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Charles D. Stiles, PhD

Publications

  • Bergthold G, Bandopadhayay P, Bi WL, Ramkissoon L, Stiles C, Segal RA, Beroukhim R, Ligon KL, Grill J, Kieran MW.Pediatric low-grade gliomas: How modern biology reshapes the clinical field.Biochim Biophys Acta. 2014 Apr;1845(2):294-307.
    24589977
  • Silbereis JC, Nobuta H, Tsai HH, Heine VM, McKinsey GL, Meijer DH, Howard MA, Petryniak MA, Potter GB, Alberta JA, Baraban SC, Stiles CD, Rubenstein JL, Rowitch DH.Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain.Neuron. 2014 Feb 5;81(3):574-87.
    24507192
  • Liu X, Ide JL, Norton I, Marchionni MA, Ebling MC, Wang LY, Davis E, Sauvageot CM, Kesari S, Kellersberger KA, Easterling ML, Santagata S, Stuart DD, Alberta J, Agar JN, Stiles CD, Agar NY.Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging.Sci Rep. 2013;3:2859.
    24091529
  • Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, MacConaill LE, Pouissant-Young T, Cho YJ, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer RJ, Hill DA, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MW, Beroukhim R, Ligon KL.Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1.Proc Natl Acad Sci U S A. 2013 May 14;110(20):8188-93.
    23633565
  • Meijer DH, Kane MF, Mehta S, Liu H, Harrington E, Taylor CM, Stiles CD, Rowitch DH.Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2.Nat Rev Neurosci. 2012 Nov;13(12):819-31.
    23165259
  • Zhou J, Stiles CD.Asleep at the switch: MEK kinases control transit to gliogenesis in developing cortex.Neuron. 2012 Sep 20;75(6):940-2.
    22998861
  • Chi AS, Batchelor TT, Dias-Santagata D, Borger D, Stiles CD, Wang DL, Curry WT, Wen PY, Ligon KL, Ellisen L, Louis DN, Iafrate AJ.Prospective, high-throughput molecular profiling of human gliomas.J. Neurooncol. 2012 Oct;110(1):89-98.
    22821383
  • Mehta S, Huillard E, Kesari S, Maire CL, Golebiowski D, Harrington EP, Alberta JA, Kane MF, Theisen M, Ligon KL, Rowitch DH, Stiles CD.The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma.Cancer Cell. 2011 Mar 8;19(3):359-71.
    21397859
  • Sun Y, Meijer DH, Alberta JA, Mehta S, Kane MF, Tien AC, Fu H, Petryniak MA, Potter GB, Liu Z, Powers JF, Runquist IS, Rowitch DH, Stiles CD.Phosphorylation state of olig2 regulates proliferation of neural progenitors.Neuron. 2011 Mar 10;69(5):906-17.
    21382551
  • Chaponis D, Barnes JW, Dellagatta JL, Kesari S, Fast E, Sauvageot C, Panagrahy D, Greene ER, Ramakrishna N, Wen PY, Kung AL, Stiles C, Kieran MW.Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas.J. Neurooncol. 2011 Jan 19.
    21246394
  • Qin Y, Yao L, King EE, Buddavarapu K, Lenci RE, Chocron ES, Lechleiter JD, Sass M, Aronin N, Schiavi F, Boaretto F, Opocher G, Toledo RA, Toledo SP, Stiles C, Aguiar RC, Dahia PL.Germline mutations in TMEM127 confer susceptibility to pheochromocytoma.Nat Genet. 2010 Mar;42(3):229-33.
    20154675
  • Wen PY,Yung WK,Lamborn KR,Norden AD,Cloughesy TF,Abrey LE,Fine HA,Chang SM,Robins HI,Fink K,Deangelis LM,Mehta M,Di Tomaso E,Drappatz J,Kesari S,Ligon KL,Aldape K,Jain RK,Stiles CD,Egorin MJ,Prados MD.Phase II study of imatinib mesylate (Gleevec(R)) for recurrent meningiomas (North American Brain Tumor Consortium Study 01-08).Neuro-oncol. 2009 Dec;11(6):853-60.
