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Vijaya Ramesh, PhD

Publications

  • Han S, Kim S, Bahl S, Li L, Burande CF, Smith N, James M, Beauchamp RL, Bhide P, DiAntonio A, Ramesh V.The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains.J Biol Chem. 2012 Aug 31;287(36):30063-72.
    22798074
  • Huson SM, Acosta MT, Belzberg AJ, Bernards A, Chernoff J, Cichowski K, Gareth Evans D, Ferner RE, Giovannini M, Korf BR, Listernick R, North KN, Packer RJ, Parada LF, Peltonen J, Ramesh V, Reilly KM, Risner JW, Schorry EK, Upadhyaya M, Viskochil DH, Zhu Y, Hunter-Schaedle K, Giancotti FG.Back to the future: proceedings from the 2010 NF Conference.Am J Med Genet A. 2011 Feb;155(2):307-21.
    21271647
  • Kissil JL, Blakeley JO, Ferner RE, Huson SM, Kalamarides M, Mautner VF, McCormick F, Morrison H, Packer R, Ramesh V, Ratner N, Rauen KA, Stevenson DA, Hunter-Schaedle K, North K.What's new in neurofibromatosis? Proceedings from the 2009 NF Conference: new frontiers.Am J Med Genet A. 2010 Feb;152A(2):269-83.
    20082461
  • Shen Y, Nunes F, Stemmer-Rachamimov A, James M, Mohapatra G, Plotkin S, Betensky RA, Engler DA, Roy J, Ramesh V, Gusella JF.Genomic profiling distinguishes familial multiple and sporadic multiple meningiomas.BMC Med Genomics. 2009;2:42.
    19589153
  • James MF,Han S,Polizzano C,Plotkin SR,Manning BD,Stemmer-Rachamimov AO,Gusella JF,Ramesh V.NF2/Merlin is a Novel Negative Regulator of mTOR Complex 1 and Activation of mTORC1 is Associated with Meningioma and Schwannoma Growth.Mol Cell Biol. 2009 Aug;29(15):4250-61.
    19451225
  • Han S,Polizzano C,Nielsen GP,Hornicek FJ,Rosenberg AE,Ramesh V.Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas.Clin Cancer Res. 2009 Mar 15;15(6):1940-6.
    19276265
  • Ehninger D,Han S,Shilyansky C,Zhou Y,Li W,Kwiatkowski DJ,Ramesh V,Silva AJ.Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis.Nat Med. 2008 Aug;14(8):843-8.
    18568033
  • Han S, Witt RM, Santos TM, Polizzano C, Sabatini BL, Ramesh V.Pam (Protein associated with Myc) functions as an E3 Ubiquitin ligase and regulates TSC/mTOR signaling.Cell Signal. 2008 Jun;20(6):1084-91.
    18308511
  • James MF, Lelke JM, Maccollin M, Plotkin SR, Stemmer-Rachamimov AO, Ramesh V, Gusella JF.Modeling NF2 with human arachnoidal and meningioma cell culture systems: NF2 silencing reflects the benign character of tumor growth.Neurobiol Dis. 2008 Feb;29(2):278-92.
    17962031
  • Beyer KS, Beauchamp RL, Lee MF, Gusella JF, Naar AM, Ramesh V.Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation.J Biol Chem. 2007 Nov 2;282(44):32152-7.
    17848560
  • Lee MF, Beauchamp RL, Beyer KS, Gusella JF, Ramesh V.Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation.Biochem Biophys Res Commun. 2006 Sep 29;348(3):826-31.
    16899217
  • Santos TM, Han S, Bowser M, Sazani K, Beauchamp RL, Murthy V, Bhide PG, Ramesh V.Alternative splicing in protein associated with Myc (Pam) influences its binding to c-Myc.J Neurosci Res. 2006 Feb 1;83(2):222-32.
    16342205
  • Nunes F, Shen Y, Niida Y, Beauchamp R, Stemmer-Rachamimov AO, Ramesh V, Gusella J, MacCollin M.Inactivation patterns of NF2 and DAL-1/4.1B (EPB41L3) in sporadic meningioma.Cancer Genet Cytogenet. 2005 Oct 15;162(2):135-9.
    16213361
  • Niida Y, Stemmer-Rachamimov AO, Logrip M, Tapon D, Perez R, Kwiatkowski DJ, Sims K, MacCollin M, Louis DN, Ramesh V.Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions.Am J Hum Genet. 2001 Sep;69(3):493-503.
    11468687
  • Murthy V, Stemmer-Rachamimov AO, Haddad LA, Roy JE, Cutone AN, Beauchamp RL, Smith N, Louis DN, Ramesh V.Developmental expression of the tuberous sclerosis proteins tuberin and hamartin.Acta Neuropathol. 2001 Mar;101(3):202-10.
