DF/HCC Program Affiliation

Leukemia, Co-Leader
Prostate Cancer

DF/HCC Associations

Member, Center Scientific Council

Research Abstract

The Pandolfi laboratory focuses on elucidating the molecular mechanisms and the genetics underlying the pathogenesis of leukemias, lymphomas and solid tumors as well as in modeling these cancers in the mouse. Dr. Pandolfi and colleagues have characterized the function of the fusion oncoproteins and the genes involved in the chromosomal translocations of acute promyelocytic leukemia (APL), as well as of major tumor suppressors such PTEN and p53 and novel proto-oncogenes such POKEMON. The elucidation of the molecular basis underlying APL pathogenesis has led to the development of novel and effective therapeutic strategies. As a result of these efforts, APL is now considered a curable disease. Novel therapeutic concepts have emerged from this work that are currently being tested in clinical trials.

Publications

• Ito K, Bernardi R, Morotti A, Matsuoka S, Saglio G, Ikeda Y, Rosenblatt J, Avigan DE, Teruya-Feldstein J, Pandolfi PP.PML targeting eradicates quiescent leukaemia-initiating cells.Nature 2008 May 11.
  18469801
• Salmena L, Carracedo A, Pandolfi PP.Tenets of PTEN tumor suppression.Cell 2008 May 2;133(3):403-14.
  18455982
• Carracedo A, Salmena L, Pandolfi PP.SnapShot: PTEN signaling pathways.Cell 2008 May 2;133(3):550.e1.
  18455993
• Hambardzumyan D, Becher OJ, Rosenblum MK, Pandolfi PP, Manova-Todorova K, Holland EC.PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo.Genes Dev 2008 Feb 15;22(4):436-48.
  18281460
• Klimek VM, Fircanis S, Maslak P, Guernah I, Baum M, Wu N, Panageas K, Wright JJ, Pandolfi PP, Nimer SD.Tolerability, pharmacodynamics, and pharmacokinetics studies of depsipeptide (romidepsin) in patients with acute myelogenous leukemia or advanced myelod
  18245545
• Sportoletti P, Grisendi S, Majid SM, Cheng K, Clohessy JG, Viale A, Teruya-Feldstein J, Pandolfi PP.Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse.Blood 2008 Apr 1;111(7):3859-62.
  18212245
• Guidez F, Parks S, Wong H, Jovanovic JV, Mays A, Gilkes AF, Mills KI, Guillemin MC, Hobbs RM, Pandolfi PP, de The H, Solomon E, Grimwade D.RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute pr
  18000064
• Bernardi R, Pandolfi PP.Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies.Nat Rev Mol Cell Biol 2007 Dec;8(12):1006-16.
  17928811
• Seandel M, James D, Shmelkov SV, Falciatori I, Kim J, Chavala S, Scherr DS, Zhang F, Torres R, Gale NW, Yancopoulos GD, Murphy A, Valenzuela DM, Hobbs RM, Pandolfi PP, Rafii S.Generation of functional multipotent adult stem cells from GPR125+ germline pro
  17882221
• Ma L, Teruya-Feldstein J, Bonner P, Bernardi R, Franz DN, Witte D, Cordon-Cardo C, Pandolfi PP.Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cance
  17671177
• Yoshida H, Ichikawa H, Tagata Y, Katsumoto T, Ohnishi K, Akao Y, Naoe T, Pandolfi PP, Kitabayashi I.PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation.Mol Cell Biol 2007 Aug;27(1
  17562868
• Salmena L, Pandolfi PP.Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation.Nat Rev Cancer 2007 Jun;7(6):409-13.
  17508027
• Maeda T, Merghoub T, Hobbs RM, Dong L, Maeda M, Zakrzewski J, van den Brink MR, Zelent A, Shigematsu H, Akashi K, Teruya-Feldstein J, Cattoretti G, Pandolfi PP.Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.Science 2007
  17495164
• Hernando E, Charytonowicz E, Dudas ME, Menendez S, Matushansky I, Mills J, Socci ND, Behrendt N, Ma L, Maki RG, Pandolfi PP, Cordon-Cardo C.The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas.Nat Med 2007 Jun;13(6):748-53.
  17496901
• Bernardi R, Guernah I, Jin D, Grisendi S, Alimonti A, Teruya-Feldstein J, Cordon-Cardo C, Simon MC, Rafii S, Pandolfi PP.PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR.Nature 2006 Aug 17;442(7104):779-85.
  16915281
• Scaglioni PP, Yung TM, Cai LF, Erdjument-Bromage H, Kaufman AJ, Singh B, Teruya-Feldstein J, Tempst P, Pandolfi PP.A CK2-dependent mechanism for degradation of the PML tumor suppressor.Cell 2006 Jul 28;126(2):269-83.
  16873060
• Trotman LC, Alimonti A, Scaglioni PP, Koutcher JA, Cordon-Cardo C, Pandolfi PP.Identification of a tumour suppressor network opposing nuclear Akt function.Nature 2006 May 25;441(7092):523-7.
  16680151
• Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M, Koutcher JA, Scher HI, Ludwig T, Gerald W, Cordon-Cardo C, Pandolfi PP.Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis.Nature 2005 Aug 4;436(7051):72
  16079851