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Jack Lawler, PhD

Publications

  • Qin L, Zhao D, Xu J, Ren X, Terwilliger EF, Parangi S, Lawler J, Dvorak HF, Zeng H.The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1.Blood. 2013 Mar 14;121(11):2154-64.
    23315169
  • Shaik S, Nucera C, Inuzuka H, Gao D, Garnaas M, Frechette G, Harris L, Wan L, Fukushima H, Husain A, Nose V, Fadda G, Sadow PM, Goessling W, North T, Lawler J, Wei W.SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2.J Exp Med. 2012 Jul 2;209(7):1289-307.
    22711876
  • Nucera C, Lawler J, Parangi S.BRAFV600E and Microenvironment in Thyroid Cancer: A Functional Link to Drive Cancer Progression.Cancer Res. 2011 Apr 1;71(7):2417-22.
    21447745
  • Nucera C, Nehs MA, Nagarkatti SS, Sadow PM, Mekel M, Fischer AH, Lin PS, Bollag GE, Lawler J, Hodin RA, Parangi S.Targeting BRAFV600E with PLX4720 Displays Potent Antimigratory and Anti-invasive Activity in Preclinical Models of Human Thyroid Cancer.Oncologist. 2011;16(3):296-309.
    21355020
  • Kazerounian S, Duquette M, Reyes MA, Lawler JT, Song K, Perruzzi C, Primo L, Khosravi-Far R, Bussolino F, Rabinovitz I, Lawler J.Priming of the vascular endothelial growth factor signaling pathway by thrombospondin-1, CD36, and spleen tyrosine kinase.Blood. 2011 Mar 4.
    21378271
  • Nucera C, Lawler J, Hodin R, Parangi S.The BRAFV600E mutation: what is it really orchestrating in thyroid cancer?.Oncotarget. 2010 Dec;1(8):751-6.
    21321384
  • Nucera C, Porrello A, Antonello ZA, Mekel M, Nehs MA, Giordano TJ, Gerald D, Benjamin LE, Priolo C, Puxeddu E, Finn S, Jarzab B, Hodin RA, Pontecorvi A, Nose V, Lawler J, Parangi S.B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression.Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10649-54.
    20498063
  • Tan K, Lawler J.The interaction of Thrombospondins with extracellular matrix proteins.J Cell Commun Signal. 2009 Dec;3(3-4):177-87.
    19830595
  • Lawler J.Megakaryocytes join the war on cancer.Blood. 2010 Jun 3;115(22):4326-7.
    20522719
  • Eroglu C, Allen NJ, Susman MW, O'Rourke NA, Park CY, Ozkan E, Chakraborty C, Mulinyawe SB, Annis DS, Huberman AD, Green EM, Lawler J, Dolmetsch R, Garcia KC, Smith SJ, Luo ZD, Rosenthal A, Mosher DF, Barres BA.Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.Cell. 2009 Oct 16;139(2):380-92.
    19818485
  • Nucera C, Nehs MA, Mekel M, Zhang X, Hodin R, Lawler J, Nose V, Parangi S.A novel orthotopic mouse model of human anaplastic thyroid carcinoma.Thyroid. 2009 Oct;19(10):1077-84.
    19772429
  • Zhang X, Kazerounian S, Duquette M, Perruzzi C, Nagy JA, Dvorak HF, Parangi S, Lawler J.Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level.FASEB J. 2009 Oct;23(10):3368-76.
    19528255
  • Lawler J.Introduction to the tumour microenvironment review series.J Cell Mol Med. 2009 Aug;13(8A):1403-4.
    19583804
  • Ren B,Song K,Parangi S,Jin T,Ye M,Humphreys R,Duquette M,Zhang X,Benhaga N,Lawler J,Khosravi-Far R.A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR.Cancer Res. 2009 May 1;69(9):3856-65.
    19366809
  • Sun J,Hopkins BD,Tsujikawa K,Perruzzi C,Adini I,Swerlick R,Bornstein P,Lawler J,Benjamin LE.Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina.Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1344-51.
    19304944
  • Yee KO, Connolly CM, Duquette M, Kazerounian S, Washington R, Lawler J.The effect of thrombospondin-1 on breast cancer metastasis.Breast Cancer Res Treat. 2009 Mar;114(1):85-96.
    18409060
  • Olerud J, Johansson M, Lawler J, Welsh N, Carlsson PO.IMPROVED VASCULAR ENGRAFTMENT AND GRAFT FUNCTION FOLLOWING INHIBITION OF THE ANGIOSTATIC FACTOR THROMBOSPONDIN-1 IN MOUSE PANCREATIC ISLETS.Diabetes. 2008 Jul;57(7):1870-7.
    18420490
  • Posey KL, Hankenson K, Veerisetty AC, Bornstein P, Lawler J, Hecht JT.Skeletal Abnormalities in Mice Lacking Extracellular Matrix Proteins, Thrombospondin-1, Thrombospondin-3, Thrombospondin-5, and Type IX Collagen.Am J Pathol. 2008 Jun;172(6):1664-74.
    18467703
  • Ali NA, Gaughan AA, Orosz CG, Baran CP, McMaken S, Wang Y, Eubank TD, Hunter M, Lichtenberger FJ, Flavahan NA, Lawler J, Marsh CB.Latency associated peptide has in vitro and in vivo immune effects independent of TGF-beta1.PLoS ONE. 2008;3(4):e1914.
