Pier Paolo Pandolfi, MD, PhD

Publications

• Nardella C, Lunardi A, Fedele G, Clohessy JG, Alimonti A, Kozma SC, Thomas G, Loda M, Pandolfi PP.Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis.Cancer Res. 2011 Mar 2
  21444676
• Finley LW, Carracedo A, Lee J, Souza A, Egia A, Zhang J, Teruya-Feldstein J, Moreira PI, Cardoso SM, Clish CB, Pandolfi PP, Haigis MC.SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization.Cancer Cell. 2011 Mar 8;19(3):416-28
  21397863
• Bernardi R, Papa A, Egia A, Coltella N, Teruya-Feldstein J, Signoretti S, Pandolfi PP.Pml represses tumour progression through inhibition of mTOR.EMBO Mol Med. 2011 Feb 17.
  21387562
• Sasaki AT, Carracedo A, Locasale JW, Anastasiou D, Takeuchi K, Kahoud ER, Haviv S, Asara JM, Pandolfi PP, Cantley LC.Ubiquitination of k-ras enhances activation and facilitates binding to select downstream effectors.Sci Signal. 2011;4(163):ra13.
  21386094
• Kandel E, Pandolfi PP.Tumor-associated oncogenes go on (phage) display.Oncotarget. 2010 Jun;1(2):84-5.
  21297221
• Carracedo A, Alimonti A, Pandolfi PP.PTEN level in tumor suppression: how much is too little?.Cancer Res. 2011 Feb 1;71(3):629-33.
  21266353
• Song MS, Carracedo A, Salmena L, Song SJ, Egia A, Malumbres M, Pandolfi PP.Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.Cell. 2011 Jan 21;144(2):187-99.
  21241890
• Epping MT, Meijer LA, Krijgsman O, Bos JL, Pandolfi PP, Bernards R.TSPYL5 suppresses p53 levels and function by physical interaction with USP7.Nat Cell Biol. 2011 Jan;13(1):102-8.
  21170034
• Snell LM, McPherson AJ, Lin GH, Sakaguchi S, Pandolfi PP, Riccardi C, Watts TH.CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection.J Immunol. 2010 Dec 15;185(12):7223-34.
  21076066
• Berger AH, Pandolfi PP.Haplo-insufficiency: a driving force in cancer.J Pathol. 2011 Jan;223(2):137-46. Review.
  21125671
• Giorgi C, Ito K, Lin HK, Santangelo C, Wieckowski MR, Lebiedzinska M, Bononi A, Bonora M, Duszynski J, Bernardi R, Rizzuto R, Tacchetti C, Pinton P, Pandolfi PP.PML regulates apoptosis at endoplasmic reticulum by modulating calcium release.Science. 2010 N
  21030605
• De Keersmaecker K, Real PJ, Gatta GD, Palomero T, Sulis ML, Tosello V, Van Vlierberghe P, Barnes K, Castillo M, Sole X, Hadler M, Lenz J, Aplan PD, Kelliher M, Kee BL, Pandolfi PP, Kappes D, Gounari F, Petrie H, Van der Meulen J, Speleman F, Paietta E, Ra
  20972433
• Berger AH, Pandolfi PP.Haplo-insufficiency: a driving force in cancer.J Pathol. 2010 Oct 6.
  21038315
• Nardella C, Carracedo A, Salmena L, Pandolfi PP.Faithfull Modeling of PTEN Loss Driven Diseases in the Mouse.Curr Top Microbiol Immunol. 2011;347:135-68.
