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Pier Paolo Pandolfi, MD, PhD

Publications

  • González-Billalabeitia E, Seitzer N, Song SJ, Song MS, Patnaik A, Liu XS, Epping MT, Papa A, Hobbs RM, Chen M, Lunardi A, Ng C, Webster KA, Signoretti S, Loda M, Asara JM, Nardella C, Clohessy JG, Cantley LC, Pandolfi PP.Vulnerabilities of PTEN-p53-deficient prostate cancers to compound PARP/PI3K inhibition.Cancer Discovery. 2014 May 27.
    24866151
  • Karreth FA, Ala U, Provero P, Pandolfi PP.Pseudogenes as Competitive Endogenous RNAs: Target Prediction and Validation.Methods Mol Biol. 2014;1167:199-212.
    24823779
  • Papa A, Wan L, Bonora M, Salmena L, Song MS, Hobbs RM, Lunardi A, Webster K, Ng C, Newton RH, Knoblauch N, Guarnerio J, Ito K, Turka LA, Beck AH, Pinton P, Bronson RT, Wei W, Pandolfi PP.Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function.Cell. 2014 Apr 24;157(3):595-610.
    24766807
  • Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W.Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.Nature. 2014 Apr 24;508(7497):541-5.
    24670654
  • Münch S, Weidtkamp-Peters S, Klement K, Grigaravicius P, Monajembashi S, Salomoni P, Pandolfi PP, Weißhart K, Hemmerich P.The Tumor Suppressor PML Specifically Accumulates at RPA/Rad51-Containing DNA Damage Repair Foci but Is Nonessential for DNA Damage-Induced Fibroblast Senescence.Mol Cell Biol. 2014 May;34(10):1733-46.
    24615016
  • Berns A, Pandolfi PP.Tumor microenvironment revisited.EMBO Rep. 2014 Apr 14.
    24731944
  • Xie H, Hanai JI, Ren JG, Kats L, Burgess K, Bhargava P, Signoretti S, Billiard J, Duffy KJ, Grant A, Wang X, Lorkiewicz PK, Schatzman S, Bousamra M, Lane AN, Higashi RM, Fan TW, Pandolfi PP, Sukhatme VP, Seth P.Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells.Cell Metab. 2014 Apr 9.
    24726384
  • Coltella N, Percio S, Valsecchi R, Cuttano R, Guarnerio J, Ponzoni M, Pandolfi PP, Melillo G, Pattini L, Bernardi R.HIF factors cooperate with PML-RARα to promote acute promyelocytic leukemia progression and relapse.EMBO Mol Med. 2014 Apr 7.
    24711541
  • Lunardi A, Webster KA, Papa A, Padmani B, Clohessy JG, Bronson RT, Pandolfi PP.Role of aberrant PI3K pathway activation in gallbladder tumorigenesis.Oncotarget. 2014 Mar 10.
    24658595
  • Fusella F, Ferretti R, Recupero D, Rocca S, Di Savino A, Tornillo G, Silengo L, Turco E, Cabodi S, Provero P, Pandolfi PP, Sapino A, Tarone G, Brancaccio M.Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway.J Pathol. 2014 Feb 24.
    24615293
  • Kats LM, Reschke M, Taulli R, Pozdnyakova O, Burgess K, Bhargava P, Straley K, Karnik R, Meissner A, Small D, Su SM, Yen K, Zhang J, Pandolfi PP.Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance.Cell Stem Cell. 2014 Mar 6;14(3):329-41.
    24440599
  • Tay Y, Karreth FA, Pandolfi PP.Aberrant ceRNA activity drives lung cancer.Cell Res. 2014 Mar;24(3):259-60.
    24525785
  • Bernardi R, Pandolfi PP.A Dialog on the First 20 Years of PML Research and the Next 20 Ahead.Frontiers In Oncology. 2014;4:23.