    19293394
  • MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, Fiorentino M, Rubin MA, Polyak K, Chan J, Wang Y, Fletcher JA, Santagata S, Corso G, Roviello F, Shivdasani R, Kieran MW, Ligon KL, Stiles CD, Hahn WC, Meyerson ML, Garraway LA.Profiling critical cancer gene mutations in clinical tumor samples.PLoS ONE. 2009;4(11):e7887.
    19924296
  • Fu H, Cai J, Clevers H, Fast E, Gray S, Greenberg R, Jain MK, Ma Q, Qiu M, Rowitch DH, Taylor CM, Stiles CD.A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development.J Neurosci. 2009 Sep 9;29(36):11399-408.
    19741146
  • Sauvageot CM,Weatherbee JL,Kesari S,Winters SE,Barnes J,Dellagatta J,Ramakrishna NR,Stiles CD,Kung AL,Kieran MW,Wen PY.Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells.Neuro-oncol. 2009 Apr;11(2):109-21.
    18682579
  • Stiles CD,Rowitch DH.Glioma stem cells: a midterm exam.Neuron. 2008 Jun 26;58(6):832-46. Review.
    18579075
  • Sauvageot CM, Kesari S, Stiles CD.Molecular pathogenesis of adult brain tumors and the role of stem cells.Neurol Clin. 2007 Nov;25(4):891-924, vii. Review.
    17964020
  • Kesari S, Jackson-Grusby L, Stiles CD."Smad"eningly erratic: target gene methylation determines whether TGFbeta promotes or suppresses malignant glioma.Dev Cell. 2007 Mar;12(3):324-5.
    17336898
  • Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, Depinho RA, Anderson DJ, Stiles CD, Rowitch DH.Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma.Neuron. 2007 Feb 15;53(4):503-17.
    17296553
  • Wen PY, Yung WK, Lamborn KR, Dahia PL, Wang Y, Peng B, Abrey LE, Raizer J, Cloughesy TF, Fink K, Gilbert M, Chang S, Junck L, Schiff D, Lieberman F, Fine HA, Mehta M, Robins HI, DeAngelis LM, Groves MD, Puduvalli VK, Levin V, Conrad C, Maher EA, Aldape K, Hayes M, Letvak L, Egorin MJ, Capdeville R, Kaplan R, Murgo AJ, Stiles C, Prados MD.Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08.Clin Cancer Res. 2006 Aug 15;12(16):4899-907.
    16914578
  • Kesari S, Stiles CD.The Bad Seed: PDGF Receptors Link Adult Neural Progenitors to Glioma Stem Cells.Neuron. 2006 Jul 20;51(2):151-3. Review.
    16846849
  • Ligon KL, Kesari S, Kitada M, Sun T, Arnett HA, Alberta JA, Anderson DJ, Stiles CD, Rowitch DH.Development of NG2 neural progenitor cells requires Olig gene function.Proc Natl Acad Sci U S A. 2006 May 16;103(20):7853-8.
    16682644
  • Sun T, Hafler BP, Kaing S, Kitada M, Ligon KL, Widlund HR, Yuk DI, Stiles CD, Rowitch DH.Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube.Dev Biol. 2006 Apr 1;292(1):152-64.
    16469306
  • Kesari S, Ramakrishna N, Sauvageot C, Stiles CD, Wen PY.Targeted molecular therapy of malignant gliomas.Curr Oncol Rep. 2006 Jan;8(1):58-70.
    16464405
  • Dahia PL, Hao K, Rogus J, Colin C, Pujana MA, Ross K, Magoffin D, Aronin N, Cascon A, Hayashida CY, Li C, Toledo SP, Stiles CD,.Novel pheochromocytoma susceptibility loci identified by integrative genomics.Cancer Res. 2005 Nov 1;65(21):9651-8.
    16266984
  • Dahia PL, Ross KN, Wright ME, Hayashida CY, Santagata S, Barontini M, Kung AL, Sanso G, Powers JF, Tischler AS, Hodin R, Heitritter S, Moore F, Dluhy R, Sosa JA, Ocal IT, Benn DE, Marsh DJ, Robinson BG, Schneider K, Garber J, Arum SM, Korbonits M, Grossman A, Pigny P, Toledo SP, Nose V, Li C, Stiles CD.A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas.PLoS Genet. 2005 Jul;1(1):72-80.
