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Gary B. Ruvkun, PhD

Publications

  • Liu Y, Samuel BS, Breen PC, Ruvkun G.Caenorhabditis elegans pathways that surveil and defend mitochondria.Nature. 2014 Apr 17;508(7496):406-10.
    24695221
  • Phillips CM, Montgomery BE, Breen PC, Roovers EF, Rim YS, Ohsumi TK, Newman MA, van Wolfswinkel JC, Ketting RF, Ruvkun G, Montgomery TA.MUT-14 and SMUT-1 DEAD Box RNA Helicases Have Overlapping Roles in Germline RNAi and Endogenous siRNA Formation.Curr Biol. 2014 Apr 14;24(8):839-44.
    24684932
  • Fischer SE, Pan Q, Breen PC, Qi Y, Shi Z, Zhang C, Ruvkun G.Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans.Genes Dev. 2013 Dec 15;27(24):2678-95.
    24352423
  • Schwartz S, Agarwala SD, Mumbach MR, Jovanovic M, Mertins P, Shishkin A, Tabach Y, Mikkelsen TS, Satija R, Ruvkun G, Carr SA, Lander ES, Fink GR, Regev A.High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis.Cell. 2013 Dec 5;155(6):1409-21.
    24269006
  • Soukas AA, Carr CE, Ruvkun G.Genetic regulation of Caenorhabditis elegans lysosome related organelle function.PLoS Genet. 2013 Oct;9(10):e1003908.
    24204312
  • Tabach Y, Golan T, Hernández-Hernández A, Messer AR, Fukuda T, Kouznetsova A, Liu JG, Lilienthal I, Levy C, Ruvkun G.Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling.Mol Syst Biol. 2013;9:692.
    24084807
  • Shi Z, Hayes G, Ruvkun G.Dual regulation of the lin-14 target mRNA by the lin-4 miRNA.PLoS ONE. 2013;8(9):e75475.
    24058689
  • Carr CE, Rowedder H, Lui CS, Zlatkovsky I, Papalias CW, Bolander J, Myers JW, Bustillo J, Rothberg JM, Zuber MT, Ruvkun G.Radiation resistance of sequencing chips for in situ life detection.Astrobiology. 2013 Jun;13(6):560-9.
    23734755
  • Shore DE, Ruvkun G.A cytoprotective perspective on longevity regulation.Trends Cell Biol. 2013 Sep;23(9):409-20.
    23726168
  • Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK, Kingston RE, Dillin A, Asara JM, Ruvkun G.DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity.Nat Cell Biol. 2013 Apr 21.
    23604319
  • Tacutu R, Shore DE, Budovsky A, de Magalhães JP, Ruvkun G, Fraifeld VE, Curran SP.Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.PLoS ONE. 2012;7(10):e48282.
    23144747
  • Zhang C, Ruvkun G.New insights into siRNA amplification and RNAi.RNA Biol. 2012 Aug 1;9(8).
    22858672
  • Shore DE, Carr CE, Ruvkun G.Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways.PLoS Genet. 2012 Jul;8(7):e1002792.
    22829775
  • Phillips CM, Montgomery TA, Breen PC, Ruvkun G.MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline.Genes Dev. 2012 Jul 1;26(13):1433-44.
    22713602
  • Wang MC, Min W, Freudiger CW, Ruvkun G, Xie XS.RNAi screening for fat regulatory genes with SRS microscopy.Nat Methods. 2011 Feb;8(2):135-8.
    21240281
  • Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G.mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans.Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1201-8.
    21245313
  • Wu X, Ruvkun G.Cancer. Germ cell genes and cancer.Science. 2010 Dec 24;330(6012):1761-2.
    21205660
  • Meli VS, Osuna B, Ruvkun G, Frand AR.MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans.Mol Biol Cell. 2010 May 15;21(10):1648-61.
    20335506
  • Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT.RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.PLoS ONE. 2009;4(12):e8210.
    20011587
  • O'Rourke EJ, Soukas AA, Carr CE, Ruvkun G.C. elegans major fats are stored in vesicles distinct from lysosome-related organelles.Cell Metab. 2009 Nov;10(5):430-5.
