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Michele A. Gadd, MD


  • Camp MS, Coopey SB, Tang R, Colwell A, Specht M, Greenup RA, Gadd MA, Brachtel E, Austen WG, Smith BL.Management of Positive Sub-areolar/Nipple Duct Margins in Nipple-Sparing Mastectomies.Breast J. 2014 Jun 2.
  • Miller CL, West JA, Bettini AC, Koerner FC, Gudewicz TM, Freer PE, Coopey SB, Gadd MA, Hughes KS, Smith BL, Rafferty E, Specht MC.Surgical excision of radial scars diagnosed by core biopsy may help predict future risk of breast cancer.Breast Cancer Res Treat. 2014 Apr 19.
  • Wong JS, Chen YH, Gadd MA, Gelman R, Lester SC, Schnitt SJ, Sgroi DC, Silver BJ, Smith BL, Troyan SL, Harris JR.Eight-year update of a prospective study of wide excision alone for small low- or intermediate-grade ductal carcinoma in situ (DCIS).Breast Cancer Res Treat. 2014 Jan;143(2):343-50.
  • Tang R, Coopey SB, Buckley JM, Aftreth OP, Fernandez LJ, Brachtel EF, Michaelson JS, Gadd MA, Specht MC, Koerner FC, Smith BL.A pilot study evaluating shaved cavity margins with micro-computed tomography: a novel method for predicting lumpectomy margin status intraoperatively.Breast J.;19(5):485-9.
  • Coopey SB, Tang R, Lei L, Freer PE, Kansal K, Colwell AS, Gadd MA, Specht MC, Austen WG, Smith BL.Increasing eligibility for nipple-sparing mastectomy.Ann Surg Oncol. 2013 Oct;20(10):3218-22.
  • Macdonald SM, Patel SA, Hickey S, Specht M, Isakoff SJ, Gadd M, Smith BL, Yeap BY, Adams J, Delaney TF, Kooy H, Lu HM, Taghian AG.Proton Therapy for Breast Cancer After Mastectomy: Early Outcomes of a Prospective Clinical Trial.Int J Radiat Oncol Biol Phys. 2013 Mar 21.
  • Boutrus RR, Abi Raad RF, Kuter I, Ancukiewicz M, Roberts L, Solomon N, Ngo T, Borick H, Ryan P, Moy B, Gadd M, Chien J, Younger J, Smith B, Taghian AG, Harris L.Circulating tumor cells as predictors of response and failure in breast cancer patients treated with preoperative chemotherapy.Int J Biol Markers. 2012 Sep 17:0.
  • Coopey SB, Mazzola E, Buckley JM, Sharko J, Belli AK, Kim EM, Polubriaginof F, Parmigiani G, Garber JE, Smith BL, Gadd MA, Specht MC, Guidi AJ, Roche CA, Hughes KS.The role of chemoprevention in modifying the risk of breast cancer in women with atypical breast lesions.Breast Cancer Res Treat. 2012 Nov 2.
  • Camp MS, Greenup RA, Taghian A, Coopey SB, Specht M, Gadd M, Hughes K, Smith BL.Application of ACOSOG Z0011 Criteria Reduces Perioperative Costs.Ann Surg Oncol. 2012 Sep 26.
  • Pashtan IM, Recht A, Ancukiewicz M, Brachtel E, Abi-Raad RF, D'Alessandro HA, Levy A, Wo JY, Hirsch AE, Kachnic LA, Goldberg S, Specht M, Gadd M, Smith BL, Powell SN, Taghian AG.External beam accelerated partial-breast irradiation using 32 gy in 8 twice-daily fractions: 5-year results of a prospective study.Int J Radiat Oncol Biol Phys. 2012 Nov 1;84(3):e271-7.
  • Miller CL, Specht MC, Skolny MN, Jammallo LS, Horick N, O'Toole J, Coopey SB, Hughes K, Gadd M, Smith BL, Taghian AG.Sentinel lymph node biopsy at the time of mastectomy does not increase the risk of lymphedema: implications for prophylactic surgery.Breast Cancer Res Treat. 2012 Oct;135(3):781-9.
  • Greenup RA, Camp MS, Taghian AG, Buckley J, Coopey SB, Gadd M, Hughes K, Specht M, Smith BL.Cost comparison of radiation treatment options after lumpectomy for breast cancer.Ann Surg Oncol. 2012 Oct;19(10):3275-81.
  • Buckley JM, Coopey SB, Sharko J, Polubriaginof F, Drohan B, Belli AK, Kim EM, Garber JE, Smith BL, Gadd MA, Specht MC, Roche CA, Gudewicz TM, Hughes KS.The feasibility of using natural language processing to extract clinical information from breast pathology reports.J Pathol Inform. 2012;3:23.
