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Terry B. Strom, MD


  • Carlson AL, Fujisaki J, Wu J, Runnels JM, Turcotte R, Celso CL, Scadden DT, Strom TB, Lin CP.Tracking single cells in live animals using a photoconvertible near-infrared cell membrane label.PLoS ONE. 2013;8(8):e69257.
  • Yang X, Kallarakal A, Saptharishi N, Jiang H, Yang Z, Xie Y, Mitra G, Zheng XX, Strom TB, Soman G.Molecular characterization and functional activity of an IL-15 antagonist MutIL-15/Fc human fusion protein.Mol Pharm. 2013 Feb 4;10(2):717-27.
  • Balasubramanian S, Kota SK, Kuchroo VK, Humphreys BD, Strom TB.TIM family proteins promote the lysosomal degradation of the nuclear receptor NUR77.Sci Signal. 2012 Dec 11;5(254):ra90.
  • Koulmanda M, Bhasin M, Fan Z, Hanidziar D, Goel N, Putheti P, Movahedi B, Libermann TA, Strom TB.Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival.Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15443-8.
  • Veenstra RG, Taylor PA, Zhou Q, Panoskaltsis-Mortari A, Hirashima M, Flynn R, Liu D, Anderson AC, Strom TB, Kuchroo VK, Blazar BR.Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells.Blood. 2012 Jul 19;120(3):682-90.
  • Gupta S, Thornley TB, Gao W, Larocca R, Turka LA, Kuchroo VK, Strom TB.Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs.J Clin Invest. 2012 Jul 2;122(7):2395-404.
  • El Essawy B, Putheti P, Gao W, Strom TB.Rapamycin Generates Graft-Homing Murine Suppressor CD8(+) T Cells That Confer Donor-Specific Graft Protection.Cell Transplant. 2011 Mar 25.
  • Park J, Gao W, Whiston R, Strom TB, Metcalfe S, Fahmy TM.Modulation of CD4+ T lymphocyte lineage outcomes with targeted, nanoparticle-mediated cytokine delivery.Mol Pharm. 2011 Feb 7;8(1):143-52.
  • Hanidziar D, Koulmanda M, Strom TB.Creating transplant tolerance by taming adverse intragraft innate immunity.F1000 Biol Rep. 2010;2:83.
  • Sánchez-Fueyo A, Strom TB.Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organs.Gastroenterology. 2011 Jan;140(1):51-64. Review.
  • Kirk A, Strom TB.Immunogenetics and transplantation.Curr Opin Immunol. 2010 Oct;22(5):631-3.
  • Fan Z, Spencer JA, Lu Y, Pitsillides CM, Singh G, Kim P, Yun SH, Toxavidis V, Strom TB, Lin CP, Koulmanda M.In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response.Nat Med. 2010 Jun;16(6):718-22.
  • Kang HG, Lee JE, Yang SH, Lee SH, Gao W, Strom TB, Oh K, Lee DS, Kim YS.Donor-strain-derived immature dendritic cell pre-treatment induced hyporesponsiveness against allogeneic antigens.Immunology. 2010 Apr;129(4):567-77.
  • Putheti P, Awasthi A, Popoola J, Gao W, Strom TB.Human CD4 memory T cells can become CD4+IL-9+ T cells.PLoS ONE. 2010;5(1):e8706.
  • Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK.TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines.Eur J Immunol. 2009 Sep;39(9):2492-501.
  • Strom TB, Koulmanda M.Recently discovered T cell subsets cannot keep their commitments.J Am Soc Nephrol. 2009 Aug;20(8):1677-80. Review.
  • Gounaris E, Blatner NR, Dennis K, Magnusson F, Gurish MF, Strom TB, Beckhove P, Gounari F, Khazaie K.T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis.Cancer Res. 2009 Jul 1;69(13):5490-7.
  • Gao W,Thompson L,Zhou Q,Putheti P,Fahmy TM,Strom TB,Metcalfe SM.Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6.Cell Cycle. 2009 May 1;8(9):1444-50.
  • Mariat C,Degauque N,Balasubramanian S,Kenny J,DeKruyff RH,Umetsu DT,Kuchroo V,Zheng XX,Strom TB.Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation.J Immunol. 2009 Feb 1;182(3):1379-85.
  • Dardalhon V,Awasthi A,Kwon H,Galileos G,Gao W,Sobel RA,Mitsdoerffer M,Strom TB,Elyaman W,Ho IC,Khoury S,Oukka M,Kuchroo VK.IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells.Nat Immunol. 2008 Dec;9(12):1347-55.
  • Strom TB,Koulmanda M.Cytokine related therapies for autoimmune disease.Curr Opin Immunol. 2008 Dec;20(6):676-81. Review.
