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David P. Ryan, MD
Publications
- Kozyreva ON, Chi D, Clark JW, Wang H, Theall KP, Ryan DP, Zhu AX.A multicenter retrospective study on clinical characteristics, treatment patterns, and outcome in elderly patients with hepatocellular carcinoma.Oncologist. 2011;16(3):310-8.
21349948 - Margalit DN, Mamon HJ, Ancukiewicz M, Kobayashi W, Ryan DP, Blaszkowsky LS, Clark J, Willett CG, Hong TS.Tolerability of Combined Modality Therapy for Rectal Cancer in Elderly Patients Aged 75 Years and Older.Int J Radiat Oncol Biol Phys. 2011 Mar 4.
21377289 - Goldberg RM, Ryan DP.Scan? Cure? Sure!.Oncologist. 2011;16(2):254-6.
21349952 - Chan JA, Blaszkowsky LS, Enzinger PC, Ryan DP, Abrams TA, Zhu AX, Temel JS, Schrag D, Bhargava P, Meyerhardt JA, Wolpin BM, Fidias P, Zheng H, Florio S, Regan E, Fuchs CS.A multicenter phase II trial of single-agent cetuximab in advanced esophageal and ga
21217058 - Hong TS, Ryan DP, Blaszkowsky LS, Mamon HJ, Kwak EL, Mino-Kenudson M, Adams J, Yeap B, Winrich B, Delaney TF, Fernandez-Del Castillo C.Phase I Study of Preoperative Short-Course Chemoradiation with Proton Beam Therapy and Capecitabine for Resectable Pancr
20421151 - Kachnic LA, Tsai HK, Coen JJ, Blaszkowsky LS, Hartshorn K, Kwak EL, Willins JD, Ryan DP, Hong TS.Dose-painted Intensity-modulated Radiation Therapy for Anal Cancer: A Multi-institutional Report of Acute Toxicity and Response to Therapy.Int J Radiat Oncol
21095071 - Zhu AX, Duda DG, Ancukiewicz M, di Tomaso E, Clark JW, Miksad R, Fuchs CS, Ryan DP, Jain RK.Exploratory analysis of early toxicity of sunitinib in advanced hepatocellular carcinoma patients: Kinetics and potential biomarker value.Clin Cancer Res. 2010 Sep
20843836 - Murphy JE, Ryan DP.American Society of Clinical Oncology 2010 colorectal update.Expert Rev Anticancer Ther. 2010 Sep;10(9):1371-3.
20836671 - Wadlow RC, Ryan DP.The role of targeted agents in preoperative chemoradiation for rectal cancer.Cancer. 2010 Aug 1;116(15):3537-48. Review.
20564106 - Miyamoto DT, Mamon HJ, Ryan DP, Willett CG, Ancukiewicz M, Kobayashi WK, Blaszkowsky L, Castillo CF, Hong TS.Outcomes and Tolerability of Chemoradiation Therapy for Pancreatic Cancer Patients Aged 75 Years or Older.Int J Radiat Oncol Biol Phys. 2010 Jul 1
19800182 - Mak RH, Mamon HJ, Ryan DP, Miyamoto DT, Ancukiewicz M, Kobayashi WK, Willett CG, Choi NC, Blaszkowsky LS, Hong TS.Toxicity and outcomes after chemoradiation for esophageal cancer in patients age 75 or older.Diseases Of The Esophagus : Official Journal Of
19788436 - Ryan DP, Engelman JA, Ferrone CR, Sahani DV, Lisovsky M.Case records of the Massachusetts General Hospital. Case 19-2010. A 35-year-old man with adenocarcinoma of the cecum.N Engl J Med. 2010 Jun 24;362(25):2411-9.