  20549475
• Fagoonee S, Hobbs RM, De Chiara L, Cantarella D, Piro RM, Tolosano E, Medico E, Provero P, Pandolfi PP, Silengo L, Altruda F.Generation of Functional Hepatocytes from Mouse Germline Cell-derived Pluripotent Stem Cells in vitro.Stem Cells Dev. 2010 Aug;19(
  20331356
• Furic L, Rong L, Larsson O, Koumakpayi IH, Yoshida K, Brueschke A, Petroulakis E, Robichaud N, Pollak M, Gaboury LA, Pandolfi PP, Saad F, Sonenberg N.eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression.Proc Natl
  20679199
• Hobbs RM, Seandel M, Falciatori I, Rafii S, Pandolfi PP.Plzf regulates germline progenitor self-renewal by opposing mTORC1.Cell. 2010 Aug 6;142(3):468-79.
  20691905
• Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP.A coding-independent function of gene and pseudogene mRNAs regulates tumour biology.Nature. 2010 Jun 24;465(7301):1033-8.
  20577206
• Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung MC, Pandolfi PP, Lin HK.Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.Nat Cell Biol. 2010 May;12(5):457-67.
  20383141
• Alimonti A, Carracedo A, Clohessy JG, Trotman LC, Nardella C, Egia A, Salmena L, Sampieri K, Haveman WJ, Brogi E, Richardson AL, Zhang J, Pandolfi PP.Subtle variations in Pten dose determine cancer susceptibility.Nat Genet. 2010 May;42(5):454-8.
  20400965
• Cheng K, Sportoletti P, Ito K, Clohessy JG, Teruya-Feldstein J, Kutok JL, Pandolfi PP.The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.Blood. 2010 Apr 22;115(16):3341-5.
  19666870
• Poliseno L, Salmena L, Riccardi L, Fornari A, Song MS, Hobbs RM, Sportoletti P, Varmeh S, Egia A, Fedele G, Rameh L, Loda M, Pandolfi PP.Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its
  20388916
• Lin HK, Chen Z, Wang G, Nardella C, Lee SW, Chan CH, Yang WL, Wang J, Egia A, Nakayama KI, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP.Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.Nature. 2010 Mar 18;464(7287):374
  20237562
• Ferretti R, Palumbo V, Di Savino A, Velasco S, Sbroggiò M, Sportoletti P, Micale L, Turco E, Silengo L, Palumbo G, Hirsch E, Teruya-Feldstein J, Bonaccorsi S, Pandolfi PP, Gatti M, Tarone G, Brancaccio M.Morgana/chp-1, a ROCK Inhibitor Involved in Centro
  20230755
• Alimonti A, Nardella C, Chen Z, Clohessy JG, Carracedo A, Trotman LC, Cheng K, Varmeh S, Kozma SC, Thomas G, Rosivatz E, Woscholski R, Cognetti F, Scher HI, Pandolfi PP.A novel type of cellular senescence that can be enhanced in mouse models and human tum
  20197621
• Ciraolo E, Morello F, Hobbs RM, Wolf F, Marone R, Iezzi M, Lu X, Mengozzi G, Altruda F, Sorba G, Guan K, Pandolfi PP, Wymann MP, Hirsch E.Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.Mol Biol Cell. 2010 Mar;21(5
  20053680
• Berger AH, Niki M, Morotti A, Taylor BS, Socci ND, Viale A, Brennan C, Szoke J, Motoi N, Rothman PB, Teruya-Feldstein J, Gerald WL, Ladanyi M, Pandolfi PP.Identification of DOK genes as lung tumor suppressors.Nat Genet. 2010 Mar;42(3):216-23.
  20139980
• Nie D, Di Nardo A, Han JM, Baharanyi H, Kramvis I, Huynh T, Dabora S, Codeluppi S, Pandolfi PP, Pasquale EB, Sahin M.Tsc2-Rheb signaling regulates EphA-mediated axon guidance.Nat Neurosci. 2010 Feb;13(2):163-72.
  20062052
• Alonzo ES, Gottschalk RA, Das J, Egawa T, Hobbs RM, Pandolfi PP, Pereira P, Nichols KE, Koretzky GA, Jordan MS, Sant'Angelo DB.Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR si
  20038637
• Mihich E, Pandolfi PP, Livingston D.Twenty-first annual Pezcoller Symposium: Unconventional Therapeutic Targets in Cancer.Cancer Res. 2010 Jan 1;70(1):14-7.
