DF/HCC Program Affiliation

Cancer Imaging

Research Abstract

Our laboratory studies the biophysical effects of densely ionizing radiation and its application to experimental cancer therapy. The interaction of alpha particles as well as Auger and Koster-Cronig electrons wtih chromosal DNA and its consituents is a central focus. Biological endpoints include double strand breaks, clonal survival, transformation and mutagenesis. The information obtained from these studies is used in the development of agents for targeted radionuclide therapy.We are also interested in cell surface enzymes and mitochondrial membranes as targets for radio-labeled imaging and therapeutic probes.

Publications

• Pospisil P, Wang K, Al Aowad AF, Iyer LK, Adelstein SJ, Kassis AI.Computational modeling and experimental evaluation of a novel prodrug for targeting the extracellular space of prostate tumors.Cancer Res 2007 Mar 1;67(5):2197-205.
  17332350
• Balagurumoorthy P, Chen K, Bash RC, Adelstein SJ, Kassis AI.Mechanisms underlying production of double-strand breaks in plasmid DNA after decay of 125I-Hoechst.Radiat Res 2006 Aug;166(2):333-44.
  16881734
• Kishikawa H, Wang K, Adelstein SJ, Kassis AI.Inhibitory and stimulatory bystander effects are differentially induced by Iodine-125 and Iodine-123.Radiat Res 2006 Jun;165(6):688-94.
  16802869
• Adelstein SJ, Kassis AI, Bodei L, Mariani G.Radiotoxicity of iodine-125 and other auger-electron-emitting radionuclides: background to therapy.Cancer Biother Radiopharm 2003 Jun;18(3):301-16.
  12954118
• Kassis AI, Wen PY, Van den Abbeele AD, Baranowska-Kortylewicz J, Makrigiorgos GM, Metz KR, Matalka KZ, Cook CU, Sahu SK, Black PM, Adelstein SJ.5-[125I]iodo-2'-deoxyuridine in the radiotherapy of brain tumors in rats.J Nucl Med 1998 Jul;39(7):1148-54.
  9669385
• Kassis AI, Korideck H, Wang K, Pospisil P, Adelstein SJ.Novel prodrugs for targeting diagnostic and therapeutic radionuclides to solid tumors.Molecules 2008;13(2):391-404.
  18305426
• Wong RC, Favaloro EJ, Adelstein S, Baumgart K, Bird R, Brighton TA, Empson M, Gillis D, Hendle MJ, Laurent R, Mallon D, Pollock W, Smith S, Steele RH, Wilson RJ.Consensus guidelines on anti-beta 2 glycoprotein I testing and reporting.Pathology 2008 Jan;40
  18038317
• Wang K, Adelstein SJ, Kassis AI.DMSO increases radioiodination yield of radiopharmaceuticals.Appl Radiat Isot 2008 Jan;66(1):50-9.
  17931872
• Wang K, Kirichian AM, Aowad AF, Adelstein SJ, Kassis AI.Evaluation of chemical, physical, and biologic properties of tumor-targeting radioiodinated quinazolinone derivative.Bioconjug Chem 2007 May-Jun;18(3):754-64.
  17385903
• Chen K, Aowad AF, Adelstein SJ, Kassis AI.Molecular-docking-guided design, synthesis, and biologic evaluation of radioiodinated quinazolinone prodrugs.J Med Chem 2007 Feb 22;50(4):663-73.
  17256924
• Chen K, Wang K, Kirichian AM, Al Aowad AF, Iyer LK, Adelstein SJ, Kassis AI.In silico design, synthesis, and biological evaluation of radioiodinated quinazolinone derivatives for alkaline phosphatase-mediated cancer diagnosis and therapy.Mol Cancer Ther 2
  17172404
• Urashima T, Nagasawa H, Wang K, Adelstein SJ, Little JB, Kassis AI.Induction of apoptosis in human tumor cells after exposure to Auger electrons: comparison with gamma-ray exposure.Nucl Med Biol 2006 Nov;33(8):1055-63.
  17127180
• Pospisil P, Iyer LK, Adelstein SJ, Kassis AI.A combined approach to data mining of textual and structured data to identify cancer-related targets.BMC Bioinformatics 2006 Jul 20;7(1):354.
