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Michael E. Greenberg, PhD

Publications

  • Spiegel I, Mardinly AR, Gabel HW, Bazinet JE, Couch CH, Tzeng CP, Harmin DA, Greenberg ME.Npas4 Regulates Excitatory-Inhibitory Balance within Neural Circuits through Cell-Type-Specific Gene Programs.Cell. 2014 May 22;157(5):1216-29.
    24855953
  • Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, Lin JD, Greenberg ME, Spiegelman BM.Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway.Cell Metab. 2013 Nov 5;18(5):649-59.
    24120943
  • Bloodgood BL, Sharma N, Browne HA, Trepman AZ, Greenberg ME.The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition.Nature. 2013 Nov 7;503(7474):121-5.
    24201284
  • Gabel HW, Greenberg ME.Genetics. The maturing brain methylome.Science. 2013 Aug 9;341(6146):626-7.
    23929975
  • Soskis MJ, Ho HY, Bloodgood BL, Robichaux MA, Malik AN, Ataman B, Rubin AA, Zieg J, Zhang C, Shokat KM, Sharma N, Cowan CW, Greenberg ME.A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development.Nat Neurosci. 2012 Nov 11.
    23143520
  • Kim TK, Hemberg M, Gray JM, Costa AM, Bear DM, Wu J, Harmin DA, Laptewicz M, Barbara-Haley K, Kuersten S, Markenscoff-Papadimitriou E, Kuhl D, Bito H, Worley PF, Kreiman G, Greenberg ME.Widespread transcription at neuronal activity-regulated enhancers.Nature. 2010 May 13;465(7295):182-7.
    20393465
  • Ross SE, Mardinly AR, McCord AE, Zurawski J, Cohen S, Jung C, Hu L, Mok SI, Shah A, Savner EM, Tolias C, Corfas R, Chen S, Inquimbert P, Xu Y, McInnes RR, Rice FL, Corfas G, Ma Q, Woolf CJ, Greenberg ME.Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice.Neuron. 2010 Mar 25;65(6):886-98.
    20346763
  • Greer PL, Hanayama R, Bloodgood BL, Mardinly AR, Lipton DM, Flavell SW, Kim TK, Griffith EC, Waldon Z, Maehr R, Ploegh HL, Chowdhury S, Worley PF, Steen J, Greenberg ME.The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.Cell. 2010 Mar 5;140(5):704-16.
    20211139
  • Cohen S, Greenberg ME.A bird's-eye view of MeCP2 binding.Mol Cell. 2010 Feb 26;37(4):451-2.
    20188662
  • Shi L, Butt B, Ip FC, Dai Y, Jiang L, Yung WH, Greenberg ME, Fu AK, Ip NY.Ephexin1 is required for structural maturation and neurotransmission at the neuromuscular junction.Neuron. 2010 Jan 28;65(2):204-16.
    20152127
  • Bracaglia G, Conca B, Bergo A, Rusconi L, Zhou Z, Greenberg ME, Landsberger N, Soddu S, Kilstrup-Nielsen C.Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis.EMBO Rep. 2009 Dec;10(12):1327-33.
    19820693
  • Greenberg ME, Xu B, Lu B, Hempstead BL.New insights in the biology of BDNF synthesis and release: implications in CNS function.J Neurosci. 2009 Oct 14;29(41):12764-7. Review.
    19828787
  • Wood L, Gray NW, Zhou Z, Greenberg ME, Shepherd GM.Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency.J Neurosci. 2009 Oct 7;29(40):12440-8.
    19812320
  • Siegel G,Obernosterer G,Fiore R,Oehmen M,Bicker S,Christensen M,Khudayberdiev S,Leuschner PF,Busch CJ,Kane C,Hubel K,Dekker F,Hedberg C,Rengarajan B,Drepper C,Waldmann H,Kauppinen S,Greenberg ME,Draguhn A,Rehmsmeier M,Martinez J,Schratt GM.A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis.Nat Cell Biol. 2009 Jun;11(6):705-16.
    19465924
  • Pazyra-Murphy MF,Hans A,Courchesne SL,Karch C,Cosker KE,Heerssen HM,Watson FL,Kim T,Greenberg ME,Segal RA.A retrograde neuronal survival response: target-derived neurotrophins regulate MEF2D and bcl-w.J Neurosci. 2009 May 20;29(20):6700-9.
    19458239
  • Fiore R,Khudayberdiev S,Christensen M,Siegel G,Flavell SW,Kim TK,Greenberg ME,Schratt G.Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels.EMBO J. 2009 Mar 18;28(6):697-710.