    18392110
  • Punekar S, Zak S, Kalter VG, Dobransky L, Punekar I, Lawler JW, Gutierrez LS.Thrombospondin 1 and its mimetic peptide ABT-510 decrease angiogenesis and inflammation in a murine model of inflammatory bowel disease.Pathobiology. 2008;75(1):9-21.
    18334835
  • Tan K, Duquette M, Liu JH, Shanmugasundaram K, Joachimiak A, Gallagher JT, Rigby AC, Wang JH, Lawler J.Heparin-induced cis- and trans-dimerization modes of the thrombospondin-1 N-terminal domain.J Biol Chem. 2008 Feb 15;283(7):3932-41.
    18065761
  • Daniel C, Schaub K, Amann K, Lawler J, Hugo C.Thrombospondin-1 is an endogenous activator of TGF-beta in experimental diabetic nephropathy in vivo.Diabetes. 2007 Dec;56(12):2982-9.
    17878288
  • Zhang X, Xu J, Lawler J, Terwilliger E, Parangi S.Adeno-associated virus-mediated antiangiogenic gene therapy with thrombospondin-1 type 1 repeats and endostatin.Clin Cancer Res. 2007 Jul 1;13(13):3968-76.
    17606731
  • Chen FH, Herndon ME, Patel N, Hecht JT, Tuan RS, Lawler J.Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan.J Biol Chem. 2007 Aug 24;282(34):24591-8.
    17588949
  • Budhani F, Leonard KA, Bergdahl A, Gao J, Lawler J, Davis EC.Vascular response to intra-arterial injury in the thrombospondin-1 null mouse.J Mol Cell Cardiol. 2007 Aug;43(2):210-4.
    17583726
  • Zhang X, Lawler J.Thrombospondin-based antiangiogenic therapy.Microvasc Res. 2007 Sep-Nov;74(2-3):90-9. Review.
    17559888
  • Yee KO, Streit M, Hawighorst T, Detmar M, Lawler J.Expression of the type-1 repeats of thrombospondin-1 inhibits tumor growth through activation of transforming growth factor-beta.Am J Pathol. 2004 Aug;165(2):541-52.
    15277228
  • Lawler J, Detmar M.Tumor progression: the effects of thrombospondin-1 and -2.Int J Biochem Cell Biol. 2004 Jun;36(6):1038-45.
    15094119
  • Cursiefen C, Masli S, Ng TF, Dana MR, Bornstein P, Lawler J, Streilein JW.Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis.Invest Ophthalmol Vis Sci. 2004 Apr;45(4):1117-24.
    15037577
  • Hamano Y, Sugimoto H, Soubasakos MA, Kieran M, Olsen BR, Lawler J, Sudhakar A, Kalluri R.Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression.Cancer Res. 2004 Mar 1;64(5):1570-4.
    14996710
  • Wang S, Herndon ME, Ranganathan S, Godyna S, Lawler J, Argraves WS, Liau G.Internalization but not binding of thrombospondin-1 to low density lipoprotein receptor-related protein-1 requires heparan sulfate proteoglycans.J Cell Biochem. 2004 Mar 1;91(4):766-76.
    14991768
  • Niu Q, Perruzzi C, Voskas D, Lawler J, Dumont DJ, Benjamin LE.Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1.Cancer Biol Ther. 2004 Apr;3(4):402-5.
    14739779
  • Bocci G, Francia G, Man S, Lawler J, Kerbel RS.Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy.Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12917-22.
    14561896
  • Tan K, Duquette M, Liu JH, Dong Y, Zhang R, Joachimiak A, Lawler J, Wang JH.Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication.J Cell Biol. 2002 Oct 28;159(2):373-82.
    12391027
  • Agah A, Kyriakides TR, Lawler J, Bornstein P.The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double-TSP1/TSP2-null mice.Am J Pathol. 2002 Sep;161(3):831-9.
    12213711
  • Lawler J.Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth.J Cell Mol Med. 2002 Jan-Mar;6(1):1-12.
    12003665
  • Lawler J, Miao WM, Duquette M, Bouck N, Bronson RT, Hynes RO.Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice.Am J Pathol. 2001 Nov;159(5):1949-56.
    11696456
  • Miao WM, Seng WL, Duquette M, Lawler P, Laus C, Lawler J.Thrombospondin-1 type 1 repeat recombinant proteins inhibit tumor growth through transforming growth factor-beta-dependent and -independent mechanisms.Cancer Res. 2001 Nov 1;61(21):7830-9.
    11691800
  • Rodriguez-Manzaneque JC, Lane TF, Ortega MA, Hynes RO, Lawler J, Iruela-Arispe ML.Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor.Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12485-90.
    11606713
  • Miao WM, Vasile E, Lane WS, Lawler J.CD36 associates with CD9 and integrins on human blood platelets.Blood. 2001 Mar 15;97(6):1689-96.
    11238109
  • Streit M, Velasco P, Brown LF, Skobe M, Richard L, Riccardi L, Lawler J, Detmar M.Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas.Am J Pathol. 1999 Aug;155(2):441-52.
    10433937
  • Lawler J, Sunday M, Thibert V, Duquette M, George EL, Rayburn H, Hynes RO.Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia.J Clin Invest. 1998 Mar 1;101(5):982-92.
    9486968