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Sridhar Ramaswamy, MD

Publications

  • Luo X, Mitra D, Sullivan RJ, Wittner BS, Kimura AM, Pan S, Hoang MP, Brannigan BW, Lawrence DP, Flaherty KT, Sequist LV, McMahon M, Bosenberg MW, Stott SL, Ting DT, Ramaswamy S, Toner M, Fisher DE, Maheswaran S, Haber DA.Isolation and Molecular Characterization of Circulating Melanoma Cells.Cell Rep. 2014 Apr 16.
    24746818
  • Foudi A, Kramer DJ, Qin J, Ye D, Behlich AS, Mordecai S, Preffer FI, Amzallag A, Ramaswamy S, Hochedlinger K, Orkin SH, Hock H.Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation.J Exp Med. 2014 Apr 7.
    24711581
  • McMullin RP, Wittner BS, Yang C, Denton-Schneider BR, Hicks D, Singavarapu R, Moulis S, Lee J, Akbari MR, Narod SA, Aldape KD, Steeg PS, Ramaswamy S, Sgroi DC.A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity.Breast Cancer Res. 2014 Mar 14;16(2):R25.
    24625110
  • Faber AC, Coffee EM, Costa C, Dastur A, Ebi H, Hata AN, Yeo AT, Edelman EJ, Song Y, Tam AT, Boisvert JL, Milano RJ, Roper J, Kodack DP, Jain RK, Corcoran RB, Rivera MN, Ramaswamy S, Hung KE, Benes CH, Engelman JA.mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.Cancer Discovery. 2014 Jan;4(1):42-52.
    24163374
  • Javaid S, Zhang J, Anderssen E, Black JC, Wittner BS, Tajima K, Ting DT, Smolen GA, Zubrowski M, Desai R, Maheswaran S, Ramaswamy S, Whetstine JR, Haber DA.Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1.Cell Rep. 2013 Dec 26;5(6):1679-89.
    24360956
  • Liu M, Roth A, Yu M, Morris R, Bersani F, Rivera MN, Lu J, Shioda T, Vasudevan S, Ramaswamy S, Maheswaran S, Diederichs S, Haber DA.The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis.Genes Dev. 2013 Dec 1;27(23):2543-8.
    24298054
  • Chen EY, Dobrinski KP, Brown KH, Clagg R, Edelman E, Ignatius MS, Chen JY, Brockmann J, Nielsen GP, Ramaswamy S, Keller C, Lee C, Langenau DM.Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma.PLoS Genet. 2013 Aug;9(8):e1003727.
    24009521
  • Keliher EJ, Reiner T, Earley S, Klubnick J, Tassa C, Lee AJ, Ramaswamy S, Bardeesy N, Hanahan D, Depinho RA, Castro CM, Weissleder R.Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection.Neoplasia. 2013 Jul;15(7):684-93.
    23814481
  • Desmet CJ, Gallenne T, Prieur A, Reyal F, Visser NL, Wittner BS, Smit MA, Geiger TR, Laoukili J, Iskit S, Rodenko B, Zwart W, Evers B, Horlings H, Ajouaou A, Zevenhoven J, van Vliet M, Ramaswamy S, Wessels LF, Peeper DS.Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis.Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5139-44.
    23483055
  • Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, Isakoff SJ, Ciciliano JC, Wells MN, Shah AM, Concannon KF, Donaldson MC, Sequist LV, Brachtel E, Sgroi D, Baselga J, Ramaswamy S, Toner M, Haber DA, Maheswaran S.Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition.Science. 2013 Feb 1;339(6119):580-4.
    23372014
  • Polo JM, Anderssen E, Walsh RM, Schwarz BA, Nefzger CM, Lim SM, Borkent M, Apostolou E, Alaei S, Cloutier J, Bar-Nur O, Cheloufi S, Stadtfeld M, Figueroa ME, Robinton D, Natesan S, Melnick A, Zhu J, Ramaswamy S, Hochedlinger K.A molecular roadmap of reprogramming somatic cells into iPS cells.Cell. 2012 Dec 21;151(7):1617-32.
    23260147
  • Yang W, Soares J, Greninger P, Edelman EJ, Lightfoot H, Forbes S, Bindal N, Beare D, Smith JA, Thompson IR, Ramaswamy S, Futreal PA, Haber DA, Stratton MR, Benes C, McDermott U, Garnett MJ.Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells.Nucleic Acids Res. 2013 Jan;41(Database issue):D955-61.
    23180760
  • Miyamoto DT, Lee RJ, Stott SL, Ting DT, Wittner BS, Ulman M, Smas ME, Lord JB, Brannigan BW, Trautwein J, Bander NH, Wu CL, Sequist LV, Smith MR, Ramaswamy S, Toner M, Maheswaran S, Haber DA.Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer.Cancer Discovery. 2012 Nov;2(11):995-1003.