    11307618
  • Stemmer-Rachamimov AO, Wiederhold T, Nielsen GP, James M, Pinney-Michalowski D, Roy JE, Cohen WA, Ramesh V, Louis DN.NHE-RF, a merlin-interacting protein, is primarily expressed in luminal epithelia, proliferative endometrium, and estrogen receptor-positive breast carcinomas.Am J Pathol. 2001 Jan;158(1):57-62.
    11141479
  • Choy YS, Dabora SL, Hall F, Ramesh V, Niida Y, Franz D, Kasprzyk-Obara J, Reeve MP, Kwiatkowski DJ.Superiority of denaturing high performance liquid chromatography over single-stranded conformation and conformation-sensitive gel electrophoresis for mutation detection in TSC2.Ann Hum Genet. 1999 Sep;63 ( Pt 5):383-91.
    10735580
  • Niida Y, Lawrence-Smith N, Banwell A, Hammer E, Lewis J, Beauchamp RL, Sims K, Ramesh V, Ozelius L.Analysis of both TSC1 and TSC2 for germline mutations in 126 unrelated patients with tuberous sclerosis.Hum Mutat. 1999;14(5):412-22.
    10533067
  • Castells A, Ino Y, Louis DN, Ramesh V, Gusella JF, Rustgi AK.Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer.Gastroenterology. 1999 Oct;117(4):831-7.
    10500065
  • Stemmer-Rachamimov AO, Nielsen GP, Rosenberg AE, Louis DN, Jones D, Ramesh V, Gusella JF, Jacoby LB.The NF2 gene and merlin protein in human osteosarcomas.Neurogenetics. 1998 Dec;2(1):73-4.
    9933303
  • Stemmer-Rachamimov AO, Ino Y, Lim ZY, Jacoby LB, MacCollin M, Gusella JF, Ramesh V, Louis DN.Loss of the NF2 gene and merlin occur by the tumorlet stage of schwannoma development in neurofibromatosis 2.J Neuropathol Exp Neurol. 1998 Dec;57(12):1164-7.
    9862639
  • Beauchamp RL, Banwell A, McNamara P, Jacobsen M, Higgins E, Northrup H, Short P, Sims K, Ozelius L, Ramesh V.Exon scanning of the entire TSC2 gene for germline mutations in 40 unrelated patients with tuberous sclerosis.Hum Mutat. 1998;12(6):408-16.
    9829910
  • Xu L, Gonzalez-Agosti C, Beauchamp R, Pinney D, Sterner C, Ramesh V.Analysis of molecular domains of epitope-tagged merlin isoforms in Cos-7 cells and primary rat Schwann cells.Exp Cell Res. 1998 Jan 10;238(1):231-40.
    9457076
  • Murthy A, Gonzalez-Agosti C, Cordero E, Pinney D, Candia C, Solomon F, Gusella J, Ramesh V.NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins.J Biol Chem. 1998 Jan 16;273(3):1273-6.
    9430655
  • Stemmer-Rachamimov AO, Xu L, Gonzalez-Agosti C, Burwick JA, Pinney D, Beauchamp R, Jacoby LB, Gusella JF, Ramesh V, Louis DN.Universal absence of merlin, but not other ERM family members, in schwannomas.Am J Pathol. 1997 Dec;151(6):1649-54.
    9403715
  • Stemmer-Rachamimov AO, Gonzalez-Agosti C, Xu L, Burwick JA, Beauchamp R, Pinney D, Louis DN, Ramesh V.Expression of NF2-encoded merlin and related ERM family proteins in the human central nervous system.J Neuropathol Exp Neurol. 1997 Jun;56(6):735-42.
    9184664
  • McClatchey AI, Saotome I, Ramesh V, Gusella JF, Jacks T.The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation.Genes Dev. 1997 May 15;11(10):1253-65.
    9171370
  • Gonzalez-Agosti C, Xu L, Pinney D, Beauchamp R, Hobbs W, Gusella J, Ramesh V.The merlin tumor suppressor localizes preferentially in membrane ruffles.Oncogene. 1996 Sep 19;13(6):1239-47.
    8808698
  • Jacoby LB, MacCollin M, Barone R, Ramesh V, Gusella JF.Frequency and distribution of NF2 mutations in schwannomas.Genes Chromosomes Cancer. 1996 Sep;17(1):45-55.
    8889506
  • Gusella JF, Ramesh V, MacCollin M, Jacoby LB.Neurofibromatosis 2: loss of merlin's protective spell.Curr Opin Genet Dev. 1996 Feb;6(1):87-92.
    8791482
  • Rustgi AK, Xu L, Pinney D, Sterner C, Beauchamp R, Schmidt S, Gusella JF, Ramesh V.Neurofibromatosis 2 gene in human colorectal cancer.Cancer Genet Cytogenet. 1995 Oct 1;84(1):24-6.
