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Peter V. Hauschka, PhD

Publications

  • Phillips JA, Mortensen LJ, Ruiz JP, Sridharan R, Kumar S, Torres M, Sharma P, Lin CP, Karp JM, Hauschka PV.Advances in Single-cell Tracking of Mesenchymal Stem Cells (MSCs) During Musculoskeletal Regeneration.Orthop J Harv Med Sch. 2012 Dec 1;14:22-28.
    24244929
  • Zhang Z, Wang H, Ikeda S, Fahey F, Bielenberg D, Smits P, Hauschka PV.Notch3 in human breast cancer cell lines regulates osteoblast-cancer cell interactions and osteolytic bone metastasis.Am J Pathol. 2010 Sep;177(3):1459-69.
    20651241
  • Sharma P, Patntirapong S, Hann S, Hauschka PV.RANKL-RANK signaling regulates expression of xenotropic and polytropic virus receptor (XPR1) in osteoclasts.Biochem Biophys Res Commun. 2010 Aug 20;399(2):129-32.
    20633538
  • Cai X, Lin Y, Friedrich CC, Neville C, Pomerantseva I, Sundback CA, Sharma P, Zhang Z, Vacanti JP, Hauschka PV, Grottkau BE.Bone marrow derived pluripotent cells are pericytes which contribute to vascularization.Stem Cell Rev. 2009 Dec;5(4):437-45.
    20058207
  • Naveiras O, Nardi V, Wenzel PL, Hauschka PV, Fahey F, Daley GQ.Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment.Nature. 2009 Jul 9;460(7252):259-63.
    19516257
  • Kozloff KM,Quinti L,Patntirapong S,Hauschka PV,Tung CH,Weissleder R,Mahmood U.Non-invasive optical detection of cathepsin K-mediated fluorescence reveals osteoclast activity in vitro and in vivo.Bone. 2009 Feb;44(2):190-8.
    19007918
  • Yang Q,McHugh KP,Patntirapong S,Gu X,Wunderlich L,Hauschka PV.VEGF enhancement of osteoclast survival and bone resorption involves VEGF receptor-2 signaling and beta3-integrin.Matrix Biol. 2008 Sep;27(7):589-99.
    18640270
  • Krum SA, Miranda-Carboni GA, Hauschka PV, Carroll JS, Lane TF, Freedman LP, Brown M.Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival.EMBO J. 2008 Feb 6;27(3):535-45.
    18219273
  • MacDonald BT, Joiner DM, Oyserman SM, Sharma P, Goldstein SA, He X, Hauschka PV.Bone mass is inversely proportional to Dkk1 levels in mice.Bone. 2007 Sep;41(3):331-9.
    17613296
  • Sharma P, Solomon KR, Hauschka PV.High-throughput tool for discovery of bone regulating factors.Biotechniques. 2006 Nov;41(5):539-40, 542.
    17140108
  • Gagari E, Rand MK, Tayari L, Vastardis H, Sharma P, Hauschka PV, Damoulis PD.Expression of stem cell factor and its receptor, c-kit, in human oral mesenchymal cells.Eur J Oral Sci. 2006 Oct;114(5):409-15.
    17026507
  • Boucher K, Siegel CS, Sharma P, Hauschka PV, Solomon KR.HMG-CoA reductase inhibitors induce apoptosis in pericytes.Microvasc Res. 2006 Mar;71(2):91-102.
    16427097
  • Massť PG, Boskey AL, Ziv I, Hauschka P, Donovan SM, Howell DS, Cole DE.Chemical and biomechanical characterization of hyperhomocysteinemic bone disease in an animal model.BMC Musculoskelet Disord. 2003 Feb 20;4:2.
    12597778
  • Danciu TE, Adam RM, Naruse K, Freeman MR, Hauschka PV.Calcium regulates the PI3K-Akt pathway in stretched osteoblasts.FEBS Lett. 2003 Feb 11;536(1-3):193-7.
    12586362
  • Wang ML, Hauschka PV, Tuan RS, Steinbeck MJ.Exposure to particles stimulates superoxide production by human THP-1 macrophages and avian HD-11EM osteoclasts activated by tumor necrosis factor-alpha and PMA.J Arthroplasty. 2002 Apr;17(3):335-46.
    11938511
  • Solomon KR, Adolphson LD, Wank DA, McHugh KP, Hauschka PV.Caveolae in human and murine osteoblasts.J Bone Miner Res. 2000 Dec;15(12):2391-401.
    11127204
  • Hauschka PV, Damoulis PD.Functions of nitric oxide in bone.Biochem Soc Trans. 1998 Feb;26(1):39-44.
    10909754
  • Chen L, Adar R, Yang X, Monsonego EO, Li C, Hauschka PV, Yayon A, Deng CX.Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis.J Clin Invest. 1999 Dec;104(11):1517-25.
    10587515
  • Steinbeck MJ, Kim JK, Trudeau MJ, Hauschka PV, Karnovsky MJ.Involvement of hydrogen peroxide in the differentiation of clonal HD-11EM cells into osteoclast-like cells.J Cell Physiol. 1998 Sep;176(3):574-87.
    9699510
  • Damoulis PD, Hauschka PV.Nitric oxide acts in conjunction with proinflammatory cytokines to promote cell death in osteoblasts.J Bone Miner Res. 1997 Mar;12(3):412-22.
    9076584
  • Nagy L, Kusstatscher S, Hauschka PV, Szabo S.Role of cysteine proteases and protease inhibitors in gastric mucosal damage induced by ethanol or ammonia in the rat.J Clin Invest. 1996 Aug 15;98(4):1047-54.