20573930 - Zhu AX, Meyerhardt JA, Blaszkowsky LS, Kambadakone AR, Muzikansky A, Zheng H, Clark JW, Abrams TA, Chan JA, Enzinger PC, Bhargava P, Kwak EL, Allen JN, Jain SR, Stuart K, Horgan K, Sheehan S, Fuchs CS, Ryan DP, Sahani DV.Efficacy and safety of gemcitabine
19932054 - Engstrom PF, Arnoletti JP, Benson AB, Berlin JD, Berry JM, Chen YJ, Choti MA, Cooper HS, Dilawari RA, Early DS, Enzinger PC, Fakih MG, Fleshman J, Fuchs C, Grem JL, Knol JA, Leong LA, Lin E, Mulcahy MF, Rohren E, Ryan DP, Saltz L, Shibata D, Skibber JM, S
20064293 - Engstrom PF, Arnoletti JP, Benson AB, Chen YJ, Choti MA, Cooper HS, Covey A, Dilawari RA, Early DS, Enzinger PC, Fakih MG, Fleshman J, Fuchs C, Grem JL, Kiel K, Knol JA, Leong LA, Lin E, Mulcahy MF, Rao S, Ryan DP, Saltz L, Shibata D, Skibber JM, Sofocleo
19755046 - Engstrom PF, Arnoletti JP, Benson AB, Chen YJ, Choti MA, Cooper HS, Covey A, Dilawari RA, Early DS, Enzinger PC, Fakih MG, Fleshman J, Fuchs C, Grem JL, Kiel K, Knol JA, Leong LA, Lin E, Mulcahy MF, Rao S, Ryan DP, Saltz L, Shibata D, Skibber JM, Sofocleo
19755047 - Zhu AX,Sahani DV,Duda DG,di Tomaso E,Ancukiewicz M,Catalano OA,Sindhwani V,Blaszkowsky LS,Yoon SS,Lahdenranta J,Bhargava P,Meyerhardt J,Clark JW,Kwak EL,Hezel AF,Miksad R,Abrams TA,Enzinger PC,Fuchs CS,Ryan DP,Jain RK.Efficacy, Safety, and Potential Bioma
19470923 - Zawacki WJ,Walker TG,DeVasher E,Halpern EF,Waltman AC,Wicky ST,Ryan DP,Kalva SP.Wound dehiscence or failure to heal following venous access port placement in patients receiving bevacizumab therapy.J Vasc Interv Radiol. 2009 May;20(5):624-7; quiz 571.
19328717 - Goulart BH,Clark JW,Lauwers GY,Ryan DP,Grenon N,Muzikansky A,Zhu AX.Long term survivors with metastatic pancreatic adenocarcinoma treated with gemcitabine: a retrospective analysis.J Hematol Oncol. 2009;2:13.
19291303 - Kulke MH,Hornick JL,Frauenhoffer C,Hooshmand S,Ryan DP,Enzinger PC,Meyerhardt JA,Clark JW,Stuart K,Fuchs CS,Redston MS.O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors.Clin
19118063 - Zhu AX,Ready N,Clark JW,Safran H,Amato A,Salem N,Pace S,He X,Zvereva N,Lynch TJ,Ryan DP,Supko JG.Phase I and pharmacokinetic study of gimatecan given orally once a week for 3 of 4 weeks in patients with advanced solid tumors.Clin Cancer Res. 2009 Jan 1;15
19118068 - Wolpin BM,Hezel AF,Abrams T,Blaszkowsky LS,Meyerhardt JA,Chan JA,Enzinger PC,Allen B,Clark JW,Ryan DP,Fuchs CS.Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer.J Clin Oncol. 2009 Jan 10;27(2):193-8.
19047305 - Wright FC,Gagliardi AR,Law CH,Last LD,Klevan AE,Hongjinda S,Stitt LW,Klar N,Ryan DP,Smith AJ.A randomized controlled trial to improve lymph node assessment in stage II colon cancer.Arch Surg. 2008 Nov;143(11):1050-5; discussion 1055.
19015462 - Kulke MH,Lenz HJ,Meropol NJ,Posey J,Ryan DP,Picus J,Bergsland E,Stuart K,Tye L,Huang X,Li JZ,Baum CM,Fuchs CS.Activity of sunitinib in patients with advanced neuroendocrine tumors.J Clin Oncol. 2008 Jul 10;26(20):3403-10.
18612155 - Asomaning K,Reid AE,Zhou W,Heist RS,Zhai R,Su L,Kwak EL,Blaszkowsky L,Zhu AX,Ryan DP,Christiani DC,Liu G.MDM2 promoter polymorphism and pancreatic cancer risk and prognosis.Clin Cancer Res. 2008 Jun 15;14(12):4010-5.