    16103922
  • McKee AE, Minet E, Stern C, Riahi S, Stiles CD, Silver PA.A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.BMC Dev Biol. 2005 Jul 20;5:14.
    16033648
  • Kesari S, Ramakrishna N, Sauvageot C, Stiles CD, Wen PY.Targeted molecular therapy of malignant gliomas.Curr Neurol Neurosci Rep. 2005 May;5(3):186-97.
    15865884
  • Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q.Mouse brain organization revealed through direct genome-scale TF expression analysis.Science. 2004 Dec 24;306(5705):2255-7.
    15618518
  • Arnett HA, Fancy SP, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ, Stiles CD.bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.Science. 2004 Dec 17;306(5704):2111-5.
    15604411
  • Sauvageot C, Dahia PL, Lipan O, Park JK, Chang MS, Alberta JA, Stiles CD.Distinct temporal genetic signatures of neurogenic and gliogenic cues in cortical stem cell cultures.J Neurobiol. 2005 Jan;62(1):121-33.
    15389679
  • Lu QR, Sun T, Zhu Z, Ma N, Garcia M, Stiles CD, Rowitch DH.Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection.Cell. 2002 Apr 5;109(1):75-86.
    11955448
  • Alberta JA, Park SK, Mora J, Yuk D, Pawlitzky I, Iannarelli P, Vartanian T, Stiles CD, Rowitch DH.Sonic hedgehog is required during an early phase of oligodendrocyte development in mammalian brain.Mol Cell Neurosci. 2001 Oct;18(4):434-41.
    11640898
  • Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM.Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors.Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10851-6.
    11526205
  • Tekki-Kessaris N, Woodruff R, Hall AC, Gaffield W, Kimura S, Stiles CD, Rowitch DH, Richardson WD.Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon.Development. 2001 Jul;128(13):2545-54.
    11493571
  • Kim HA, Ratner N, Roberts TM, Stiles CD.Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1.J Neurosci. 2001 Feb 15;21(4):1110-6.
    11160381
  • Wang WL, Healy ME, Sattler M, Verma S, Lin J, Maulik G, Stiles CD, Griffin JD, Johnson BE, Salgia R.Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571.Oncogene. 2000 Jul 20;19(31):3521-8.
    10918610
  • Kim HA, Pomeroy SL, Whoriskey W, Pawlitzky I, Benowitz LI, Sicinski P, Stiles CD, Roberts TM.A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1.Neuron. 2000 May;26(2):405-16.
    10839359
  • Park JK, Williams BP, Alberta JA, Stiles CD.Bipotent cortical progenitor cells process conflicting cues for neurons and glia in a hierarchical manner.J Neurosci. 1999 Dec 1;19(23):10383-9.
    10575035
  • Watson FL, Porcionatto MA, Bhattacharyya A, Stiles CD, Segal RA.TrkA glycosylation regulates receptor localization and activity.J Neurobiol. 1999 May;39(2):323-36.
    10235685
  • Kim JY, Sutton ME, Lu DJ, Cho TA, Goumnerova LC, Goritchenko L, Kaufman JR, Lam KK, Billet AL, Tarbell NJ, Wu J, Allen JC, Stiles CD, Segal RA, Pomeroy SL.Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas.Cancer Res. 1999 Feb 1;59(3):711-9.
    9973222
  • Dahia PL, Aguiar RC, Alberta J, Kum JB, Caron S, Sill H, Marsh DJ, Ritz J, Freedman A, Stiles C, Eng C.PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies.Hum Mol Genet. 1999 Feb;8(2):185-93.
    9931326
  • Reinertsen KK, Bronson RT, Stiles CD, Wang C.Temporal and spatial specificity of PDGF alpha receptor promoter in transgenic mice.Gene Expr. 1997;6(5):301-14.