    24575390
  • Saoncella S, Tassone B, Deklic E, Avolio F, Jon C, Tornillo G, De Luca E, Di Iorio E, Piva R, Cabodi S, Turco E, Pandolfi PP, Calautti E.Nuclear Akt2 opposes limbal keratinocyte stem cell self-renewal by repressing a FOXO-mTORC1 signaling pathway.Stem Cells. 2014 Mar;32(3):754-69.
    24123662
  • Rau R, Magoon D, Greenblatt S, Li L, Annesley C, Duffield AS, Huso D, McIntyre E, Clohessy JG, Reschke M, Pandolfi PP, Small D, Brown P.NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease.Exp Hematol. 2014 Feb;42(2):101-13.e5.
    24184354
  • Song SJ, Pandolfi PP.miR-22 in tumorigenesis.Cell Cycle. 2014 Jan 1;13(1):11-2.
    24231768
  • Lunardi A, Nardella C, Clohessy JG, Pandolfi PP.Of model pets and cancer models: an introduction to mouse models of cancer.Cold Spring Harb Protoc. 2014 Jan;2014(1):17-31.
    24371312
  • Bohn O, Maeda T, Filatov A, Lunardi A, Pandolfi PP, Teruya-Feldstein J.Utility of LRF/Pokemon and NOTCH1 Protein Expression in the Distinction of Nodular Lymphocyte-Predominant Hodgkin Lymphoma and Classical Hodgkin Lymphoma.Int J Surg Pathol. 2013 Dec 10.
    24326827
  • Wegiel B, Gallo D, Csizmadia E, Harris C, Belcher J, Vercellotti GM, Penacho N, Seth P, Sukhatme V, Ahmed A, Pandolfi PP, Helczynski L, Bjartell A, Persson JL, Otterbein LE.Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth.Cancer Res. 2013 Dec 1;73(23):7009-21.
    24121491
  • Berger AH, Chen M, Morotti A, Janas JA, Niki M, Bronson RT, Taylor BS, Ladanyi M, Van Aelst L, Politi K, Varmus HE, Pandolfi PP.DOK2 inhibits EGFR-mutated lung adenocarcinoma.PLoS ONE. 2013;8(11):e79526.
    24255704
  • Abate-Shen C, Pandolfi PP.Effective utilization and appropriate selection of genetically engineered mouse models for translational integration of mouse and human trials.Cold Spring Harb Protoc. 2013 Nov;2013(11).
    24173311
  • Karreth FA, Pandolfi PP.ceRNA cross-talk in cancer: when ce-bling rivalries go awry.Cancer Discovery. 2013 Oct;3(10):1113-21.
    24072616
  • Papa A, Chen M, Pandolfi PP.Pills of PTEN? In and out for tumor suppression.Cell Res. 2013 Oct;23(10):1155-6.
    23917528
  • Reschke M, Clohessy JG, Seitzer N, Goldstein DP, Breitkopf SB, Schmolze DB, Ala U, Asara JM, Beck AH, Pandolfi PP.Characterization and analysis of the composition and dynamics of the mammalian riboproteome.Cell Rep. 2013 Sep 26;4(6):1276-87.
    24055062
  • Fagoonee S, Bearzi C, Di Cunto F, Clohessy JG, Rizzi R, Reschke M, Tolosano E, Provero P, Pandolfi PP, Silengo L, Altruda F.The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells.PLoS ONE. 2013;8(8):e72300.
    24015231
  • Stroopinsky D, Rosenblatt J, Ito K, Mills H, Yin L, Rajabi H, Vasir B, Kufe T, Luptakova K, Arnason J, Nardella C, Levine JD, Joyce RM, Galinsky I, Reiter Y, Stone RM, Pandolfi PP, Kufe D, Avigan D.MUC1 is a potential target for the treatment of acute myeloid leukemia stem cells.Cancer Res. 2013 Sep 1;73(17):5569-79.
    23867470
  • Song SJ, Poliseno L, Song MS, Ala U, Webster K, Ng C, Beringer G, Brikbak NJ, Yuan X, Cantley LC, Richardson AL, Pandolfi PP.MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.Cell. 2013 Jul 18;154(2):311-24.