  20028862
• Maeda T, Ito K, Merghoub T, Poliseno L, Hobbs RM, Wang G, Dong L, Maeda M, Dore LC, Zelent A, Luzzatto L, Teruya-Feldstein J, Weiss MJ, Pandolfi PP.LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptos
  19853566
• Khanna-Gupta A, Chen J, Sliver M. Sun H, Abayasekara N, Halene, S, Spotoloetti P, Pandlofi PP, Berliner N.Nucleophosmin-1 interacts with CCAAT enhancer binding protein alpha (C/EBPalpha) to facilitate granulocyte maturation: implications in MDS and AML.Bl
• Chen Z, Carracedo A, Lin HK, Koutcher JA, Behrendt N, Egia A, Alimonti A, Carver BS, Gerald W, Teruya-Feldstein J, Loda M, Pandolfi PP.Differential p53-independent outcomes of p19(Arf) loss in oncogenesis.Sci Signal. 2009;2(84):ra44.
  19690330
• Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H.TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity.Proc Natl Acad
  19617548
• Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC.Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signal
  19647222
• Gutierrez A,Sanda T,Grebliunaite R,Carracedo A,Salmena L,Ahn Y,Dahlberg S,Neuberg D,Moreau LA,Winter SS,Larson R,Zhang J,Protopopov A,Chin L,Pandolfi PP,Silverman LB,Hunger SP,Sallan SE,Look AT.High frequency of PTEN, PI3K and AKT abnormalities in T cell
  19458356
• Xu D, Holko M, Sadler AJ, Scott B, Higashiyama S, Berkofsky-Fessler W, McConnell MJ, Pandolfi PP, Licht JD, Williams BR.Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity.Immunity. 2009 Jun 19;30(6):802-16.
  19523849
• Carver BS,Tran J,Gopalan A,Chen Z,Shaikh S,Carracedo A,Alimonti A,Nardella C,Varmeh S,Scardino PT,Cordon-Cardo C,Gerald W,Pandolfi PP.Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.Nat Genet. 2009 May;41
  19396168
• Clohessy JG,Pandolfi PP.beta-tting on p63 as a metastatic suppressor.Cell. 2009 Apr 3;137(1):28-30.
  19345184
• Fumagalli S,Di Cara A,Neb-Gulati A,Natt F,Schwemberger S,Hall J,Babcock GF,Bernardi R,Pandolfi PP,Thomas G.Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction.Nat Ce
  19287375
• Lin HK,Wang G,Chen Z,Teruya-Feldstein J,Liu Y,Chan CH,Yang WL,Erdjument-Bromage H,Nakayama KI,Nimer S,Tempst P,Pandolfi PP.Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.Nat Cell Biol. 2009 Apr;11(
  19270694
• Distefano G,Boca M,Rowe I,Wodarczyk C,Ma L,Piontek KB,Germino GG,Pandolfi PP,Boletta A.Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and
  19255143
• Ito K,Bernardi R,Pandolfi PP.A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell.Curr Opin Genet Dev. 2009 Feb;19(1):51-9. Review.
  19216069
• Carver BS,Tran J,Chen Z,Carracedo-Perez A,Alimonti A,Nardella C,Gopalan A,Scardino PT,Cordon-Cardo C,Gerald W,Pandolfi PP.ETS rearrangements and prostate cancer initiation.Nature. 2009 Feb 12;457(7231):E1; discussion E2-3.
  19212347
• Nardella C,Carracedo A,Alimonti A,Hobbs RM,Clohessy JG,Chen Z,Egia A,Fornari A,Fiorentino M,Loda M,Kozma SC,Thomas G,Cordon-Cardo C,Pandolfi PP.Differential requirement of mTOR in postmitotic tissues and tumorigenesis.Sci Signal. 2009;2(55):ra2.
