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Joan V. Ruderman, PhD


  • Selenko P, Serber Z, Gadea B, Ruderman J, Wagner G.Quantitative NMR analysis of the protein G B1 domain in Xenopus laevis egg extracts and intact oocytes.Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11904-9.
  • Liu Q, Ruderman JV.Aurora A, mitotic entry, and spindle bipolarity.Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5811-6.
  • Gadea BB, Ruderman JV.Aurora B is required for mitotic chromatin-induced phosphorylation of Op18/Stathmin.Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4493-8.
  • Stanford JS, Ruderman JV.Changes in Regulatory Phosphorylation of cdc25C Ser287 and wee1 Ser549 during Normal Cell Cycle Progression and Checkpoint Arrests.Mol Biol Cell. 2005 Dec;16(12):5749-60.
  • Gadea BB, Ruderman JV.Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extracts.Mol Biol Cell. 2005 Mar;16(3):1305-18.
  • Crane R, Kloepfer A, Ruderman JV.Requirements for the destruction of human Aurora-A.J Cell Sci. 2004 Dec 1;117(Pt 25):5975-83.
  • Crane R, Gadea B, Littlepage L, Wu H, Ruderman JV.Aurora A, meiosis and mitosis.Biol Cell. 2004 Apr;96(3):215-29.
  • Lieberman SL, Ruderman JV.CK2 beta, which inhibits Mos function, binds to a discrete domain in the N-terminus of Mos.Dev Biol. 2004 Apr 15;268(2):271-9.
  • Stanford JS, Lieberman SL, Wong VL, Ruderman JV.Regulation of the G2/M transition in oocytes of xenopus tropicalis.Dev Biol. 2003 Aug 15;260(2):438-48.
  • Duckworth BC, Weaver JS, Ruderman JV.G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16794-9.
  • Littlepage LE, Wu H, Andresson T, Deanehan JK, Amundadottir LT, Ruderman JV.Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A.Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15440-5.
  • Littlepage LE, Ruderman JV.Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit.Genes Dev. 2002 Sep 1;16(17):2274-85.
  • Topper LM, Bastians H, Ruderman JV, Gorbsky GJ.Elevating the level of Cdc34/Ubc3 ubiquitin-conjugating enzyme in mitosis inhibits association of CENP-E with kinetochores and blocks the metaphase alignment of chromosomes.J Cell Biol. 2001 Aug 20;154(4):707-17.
  • Yam CH, Siu WY, Kaganovich D, Ruderman JV, Poon RY.Cleavage of cyclin A at R70/R71 by the bacterial protease OmpT.Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):497-501.
  • Tian J, Kim S, Heilig E, Ruderman JV.Identification of XPR-1, a progesterone receptor required for Xenopus oocyte activation.Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14358-63.
  • Mendez R, Hake LE, Andresson T, Littlepage LE, Ruderman JV, Richter JD.Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA.Nature. 2000 Mar 16;404(6775):302-7.
  • Bastians H, Topper LM, Gorbsky GL, Ruderman JV.Cell cycle-regulated proteolysis of mitotic target proteins.Mol Biol Cell. 1999 Nov;10(11):3927-41.
  • Farruggio DC, Townsley FM, Ruderman JV.Cdc20 associates with the kinase aurora2/Aik.Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7306-11.
  • Arvand A, Bastians H, Welford SM, Thompson AD, Ruderman JV, Denny CT.EWS/FLI1 up regulates mE2-C, a cyclin-selective ubiquitin conjugating enzyme involved in cyclin B destruction.Oncogene. 1998 Oct 22;17(16):2039-45.
  • Andrésson T, Ruderman JV.The kinase Eg2 is a component of the Xenopus oocyte progesterone-activated signaling pathway.EMBO J. 1998 Oct 1;17(19):5627-37.
  • Townsley FM, Ruderman JV.Proteolytic ratchets that control progression through mitosis.Trends Cell Biol. 1998 Jun;8(6):238-44.
  • Townsley FM, Ruderman JV.Functional analysis of the Saccharomyces cerevisiae UBC11 gene.Yeast. 1998 Jun 15;14(8):747-57.