    23830207
  • Song SJ, Ito K, Ala U, Kats L, Webster K, Sun SM, Jongen-Lavrencic M, Manova-Todorova K, Teruya-Feldstein J, Avigan DE, Delwel R, Pandolfi PP.The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation.Cell Stem Cell. 2013 Jul 3;13(1):87-101.
    23827711
  • Lunardi A, Ala U, Epping MT, Salmena L, Clohessy JG, Webster KA, Wang G, Mazzucchelli R, Bianconi M, Stack EC, Lis R, Patnaik A, Cantley LC, Bubley G, Cordon-Cardo C, Gerald WL, Montironi R, Signoretti S, Loda M, Nardella C, Pandolfi PP.A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.Nat Genet. 2013 Jul;45(7):747-55.
    23727860
  • Wang G, Lunardi A, Zhang J, Chen Z, Ala U, Webster KA, Tay Y, Gonzalez-Billalabeitia E, Egia A, Shaffer DR, Carver B, Liu XS, Taulli R, Kuo WP, Nardella C, Signoretti S, Cordon-Cardo C, Gerald WL, Pandolfi PP.Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion.Nat Genet. 2013 Jul;45(7):739-46.
    23727861
  • Lieberman J, Slack F, Pandolfi PP, Chinnaiyan A, Agami R, Mendell JT.Noncoding RNAs and cancer.Cell. 2013 Mar 28;153(1):9-10.
    23781554
  • Haupt S, Mitchell C, Corneille V, Shortt J, Fox S, Pandolfi PP, Castillo-Martin M, Bonal DM, Cordon-Carlo C, Lozano G, Haupt Y.Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner.Cell Cycle. 2013 May 8;12(11).
    23656786
  • Lunardi A, Guarnerio J, Wang G, Maeda T, Pandolfi PP.Role of LRF/Pokemon in lineage fate decisions.Blood. 2013 Apr 11;121(15):2845-53.
    23396304
  • Ala U, Karreth FA, Bosia C, Pagnani A, Taulli R, Léopold V, Tay Y, Provero P, Zecchina R, Pandolfi PP.Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments.Proc Natl Acad Sci U S A. 2013 Mar 27.
    23536298
  • Carracedo A, Cantley LC, Pandolfi PP.Cancer metabolism: fatty acid oxidation in the limelight.Nat Rev Cancer. 2013 Apr;13(4):227-32.
    23446547
  • Papa A, Cordon-Cardo C, Bernardi R, Pandolfi PP.Compound In Vivo Inactivation of Pml and p53 Uncovers a Functional Interaction in Angiosarcoma Suppression.Genes Cancer. 2012 Sep;3(9-10):599-603.
    23486996
  • Nguyen AH, Tremblay M, Haigh K, Koumakpayi IH, Paquet M, Pandolfi PP, Mes-Masson AM, Saad F, Haigh JJ, Bouchard M.Gata3 antagonizes cancer progression in Pten-deficient prostates.Hum Mol Genet. 2013 Mar 6.
    23428429
  • Juvekar A, Burga LN, Hu H, Lunsford EP, Ibrahim YH, Balmañà J, Rajendran A, Papa A, Spencer K, Lyssiotis CA, Nardella C, Pandolfi PP, Baselga J, Scully R, Asara JM, Cantley LC, Wulf GM.Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer.Cancer Discovery. 2012 Nov;2(11):1048-63.
    22915751
  • Ito K, Carracedo A, Weiss D, Arai F, Ala U, Avigan DE, Schafer ZT, Evans RM, Suda T, Lee CH, Pandolfi PP.A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.Nat Med. 2012 Sep;18(9):1350-8.
    22902876
  • Liu Y, Liu F, Yu H, Zhao X, Sashida G, Deblasio A, Harr M, She QB, Chen Z, Lin HK, Di Giandomenico S, Elf SE, Yang Y, Miyata Y, Huang G, Menendez S, Mellinghoff IK, Rosen N, Pandolfi PP, Hedvat CV, Nimer SD.Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus.Sci Signal. 2012;5(247):ra77.
