 2012 Jan 18.
  • Xu F, Celli J, Rizvi I, Moon S, Hasan T, Demirci U.A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform.Biotechnol J. 2011 Feb;6(2):204-12.
  • Rai P, Mallidi S, Zheng X, Rahmanzadeh R, Mir Y, Elrington S, Khurshid A, Hasan T.Development and applications of photo-triggered theranostic agents.Adv Drug Deliv Rev. 2010 Aug 30;62(11):1094-124.
  • Rizvi I, Celli JP, Evans CL, Abu-Yousif AO, Muzikansky A, Pogue BW, Finkelstein D, Hasan T.Synergistic enhancement of carboplatin efficacy with photodynamic therapy in a three-dimensional model for micrometastatic ovarian cancer.Cancer Res. 2010 Nov 15;70(22):9319-28.
  • Rahmanzadeh R, Rai P, Celli JP, Rizvi I, Baron-Lühr B, Gerdes J, Hasan T.Ki-67 as a molecular target for therapy in an in vitro three-dimensional model for ovarian cancer.Cancer Res. 2010 Nov 15;70(22):9234-42.
  • Celli JP, Rizvi I, Evans CL, Abu-Yousif AO, Hasan T.Quantitative imaging reveals heterogeneous growth dynamics and treatment-dependent residual tumor distributions in a three-dimensional ovarian cancer model.J Biomed Opt.;15(5):051603.
  • Pogue BW, Samkoe KS, Hextrum S, O'Hara JA, Jermyn M, Srinivasan S, Hasan T.Imaging targeted-agent binding in vivo with two probes.J Biomed Opt.;15(3):030513.
  • Gruber JD, Paliwal A, Krishnaswamy V, Ghadyani H, Jermyn M, O'Hara JA, Davis SC, Kerley-Hamilton JS, Shworak NW, Maytin EV, Hasan T, Pogue BW.System development for high frequency ultrasound-guided fluorescence quantification of skin layers.J Biomed Opt.;15(2):026028.
  • Celli JP, Spring BQ, Rizvi I, Evans CL, Samkoe KS, Verma S, Pogue BW, Hasan T.Imaging and photodynamic therapy: mechanisms, monitoring, and optimization.Chem. Rev. . 2010 May 12;110(5):2795-838. Review.
  • Joo C, Evans CL, Stepinac T, Hasan T, de Boer JF.Diffusive and directional intracellular dynamics measured by field-based dynamic light scattering.Opt Express. 2010 Feb 1;18(3):2858-71.
  • Abu-Yousif AO, Rizvi I, Evans CL, Celli JP, Hasan T.PuraMatrix encapsulation of cancer cells.Journal Of Visualized Experiments : Jo Ve. 2009(34).
  • Samkoe KS, Chen A, Rizvi I, O'Hara JA, Hoopes PJ, Pereira SP, Hasan T, Pogue BW.Imaging tumor variation in response to photodynamic therapy in pancreatic cancer xenograft models.Int J Radiat Oncol Biol Phys. 2010 Jan 1;76(1):251-9.
  • Gibbs-Strauss SL, Samkoe KS, O'Hara JA, Davis SC, Hoopes PJ, Hasan T, Pogue BW.Detecting epidermal growth factor receptor tumor activity in vivo during cetuximab therapy of murine gliomas.Acad Radiol. 2010 Jan;17(1):7-17.
  • Evans CL,Rizvi I,Hasan T,de Boer JF.In vitro ovarian tumor growth and treatment response dynamics visualized with time-lapse OCT imaging.Opt Express. 2009 May 25;17(11):8892-906.
  • Akilov OE, Kosaka S, Maytin EV, Hasan T.Prospects for the use of differentiation-modulating agents as adjuvant of photodynamic therapy for proliferative dermatoses.J Dermatol. 2008 Apr;35(4):197-205. Review.
  • Styer AK, Sullivan BT, Puder M, Arsenault D, Petrozza JC, Serikawa T, Chang S, Hasan T, Gonzalez RR, Rueda BR.Ablation of leptin signaling disrupts the establishment, development, and maintenance of endometriosis-like lesions in a murine model.Endocrinology. 2008 Feb;149(2):506-14.
  • Akilov OE, Donovan MJ, Stepinac T, Carter CR, Whitcomb JP, Hasan T, McDowell MA.T helper type 1 cytokines and keratinocyte growth factor play a critical role in pseudoepitheliomatous hyperplasia initiation during cutaneous leishmaniasis.Arch Dermatol Res. 2007 Sep;299(7):315-25.
  • Zhou X, Chen B, Hoopes PJ, Hasan T, Pogue BW.Tumor vascular area correlates with photosensitizer uptake: analysis of verteporfin microvascular delivery in the dunning rat prostate tumor.Photochem Photobiol. 2006 Sep-Oct;82(5):1348-57.
  • Sinha AK, Anand S, Ortel BJ, Chang Y, Mai Z, Hasan T, Maytin EV.Methotrexate used in combination with aminolaevulinic acid for photodynamic killing of prostate cancer cells.Br J Cancer. 2006 Aug 21;95(4):485-95.
  • Casas A, Perotti C, Ortel B, Di Venosa G, Saccoliti M, Batlle A, Hasan T.Tumor cell lines resistant to ALA-mediated photodynamic therapy and possible tools to target surviving cells.Int J Oncol. 2006 Aug;29(2):397-405.
  • Solban N, Selbo PK, Pl SK, Sinha AK, Alok SK, Chang SK, Sung CK, Hasan T.Mechanistic investigation and implications of photodynamic therapy induction of vascular endothelial growth factor in prostate cancer.Cancer Res. 2006 Jun 1;66(11):5633-40.
  • Zhou X, Pogue BW, Chen B, Demidenko E, Joshi R, Hoopes J, Hasan T.Pretreatment photosensitizer dosimetry reduces variation in tumor response.Int J Radiat Oncol Biol Phys. 2006 Mar 15;64(4):1211-20.
  • del Carmen MG, Rizvi I, Chang Y, Moor AC, Oliva E, Sherwood M, Pogue B, Hasan T.Synergism of epidermal growth factor receptor-targeted immunotherapy with photodynamic treatment of ovarian cancer in vivo.J Natl Cancer Inst. 2005 Oct 19;97(20):1516-24.
  • Savellano MD, Hasan T.Photochemical targeting of epidermal growth factor receptor: a mechanistic study.Clin Cancer Res. 2005 Feb 15;11(4):1658-68.
  • Chen B, Pogue BW, Zhou X, O'Hara JA, Solban N, Demidenko E, Hoopes PJ, Hasan T.Effect of tumor host microenvironment on photodynamic therapy in a rat prostate tumor model.Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):720-7.
  • Duska LR, Wimberly J, Deutsch TF, Ortel B, Haas J, Houck K, Hasan T.Detection of female lower genital tract dysplasia using orally administered 5-aminolevulinic acid induced protoporphyrin IX: a preliminary study.Gynecol Oncol. 2002 Apr;85(1):125-8.
  • Molpus KL, Kato D, Hamblin MR, Lilge L, Bamberg M, Hasan T.Intraperitoneal photodynamic therapy of human epithelial ovarian carcinomatosis in a xenograft murine model.Cancer Res. 1996 Mar 1;56(5):1075-82.