  • Koulmanda M,Bhasin M,Hoffman L,Fan Z,Qipo A,Shi H,Bonner-Weir S,Putheti P,Degauque N,Libermann TA,Auchincloss H Jr,Flier JS,Strom TB.Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16242-7.
  • Feng G,Gao W,Strom TB,Oukka M,Francis RS,Wood KJ,Bushell A.Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells.Eur J Immunol. 2008 Sep;38(9):2512-27.
  • Tzianabos AO,Holsti MA,Zheng XX,Stucchi AF,Kuchroo VK,Strom TB,Glimcher LH,Cruikshank WW.Functional Th1 cells are required for surgical adhesion formation in a murine model.J Immunol. 2008 May 15;180(10):6970-6.
  • Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK.TIM-4 expressed on APCs induces T cell expansion and survival.J Immunol. 2008 Apr 1;180(7):4706-13.
  • Muthukumarana PA, Zheng XX, Rosengard BR, Strom TB, Metcalfe SM.In primed allo-tolerance, TIM-3-Ig rapidly suppresses TGFbeta, but has no immediate effect on Foxp3.Transpl Int. 2008 Jun;21(6):593-7.
  • Degauque N, Mariat C, Kenny J, Zhang D, Gao W, Vu MD, Alexopoulos S, Oukka M, Umetsu DT, DeKruyff RH, Kuchroo V, Zheng XX, Strom TB.Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice.J Clin Invest. 2008 Feb;118(2):735-41.
  • Degauque N, Mariat C, Kenny J, Sanchez-Fueyo A, Alexopoulos SP, Kuchroo V, Zheng XX, Strom TB.Regulation of T-cell immunity by T-cell immunoglobulin and mucin domain proteins.Transplantation. 2007 Jul 15;84(1 Suppl):S12-6.
  • Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, Imitola J, Korn T, Anderson AC, Zhang Z, Gutierrez C, Moll T, Sobel RA, Umetsu DT, Yagita H, Akiba H, Strom T, Sayegh MH, DeKruyff RH, Khoury SJ, Kuchroo VK.Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function.J Exp Med. 2007 Jul 9;204(7):1691-702.
  • Korn T, Bettelli E, Gao W, Awasthi A, Jager A, Strom TB, Oukka M, Kuchroo VK.IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.Nature. 2007 Jul 26;448(7152):484-7.
  • Gao W, Lu Y, El Essawy B, Oukka M, Kuchroo VK, Strom TB.Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells.Am J Transplant. 2007 Jul;7(7):1722-32.
  • Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC.Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.J Exp Med. 2007 Jun 11;204(6):1257-65.
  • Sanchez-Fueyo A, Domenig CM, Mariat C, Alexopoulos S, Zheng XX, Strom TB.Influence of direct and indirect allorecognition pathways on CD4+CD25+ regulatory T-cell function in transplantation.Transpl Int. 2007 Jun;20(6):534-41.
  • Koyama I, Nadazdin O, Boskovic S, Ochiai T, Smith RN, Sykes M, Sogawa H, Murakami T, Strom TB, Colvin RB, Sachs DH, Benichou G, Cosimi AB, Kawai T.Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft.Am J Transplant. 2007 May;7(5):1055-61.
  • El Essawy B, Otu HH, Choy B, Zheng XX, Libermann TA, Strom TB.Proteomic analysis of the allograft response.Transplantation. 2006 Jul 27;82(2):267-74.
  • Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK.Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.Nature. 2006 May 11;441(7090):235-8.
  • Kato K, Jeanneau C, Tarp MA, Benet-Pagès A, Lorenz-Depiereux B, Bennett EP, Mandel U, Strom TM, Clausen H.Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation.J Biol Chem. 2006 Jul 7;281(27):18370-7.
  • Koulmanda M, Smith RN, Qipo A, Weir G, Auchincloss H, Strom TB.Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term anti-CD154-based therapy: nonimmunologic graft failure?.Am J Transplant. 2006 Apr;6(4):687-96.
  • Diem Vu M, Li Y, Strom TB, Li XC.Mycophenolate mofetil is compatible with CD28/CD154 costimulatory blockade in preventing transplant rejection.Transplantation. 2005 Mar 27;79(6):736.
  • McDaid J, Yamashita K, Chora A, Ollinger R, Strom TB, Li XC, Bach FH, Soares MP.Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells.FASEB J. 2005 Mar;19(3):458-60.
  • Sánchez-Fueyo A, Strom TB.Immunological tolerance and liver transplantation.J Hepatol. 2004 Nov;41(5):698-705.
