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Othon Iliopoulos, MD


  • Laviolette LA, Wilson J, Koller J, Neil C, Hulick P, Rejtar T, Karger B, Teh BT, Iliopoulos O.Human folliculin delays cell cycle progression through late S and G2/M-phases: effect of phosphorylation and tumor associated mutations.PLoS ONE. 2013;8(7):e66775.
  • Gameiro PA, Laviolette LA, Kelleher JK, Iliopoulos O, Stephanopoulos G.Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the TCA cycle.J Biol Chem. 2013 Mar 15.
  • Gameiro PA, Yang J, Metelo AM, Pérez-Carro R, Baker R, Wang Z, Arreola A, Rathmell WK, Olumi A, López-Larrubia P, Stephanopoulos G, Iliopoulos O.In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation.Cell Metab. 2013 Mar 5;17(3):372-85.
  • Nicolay BN, Gameiro PA, Tschöp K, Korenjak M, Heilmann AM, Asara JM, Stephanopoulos G, Iliopoulos O, Dyson NJ.Loss of RBF1 changes glutamine catabolism.Genes Dev. 2013 Jan 15;27(2):182-96.
  • Tousi F, Bones J, Iliopoulos O, Hancock WS, Hincapie M.Multidimensional liquid chromatography platform for profiling alterations of clusterin N-glycosylation in the plasma of patients with renal cell carcinoma.J Chromatogr A. 2012 Sep 21;1256:121-8.
  • Rafalko A, Iliopoulos O, Fusaro VA, Hancock W, Hincapie M.Immunoaffinity Enrichment and Liquid Chromatography-Selected Reaction Monitoring Mass Spectrometry for Quantitation of Carbonic Anhydrase 12 in Cultured Renal Carcinoma Cells.Anal Chem. 2010 Oct 11.
  • Zimmer M, Lamb J, Ebert BL, Lynch M, Neil C, Schmidt E, Golub TR, Iliopoulos O.The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.Cancer Res. 2010 Apr 15;70(8):3071-9.
  • Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R.The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.Cell. 2010 Jan 22;140(2):280-93.
  • Hulick P, Zimmer M, Margulis V, Skates S, Hamel M, Dahl DM, Michaelson DM, Libermann T, Signoretti S, Carney W, Wood C, Iliopoulos O.Blood Levels of Carbonic Anhydrase 9 Correlate with Clear Cell Renal Cell Carcinoma Activity.Clin. Proteomics.;5(1):37-45.
  • Zimmer M,Ebert BL,Neil C,Brenner K,Papaioannou I,Melas A,Tolliday N,Lamb J,Pantopoulos K,Golub T,Iliopoulos O.Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.Mol Cell. 2008 Dec 26;32(6):838-48.
  • Bhatt RS, Landis DM, Zimmer M, Torregrossa J, Chen S, Sukhatme VP, Iliopoulos O, Balk S, Bubley GJ.Hypoxia-inducible factor-2alpha: effect on radiation sensitivity and differential regulation by an mTOR inhibitor.BJU Int. 2008 Aug;102(3):358-63.
  • Michaelson MD,Iliopoulos O,McDermott DF,McGovern FJ,Harisinghani MG,Oliva E.Case records of the Massachusetts General Hospital. Case 17-2008. A 63-year-old man with metastatic renal-cell carcinoma.N Engl J Med. 2008 May 29;358(22):2389-96.
  • Iliopoulos O.Molecular biology of renal cell cancer and the identification of therapeutic targets.J Clin Oncol. 2006 Dec 10;24(35):5593-600. Review.
  • Mizukami Y, Jo WS, Duerr EM, Gala M, Li J, Zhang X, Zimmer MA, Iliopoulos O, Zukerberg LR, Kohgo Y, Lynch MP, Rueda BR, Chung DC.Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells.Nat Med. 2005 Sep;11(9):992-7.
  • Atkins MB, Avigan DE, Bukowski RM, Childs RW, Dutcher JP, Eisen TG, Figlin RA, Finke JH, Flanigan RC, George DJ, Goldberg SN, Gordon MS, Iliopoulos O, Kaelin WG, Linehan WM, Lipton A, Motzer RJ, Novick AC, Stadler WM, Teh BT, Yang JC, King L.Innovations and challenges in renal cancer: consensus statement from the first international conference.Clin Cancer Res. 2004 Sep 15;10(18 Pt 2):6277S-81S.
  • Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O, Chung DC.Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer.Cancer Res. 2004 Mar 1;64(5):1765-72.
  • Zimmer M, Doucette D, Siddiqui N, Iliopoulos O.Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.Mol Cancer Res. 2004 Feb;2(2):89-95.
  • Iliopoulos O.von Hippel-Lindau disease: genetic and clinical observations.Front Horm Res. 2001;28:131-66.
  • Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, Iliopoulos O, Lane WS, Kaelin WG, Elledge SJ, Conaway RC, Harper JW, Conaway JW.Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.Science. 1999 Apr 23;284(5414):657-61.
  • Lieubeau-Teillet B, Rak J, Jothy S, Iliopoulos O, Kaelin W, Kerbel RS.von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids.Cancer Res. 1998 Nov 1;58(21):4957-62.
  • Iliopoulos O, Ohh M, Kaelin WG.pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation.Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11661-6.
  • Ohh M, Yauch RL, Lonergan KM, Whaley JM, Stemmer-Rachamimov AO, Louis DN, Gavin BJ, Kley N, Kaelin WG, Iliopoulos O.The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix.Mol Cell. 1998 Jun;1(7):959-68.
  • Lonergan KM, Iliopoulos O, Ohh M, Kamura T, Conaway RC, Conaway JW, Kaelin WG.Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2.Mol Cell Biol. 1998 Feb;18(2):732-41.
  • Iliopoulos O, Kaelin WG.The molecular basis of von Hippel-Lindau disease.Mol Med. 1997 May;3(5):289-93.
  • Corless CL, Kibel AS, Iliopoulos O, Kaelin WG.Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues.Hum Pathol. 1997 Apr;28(4):459-64.
  • Iliopoulos O, Levy AP, Jiang C, Kaelin WG, Goldberg MA.Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10595-9.
  • Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG.Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C.Science. 1995 Sep 8;269(5229):1444-6.
  • Iliopoulos O, Kibel A, Gray S, Kaelin WG.Tumour suppression by the human von Hippel-Lindau gene product.Nat Med. 1995 Aug;1(8):822-6.
  • Wen SF, Parthasarathy R, Iliopoulos O, Oberley TD.Acute renal failure following binge drinking and nonsteroidal antiinflammatory drugs.Am J Kidney Dis. 1992 Sep;20(3):281-5.
  • Iliopoulos O, Baroody FM, Naclerio RM, Bochner BS, Kagey-Sobotka A, Lichtenstein LM.Histamine-containing cells obtained from the nose hours after antigen challenge have functional and phenotypic characteristics of basophils.J Immunol. 1992 Apr 1;148(7):2223-8.
  • Iliopoulos O, Proud D, Adkinson NF, Creticos PS, Norman PS, Kagey-Sobotka A, Lichtenstein LM, Naclerio RM.Effects of immunotherapy on the early, late, and rechallenge nasal reaction to provocation with allergen: changes in inflammatory mediators and cells.J Allergy Clin Immunol. 1991 Apr;87(4):855-66.
  • Iliopoulos O, Proud D, Adkinson NF, Norman PS, Kagey-Sobotka A, Lichtenstein LM, Naclerio RM.Relationship between the early, late, and rechallenge reaction to nasal challenge with antigen: observations on the role of inflammatory mediators and cells.J Allergy Clin Immunol. 1990 Dec;86(6 Pt 1):851-61.
  • Charlesworth EN, Iliopoulos O, MacDonald SM, Kagey-Sobotka A, Lichtenstein LM.Cells and secretagogues involved in the human late-phase response.Int Arch Allergy Appl Immunol. 1989;88(1-2):50-3.
  • Iliopoulos O, Proud D, Norman PS, Lichtenstein LM, Kagey-Sobotka A, Naclerio RM.Nasal challenge with cold, dry air induces a late-phase reaction.Am Rev Respir Dis. 1988 Aug;138(2):400-5.
  • Togias A, Naclerio RM, Proud D, Pipkorn U, Bascom R, Iliopoulos O, Kagey-Sobotka A, Norman PS, Lichtenstein LM.Studies on the allergic and nonallergic nasal inflammation.J Allergy Clin Immunol. 1988 May;81(5 Pt 1):782-90.