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Richard L. Stevens, PhD


  • Kaieda S, Wang JX, Shnayder R, Fishgal N, Hei H, Lee RT, Stevens RL, Nigrovic PA.Interleukin-33 primes mast cells for activation by IgG immune complexes.PLoS ONE. 2012;7(10):e47252.
  • Simarro M, Giannattasio G, Xing W, Lundequist EM, Stewart S, Stevens RL, Orduña A, Boyce JA, Anderson PJ.The translational repressor T-cell intracellular antigen-1 (TIA-1) is a key modulator of Th2 and Th17 responses driving pulmonary inflammation induced by exposure to house dust mite.Immunol Lett. 2012 Aug 30;146(1-2):8-14.
  • Hamilton MJ, Sinnamon MJ, Lyng GD, Glickman JN, Wang X, Xing W, Krilis SA, Blumberg RS, Adachi R, Lee DM, Stevens RL.Essential role for mast cell tryptase in acute experimental colitis.Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):290-5.
  • Kaieda S, Shin K, Nigrovic PA, Seki K, Lee RT, Stevens RL, Lee DM.Synovial fibroblasts promote the expression and granule accumulation of tryptase via interleukin-33 and its receptor ST-2 (IL1RL1).J Biol Chem. 2010 Jul 9;285(28):21478-86.
  • Sun J, Zhang J, Lindholt JS, Sukhova GK, Liu J, He A, Abrink M, Pejler G, Stevens RL, Thompson RW, Ennis TL, Gurish MF, Libby P, Shi GP.Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation.Circulation. 2009 Sep 15;120(11):973-82.
  • Katsoulotos GP, Qi M, Qi JC, Tanaka K, Hughes WE, Molloy TJ, Adachi R, Stevens RL, Krilis SA.The Diacylglycerol-dependent translocation of ras guanine nucleotide-releasing protein 4 inside a human mast cell line results in substantial phenotypic changes, including expression of interleukin 13 receptor alpha2.J Biol Chem. 2008 Jan 18;283(3):1610-21.
  • Thakurdas SM, Melicoff E, Sansores-Garcia L, Moreira DC, Petrova Y, Stevens RL, Adachi R.The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections.J Biol Chem. 2007 Jul 20;282(29):20809-15.
  • Stevens RL, Adachi R.Protease-proteoglycan complexes of mouse and human mast cells and importance of their beta-tryptase-heparin complexes in inflammation and innate immunity.Immunol Rev. 2007 Jun;217:155-67. Review.
  • Habuchi H, Nagai N, Sugaya N, Atsumi F, Stevens RL, Kimata K.Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality.J Biol Chem. 2007 May 25;282(21):15578-88.
  • Abonia JP, Friend DS, Austen WG, Moore FD, Carroll MC, Chan R, Afnan J, Humbles A, Gerard C, Knight P, Kanaoka Y, Yasuda S, Morokawa N, Austen KF, Stevens RL, Gurish MF.Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle.J Immunol. 2005 Jun 1;174(11):7285-91.
  • Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL.Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22.Blood. 2005 May 15;105(10):3893-901.
  • Wong GW, Yasuda S, Morokawa N, Li L, Stevens RL.Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns.J Biol Chem. 2004 Jan 23;279(4):2438-52.
  • Walsh JC, DeKoter RP, Lee HJ, Smith ED, Lancki DW, Gurish MF, Friend DS, Stevens RL, Anastasi J, Singh H.Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates.Immunity. 2002 Nov;17(5):665-76.
  • Wong GW, Foster PS, Yasuda S, Qi JC, Mahalingam S, Mellor EA, Katsoulotos G, Li L, Boyce JA, Krilis SA, Stevens RL.Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer .J Biol Chem. 2002 Nov 1;277(44):41906-15.
  • Yang Y, Li L, Wong GW, Krilis SA, Madhusudhan MS, Sali A, Stevens RL.RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demon.J Biol Chem. 2002 Jul 12;277(28):25756-74.
  • Humphries DE, Wong GW, Friend DS, Gurish MF, Qiu WT, Huang C, Sharpe AH, Stevens RL.Heparin is essential for the storage of specific granule proteases in mast cells.Nature. 1999 Aug 19;400(6746):769-72.