    23092893
  • Khanna-Gupta A, Abayasekara N, Levine M, Sun H, Virgilio M, Nia N, Halene S, Sportoletti P, Jeong JY, Pandolfi PP, Berliner N.Up-regulation of translation eukaryotic initiation factor 4E in nucleophosmin 1 haploinsufficient cells results in changes in CCAAT enhancer-binding protein α activity: implications in myelodysplastic syndrome and acute myeloid leukemia.J Biol Chem. 2012 Sep 21;287(39):32728-37.
    22851180
  • Besin G, Yousefi M, Saba I, Klinck R, Pandolfi PP, Duplay P.Dok-1 overexpression promotes development of γδ natural killer T cells.Eur J Immunol. 2012 Sep;42(9):2491-504.
    22736313
  • Clohessy JG, Reschke M, Pandolfi PP.Found in translation of mTOR signaling.Cell Res. 2012 Sep;22(9):1315-8.
    22641373
  • Taulli R, Pandolfi PP."Snorkeling" for missing players in cancer.J Clin Invest. 2012 Aug 1;122(8):2765-8.
    22751102
  • Wolyniec K, Shortt J, de Stanchina E, Levav-Cohen Y, Alsheich-Bartok O, Louria-Hayon I, Corneille V, Kumar B, Woods SJ, Opat S, Johnstone RW, Scott CL, Segal D, Pandolfi PP, Fox S, Strasser A, Jiang YH, Lowe SW, Haupt S, Haupt Y.E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis.Blood. 2012 Jul 26;120(4):822-32.
    22689861
  • Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W.Acetylation-dependent regulation of Skp2 function.Cell. 2012 Jul 6;150(1):179-93.
    22770219
  • Nardella C, Lunardi A, Fedele G, Clohessy JG, Alimonti A, Kozma SC, Thomas G, Loda M, Pandolfi PP.Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis.Cancer Res. 2011 Mar 28.
    21444676
  • Finley LW, Carracedo A, Lee J, Souza A, Egia A, Zhang J, Teruya-Feldstein J, Moreira PI, Cardoso SM, Clish CB, Pandolfi PP, Haigis MC.SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization.Cancer Cell. 2011 Mar 8;19(3):416-28.
    21397863
  • Sasaki AT, Carracedo A, Locasale JW, Anastasiou D, Takeuchi K, Kahoud ER, Haviv S, Asara JM, Pandolfi PP, Cantley LC.Ubiquitination of k-ras enhances activation and facilitates binding to select downstream effectors.Sci Signal. 2011;4(163):ra13.
    21386094
  • Bernardi R, Papa A, Egia A, Coltella N, Teruya-Feldstein J, Signoretti S, Pandolfi PP.Pml represses tumour progression through inhibition of mTOR.EMBO Mol Med. 2011 Feb 17.
    21387562
  • Kandel E, Pandolfi PP.Tumor-associated oncogenes go on (phage) display.Oncotarget. 2010 Jun;1(2):84-5.
    21297221
  • Carracedo A, Alimonti A, Pandolfi PP.PTEN level in tumor suppression: how much is too little?.Cancer Res. 2011 Feb 1;71(3):629-33.
    21266353
  • Song MS, Carracedo A, Salmena L, Song SJ, Egia A, Malumbres M, Pandolfi PP.Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.Cell. 2011 Jan 21;144(2):187-99.
    21241890
  • Epping MT, Meijer LA, Krijgsman O, Bos JL, Pandolfi PP, Bernards R.TSPYL5 suppresses p53 levels and function by physical interaction with USP7.Nat Cell Biol. 2011 Jan;13(1):102-8.
    21170034
  • Snell LM, McPherson AJ, Lin GH, Sakaguchi S, Pandolfi PP, Riccardi C, Watts TH.CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection.J Immunol. 2010 Dec 15;185(12):7223-34.
    21076066
  • Berger AH, Pandolfi PP.Haplo-insufficiency: a driving force in cancer.J Pathol. 2011 Jan;223(2):137-46. Review.