  • Bafford A, Gadd M, Gu X, Lipsitz S, Golshan M.Diminishing morbidity with the increased use of sentinel node biopsy in breast carcinoma.Am J Surg. 2010 Sep;200(3):374-7.
  • Colwell AS, Gadd M, Smith BL, Austen WG.An inferolateral approach to nipple-sparing mastectomy: optimizing mastectomy and reconstruction.Ann Plast Surg. 2010 Aug;65(2):140-3.
  • Wo JY, Taghian AG, Nguyen PL, Raad RA, Sreedhara M, Bellon JR, Wong JS, Gadd MA, Smith BL, Harris JR.The Association Between Biological Subtype and Isolated Regional Nodal Failure After Breast-Conserving Therapy.Int J Radiat Oncol Biol Phys. 2010 May 1;77(1):188-96.
  • Samphao S, Wheeler AJ, Rafferty E, Michaelson JS, Specht MC, Gadd MA, Hughes KS, Smith BL.Diagnosis of breast cancer in women age 40 and younger: delays in diagnosis result from underuse of genetic testing and breast imaging.Am J Surg. 2009 Oct;198(4):538-43.
  • Murphy CD,Lee JM,Drohan B,Euhus DM,Kopans DB,Gadd MA,Rafferty EA,Specht MC,Smith BL,Hughes KS.The American Cancer Society guidelines for breast screening with magnetic resonance imaging: an argument for genetic testing.Cancer. 2008 Dec 1;113(11):3116-20.
  • Gradishar WJ,Bellon JR,Gadd MA,D'Alessandro HA,Braaten K.Case records of the Massachusetts General Hospital. Case 30-2008. A 47-year-old woman with a mass in the breast and a solitary lesion in the spine.N Engl J Med. 2008 Sep 25;359(13):1382-91.
  • Murphy CD,Jones JL,Javid SH,Michaelson JS,Nolan ME,Lipsitz SR,Specht MC,Lesnikoski BA,Hughes KS,Gadd MA,Smith BL.Do sentinel node micrometastases predict recurrence risk in ductal carcinoma in situ and ductal carcinoma in situ with microinvasion?.Am J Surg. 2008 Oct;196(4):566-8.
  • Kirstein LJ,Rafferty E,Specht MC,Moore RH,Taghian AG,Hughes KS,Gadd MA,Smith BL.Outcomes of multiple wire localization for larger breast cancers: when can mastectomy be avoided?.J Am Coll Surg. 2008 Sep;207(3):342-6.
  • Katz A, Smith BL, Golshan M, Niemierko A, Kobayashi W, Raad RA, Kelada A, Rizk L, Wong JS, Bellon JR, Gadd M, Specht M, Taghian AG.Nomogram for the prediction of having four or more involved nodes for sentinel lymph node-positive breast cancer.J Clin Oncol. 2008 May 1;26(13):2093-8.
  • Dominguez FJ, Golshan M, Black DM, Hughes KS, Gadd MA, Christian R, Lesnikoski BA, Specht M, Michaelson J, Smith BL.Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ.Ann Surg Oncol. 2008 Jan;15(1):268-73.
  • Black D, Specht M, Lee JM, Dominguez F, Gadd M, Hughes K, Rafferty E, Smith B.Detecting occult malignancy in prophylactic mastectomy: preoperative MRI versus sentinel lymph node biopsy.Ann Surg Oncol. 2007 Sep;14(9):2477-84.
  • Dominguez FJ, Lawrence C, Halpern EF, Drohan B, Grinstein G, Black DM, Smith BL, Gadd MA, Specht M, Kopans DB, Moore RH, Hughes SS, Roche CA, Hughes KS.Accuracy of Self-Reported Personal History of Cancer in an Outpatient Breast Center.J Genet Couns. 2007 Jun;16(3):341-5.
  • Kozak KR, Smith BL, Adams J, Kornmehl E, Katz A, Gadd M, Specht M, Hughes K, Gioioso V, Lu HM, Braaten K, Recht A, Powell SN, DeLaney TF, Taghian AG.Accelerated partial-breast irradiation using proton beams: initial clinical experience.Int J Radiat Oncol Biol Phys. 2006 Nov 1;66(3):691-8.
  • Zabicki K, Colbert JA, Dominguez FJ, Gadd MA, Hughes KS, Jones JL, Specht MC, Michaelson JS, Smith BL.Breast Cancer Diagnosis in Women </= 40 versus 50 to 60 Years: Increasing Size and Stage Disparity Compared With Older Women Over Time.Ann Surg Oncol. 2006 Aug;13(8):1072-7.