18559624 - Kozuch PS, Rocha-Lima CM, Dragovich T, Hochster H, O'Neil BH, Atiq OT, Pipas JM, Ryan DP, Lenz HJ.Bortezomib with or without irinotecan in relapsed or refractory colorectal cancer: results from a randomized phase II study.J Clin Oncol. 2008 May 10;26(
18467723 - Haver KE, Hartnick CJ, Ryan DP, Shailam R, Mark EJ.Case records of the Massachusetts General Hospital. Case 10-2008. A 10-year-old girl with dyspnea on exertion.N Engl J Med. 2008 Mar 27;358(13):1382-90.
18367742 - Crippa S, Dominguez I, Rodriguez JR, Razo O, Thayer SP, Ryan DP, Warshaw AL, Fernandez-Del Castillo C.Quality of life in pancreatic cancer: analysis by stage and treatment.J Gastrointest Surg. 2008 May;12(5):783-94.
18317851 - Meyerhardt JA, Zhu AX, Stuart K, Ryan DP, Blaszkowsky L, Lehman N, Earle CC, Kulke MH, Bhargava P, Fuchs CS.Phase-II Study of Gemcitabine and Cisplatin in Patients with Metastatic Biliary and Gallbladder Cancer.Dig Dis Sci. 2008 Feb;53(2):564-70.
17597402 - Wheatley-Price P, Asomaning K, Reid A, Zhai R, Su L, Zhou W, Zhu A, Ryan DP, Christiani DC, Liu G.Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma.Cancer. 2008 Mar 1;112(5
18205184 - Kachnic LA, Hong TS, Ryan DP.Rectal cancer at the crossroads: the dilemma of clinically staged T3, N0, M0 disease.J Clin Oncol. 2008 Jan 20;26(3):350-1.
18202407 - Zuckerman DS, Ryan DP.Adjuvant therapy for pancreatic cancer: a review.Cancer. 2008 Jan 15;112(2):243-9. Review.
18050292 - Kulke MH, Blaszkowsky LS, Ryan DP, Clark JW, Meyerhardt JA, Zhu AX, Enzinger PC, Kwak EL, Muzikansky A, Lawrence C, Fuchs CS.Capecitabine plus erlotinib in gemcitabine-refractory advanced pancreatic cancer.J Clin Oncol. 2007 Oct 20;25(30):4787-92.
17947726 - Ryan DP, Duncan JL, Lee C, Kuchel PW, Matthews JM.Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12.Proteins. 2008 Mar;70(4):1461-74.
17910069 - Meyerhardt JA, Clark JW, Supko JG, Eder JP, Ogino S, Stewart CF, D'Amato F, Dancey J, Enzinger PC, Zhu AX, Ryan DP, Earle CC, Mayer RJ, Michelini A, Kinsella K, Fuchs CS.Phase I study of gefitinib, irinotecan, 5-fluorouracil and leucovorin in patients
17216531 - Meyerhardt J, Stuart K, Fuchs C, Zhu A, Earle C, Bhargava P, Blaszkowsky L, Enzinger P, Mayer R, Battu S, Lawrence C, Ryan D.Phase II study of FOLFOX, bevacizumab and erlotinib as first-line therapy for patients with metastastic colorectal cancer.Ann Onco
17483115 - Zhu AX, Stuart K, Blaszkowsky LS, Muzikansky A, Reitberg DP, Clark JW, Enzinger PC, Bhargava P, Meyerhardt JA, Horgan K, Fuchs CS, Ryan DP.Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma.Cancer. 2007 Aug 1;110(3):581-9.
17583545 - Kozak KR, Kachnic LA, Adams J, Crowley EM, Alexander BM, Mamon HJ, Fernandez-Del Castillo C, Ryan DP, DeLaney TF, Hong TS.Dosimetric feasibility of hypofractionated proton radiotherapy for neoadjuvant pancreatic cancer treatment.Int J Radiat Oncol Biol Ph
17544599 - Hezel AF, Ryan DP.Emerging therapies for colorectal cancer.Expert Opin Investig Drugs. 2007 Jun;16(6):867-76. Review.
17501698 - Ogino S, Meyerhardt JA, Kawasaki T, Clark JW, Ryan DP, Kulke MH, Enzinger PC, Wolpin BM, Loda M, Fuchs CS.CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma.Virchows Ar
17372756 - Berkenblit A, Eder JP, Ryan DP, Seiden MV, Tatsuta N, Sherman ML, Dahl TA, Dezube BJ, Supko JG.Phase I clinical trial of STA-4783 in combination with paclitaxel in patients with refractory solid tumors.Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):584-90.