  • Sadler KC, Ruderman JV.Components of the signaling pathway linking the 1-methyladenine receptor to MPF activation and maturation in starfish oocytes.Dev Biol. 1998 May 1;197(1):25-38.
  • Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV.Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase.Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2362-7.
  • Ruderman JV, Sudakin V, Hershko A.Preparation of clam oocyte extracts for cell cycle studies.Methods Enzymol. 1997;283:614-22.
  • Aristarkhov A, Eytan E, Moghe A, Admon A, Hershko A, Ruderman JV.E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins.Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4294-9.
  • Shibuya EK, Morris J, Rapp UR, Ruderman JV.Activation of the Xenopus oocyte mitogen-activated protein kinase pathway by Mos is independent of Raf.Cell Growth Differ. 1996 Feb;7(2):235-41.
  • Lahav-Baratz S, Sudakin V, Ruderman JV, Hershko A.Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase.Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9303-7.
  • Sudakin V, Ganoth D, Dahan A, Heller H, Hershko J, Luca FC, Ruderman JV, Hershko A.The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.Mol Biol Cell. 1995 Feb;6(2):185-97.
  • Hershko A, Ganoth D, Sudakin V, Dahan A, Cohen LH, Luca FC, Ruderman JV, Eytan E.Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2.J Biol Chem. 1994 Feb 18;269(7):4940-6.
  • Zheng XF, Ruderman JV.Functional analysis of the P box, a domain in cyclin B required for the activation of Cdc25.Cell. 1993 Oct 8;75(1):155-64.
  • Shibuya EK, Ruderman JV.Mos induces the in vitro activation of mitogen-activated protein kinases in lysates of frog oocytes and mammalian somatic cells.Mol Biol Cell. 1993 Aug;4(8):781-90.
  • Ruderman JV.MAP kinase and the activation of quiescent cells.Curr Opin Cell Biol. 1993 Apr;5(2):207-13.
  • Zhang H, Ruderman JV.Differential replication capacities of G1 and S-phase extracts from sea urchin eggs.J Cell Sci. 1993 Feb;104 ( Pt 2):565-72.
  • Shibuya EK, Boulton TG, Cobb MH, Ruderman JV.Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest.EMBO J. 1992 Nov;11(11):3963-75.
  • Shibuya EK, Polverino AJ, Chang E, Wigler M, Ruderman JV.Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes.Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9831-5.
  • Hunt T, Luca FC, Ruderman JV.The requirements for protein synthesis and degradation, and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryo.J Cell Biol. 1992 Feb;116(3):707-24.
  • Luca FC, Shibuya EK, Dohrmann CE, Ruderman JV.Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction.EMBO J. 1991 Dec;10(13):4311-20.
  • Motokura T, Bloom T, Kim HG, Jüppner H, Ruderman JV, Kronenberg HM, Arnold A.A novel cyclin encoded by a bcl1-linked candidate oncogene.Nature. 1991 Apr 11;350(6318):512-5.
  • Luca FC, Ruderman JV.Control of programmed cyclin destruction in a cell-free system.J Cell Biol. 1989 Nov;109(5):1895-909.
  • Westendorf JM, Swenson KI, Ruderman JV.The role of cyclin B in meiosis I.J Cell Biol. 1989 Apr;108(4):1431-44.
  • Minshull J, Pines J, Golsteyn R, Standart N, Mackie S, Colman A, Blow J, Ruderman JV, Wu M, Hunt T.The role of cyclin synthesis, modification and destruction in the control of cell division.J Cell Sci Suppl. 1989;12:77-97.
  • Swenson KI, Borgese N, Pietrini G, Ruderman JV.Three translationally regulated mRNAs are stored in the cytoplasm of clam oocytes.Dev Biol. 1987 Sep;123(1):10-6.
  • Rosenthal ET, Ruderman JV.Widespread changes in the translation and adenylation of maternal messenger RNAs following fertilization of Spisula oocytes.Dev Biol. 1987 May;121(1):237-46.
  • Standart N, Hunt T, Ruderman JV.Differential accumulation of ribonucleotide reductase subunits in clam oocytes: the large subunit is stored as a polypeptide, the small subunit as untranslated mRNA.J Cell Biol. 1986 Dec;103(6 Pt 1):2129-36.