  19176516
• Lapi E,Di Agostino S,Donzelli S,Gal H,Domany E,Rechavi G,Pandolfi PP,Givol D,Strano S,Lu X,Blandino G.PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.Mol Cell. 2008 Dec 26;32(6):803-14.
  19111660
• Carracedo A,Baselga J,Pandolfi PP.Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors.Cell Cycle. 2008 Dec 15;7(24):3805-9. Review.
  19098454
• Nasr R,Guillemin MC,Ferhi O,Soilihi H,Peres L,Berthier C,Rousselot P,Robledo-Sarmiento M,Lallemand-Breitenbach V,Gourmel B,Vitoux D,Pandolfi PP,Rochette-Egly C,Zhu J,de The H.Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA de
  19029980
• Maggi LB Jr,Kuchenruether M,Dadey DY,Schwope RM,Grisendi S,Townsend RR,Pandolfi PP,Weber JD.Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.Mol Cell Biol. 2008 Dec;28(23):7050-65.
  18809582
• Shima Y,Shima T,Chiba T,Irimura T,Pandolfi PP,Kitabayashi I.PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation.Mol Cell Biol. 2008 Dec;28(23):7126-38.
  18809579
• Teitell MA,Pandolfi PP.Molecular genetics of acute lymphoblastic leukemia.Annu Rev Pathol. 2009;4:175-98. Review.
  18783329
• Cheng S,Hsia CY,Feng B,Liou ML,Fang X,Pandolfi PP,Liou HC.BCR-mediated apoptosis associated with negative selection of immature B cells is selectively dependent on Pten.Cell Res. 2009 Feb;19(2):196-207.
  18781138
• Carracedo A,Ma L,Teruya-Feldstein J,Rojo F,Salmena L,Alimonti A,Egia A,Sasaki AT,Thomas G,Kozma SC,Papa A,Nardella C,Cantley LC,Baselga J,Pandolfi PP.Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human can
  18725988
• Song MS,Salmena L,Carracedo A,Egia A,Lo-Coco F,Teruya-Feldstein J,Pandolfi PP.The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network.Nature. 2008 Oct 9;455(7214):813-7.
  18716620
• Nardella C,Chen Z,Salmena L,Carracedo A,Alimonti A,Egia A,Carver B,Gerald W,Cordon-Cardo C,Pandolfi PP.Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.Genes Dev. 2008 Aug 15;22(16):2172-7.
  18708577
• Hayakawa F,Abe A,Kitabayashi I,Pandolfi PP,Naoe T.Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis.J Biol Chem. 2008 Sep 5;283(36):24420-5.
  18621739
• Chen S,Ndhlovu LC,Takahashi T,Takeda K,Ikarashi Y,Kikuchi T,Murata K,Pandolfi PP,Riccardi C,Ono M,Sugamura K,Ishii N.Co-inhibitory roles for glucocorticoid-induced TNF receptor in CD1d-dependent natural killer T cells.Eur J Immunol. 2008 Aug;38(8):2229-40
  18624295
• Poliseno L,Pitto L,Simili M,Mariani L,Riccardi L,Ciucci A,Rizzo M,Evangelista M,Mercatanti A,Pandolfi PP,Rainaldi G.The proto-oncogene LRF is under post-transcriptional control of MiR-20a: implications for senescence.PLoS ONE. 2008;3(7):e2542.
  18596985
• Ito K, Bernardi R, Morotti A, Matsuoka S, Saglio G, Ikeda Y, Rosenblatt J, Avigan DE, Teruya-Feldstein J, Pandolfi PP.PML targeting eradicates quiescent leukaemia-initiating cells.Nature. 2008 Jun 19;453(7198):1072-8.
  18469801
• Carracedo A, Salmena L, Pandolfi PP.SnapShot: PTEN signaling pathways.Cell. 2008 May 2;133(3):550.e1.