17255281 - Zhu AX, Clark JW, Ryan DP, Meyerhardt JA, Enzinger PC, Earle CC, Fuchs CS, Regan E, Anbe H, Houghton M, Zhang J, Urrea P, Kulke MH.Phase I and pharmacokinetic study of S-1 administered for 14 days in a 21-day cycle in patients with advanced upper gastroin
16786333 - Ryan DP, O'Neil BH, Supko JG, Rocha Lima CM, Dees EC, Appleman LJ, Clark J, Fidias P, Orlowski RZ, Kashala O, Eder JP, Cusack JC.A Phase I study of bortezomib plus irinotecan in patients with advanced solid tumors.Cancer. 2006 Dec 1;107(11):2688-97.
17075878 - Ryan DP, Appleman LJ, Lynch T, Supko JG, Fidias P, Clark JW, Fishman M, Zhu AX, Enzinger PC, Kashala O, Cusack J, Eder JP.Phase I clinical trial of bortezomib in combination with gemcitabine in patients with advanced solid tumors.Cancer. 2006 Nov 15;107(1
17036355 - Ryan DP.Nonsurgical approaches to colorectal cancer.Oncologist. 2006 Oct;11(9):999-1002. Review.
17030641 - Wolpin BM, Clark JW, Meyerhardt JA, Earle CC, Ryan DP, Enzinger PC, Zhu AX, Blaszkowsky L, Battu S, Fuchs CS.Phase I study of gefitinib plus FOLFIRI in previously untreated patients with metastatic colorectal cancer.Clin Colorectal Cancer. 2006 Sep;6(3):2
17026790 - Kulke MH, Bergsland EK, Ryan DP, Enzinger PC, Lynch TJ, Zhu AX, Meyerhardt JA, Heymach JV, Fogler WE, Sidor C, Michelini A, Kinsella K, Venook AP, Fuchs CS.Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors.J Cl
16877721 - Kulke MH, Wu B, Ryan DP, Enzinger PC, Zhu AX, Clark JW, Earle CC, Michelini A, Fuchs CS.A phase II trial of irinotecan and cisplatin in patients with metastatic neuroendocrine tumors.Dig Dis Sci. 2006 Jun;51(6):1033-8.
16865563 - Garland LL, Hidalgo M, Mendelson DS, Ryan DP, Arun BK, Lovalvo JL, Eiseman IA, Olson SC, Lenehan PF, Eder JP.A phase I clinical and pharmacokinetic study of oral CI-1033 in combination with docetaxel in patients with advanced solid tumors.Clin Cancer Res.
16857802 - Kwak EL, Jankowski J, Thayer SP, Lauwers GY, Brannigan BW, Harris PL, Okimoto RA, Haserlat SM, Driscoll DR, Ferry D, Muir B, Settleman J, Fuchs CS, Kulke MH, Ryan DP, Clark JW, Sgroi DC, Haber DA, Bell DW.Epidermal growth factor receptor kinase domain mut
16857803 - Meyerhardt JA, Heseltine D, Ogino S, Clark JW, Enzinger PC, Ryan DP, Earle CC, Zhu AX, Fuchs CS.Efficacy of cetuximab after treatment with oral epidermal growth factor receptor tyrosine kinase inhibitor-based chemotherapy in metastatic colorectal cancer.C
16796793 - Ryan DP, Niedzwiecki D, Hollis D, Mediema BE, Wadler S, Tepper JE, Goldberg RM, Mayer RJ.Phase I/II Study of Preoperative Oxaliplatin, Fluorouracil, and External-Beam Radiation Therapy in Patients With Locally Advanced Rectal Cancer: Cancer and Leukemia G
16636336 - Bendell JC, Lauwers GY, Willett C, Clark JW, Warshaw AL, Wain JC, Ryan DP.Pancreatoblastoma in a teenage patient.Clin Adv Hematol Oncol. 2006 Feb;4(2):150-3; discussion 154.