  16857057
• Semnani ES, Wang K, Adelstein SJ, Kassis AI.5-[123I/125I]iodo-2'-deoxyuridine in metastatic lung cancer: radiopharmaceutical formulation affects targeting.J Nucl Med 2005 May;46(5):800-6.
  15872354
• Kassis AI, Kirichian AM, Wang K, Semnani ES, Adelstein SJ.Therapeutic potential of 5-[125I]iodo-2'-deoxyuridine and methotrexate in the treatment of advanced neoplastic meningitis.Int J Radiat Biol 2004 Nov-Dec;80(11-12):941-6.
  15764406
• Chen K, Adelstein SJ, Kassis AI.Molecular simulation of ligand-binding with DNA: implications for 125I-labeled pharmaceutical design.Int J Radiat Biol 2004 Nov-Dec;80(11-12):921-6.
  15764403
• Urashima T, Wang K, Adelstein SJ, Kassis AI.Activation of diverse pathways to apoptosis by (125)IdUrd and gamma-photon exposure.Int J Radiat Biol 2004 Nov-Dec;80(11-12):867-74.
  15764395
• Kassis AI, Adelstein SJ.Radiobiologic principles in radionuclide therapy.J Nucl Med 2005 Jan;46 Suppl 1:4S-12S.
  15653646
• Britz-Cunningham SH, Adelstein SJ.Molecular targeting with radionuclides: state of the science.J Nucl Med 2003 Dec;44(12):1945-61.
  14660721
• Adelstein SJ.Biologic responses to low doses of ionizing radiation: adaptive response versus bystander effect.J Nucl Med 2003 Jan;44(1):125; author reply 125-6.
  12515886
• Xue LY, Butler NJ, Makrigiorgos GM, Adelstein SJ, Kassis AI.Bystander effect produced by radiolabeled tumor cells in vivo.Proc Natl Acad Sci U S A 2002 Oct 15;99(21):13765-70.
  12368480
• Ho NH, Harapanhalli RS, Dahman BA, Chen K, Wang K, Adelstein SJ, Kassis AI.Synthesis and biologic evaluation of a radioiodinated quinazolinone derivative for enzyme-mediated insolubilization therapy.Bioconjug Chem 2002 Mar-Apr;13(2):357-64.
  11906274
• Adelstein SJ.Robley Evans and what physics can do for medicine.Cancer Biother Radiopharm 2001 Jun;16(3):179-85.
  11471483
• Walicka MA, Adelstein SJ, Kassis AI.Chemical modification of 5-[125I]iodo-2'-deoxyuridine toxicity in mammalian cells in vitro.Int J Radiat Biol 2001 May;77(5):625-30.
  11382341
• Adelstein SJ.The 2000 NCRP Lauriston S. Taylor lecture--administered radioactivity: unde venimus quoque imus. National Council on Radiation Protection and Measurements.Health Phys 2001 Apr;80(4):317-24.
  11281198
• Walicka MA, Ding Y, Adelstein SJ, Kassis AI.Morphological transformation of C3H 10T1/2 cells by 99mTc-cardiolite.J Nucl Med 2000 Sep;41(9):1545-51.
  10994737
• Walicka MA, Ding Y, Adelstein SJ, Kassiss AI.Toxicity of DNA-incorporated iodine-125: quantifying the direct and indirect effects.Radiat Res 2000 Sep;154(3):326-30.
  10956440
• Walicka MA, Adelstein SJ, Kassis AI.Indirect mechanisms contribute to biological effects produced by decay of DNA-incorporated iodine-125 in mammalian cells in vitro: clonogenic survival.Radiat Res 1998 Feb;149(2):142-6.
  9457893
• Walicka MA, Adelstein SJ, Kassis AI.Indirect mechanisms contribute to biological effects produced by decay of DNA-incorporated iodine-125 in mammalian cells in vitro: double-strand breaks.Radiat Res 1998 Feb;149(2):134-41.
  9457892
• Sahu SK, Wen PY, Foulon CF, Nagel JS, Black PM, Adelstein SJ, Kassis AI.Intrathecal 5-[125I]iodo-2'-deoxyuridine in a rat model of leptomeningeal metastases.J Nucl Med 1997 Mar;38(3):386-90.
  9074525
• Kassis AI, Adelstein SJ, Mariani G.Radiolabeled nucleoside analogs in cancer diagnosis and therapy.Q J Nucl Med 1996 Sep;40(3):301-19.