  • Wong JS, Kaelin CM, Troyan SL, Gadd MA, Gelman R, Lester SC, Schnitt SJ, Sgroi DC, Silver BJ, Harris JR, Smith BL.Prospective study of wide excision alone for ductal carcinoma in situ of the breast.J Clin Oncol. 2006 Mar 1;24(7):1031-6.
  • Taghian AG, Kozak KR, Doppke KP, Katz A, Smith BL, Gadd M, Specht M, Hughes K, Braaten K, Kachnic LA, Recht A, Powell SN.Initial dosimetric experience using simple three-dimensional conformal external-beam accelerated partial-breast irradiation.Int J Radiat Oncol Biol Phys. 2006 Mar 15;64(4):1092-9.
  • Partridge AH, Wong JS, Knudsen K, Gelman R, Sampson E, Gadd M, Bishop KL, Harris JR, Winer EP.Offering participants results of a clinical trial: sharing results of a negative study.Lancet. 2005 Mar 12-18;365(9463):963-4.
  • Elias N, Tanabe KK, Sober AJ, Gadd MA, Mihm MC, Goodspeed B, Cosimi AB.Is completion lymphadenectomy after a positive sentinel lymph node biopsy for cutaneous melanoma always necessary?.Arch Surg. 2004 Apr;139(4):400-4; discussion 404-5.
  • Yang C, Ionescu-Tiba V, Burns K, Gadd M, Zukerberg L, Louis DN, Sgroi D, Schmidt EV.The role of the cyclin D1-dependent kinases in ErbB2-mediated breast cancer.Am J Pathol. 2004 Mar;164(3):1031-8.
  • Evans HL, Krag DN, Teates CD, Patterson JW, Meijer S, Harlow SP, Tanabe KK, Loggie BW, Whitworth PW, Kusminsky RE, Carp NZ, Gadd MA, Slingluff CL.Lymphoscintigraphy and sentinel node biopsy accurately stage melanoma in patients presenting after wide local excision.Ann Surg Oncol. 2003 May;10(4):416-25.
  • Ma XJ, Salunga R, Tuggle JT, Gaudet J, Enright E, McQuary P, Payette T, Pistone M, Stecker K, Zhang BM, Zhou YX, Varnholt H, Smith B, Gadd M, Chatfield E, Kessler J, Baer TM, Erlander MG, Sgroi DC.Gene expression profiles of human breast cancer progression.Proc Natl Acad Sci U S A. 2003 May 13;100(10):5974-9.
  • Burstein HJ, Harris LN, Gelman R, Lester SC, Nunes RA, Kaelin CM, Parker LM, Ellisen LW, Kuter I, Gadd MA, Christian RL, Kennedy PR, Borges VF, Bunnell CA, Younger J, Smith BL, Winer EP.Preoperative therapy with trastuzumab and paclitaxel followed by sequential adjuvant doxorubicin/cyclophosphamide for HER2 overexpressing stage II or III breast cancer: a pilot study.J Clin Oncol. 2003 Jan 1;21(1):46-53.
  • Gadd M, Pisc C, Branda J, Ionescu-Tiba V, Nikolic Z, Yang C, Wang T, Shackleford GM, Cardiff RD, Schmidt EV.Regulation of cyclin D1 and p16(INK4A) is critical for growth arrest during mammary involution.Cancer Res. 2001 Dec 15;61(24):8811-9.
  • Greenberg DB, Jonasch E, Gadd MA, Ryan BF, Everett JR, Sober AJ, Mihm MA, Tanabe KK, Ott M, Haluska FG.Adjuvant therapy of melanoma with interferon-alpha-2b is associated with mania and bipolar syndromes.Cancer. 2000 Jul 15;89(2):356-62.
  • Jonasch E, Kumar UN, Linette GP, Hodi FS, Soiffer RJ, Ryan BF, Sober AJ, Mihm MC, Tsao H, Langley RG, Cosimi BA, Gadd MA, Tanabe KK, Souba W, Haynes HA, Barnhill R, Osteen R, Haluska FG.Adjuvant high-dose interferon alfa-2b in patients with high-risk melanoma.Cancer J. 2000 May-Jun;6(3):139-45.
  • Wrone DA, Tanabe KK, Cosimi AB, Gadd MA, Souba WW, Sober AJ.Lymphedema after sentinel lymph node biopsy for cutaneous melanoma: a report of 5 cases.Arch Dermatol. 2000 Apr;136(4):511-4.
  • Yu LL, Flotte TJ, Tanabe KK, Gadd MA, Cosimi AB, Sober AJ, Mihm MC, Duncan LM.Detection of microscopic melanoma metastases in sentinel lymph nodes.Cancer. 1999 Aug 15;86(4):617-27.