16728924 - Zhu AX, Blaszkowsky LS, Ryan DP, Clark JW, Muzikansky A, Horgan K, Sheehan S, Hale KE, Enzinger PC, Bhargava P, Stuart K.Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma.J Cli
16622265 - Meyerhardt JA, Zhu AX, Enzinger PC, Ryan DP, Clark JW, Kulke MH, Earle CC, Vincitore M, Michelini A, Sheehan S, Fuchs CS.Phase II study of capecitabine, oxaliplatin, and erlotinib in previously treated patients with metastastic colorectal cancer.J Clin On
16622264 - Ryan DP, Sunde M, Kwan AH, Marianayagam NJ, Nancarrow AL, Vanden Hoven RN, Thompson LS, Baca M, Mackay JP, Visvader JE, Matthews JM.Identification of the Key LMO2-binding Determinants on Ldb1.J Mol Biol. 2006 May 26;359(1):66-75.
16616188 - George S, Desai J, Paul Eder J, Manola J, Ryan DP, Appleman LJ, Demetri GD.Selective kinase inhibition with daily imatinib intensifies toxicity of chemotherapy in patients with solid tumours.Eur J Cancer. 2006 May;42(7):864-70.
16503137 - McCollum AD, Wu B, Clark JW, Kulke MH, Enzinger PC, Ryan DP, Earle CC, Michelini A, Fuchs CS.The combination of capecitabine and thalidomide in previously treated, refractory metastatic colorectal cancer.Am J Clin Oncol. 2006 Feb;29(1):40-4.
16462501 - Kulke MH, Stuart K, Enzinger PC, Ryan DP, Clark JW, Muzikansky A, Vincitore M, Michelini A, Fuchs CS.Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors.J Clin Oncol. 2006 Jan 20;24(3):401-6.
16421420 - Wright FC, Law CH, Last LD, Klar N, Ryan DP, Smith AJ.A blended knowledge translation initiative to improve colorectal cancer staging [ISRCTN56824239].BMC Health Serv Res. 2006;6:4.
16412251 - Eder JP, Ryan DP, Appleman L, Zhu AX, Puchalski T, He X, Sonnichsen DS, Cooper M, Wright J, Clark JW, Supko JG.Phase I clinical trial of the farnesyltransferase inhibitor BMS-214662 administered as a weekly 24 h continuous intravenous infusion in patients
16362299 - Burstein HJ, Parker LM, Keshaviah A, Doherty J, Partridge AH, Schapira L, Ryan PD, Younger J, Harris LN, Moy B, Come SE, Schumer ST, Bunnell CA, Haldoupis M, Gelman R, Winer EP.Efficacy of pegfilgrastim and darbepoetin alfa as hematopoietic support for do
16293865 - Cunningham C, Appleman LJ, Kirvan-Visovatti M, Ryan DP, Regan E, Vukelja S, Bonate PL, Ruvuna F, Fram RJ, Jekunen A, Weitman S, Hammond LA, Eder JP.Phase I and pharmacokinetic study of the dolastatin-15 analogue tasidotin (ILX651) administered intravenous
16278405 - Willett CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, Kozin SV, Petit L, Jain RK, Chung DC, Sahani DV, Kalva SP, Cohen KS, Scadden DT, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Shellito PC, Mino-Kenudson M, Lauwers GY.Surrogate mark
16258121 - Ogino S, Meyerhardt JA, Cantor M, Brahmandam M, Clark JW, Namgyal C, Kawasaki T, Kinsella K, Michelini AL, Enzinger PC, Kulke MH, Ryan DP, Loda M, Fuchs CS.Molecular alterations in tumors and response to combination chemotherapy with gefitinib for advance
16166444 - Hamilton AL, Eder JP, Pavlick AC, Clark JW, Liebes L, Garcia-Carbonero R, Chachoua A, Ryan DP, Soma V, Farrell K, Kinchla N, Boyden J, Yee H, Zeleniuch-Jacquotte A, Wright J, Elliott P, Adams J, Muggia FM.Proteasome inhibition with bortezomib (PS-341): a
16135477 - Garcia-Carbonero R, Supko JG, Maki RG, Manola J, Ryan DP, Harmon D, Puchalski TA, Goss G, Seiden MV, Waxman A, Quigley MT, Lopez T, Sancho MA, Jimeno J, Guzman C, Demetri GD.Ecteinascidin-743 (ET-743) for chemotherapy-naive patients with advanced soft tis
16110008 - Kalva SP, Sahani DV, Ryan D, Fischman AJ, Hahn PF, Mueller P, Saini S.Detection of liver metastases from gastrointestinal cancer: comparision of high resolution MnDPDP enhanced MRI and FDG-PET.Acad Radiol. 2005 May;12 Suppl 1:S17-20.