  18455993
• Salmena L, Carracedo A, Pandolfi PP.Tenets of PTEN tumor suppression.Cell. 2008 May 2;133(3):403-14.
  18455982
• Hambardzumyan D, Becher OJ, Rosenblum MK, Pandolfi PP, Manova-Todorova K, Holland EC.PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo.Genes Dev. 2008 Feb 15;22(4):436-48
  18281460
• Klimek VM, Fircanis S, Maslak P, Guernah I, Baum M, Wu N, Panageas K, Wright JJ, Pandolfi PP, Nimer SD.Tolerability, pharmacodynamics, and pharmacokinetics studies of depsipeptide (romidepsin) in patients with acute myelogenous leukemia or advanced myelod
  18245545
• Sportoletti P, Grisendi S, Majid SM, Cheng K, Clohessy JG, Viale A, Teruya-Feldstein J, Pandolfi PP.Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse.Blood. 2008 Apr 1;111(7):3859-62.
  18212245
• Guidez F, Parks S, Wong H, Jovanovic JV, Mays A, Gilkes AF, Mills KI, Guillemin MC, Hobbs RM, Pandolfi PP, de The H, Solomon E, Grimwade D.RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute pr
  18000064
• Bernardi R, Pandolfi PP.Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies.Nat Rev Mol Cell Biol. 2007 Dec;8(12):1006-16. Review.
  17928811
• Seandel M, James D, Shmelkov SV, Falciatori I, Kim J, Chavala S, Scherr DS, Zhang F, Torres R, Gale NW, Yancopoulos GD, Murphy A, Valenzuela DM, Hobbs RM, Pandolfi PP, Rafii S.Generation of functional multipotent adult stem cells from GPR125+ germline pro
  17882221
• Ma L, Teruya-Feldstein J, Bonner P, Bernardi R, Franz DN, Witte D, Cordon-Cardo C, Pandolfi PP.Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cance
  17671177
• Yoshida H, Ichikawa H, Tagata Y, Katsumoto T, Ohnishi K, Akao Y, Naoe T, Pandolfi PP, Kitabayashi I.PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation.Mol Cell Biol. 2007 Aug;27(
  17562868
• Salmena L, Pandolfi PP.Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation.Nat Rev Cancer. 2007 Jun;7(6):409-13. Review.
  17508027
• Hernando E, Charytonowicz E, Dudas ME, Menendez S, Matushansky I, Mills J, Socci ND, Behrendt N, Ma L, Maki RG, Pandolfi PP, Cordon-Cardo C.The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas.Nat Med. 2007 Jun;13(6):748-53.
  17496901
• Maeda T, Merghoub T, Hobbs RM, Dong L, Maeda M, Zakrzewski J, van den Brink MR, Zelent A, Shigematsu H, Akashi K, Teruya-Feldstein J, Cattoretti G, Pandolfi PP.Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.Science. 2007
  17495164
• Bernardi R, Guernah I, Jin D, Grisendi S, Alimonti A, Teruya-Feldstein J, Cordon-Cardo C, Simon MC, Rafii S, Pandolfi PP.PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR.Nature. 2006 Aug 17;442(7104):779-85.
  16915281
• Scaglioni PP, Yung TM, Cai LF, Erdjument-Bromage H, Kaufman AJ, Singh B, Teruya-Feldstein J, Tempst P, Pandolfi PP.A CK2-dependent mechanism for degradation of the PML tumor suppressor.Cell. 2006 Jul 28;126(2):269-83.
  16873060
• Trotman LC, Alimonti A, Scaglioni PP, Koutcher JA, Cordon-Cardo C, Pandolfi PP.Identification of a tumour suppressor network opposing nuclear Akt function.Nature. 2006 May 25;441(7092):523-7.
  16680151
• Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M, Koutcher JA, Scher HI, Ludwig T, Gerald W, Cordon-Cardo C, Pandolfi PP.Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis.Nature. 2005 Aug 4;436(7051):7
  16079851