  8961807
• Mariani G, Di Sacco S, Volterrani D, Di Luca L, Buralli S, Di Stefano R, Baranowska-Kortylewicz J, Bonora D, Matteucci F, Ricci S, Bellina CR, Falcone A, Salvadori PA, Mosca F, Adelstein SJ, Kassis AI.Tumor targeting by intra-arterial infusion of 5-[123I]
  8676199
• Kassis AI, Tumeh SS, Wen PY, Baranowska-Kortylewicz J, Van den Abbeele AD, Zimmerman RE, Carvalho PA, Garada BM, DeSisto WC, Bailey NO, Castronovo FP, Mariani G, Black PM, Adelstein SJ.Intratumoral administration of 5-[123I]iodo-2'-deoxyuridine in a patie
  8676198
• Mariani G, Collecchi P, Baldassarri S, Di Luca L, Buralli S, Fontanini G, Baranowska-Kortylewicz J, Adelstein SJ, Kassis AI.Tumor uptake and mitotic activity pattern of 5-[125I]iodo-2'- deoxyuridine after intravesical infusion in patients with bladder can
  8676197
• Kassis AI, Adelstein SJ.Preclinical animal studies with radioiododeoxyuridine.J Nucl Med 1996 Apr;37(4 Suppl):10S-12S.
  8676195
• Van den Abbeele AD, Tutrone RF, Berman RM, Baranowska-Kortylewicz J, Barclay PD, Richie JP, Adelstein SJ, Kassis AI.Tumor-targeting potential of radioiodinated iododeoxyuridine in bladder cancer.J Nucl Med 1996 Feb;37(2):315-20.
  8667069
• Mariani G, Di Sacco S, Bonini R, Di Luca L, Buralli S, Bonora D, Ricci S, Baranowska-Kortylewicz J, Adelstein SJ, Falcone A, Kassis AI.Biochemical modulation by 5-fluorouracil and 1-folinic acid of tumor uptake of intra-arterial 5-[123I]iodo-2'deoxyuridin
  9004775
• Kassis AI, Adelstein SJ.5-[125]iodo-2'-deoxyuridine in the radiotherapy of solid CNS tumors in rats.Acta Oncol 1996;35(7):935-9.
  9004774
• Adelstein SJ.Merrill C. Sosman Lecture. The Auger process: a therapeutic promise?.AJR Am J Roentgenol 1993 Apr;160(4):707-13.
  8456649
• Baranowska-Kortylewicz J, Makrigiorgos GM, Van den Abbeele AD, Berman RM, Adelstein SJ, Kassis AI.5-[123I]iodo-2'-deoxyuridine in the radiotherapy of an early ascites tumor model.Int J Radiat Oncol Biol Phys 1991 Nov;21(6):1541-51.
  1938564
• Kassis AI, Van den Abbeele AD, Wen PY, Baranowska-Kortylewicz J, Aaronson RA, DeSisto WC, Lampson LA, Black PM, Adelstein SJ.Specific uptake of the auger electron-emitting thymidine analogue 5-[123I/125I]iodo-2'-deoxyuridine in rat brain tumors: diagnosti
  2379179
• Makrigiorgos GM, Adelstein SJ, Kassis AI.Cellular radiation dosimetry and its implications for estimation of radiation risks. Illustrative results with technetium 99m-labeled microspheres and macroaggregates.JAMA 1990 Aug 1;264(5):592-5.
  2366298
• Mariani G, Abbeele AD, Venkateshan CN, Kaldany A, Ito S, Adelstein SJ, Kassis AI.Monoclonal antibody internalization by tumor cells: an experimental model for potential radioimmunotherapy applications.Int J Rad Appl Instrum B 1989;16(2):147-50.
  2715008
• Zalutsky MR, Venkatesan PP, English RJ, Shortkroff S, Sledge CB, Adelstein SJ.Radiation synovectomy with 165Dy-FHMA: lymph node uptake and radiation dosimetry calculations.Int J Nucl Med Biol 1986;12(6):457-65.
  3710708
• Bloomer WD, McLaughlin WH, Lambrecht RM, Atcher RW, Mirzadeh S, Madara JL, Milius RA, Zalutsky MR, Adelstein SJ, Wolf AP.211At radiocolloid therapy: further observations and comparison with radiocolloids of 32P, 165Dy, and 90Y.Int J Radiat Oncol Biol Phys
  6706730
• Bloomer WD, McLaughlin WH, Adelstein SJ.Therapeutic implications of iodine-125 cytotoxicity.Int J Radiat Oncol Biol Phys 1982 Nov;8(11):1903-8.
  7153101