16106540 - Clark JW, Eder JP, Ryan D, Lathia C, Lenz HJ.Safety and pharmacokinetics of the dual action raf kinase and vascular endothelial growth factor receptor inhibitor, BAY 43-9006, in patients with advanced, refractory solid tumors.Clin Cancer Res. 2005 Aug 1;1
16061863 - Ryan DP, Fernandez-del Castillo C, Willett CG, Brugge WR, Sahani D, Brachtel EF.Case records of the Massachusetts General Hospital. Case 20-2005. A 58-year-old man with locally advanced pancreatic cancer.N Engl J Med. 2005 Jun 30;352(26):2734-41.
15987923 - Zhu AX, Fuchs CS, Clark JW, Muzikansky A, Taylor K, Sheehan S, Tam K, Yung E, Kulke MH, Ryan DP.A phase II study of epirubicin and thalidomide in unresectable or metastatic hepatocellular carcinoma.Oncologist. 2005 Jun-Jul;10(6):392-8.
15967833 - Gribben JG, Ryan DP, Boyajian R, Urban RG, Hedley ML, Beach K, Nealon P, Matulonis U, Campos S, Gilligan TD, Richardson PG, Marshall B, Neuberg D, Nadler LM.Unexpected association between induction of immunity to the universal tumor antigen CYP1B1 and res
15958627 - Tseng JF, Willett CG, Fernandez-del Castillo C, Ryan DP, Clark JW, Zhu AX, Rattner DW, Winkelmann JL, Warshaw AL.Patients undergoing treatment for pancreatic adenocarcinoma can mount an effective immune response to vaccinations.Pancreatology. 2005;5(1):67
15775701 - Bendell JC, Eder JP, Clark JW, Fidias P, Lynch TJ, Seiden MV, Ryan DP.Phase I dose-escalation study of tezacitabine in combination with 5-fluorouracil in patients with advanced solid tumors.Cancer. 2005 May 1;103(9):1925-31.
15772958 - Willett CG, Del Castillo CF, Shih HA, Goldberg S, Biggs P, Clark JW, Lauwers G, Ryan DP, Zhu AX, Warshaw AL.Long-term results of intraoperative electron beam irradiation (IOERT) for patients with unresectable pancreatic cancer.Ann Surg. 2005 Feb;241(2):29
15650640 - McCollum AD, Kulke MH, Ryan DP, Clark JW, Shulman LN, Mayer RJ, Bartel S, Fuchs CS.Lack of efficacy of streptozocin and doxorubicin in patients with advanced pancreatic endocrine tumors.Am J Clin Oncol. 2004 Oct;27(5):485-8.
15596916 - Kulke MH, Kim H, Stuart K, Clark JW, Ryan DP, Vincitore M, Mayer RJ, Fuchs CS.A phase II study of docetaxel in patients with metastatic carcinoid tumors.Cancer Invest. 2004;22(3):353-9.
15493355 - Heymach JV, Desai J, Manola J, Davis DW, McConkey DJ, Harmon D, Ryan DP, Goss G, Quigley T, Van den Abbeele AD, Silverman SG, Connors S, Folkman J, Fletcher CD, Demetri GD.Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft ti
15355900 - Ryan DP, Eder JP, Puchlaski T, Seiden MV, Lynch TJ, Fuchs CS, Amrein PC, Sonnichsen D, Supko JG, Clark JW.Phase I clinical trial of the farnesyltransferase inhibitor BMS-214662 given as a 1-hour intravenous infusion in patients with advanced solid tumors.