    21125671
  • Giorgi C, Ito K, Lin HK, Santangelo C, Wieckowski MR, Lebiedzinska M, Bononi A, Bonora M, Duszynski J, Bernardi R, Rizzuto R, Tacchetti C, Pinton P, Pandolfi PP.PML regulates apoptosis at endoplasmic reticulum by modulating calcium release.Science. 2010 Nov 26;330(6008):1247-51.
    21030605
  • De Keersmaecker K, Real PJ, Gatta GD, Palomero T, Sulis ML, Tosello V, Van Vlierberghe P, Barnes K, Castillo M, Sole X, Hadler M, Lenz J, Aplan PD, Kelliher M, Kee BL, Pandolfi PP, Kappes D, Gounari F, Petrie H, Van der Meulen J, Speleman F, Paietta E, Racevskis J, Wiernik PH, Rowe JM, Soulier J, Avran D, Cavé H, Dastugue N, Raimondi S, Meijerink JP, Cordon-Cardo C, Califano A, Ferrando AA.The TLX1 oncogene drives aneuploidy in T cell transformation.Nat Med. 2010 Nov;16(11):1321-7.
    20972433
  • Berger AH, Pandolfi PP.Haplo-insufficiency: a driving force in cancer.J Pathol. 2010 Oct 6.
    21038315
  • Nardella C, Carracedo A, Salmena L, Pandolfi PP.Faithfull Modeling of PTEN Loss Driven Diseases in the Mouse.Curr Top Microbiol Immunol. 2011;347:135-68.
    20549475
  • Fagoonee S, Hobbs RM, De Chiara L, Cantarella D, Piro RM, Tolosano E, Medico E, Provero P, Pandolfi PP, Silengo L, Altruda F.Generation of Functional Hepatocytes from Mouse Germline Cell-derived Pluripotent Stem Cells in vitro.Stem Cells Dev. 2010 Aug;19(8):1183-94.
    20331356
  • Furic L, Rong L, Larsson O, Koumakpayi IH, Yoshida K, Brueschke A, Petroulakis E, Robichaud N, Pollak M, Gaboury LA, Pandolfi PP, Saad F, Sonenberg N.eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression.Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14134-9.
    20679199
  • Hobbs RM, Seandel M, Falciatori I, Rafii S, Pandolfi PP.Plzf regulates germline progenitor self-renewal by opposing mTORC1.Cell. 2010 Aug 6;142(3):468-79.
    20691905
  • Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP.A coding-independent function of gene and pseudogene mRNAs regulates tumour biology.Nature. 2010 Jun 24;465(7301):1033-8.
    20577206
  • Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung MC, Pandolfi PP, Lin HK.Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.Nat Cell Biol. 2010 May;12(5):457-67.
    20383141
  • Alimonti A, Carracedo A, Clohessy JG, Trotman LC, Nardella C, Egia A, Salmena L, Sampieri K, Haveman WJ, Brogi E, Richardson AL, Zhang J, Pandolfi PP.Subtle variations in Pten dose determine cancer susceptibility.Nat Genet. 2010 May;42(5):454-8.
    20400965
  • Cheng K, Sportoletti P, Ito K, Clohessy JG, Teruya-Feldstein J, Kutok JL, Pandolfi PP.The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.Blood. 2010 Apr 22;115(16):3341-5.
    19666870
  • Poliseno L, Salmena L, Riccardi L, Fornari A, Song MS, Hobbs RM, Sportoletti P, Varmeh S, Egia A, Fedele G, Rameh L, Loda M, Pandolfi PP.Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation.Sci Signal. 2010;3(117):ra29.
    20388916
  • Lin HK, Chen Z, Wang G, Nardella C, Lee SW, Chan CH, Yang WL, Wang J, Egia A, Nakayama KI, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP.Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.Nature. 2010 Mar 18;464(7287):374-9.
    20237562
  • Ferretti R, Palumbo V, Di Savino A, Velasco S, Sbroggiò M, Sportoletti P, Micale L, Turco E, Silengo L, Palumbo G, Hirsch E, Teruya-Feldstein J, Bonaccorsi S, Pandolfi PP, Gatti M, Tarone G, Brancaccio M.Morgana/chp-1, a ROCK Inhibitor Involved in Centrosome Duplication and Tumorigenesis.Dev Cell. 2010 Mar 16;18(3):486-495.