  • Sabatos CA, Chakravarti S, Cha E, Schubart A, Sánchez-Fueyo A, Zheng XX, Coyle AJ, Strom TB, Freeman GJ, Kuchroo VK.Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance.Nat Immunol. 2003 Nov;4(11):1102-10.
  • Barouch DH, Santra S, Schmitz JE, Kuroda MJ, Fu TM, Wagner W, Bilska M, Craiu A, Zheng XX, Krivulka GR, Beaudry K, Lifton MA, Nickerson CE, Trigona WL, Punt K, Freed DC, Guan L, Dubey S, Casimiro D, Simon A, Davies ME, Chastain M, Strom TB, Gelman RS, Montefiori DC, Lewis MG, Emini EA, Shiver JW, Letvin NL.Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination.Science. 2000 Oct 20;290(5491):486-92.
  • Li Y, Li XC, Zheng XX, Wells AD, Turka LA, Strom TB.Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance.Nat Med. 1999 Nov;5(11):1298-302.
  • Wells AD, Li XC, Li Y, Walsh MC, Zheng XX, Wu Z, Nuñez G, Tang A, Sayegh M, Hancock WW, Strom TB, Turka LA.Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance.Nat Med. 1999 Nov;5(11):1303-7.
  • Li XC, Zand MS, Li Y, Zheng XX, Strom TB.On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses.J Immunol. 1998 Sep 1;161(5):2241-7.
  • Tran HM, Nickerson PW, Restifo AC, Ivis-Woodward MA, Patel A, Allen RD, Strom TB, O'Connell PJ.Distinct mechanisms for the induction and maintenance of allograft tolerance with CTLA4-Fc treatment.J Immunol. 1997 Sep 1;159(5):2232-9.
  • Zheng XX, Sayegh MH, Zheng XG, Li Y, Linsley PS, Peach R, Borriello F, Strom TB, Sharpe AH, Turka LA.The role of donor and recipient B7-1 (CD80) in allograft rejection.J Immunol. 1997 Aug 1;159(3):1169-73.
  • Tivol EA, Boyd SD, McKeon S, Borriello F, Nickerson P, Strom TB, Sharpe AH.CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice.J Immunol. 1997 Jun 1;158(11):5091-4.
  • Zheng XX, Steele AW, Hancock WW, Stevens AC, Nickerson PW, Roy-Chaudhury P, Tian Y, Strom TB.A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice.J Immunol. 1997 May 1;158(9):4507-13.
  • Perez VL, Van Parijs L, Biuckians A, Zheng XX, Strom TB, Abbas AK.Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.Immunity. 1997 Apr;6(4):411-7.
  • Borriello F, Sethna MP, Boyd SD, Schweitzer AN, Tivol EA, Jacoby D, Strom TB, Simpson EM, Freeman GJ, Sharpe AH.B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation.Immunity. 1997 Mar;6(3):303-13.
  • Strehlau J, Pavlakis M, Lipman M, Shapiro M, Vasconcellos L, Harmon W, Strom TB.Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation.Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):695-700.
  • Strom TB, Roy-Chaudhury P, Manfro R, Zheng XX, Nickerson PW, Wood K, Bushell A.The Th1/Th2 paradigm and the allograft response.Curr Opin Immunol. 1996 Oct;8(5):688-93.
  • Pavlakis M, Strehlau J, Lipman M, Shapiro M, Maslinski W, Strom TB.Intragraft IL-15 transcripts are increased in human renal allograft rejection.Transplantation. 1996 Aug 27;62(4):543-5.
  • Strehlau J, Pavlakis M, Lipman M, Maslinski W, Shapiro M, Strom TB.The intragraft gene activation of markers reflecting T-cell-activation and -cytotoxicity analyzed by quantitative RT-PCR in renal transplantation.Clin Nephrol. 1996 Jul;46(1):30-3.
  • Nickerson P, Zheng XX, Steiger J, Steele AW, Steurer W, Roy-Chaudhury P, Müller W, Strom TB.Prolonged islet allograft acceptance in the absence of interleukin 4 expression.Transpl Immunol. 1996 Mar;4(1):81-5.
  • Steiger J, Nickerson PW, Steurer W, Moscovitch-Lopatin M, Strom TB.IL-2 knockout recipient mice reject islet cell allografts.J Immunol. 1995 Jul 1;155(1):489-98.
  • Nickerson P, Steurer W, Steiger J, Zheng X, Steele AW, Strom TB.Cytokines and the Th1/Th2 paradigm in transplantation.Curr Opin Immunol. 1994 Oct;6(5):757-64.
  • Suthanthiran M, Strom TB.Renal transplantation.N Engl J Med. 1994 Aug 11;331(6):365-76.