15073096 - Zhu AX, Puchalski TA, Stanton VP, Ryan DP, Clark JW, Nesbitt S, Charlat O, Kelly P, Kreconus E, Chabner BA, Supko JG.Dihydropyrimidine dehydrogenase and thymidylate synthase polymorphisms and their association with 5-fluorouracil/leucovorin chemotherapy i
15025795 - Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK.Direct evi
14745444 - Eder JP, Garcia-Carbonero R, Clark JW, Supko JG, Puchalski TA, Ryan DP, Deluca P, Wozniak A, Campbell A, Rothermel J, LoRusso P.A phase I trial of daily oral 4'- N -benzoyl-staurosporine in combination with protracted continuous infusion 5-Fluorouraci
14739662 - Supko JG, Eder JP, Ryan DP, Seiden MV, Lynch TJ, Amrein PC, Kufe DW, Clark JW.Phase I clinical trial and pharmacokinetic study of the spicamycin analog KRN5500 administered as a 1-hour intravenous infusion for five consecutive days to patients with refrac
14613997 - Ryan DP, Clark JW, Kulke MH, Fuchs CS, Earle CC, Enzinger PC, Stuart K, Catarius KJ, Winkelmann J, Mayer RJ.A phase II study of modified deGramont 5-fluorouracil, leucovorin, and oxaliplatin in previously treated patients with metastatic colorectal cancer
14533439 - Stephen AE, Segev DL, Ryan DP, Mullins ME, Kim SH, Schnitzer JJ, Doody DP.The diagnosis of acute appendicitis in a pediatric population: to CT or not to CT.J Pediatr Surg. 2003 Mar;38(3):367-71; discsussion 367-7.
12632351 - Michaelson MD, Ryan DP, Fuchs CS, Supko JG, Garcia-Carbonero R, Paul Eder J, Clark JW.A Phase I study of 9-nitrocamptothecin given concurrently with capecitabine in patients with refractory, metastatic solid tumors.Cancer. 2003 Jan 1;97(1):148-54.
12491516 - Ryan DP, Puchalski T, Supko JG, Harmon D, Maki R, Garcia-Carbonero R, Kuhlman C, Winkelman J, Merriam P, Quigley T, Jimeno J, Manola J, Demetri GD.A phase II and pharmacokinetic study of ecteinascidin 743 in patients with gastrointestinal stromal tumors.O
12490740 - Kulke MH, Demetri GD, Sharpless NE, Ryan DP, Shivdasani R, Clark JS, Spiegelman BM, Kim H, Mayer RJ, Fuchs CS.A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer.Ca
12416897 - Puchalski TA, Ryan DP, Garcia-Carbonero R, Demetri GD, Butkiewicz L, Harmon D, Seiden MV, Maki RG, Lopez-Lazaro L, Jimeno J, Guzman C, Supko JG.Pharmacokinetics of ecteinascidin 743 administered as a 24-h continuous intravenous infusion to adult patients
12357306 - Eder JP, Supko JG, Clark JW, Puchalski TA, Garcia-Carbonero R, Ryan DP, Shulman LN, Proper J, Kirvan M, Rattner B, Connors S, Keogan MT, Janicek MJ, Fogler WE, Schnipper L, Kinchla N, Sidor C, Phillips E, Folkman J, Kufe DW.Phase I clinical trial of recom
12228197 - Fuchs CS, Clark JW, Ryan DP, Kulke MH, Kim H, Earle CC, Vincitore M, Mayer RJ, Stuart KE.A phase II trial of gemcitabine in patients with advanced hepatocellular carcinoma.Cancer. 2002 Jun 15;94(12):3186-91.
12115351 - Seiden MV, Ng SW, Supko JG, Ryan DP, Clark JW, Lynch T, Huang KC, Kwiatkowski D, Skarin A, Eder JP.A phase I clinical trial of sequentially administered doxorubicin and topotecan in refractory solid tumors.Clin Cancer Res. 2002 Mar;8(3):691-7.
11895897 - Ryan DP, Kulke MH, Fuchs CS, Grossbard ML, Grossman SR, Morgan JA, Earle CC, Shivdasani R, Kim H, Mayer RJ, Clark JW.A Phase II study of gemcitabine and docetaxel in patients with metastatic pancreatic carcinoma.Cancer. 2002 Jan 1;94(1):97-103.
11815964 - Betensky RA, Lindsey JC, Ryan LM, Wand MP.A local likelihood proportional hazards model for interval censored data.Stat Med. 2002 Jan 30;21(2):263-75.
11782064 - Ryan DP, Supko JG, Eder JP, Seiden MV, Demetri G, Lynch TJ, Fischman AJ, Davis J, Jimeno J, Clark JW.Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies.Clin
11234874 - Ryan DP, Lynch TJ, Grossbard ML, Seiden MV, Fuchs CS, Grenon N, Baccala P, Berg D, Finkelstein D, Mayer RJ, Clark JW.A phase I study of gemcitabine and docetaxel in patients with metastatic solid tumors.Cancer. 2000 Jan 1;88(1):180-5.
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