    19883620
  • Curran SP, Wu X, Riedel CG, Ruvkun G.A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants.Nature. 2009 Jun 25;459(7250):1079-84.
    19506556
  • Simon DJ,Madison JM,Conery AL,Thompson-Peer KL,Soskis M,Ruvkun GB,Kaplan JM,Kim JK.The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions.Cell. 2008 May 30;133(5):903-15.
    18510933
  • Gabel HW, Ruvkun G.The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.Nat Struct Mol Biol. 2008 May;15(5):531-3.
    18438419
  • Pierce ML, Weston MD, Fritzsch B, Gabel HW, Ruvkun G, Soukup GA.MicroRNA-183 family conservation and ciliated neurosensory organ expression.Evol Dev. 2008 Jan-Feb;10(1):106-13.
    18184361
  • Parry DH, Xu J, Ruvkun G.A whole-genome RNAi Screen for C. elegans miRNA pathway genes.Curr Biol. 2007 Dec 4;17(23):2013-22.
    18023351
  • Samuelson AV, Carr CE, Ruvkun G.Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.Genes Dev. 2007 Nov 15;21(22):2976-94.
    18006689
  • Kim N, Dempsey CM, Kuan CJ, Zoval JV, O'Rourke E, Ruvkun G, Madou MJ, Sze JY.Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans.Genetics. 2007 Oct;177(2):835-45.
    17720915
  • Curran SP, Ruvkun G.Lifespan regulation by evolutionarily conserved genes essential for viability.PLoS Genet. 2007 Apr 6;3(4):e56.
    17411345
  • Hayes GD, Ruvkun G.Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs.Cold Spring Harb Symp Quant Biol. 2006;71:21-7.
    17381276
  • Hayes GD, Frand AR, Ruvkun G.The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25.Development. 2006 Dec;133(23):4631-41.
    17065234
  • Ruvinsky I, Ohler U, Burge CB, Ruvkun G.Detection of broadly expressed neuronal genes in C. elegans.Dev Biol. 2007 Feb 15;302(2):617-26.
    17046742
  • Hu PJ, Xu J, Ruvkun G.Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling.PLoS Genet. 2006 Jul;2(7):e99.
    16839187
  • Sandoval GM, Duerr JS, Hodgkin J, Rand JB, Ruvkun G.A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans.Nat Neurosci. 2006 May;9(5):599-601.
    16604067
  • Mak HY, Nelson LS, Basson M, Johnson CD, Ruvkun G.Polygenic control of Caenorhabditis elegans fat storage.Nat Genet. 2006 Mar;38(3):363-8.
    16462744
  • Duchaine TF, Wohlschlegel JA, Kennedy S, Bei Y, Conte D, Pang K, Brownell DR, Harding S, Mitani S, Ruvkun G, Yates JR, Mello CC.Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways.Cell. 2006 Jan 27;124(2):343-54.
    16439208
  • Ruvkun G.Clarifications on miRNA and cancer.Science. 2006 Jan 6;311(5757):36-7.
    16400132
  • Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, Dupuy D, Rual JF, Hill DE, Vidal M, Ruvkun G, Kaplan JM.Systematic analysis of genes required for synapse structure and function.Nature. 2005 Jul 28;436(7050):510-7.
    16049479
  • Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G.Functional genomic analysis of RNA interference in C. elegans.Science. 2005 May 20;308(5725):1164-7.
    15790806
  • Tewari M, Hu PJ, Ahn JS, Ayivi-Guedehoussou N, Vidalain PO, Li S, Milstein S, Armstrong CM, Boxem M, Butler MD, Busiguina S, Rual JF, Ibarrola N, Chaklos ST, Bertin N, Vaglio P, Edgley ML, King KV, Albert PS, Vandenhaute J, Pandey A, Riddle DL, Ruvkun G, Vidal M.Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network.Mol Cell. 2004 Feb 27;13(4):469-82.
    14992718
  • Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G.Identification of many microRNAs that copurify with polyribosomes in mammalian neurons.Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):360-5.
    14691248
  • Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges MC.DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10412-7.
    10973497
  • Sze JY, Victor M, Loer C, Shi Y, Ruvkun G.Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant.Nature. 2000 Feb 3;403(6769):560-4.
    10676966