    20230755
  • Alimonti A, Nardella C, Chen Z, Clohessy JG, Carracedo A, Trotman LC, Cheng K, Varmeh S, Kozma SC, Thomas G, Rosivatz E, Woscholski R, Cognetti F, Scher HI, Pandolfi PP.A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.J Clin Invest. 2010 Mar 1;120(3):681-93.
    20197621
  • Ciraolo E, Morello F, Hobbs RM, Wolf F, Marone R, Iezzi M, Lu X, Mengozzi G, Altruda F, Sorba G, Guan K, Pandolfi PP, Wymann MP, Hirsch E.Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.Mol Biol Cell. 2010 Mar;21(5):704-11.
    20053680
  • Berger AH, Niki M, Morotti A, Taylor BS, Socci ND, Viale A, Brennan C, Szoke J, Motoi N, Rothman PB, Teruya-Feldstein J, Gerald WL, Ladanyi M, Pandolfi PP.Identification of DOK genes as lung tumor suppressors.Nat Genet. 2010 Mar;42(3):216-23.
    20139980
  • Nie D, Di Nardo A, Han JM, Baharanyi H, Kramvis I, Huynh T, Dabora S, Codeluppi S, Pandolfi PP, Pasquale EB, Sahin M.Tsc2-Rheb signaling regulates EphA-mediated axon guidance.Nat Neurosci. 2010 Feb;13(2):163-72.
    20062052
  • Alonzo ES, Gottschalk RA, Das J, Egawa T, Hobbs RM, Pandolfi PP, Pereira P, Nichols KE, Koretzky GA, Jordan MS, Sant'Angelo DB.Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3.J Immunol. 2010 Feb 1;184(3):1268-79.
    20038637
  • Mihich E, Pandolfi PP, Livingston D.Twenty-first annual Pezcoller Symposium: Unconventional Therapeutic Targets in Cancer.Cancer Res. 2010 Jan 1;70(1):14-7.
    20028862
  • Maeda T, Ito K, Merghoub T, Poliseno L, Hobbs RM, Wang G, Dong L, Maeda M, Dore LC, Zelent A, Luzzatto L, Teruya-Feldstein J, Weiss MJ, Pandolfi PP.LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis.Dev Cell. 2009 Oct;17(4):527-40.
    19853566
  • Khanna-Gupta A, Chen J, Sliver M. Sun H, Abayasekara N, Halene, S, Spotoloetti P, Pandlofi PP, Berliner N.Nucleophosmin-1 interacts with CCAAT enhancer binding protein alpha (C/EBPalpha) to facilitate granulocyte maturation: implications in MDS and AML.Blood..
  • Chen Z, Carracedo A, Lin HK, Koutcher JA, Behrendt N, Egia A, Alimonti A, Carver BS, Gerald W, Teruya-Feldstein J, Loda M, Pandolfi PP.Differential p53-independent outcomes of p19(Arf) loss in oncogenesis.Sci Signal. 2009;2(84):ra44.
    19690330
  • Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H.TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity.Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12453-8.
    19617548
  • Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC.Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.Cancer Cell. 2009 Aug 4;16(2):115-25.
    19647222
  • Gutierrez A,Sanda T,Grebliunaite R,Carracedo A,Salmena L,Ahn Y,Dahlberg S,Neuberg D,Moreau LA,Winter SS,Larson R,Zhang J,Protopopov A,Chin L,Pandolfi PP,Silverman LB,Hunger SP,Sallan SE,Look AT.High frequency of PTEN, PI3K and AKT abnormalities in T cell acute lymphoblastic leukemia.Blood. 2009 Jul 16;114(3):647-50.
    19458356
  • Xu D, Holko M, Sadler AJ, Scott B, Higashiyama S, Berkofsky-Fessler W, McConnell MJ, Pandolfi PP, Licht JD, Williams BR.Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity.Immunity. 2009 Jun 19;30(6):802-16.