  • Mangi AA, Smith BL, Gadd MA, Tanabe KK, Ott MJ, Souba WW.Surgical management of phyllodes tumors.Arch Surg. 1999 May;134(5):487-92; discussion 492-3.
  • Gadd MA, Cosimi AB, Yu J, Duncan LM, Yu L, Flotte TJ, Souba WW, Ott MJ, Wong LS, Sober AJ, Mihm MC, Haluska FG, Tanabe KK.Outcome of patients with melanoma and histologically negative sentinel lymph nodes.Arch Surg. 1999 Apr;134(4):381-7.
  • Tseng JF, Tanabe KK, Gadd MA, Cosimi AB, Malt RA, Haluska FG, Mihm MC, Sober AJ, Souba WW.Surgical management of primary cutaneous melanomas of the hands and feet.Ann Surg. 1997 May;225(5):544-50; discussion 550-3.
  • Hosokawa Y, Gadd M, Smith AP, Koerner FC, Schmidt EV, Arnold A.Cyclin D1 (PRAD1) alternative transcript b: full-length cDNA cloning and expression in breast cancers.Cancer Lett. 1997 Feb 26;113(1-2):123-30.
  • Jones RM, Branda J, Johnston KA, Polymenis M, Gadd M, Rustgi A, Callanan L, Schmidt EV.An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc.Mol Cell Biol. 1996 Sep;16(9):4754-64.
  • Smith BL, Gadd MA, Lawler C, MacDonald DJ, Grudberg SC, Chi FS, Carlson K, Comegno A, Souba WW.Perception of breast cancer risk among women in breast center and primary care settings: correlation with age and family history of breast cancer.Surgery. 1996 Aug;120(2):297-303.
  • Souba WW, Tanabe KK, Gadd MA, Smith BL, Bushman MS.Attitudes and opinions toward surgical research. A survey of surgical residents and their chairpersons.Ann Surg. 1996 Apr;223(4):377-83.
  • Gadd MA, Casper ES, Woodruff JM, McCormack PM, Brennan MF.Development and treatment of pulmonary metastases in adult patients with extremity soft tissue sarcoma.Ann Surg. 1993 Dec;218(6):705-12.
  • Gadd MA, Coit DG.Recurrence patterns and outcome in 1019 patients undergoing axillary or inguinal lymphadenectomy for melanoma.Arch Surg. 1992 Dec;127(12):1412-6.
  • Gadd MA, McClellan DS, Neuman TS, Hansbrough JF.Effect of hyperbaric oxygen on murine neutrophil and T-lymphocyte functions.Crit Care Med. 1990 Sep;18(9):974-9.
  • Gadd MA, Hansbrough JF.Postburn suppression of murine lymphocyte and neutrophil functions is not reversed by prostaglandin blockade.J Surg Res. 1990 Jan;48(1):84-90.
  • Hansbrough JF, Gadd MA.Temporal analysis of murine lymphocyte subpopulations by monoclonal antibodies and dual-color flow cytometry after burn and nonburn injury.Surgery. 1989 Jul;106(1):69-80.
  • Gadd MA, Hansbrough JF, Hoyt DB, Ozkan N.Defective T-cell surface antigen expression after mitogen stimulation. An index of lymphocyte dysfunction after controlled murine injury.Ann Surg. 1989 Jan;209(1):112-8.
  • Gadd MA, Hansbrough JF, Soderberg CS, Field TO.Antibody formation after murine injury.J Surg Res. 1988 Jun;44(6):649-57.
  • Hansbrough JF, Miller LM, Field TO, Gadd MA.High dose intravenous immunoglobulin therapy in burn patients: pharmacokinetics and effects on microbial opsonization and phagocytosis.Pediatr Infect Dis J. 1988 May;7(5 Suppl):S49-56.
  • Hansbrough JF, Soderberg C, Field TO, Swisher S, Brahme J, Zapata-Sirvent RL, Tonks M, Gadd MA.Analysis of murine lymphocyte subpopulations by dual-color flow cytometry: technical considerations and specificities of monoclonal antibodies directed against surface markers.J Surg Res. 1988 Feb;44(2):121-36.
  • Hansbrough JF, Field TO, Gadd MA, Soderberg C.Immune response modulation after burn injury: T cells and antibodies.J Burn Care Rehabil. 1987 Nov-Dec;8(6):509-12.
  • Cohen IT, Gadd MA.Hirschsprung's disease in a kindred: a possible clue to the genetics of the disease.J Pediatr Surg. 1982 Oct;17(5):632-4.