    23093251
  • Jalili A, Wagner C, Pashenkov M, Pathria G, Mertz KD, Widlund HR, Lupien M, Brunet JP, Golub TR, Stingl G, Fisher DE, Ramaswamy S, Wagner SN.Dual Suppression of the Cyclin-Dependent Kinase Inhibitors CDKN2C and CDKN1A in Human Melanoma.Journal of the National Cancer Institute. 2012 Nov 7;104(21):1673-9.
    22997239
  • Korenjak M, Anderssen E, Ramaswamy S, Whetstine JR, Dyson NJ.RBF Binding to both Canonical E2F Targets and Noncanonical Targets Depends on Functional dE2F/dDP Complexes.Mol Cell Biol. 2012 Nov;32(21):4375-87.
    22927638
  • Qin J, Whyte WA, Anderssen E, Apostolou E, Chen HH, Akbarian S, Bronson RT, Hochedlinger K, Ramaswamy S, Young RA, Hock H.The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.Cell Stem Cell. 2012 Sep 7;11(3):319-32.
    22770845
  • Yu M, Ting DT, Stott SL, Wittner BS, Ozsolak F, Paul S, Ciciliano JC, Smas ME, Winokur D, Gilman AJ, Ulman MJ, Xega K, Contino G, Alagesan B, Brannigan BW, Milos PM, Ryan DP, Sequist LV, Bardeesy N, Ramaswamy S, Toner M, Maheswaran S, Haber DA.RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis.Nature. 2012 Jul 26;487(7408):510-3.
    22763454
  • Garnett MJ, Edelman EJ, Heidorn SJ, Greenman CD, Dastur A, Lau KW, Greninger P, Thompson IR, Luo X, Soares J, Liu Q, Iorio F, Surdez D, Chen L, Milano RJ, Bignell GR, Tam AT, Davies H, Stevenson JA, Barthorpe S, Lutz SR, Kogera F, Lawrence K, McLaren-Douglas A, Mitropoulos X, Mironenko T, Thi H, Richardson L, Zhou W, Jewitt F, Zhang T, O'Brien P, Boisvert JL, Price S, Hur W, Yang W, Deng X, Butler A, Choi HG, Chang JW, Baselga J, Stamenkovic I, Engelman JA, Sharma SV, Delattre O, Saez-Rodriguez J, Gray NS, Settleman J, Futreal PA, Haber DA, Stratton MR, Ramaswamy S, McDermott U, Benes CH.Systematic identification of genomic markers of drug sensitivity in cancer cells.Nature. 2012 Mar 29;483(7391):570-5.
    22460902
  • Dey-Guha I, Wolfer A, Yeh AC, G Albeck J, Darp R, Leon E, Wulfkuhle J, Petricoin EF, Wittner BS, Ramaswamy S.Asymmetric cancer cell division regulated by AKT.Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12845-50.
    21757645
  • Sharma SV, Lee DY, Li B, Quinlan MP, Takahashi F, Maheswaran S, McDermott U, Azizian N, Zou L, Fischbach MA, Wong KK, Brandstetter K, Wittner B, Ramaswamy S, Classon M, Settleman J.A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations.Cell. 2010 Apr 2;141(1):69-80.
    20371346
  • Wolfer A, Wittner BS, Irimia D, Flavin RJ, Lupien M, Gunawardane RN, Meyer CA, Lightcap ES, Tamayo P, Mesirov JP, Liu XS, Shioda T, Toner M, Loda M, Brown M, Brugge JS, Ramaswamy S.MYC regulation of a "poor-prognosis" metastatic cancer cell state.Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3698-703.
    20133671
  • Ramaswamy S.Rational design of cancer-drug combinations.N Engl J Med. 2007 Jul 19;357(3):299-300.
    17634467
  • Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, Savagner P, Gitelman I, Richardson A, Weinberg RA.Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis.Cell. 2004 Jun 25;117(7):927-39.
    15210113
  • Ramaswamy S.Translating cancer genomics into clinical oncology.N Engl J Med. 2004 Apr 29;350(18):1814-6.
    15115827
  • Lamb J, Ramaswamy S, Ford HL, Contreras B, Martinez RV, Kittrell FS, Zahnow CA, Patterson N, Golub TR, Ewen ME.A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer.Cell. 2003 Aug 8;114(3):323-34.
    12914697
  • Ramaswamy S, Perou CM.DNA microarrays in breast cancer: the promise of personalised medicine.Lancet. 2003 May 10;361(9369):1576-7.
    12747872
  • Ramaswamy S, Ross KN, Lander ES, Golub TR.A molecular signature of metastasis in primary solid tumors.Nat Genet. 2003 Jan;33(1):49-54.
    12469122
  • Ramaswamy S, Golub TR.DNA microarrays in clinical oncology.J Clin Oncol. 2002 Apr 1;20(7):1932-41.
    11919254
  • Ramaswamy S, Tamayo P, Rifkin R, Mukherjee S, Yeang CH, Angelo M, Ladd C, Reich M, Latulippe E, Mesirov JP, Poggio T, Gerald W, Loda M, Lander ES, Golub TR.Multiclass cancer diagnosis using tumor gene expression signatures.Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15149-54.
    11742071