    8770878
  • Hunter GK, Hauschka PV, Poole AR, Rosenberg LC, Goldberg HA.Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins.Biochem J. 1996 Jul 1;317 ( Pt 1):59-64.
    8694787
  • Asahina I, Sampath TK, Hauschka PV.Human osteogenic protein-1 induces chondroblastic, osteoblastic, and/or adipocytic differentiation of clonal murine target cells.Exp Cell Res. 1996 Jan 10;222(1):38-47.
    8549671
  • Atkinson RA, Evans JS, Hauschka PV, Levine BA, Meats R, Triffitt JT, Virdi AS, Williams RJ.Conformational studies of osteocalcin in solution.Eur J Biochem. 1995 Sep 1;232(2):515-21.
    7556201
  • Neugebauer BM, Moore MA, Broess M, Gerstenfeld LC, Hauschka PV.Characterization of structural sequences in the chicken osteocalcin gene: expression of osteocalcin by maturing osteoblasts and by hypertrophic chondrocytes in vitro.J Bone Miner Res. 1995 Jan;10(1):157-63.
    7747623
  • Damoulis PD, Hauschka PV.Cytokines induce nitric oxide production in mouse osteoblasts.Biochem Biophys Res Commun. 1994 Jun 15;201(2):924-31.
    8003032
  • Maliakal JC, Asahina I, Hauschka PV, Sampath TK.Osteogenic protein-1 (BMP-7) inhibits cell proliferation and stimulates the expression of markers characteristic of osteoblast phenotype in rat osteosarcoma (17/2.8) cells.Growth Factors. 1994;11(3):227-34.
    7734148
  • Asahina I, Sampath TK, Nishimura I, Hauschka PV.Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria.J Cell Biol. 1993 Nov;123(4):921-33.
    8227149
  • McKee MD, Farach-Carson MC, Butler WT, Hauschka PV, Nanci A.Ultrastructural immunolocalization of noncollagenous (osteopontin and osteocalcin) and plasma (albumin and alpha 2HS-glycoprotein) proteins in rat bone.J Bone Miner Res. 1993 Apr;8(4):485-96.
    8475798
  • Taichman RS, Hauschka PV.Effects of interleukin-1 beta and tumor necrosis factor-alpha on osteoblastic expression of osteocalcin and mineralized extracellular matrix in vitro.Inflammation. 1992 Dec;16(6):587-601.
    1459694
  • Spampata R, Werther JR, Hauschka PV.Accelerated endochondral osteoinduction in the absence of bone matrix particles in a rat model system.J Oral Maxillofac Surg. 1992 Feb;50(2):140-51; discussion 151-2.
    1732488
  • Nguyen L, Dewhirst FE, Hauschka PV, Stashenko P.Interleukin-1 beta stimulates bone resorption and inhibits bone formation in vivo.Lymphokine Cytokine Res. 1991 Apr;10(1-2):15-21.
    1873357
  • Vernillo AT, Rifkin BR, Hauschka PV.Phenytoin affects osteocalcin secretion from osteoblastic rat osteosarcoma 17/2.8 cells in culture.Bone. 1990;11(5):309-12.
    2252808
  • Hauschka PV, Lian JB, Cole DE, Gundberg CM.Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone.Physiol Rev. 1989 Jul;69(3):990-1047.
    2664828
  • Auf'mkolk B, Hauschka PV, Schwartz ER.Characterization of human bone cells in culture.Calcif Tissue Int. 1985 May;37(3):228-35.
    2990642
  • Boskey AL, Wians FH, Hauschka PV.The effect of osteocalcin on in vitro lipid-induced hydroxyapatite formation and seeded hydroxyapatite growth.Calcif Tissue Int. 1985 Jan;37(1):57-62.
    3922598
  • Hauschka PV, Frenkel J, DeMuth R, Gundberg CM.Presence of osteocalcin and related higher molecular weight 4-carboxyglutamic acid-containing proteins in developing bone.J Biol Chem. 1983 Jan 10;258(1):176-82.
    6600233
  • Hauschka PV, Carr SA.Calcium-dependent alpha-helical structure in osteocalcin.Biochemistry. 1982 May 11;21(10):2538-47.
    6807342
  • Lian JB, Glimcher MJ, Roufosse AH, Hauschka PV, Gallop PM, Cohen-Solal L, Reit B.Alterations of the gamma-carboxyglutamic acid and osteocalcin concentrations in vitamin D-deficient chick bone.J Biol Chem. 1982 May 10;257(9):4999-5003.
    6802844
  • Hauschka PV, Carr SA, Biemann K.Primary structure of monkey osteocalcin.Biochemistry. 1982 Feb 16;21(4):638-42.
    6978733
  • Carr SA, Hauschka PV, Biemann K.Gas chromatographic mass spectrometric sequence determination of osteocalcin, a gamma-carboxyglutamic acid-containing protein from chicken bone.J Biol Chem. 1981 Oct 10;256(19):9944-50.
    6792200
  • Gallop PM, Lian JB, Hauschka PV.Carboxylated calcium-binding proteins and vitamin K.N Engl J Med. 1980 Jun 26;302(26):1460-6.
    6990261
  • Hauschka PV.Quantitative determination of gamma-carboxyglutamic acid in proteins.Anal Biochem. 1977 May 15;80(1):212-23.
    883632
  • Hauschka PV, Lian JB, Gallop PM.Direct identification of the calcium-binding amino acid, gamma-carboxyglutamate, in mineralized tissue.Proc Natl Acad Sci U S A. 1975 Oct;72(10):3925-9.
    1060074
  • Hauschka PV.Analysis of nucleotide pools in animal cells.Methods Cell Biol. 1973;7:361-462.
    4592524