    9368101
  • Kwon YK, Bhattacharyya A, Alberta JA, Giannobile WV, Cheon K, Stiles CD, Pomeroy SL.Activation of ErbB2 during wallerian degeneration of sciatic nerve.J Neurosci. 1997 Nov 1;17(21):8293-9.
    9334404
  • Alberta JA, Stiles CD.Phosphorylation-directed antibodies in high-flux screens for compounds that modulate signal transduction.Biotechniques. 1997 Sep;23(3):490-3.
    9298221
  • Bhattacharyya A, Watson FL, Bradlee TA, Pomeroy SL, Stiles CD, Segal RA.Trk receptors function as rapid retrograde signal carriers in the adult nervous system.J Neurosci. 1997 Sep 15;17(18):7007-16.
    9278536
  • Williams BP, Park JK, Alberta JA, Muhlebach SG, Hwang GY, Roberts TM, Stiles CD.A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells.Neuron. 1997 Apr;18(4):553-62.
    9136765
  • Segal RA, Bhattacharyya A, Rua LA, Alberta JA, Stephens RM, Kaplan DR, Stiles CD.Differential utilization of Trk autophosphorylation sites.J Biol Chem. 1996 Aug 16;271(33):20175-81.
    8702742
  • Freter RR, Alberta JA, Hwang GY, Wrentmore AL, Stiles CD.Platelet-derived growth factor induction of the immediate-early gene MCP-1 is mediated by NF-kappaB and a 90-kDa phosphoprotein coactivator.J Biol Chem. 1996 Jul 19;271(29):17417-24.
    8663287
  • Segal RA, Pomeroy SL, Stiles CD.Axonal growth and fasciculation linked to differential expression of BDNF and NT3 receptors in developing cerebellar granule cells.J Neurosci. 1995 Jul;15(7 Pt 1):4970-81.
    7623126
  • Guha A, Glowacka D, Carroll R, Dashner K, Black PM, Stiles CD.Expression of platelet derived growth factor and platelet derived growth factor receptor mRNA in a glioblastoma from a patient with Li-Fraumeni syndrome.J Neurol Neurosurg Psychiatry. 1995 Jun;58(6):711-4.
    7608673
  • Guha A, Dashner K, Black PM, Wagner JA, Stiles CD.Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop.Int J Cancer. 1995 Jan 17;60(2):168-73.
    7829210
  • Freter RR, Alberta JA, Lam KK, Stiles CD.A new platelet-derived growth factor-regulated genomic element which binds a serine/threonine phosphoprotein mediates induction of the slow immediate-early gene MCP-1.Mol Cell Biol. 1995 Jan;15(1):315-25.
    7799939
  • Segal RA, Goumnerova LC, Kwon YK, Stiles CD, Pomeroy SL.Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma.Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12867-71.
    7809137
  • Shamah SM, Stiles CD, Guha A.Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells.Mol Cell Biol. 1993 Dec;13(12):7203-12.
    8246942
  • Epstein RJ, Druker BJ, Roberts TM, Stiles CD.Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor.Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10435-9.
    1359539
  • Mercola M, Deininger PL, Shamah SM, Porter J, Wang CY, Stiles CD.Dominant-negative mutants of a platelet-derived growth factor gene.Genes Dev. 1990 Dec;4(12B):2333-41.
    2279701
  • Armelin HA, Armelin MC, Kelly K, Stewart T, Leder P, Cochran BH, Stiles CD.Functional role for c-myc in mitogenic response to platelet-derived growth factor.Nature. 1984 Aug 23-29;310(5979):655-60.
    6088986
  • Cochran BH, Reffel AC, Stiles CD.Molecular cloning of gene sequences regulated by platelet-derived growth factor.Cell. 1983 Jul;33(3):939-47.
    6872001
  • Antoniades HN, Scher CD, Stiles CD.Purification of human platelet-derived growth factor.Proc Natl Acad Sci U S A. 1979 Apr;76(4):1809-13.
    287022
  • Stiles CD, Capone GT, Scher CD, Antoniades HN, Van Wyk JJ, Pledger WJ.Dual control of cell growth by somatomedins and platelet-derived growth factor.Proc Natl Acad Sci U S A. 1979 Mar;76(3):1279-83.
    312500