    7497438
  • Shih VE, Fringer JM, Mandell R, Kraus JP, Berry GT, Heidenreich RA, Korson MS, Levy HL, Ramesh V.A missense mutation (I278T) in the cystathionine beta-synthase gene prevalent in pyridoxine-responsive homocystinuria and associated with mild clinical phenotype.Am J Hum Genet. 1995 Jul;57(1):34-9.
    7611293
  • Xu L, Sterner C, Maheshwar MM, Wilson PJ, Nellist M, Short PM, Haines JL, Sampson JR, Ramesh V.Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues.Genomics. 1995 Jun 10;27(3):475-80.
    7558029
  • Wellenreuther R, Kraus JA, Lenartz D, Menon AG, Schramm J, Louis DN, Ramesh V, Gusella JF, Wiestler OD, von Deimling A.Analysis of the neurofibromatosis 2 gene reveals molecular variants of meningioma.Am J Pathol. 1995 Apr;146(4):827-32.
    7717450
  • Louis DN, Ramesh V, Gusella JF.Neuropathology and molecular genetics of neurofibromatosis 2 and related tumors.Brain Pathol. 1995 Apr;5(2):163-72.
    7670657
  • Tikoo A, Varga M, Ramesh V, Gusella J, Maruta H.An anti-Ras function of neurofibromatosis type 2 gene product (NF2/Merlin).J Biol Chem. 1994 Sep 23;269(38):23387-90.
    8089100
  • Jacoby LB, MacCollin M, Louis DN, Mohney T, Rubio MP, Pulaski K, Trofatter JA, Kley N, Seizinger B, Ramesh V.Exon scanning for mutation of the NF2 gene in schwannomas.Hum Mol Genet. 1994 Mar;3(3):413-9.
    8012353
  • Haase VH, Trofatter JA, MacCollin M, Tarttelin E, Gusella JF, Ramesh V.The murine NF2 homologue encodes a highly conserved merlin protein with alternative forms.Hum Mol Genet. 1994 Mar;3(3):407-11.
    8012352
  • Bianchi AB, Hara T, Ramesh V, Gao J, Klein-Szanto AJ, Morin F, Menon AG, Trofatter JA, Gusella JF, Seizinger BR.Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types.Nat Genet. 1994 Feb;6(2):185-92.
    8162073
  • MacCollin M, Mohney T, Trofatter J, Wertelecki W, Ramesh V, Gusella J.DNA diagnosis of neurofibromatosis 2. Altered coding sequence of the merlin tumor suppressor in an extended pedigree.JAMA. 1993 Nov 17;270(19):2316-20.
    8230593
  • Park JK, Herron BJ, O'Donnell JJ, Shih VE, Ramesh V.Three novel mutations of the ornithine aminotransferase (OAT) gene in gyrate atrophy.Genomics. 1992 Oct;14(2):553-4.
    1427882
  • Ramesh V, Cheng SV, Kozak CA, Herron BJ, Shih VE, Taylor BA, Gusella JF.Mapping of ornithine aminotransferase gene sequences to mouse chromosomes 7, X, and 3.Mamm Genome. 1992;3(1):17-22.
    1349842
  • McClatchey AI, Kaufman DL, Berson EL, Tobin AJ, Shih VE, Gusella JF, Ramesh V.Splicing defect at the ornithine aminotransferase (OAT) locus in gyrate atrophy.Am J Hum Genet. 1990 Nov;47(5):790-4.
    2220818
  • Ramesh V, McClatchey AI, Ramesh N, Benoit LA, Berson EL, Shih VE, Gusella JF.Molecular basis of ornithine aminotransferase deficiency in B-6-responsive and -nonresponsive forms of gyrate atrophy.Proc Natl Acad Sci U S A. 1988 Jun;85(11):3777-80.
    3375240
  • Ramesh V, Benoit LA, Crawford P, Harvey PT, Shows TB, Shih VE, Gusella JF.The ornithine aminotransferase (OAT) locus: analysis of RFLPs in gyrate atrophy.Am J Hum Genet. 1988 Feb;42(2):365-72.
    2893548
  • Wu J, Ramesh V, Kidd JR, Castiglione CM, Myers S, Carson N, Anderson L, Gusella JF, Simpson NE, Kidd KK.The ornithine aminotransferase (OAT) locus is linked and distal to D10S20 on the long arm of chromosome 10.Cytogenet Cell Genet. 1988;48(2):126-7.
    3197452
  • Ramesh V, Eddy R, Bruns GA, Shih VE, Shows TB, Gusella JF.Localization of the ornithine aminotransferase gene and related sequences on two human chromosomes.Hum Genet. 1987 Jun;76(2):121-6.
    2886418
  • Ramesh V, Shaffer MM, Allaire JM, Shih VE, Gusella JF.Investigation of gyrate atrophy using a cDNA clone for human ornithine aminotransferase.DNA. 1986 Dec;5(6):493-501.
    3816496