    19523849
  • Carver BS,Tran J,Gopalan A,Chen Z,Shaikh S,Carracedo A,Alimonti A,Nardella C,Varmeh S,Scardino PT,Cordon-Cardo C,Gerald W,Pandolfi PP.Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.Nat Genet. 2009 May;41(5):619-24.
    19396168
  • Clohessy JG,Pandolfi PP.beta-tting on p63 as a metastatic suppressor.Cell. 2009 Apr 3;137(1):28-30.
    19345184
  • Fumagalli S,Di Cara A,Neb-Gulati A,Natt F,Schwemberger S,Hall J,Babcock GF,Bernardi R,Pandolfi PP,Thomas G.Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction.Nat Cell Biol. 2009 Apr;11(4):501-8.
    19287375
  • Lin HK,Wang G,Chen Z,Teruya-Feldstein J,Liu Y,Chan CH,Yang WL,Erdjument-Bromage H,Nakayama KI,Nimer S,Tempst P,Pandolfi PP.Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.Nat Cell Biol. 2009 Apr;11(4):420-32.
    19270694
  • Distefano G,Boca M,Rowe I,Wodarczyk C,Ma L,Piontek KB,Germino GG,Pandolfi PP,Boletta A.Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.Mol Cell Biol. 2009 May;29(9):2359-71.
    19255143
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  • Teitell MA,Pandolfi PP.Molecular genetics of acute lymphoblastic leukemia.Annu Rev Pathol. 2009;4:175-98. Review.
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  • Poliseno L,Pitto L,Simili M,Mariani L,Riccardi L,Ciucci A,Rizzo M,Evangelista M,Mercatanti A,Pandolfi PP,Rainaldi G.The proto-oncogene LRF is under post-transcriptional control of MiR-20a: implications for senescence.PLoS ONE. 2008;3(7):e2542.
    18596985
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  • Salmena L, Carracedo A, Pandolfi PP.Tenets of PTEN tumor suppression.Cell. 2008 May 2;133(3):403-14.
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  • Hambardzumyan D, Becher OJ, Rosenblum MK, Pandolfi PP, Manova-Todorova K, Holland EC.PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo.Genes Dev. 2008 Feb 15;22(4):436-48.
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  • Sportoletti P, Grisendi S, Majid SM, Cheng K, Clohessy JG, Viale A, Teruya-Feldstein J, Pandolfi PP.Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse.Blood. 2008 Apr 1;111(7):3859-62.
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  • Guidez F, Parks S, Wong H, Jovanovic JV, Mays A, Gilkes AF, Mills KI, Guillemin MC, Hobbs RM, Pandolfi PP, de The H, Solomon E, Grimwade D.RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia.Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18694-9.
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  • Bernardi R, Pandolfi PP.Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies.Nat Rev Mol Cell Biol. 2007 Dec;8(12):1006-16. Review.
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  • Maeda T, Merghoub T, Hobbs RM, Dong L, Maeda M, Zakrzewski J, van den Brink MR, Zelent A, Shigematsu H, Akashi K, Teruya-Feldstein J, Cattoretti G, Pandolfi PP.Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.Science. 2007 May 11;316(5826):860-6.
    17495164
  • Bernardi R, Guernah I, Jin D, Grisendi S, Alimonti A, Teruya-Feldstein J, Cordon-Cardo C, Simon MC, Rafii S, Pandolfi PP.PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR.Nature. 2006 Aug 17;442(7104):779-85.
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  • Scaglioni PP, Yung TM, Cai LF, Erdjument-Bromage H, Kaufman AJ, Singh B, Teruya-Feldstein J, Tempst P, Pandolfi PP.A CK2-dependent mechanism for degradation of the PML tumor suppressor.Cell. 2006 Jul 28;126(2):269-83.
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    16680151
  • Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M, Koutcher JA, Scher HI, Ludwig T, Gerald W, Cordon-Cardo C, Pandolfi PP.Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis.Nature. 2005 Aug 4;436(7051):725-30.
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