  • Alexandraki D, Ruderman JV.Expression of alpha- and beta-tubulin genes during development of sea urchin embryos.Dev Biol. 1985 Jun;109(2):436-51.
  • Standart NM, Bray SJ, George EL, Hunt T, Ruderman JV.The small subunit of ribonucleotide reductase is encoded by one of the most abundant translationally regulated maternal RNAs in clam and sea urchin eggs.J Cell Biol. 1985 Jun;100(6):1968-76.
  • Sjöberg BM, Eklund H, Fuchs JA, Carlson J, Standart NM, Ruderman JV, Bray SJ, Hunt T.Identification of the stable free radical tyrosine residue in ribonucleotide reductase. A sequence comparison.FEBS Lett. 1985 Apr 8;183(1):99-102.
  • Alexandraki D, Ruderman JV.Multiple polymorphic alpha- and beta-tubulin mRNAs are present in sea urchin eggs.Proc Natl Acad Sci U S A. 1985 Jan;82(1):134-8.
  • Tansey TR, Ruderman JV.Differential mRNA accumulation and translation during Spisula development.Dev Biol. 1983 Oct;99(2):338-51.
  • Rosenthal ET, Tansey TR, Ruderman JV.Sequence-specific adenylations and deadenylations accompany changes in the translation of maternal messenger RNA after fertilization of Spisula oocytes.J Mol Biol. 1983 May 25;166(3):309-27.
  • Alexandraki D, Ruderman JV.Evolution of alpha q- and beta-tubulin genes as inferred by the nucleotide sequences of sea urchin cDNA clones.J Mol Evol. 1983;19(6):397-410.
  • Rosenthal ET, Brandhorst BP, Ruderman JV.Translationally mediated changes in patterns of protein synthesis during maturation of starfish oocytes.Dev Biol. 1982 May;91(1):215-20.
  • Alexandraki D, Ruderman JV.Sequence heterogeneity, multiplicity, and genomic organization of alpha- and beta-tubulin genes in sea urchins.Mol Cell Biol. 1981 Dec;1(12):1125-37.
  • Ruderman JV, Schmidt MR.RNA transcription and translation in sea urchin oocytes and eggs.Dev Biol. 1981 Jan 30;81(2):220-8.
  • Rosenthal ET, Hunt T, Ruderman JV.Selective translation of mRNA controls the pattern of protein synthesis during early development of the surf clam, Spisula solidissima.Cell. 1980 Jun;20(2):487-94.
  • Ruderman JV, Woodland HR, Sturgess EA.Modulations of histone messenger RNA during the early development of Xenopus laevis.Dev Biol. 1979 Jul;71(1):71-82.
  • Ruderman JV, Pardue ML.A portion of all major classes of histone messenger RNA in amphibian oocytes is polyadenylated.J Biol Chem. 1978 Mar 25;253(6):2018-25.
  • Ruderman JV, Pardue ML.Cell-free translation analysis of messenger RNA in echinoderm and amphibian early development.Dev Biol. 1977 Oct 1;60(1):48-68.
  • Kamalay JC, Ruderman JV, Goldberg RB.DNA sequence repetition in the genome of the American oyster.Biochim Biophys Acta. 1976 May 3;432(2):121-8.
  • Goldberg RB, Crain WR, Ruderman JV, Moore GP, Barnett TR, Higgins RC, Gelfand RA, Galau GA, Britten RJ, Davidson EH.DNA sequence organization in the genomes of five marine invertebrates.Chromosoma. 1975 Jul 21;51(3):225-51.
  • Ruderman JV, Gross PR.Histones and histone synthesis in sea urchin development.Dev Biol. 1974 Feb;36(2):286-98.
  • Ruderman JV, Baglioni C, Gross PR.Histone mRNA and histone synthesis during embryogenesis.Nature. 1974 Jan 4;247(435):36-8.
  • Gross PR, Gross KW, Skoultchi AI, Ruderman JV.Maternal mRNA and protein synthesis in the embryo.Acta Endocrinol Suppl (Copenh). 1973;180:244-62.