    19197241
  • Flavell SW,Kim TK,Gray JM,Harmin DA,Hemberg M,Hong EJ,Markenscoff-Papadimitriou E,Bear DM,Greenberg ME.Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection.Neuron. 2008 Dec 26;60(6):1022-38.
    19109909
  • Hong EJ,McCord AE,Greenberg ME.A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition.Neuron. 2008 Nov 26;60(4):610-24.
    19038219
  • Greer PL,Greenberg ME.From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function.Neuron. 2008 Sep 25;59(6):846-60. Review.
    18817726
  • Lin Y,Bloodgood BL,Hauser JL,Lapan AD,Koon AC,Kim TK,Hu LS,Malik AN,Greenberg ME.Activity-dependent regulation of inhibitory synapse development by Npas4.Nature. 2008 Oct 30;455(7217):1198-204.
    18815592
  • Zieg J,Greer PL,Greenberg ME.SnapShot: Ca(2+)-dependent transcription in neurons.Cell. 2008 Sep 19;134(6):1080-1080.e2.
    18805099
  • Cohen S,Zhou Z,Greenberg ME.Medicine. Activating a repressor.Science. 2008 May 30;320(5880):1172-3.
    18511680
  • Singh KK, Park KJ, Hong EJ, Kramer BM, Greenberg ME, Kaplan DR, Miller FD.Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration.Nat Neurosci. 2008 Jun;11(6):649-58.
    18382462
  • Ma YC, Song MR, Park JP, Henry Ho HY, Hu L, Kurtev MV, Zieg J, Ma Q, Pfaff SL, Greenberg ME.Regulation of motor neuron specification by phosphorylation of neurogenin 2.Neuron. 2008 Apr 10;58(1):65-77. Review.
    18400164
  • Kim DS, Ross SE, Trimarchi JM, Aach J, Greenberg ME, Cepko CL.Identification of molecular markers of bipolar cells in the murine retina.J Comp Neurol. 2008 Feb 7;507(5):1795-1810.
    18260140
  • Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ.Dual role of proapoptotic BAD in insulin secretion and beta cell survival.Nat Med. 2008 Feb;14(2):144-53.
    18223655
  • Ogier M, Wang H, Hong E, Wang Q, Greenberg ME, Katz DM.Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome.J Neurosci. 2007 Oct 3;27(40):10912-7.
    17913925
  • Zhou P, Porcionatto M, Pilapil M, Chen Y, Choi Y, Tolias KF, Bikoff JB, Hong EJ, Greenberg ME, Segal RA.Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors.Neuron. 2007 Jul 5;55(1):53-68.
    17610817
  • Tolias KF, Bikoff JB, Kane CG, Tolias CS, Hu L, Greenberg ME.The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development.Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7265-70.
    17440041
  • Paradis S, Harrar DB, Lin Y, Koon AC, Hauser JL, Griffith EC, Zhu L, Brass LF, Chen C, Greenberg ME.An RNAi-based approach identifies molecules required for glutamatergic and GABAergic synapse development.Neuron. 2007 Jan 18;53(2):217-32.
    17224404
  • Fu WY, Chen Y, Sahin M, Zhao XS, Shi L, Bikoff JB, Lai KO, Yung WH, Fu AK, Greenberg ME, Ip NY.Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.Nat Neurosci. 2007 Jan;10(1):67-76.
    17143272
  • Zhou Z, Hong EJ, Cohen S, Zhao WN, Ho HY, Schmidt L, Chen WG, Lin Y, Savner E, Griffith EC, Hu L, Steen JA, Weitz CJ, Greenberg ME.Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation.Neuron. 2006 Oct 19;52(2):255-69.
    17046689
  • Marinescu VD, Kohane IS, Kim TK, Harmin DA, Greenberg ME, Riva A.START: an automated tool for serial analysis of chromatin occupancy data.Bioinformatics. 2006 Apr 15;22(8):999-1001.
    16500934
  • Flavell SW, Cowan CW, Kim TK, Greer PL, Lin Y, Paradis S, Griffith EC, Hu LS, Chen C, Greenberg ME.Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number.Science. 2006 Feb 17;311(5763):1008-12.
    16484497
  • Ge W, He F, Kim KJ, Blanchi B, Coskun V, Nguyen L, Wu X, Zhao J, Heng JI, Martinowich K, Tao J, Wu H, Castro D, Sobeih MM, Corfas G, Gleeson JG, Greenberg ME, Guillemot F, Sun YE.Coupling of cell migration with neurogenesis by proneural bHLH factors.Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1319-24.
    16432194
  • Schratt GM, Tuebing F, Nigh EA, Kane CG, Sabatini ME, Kiebler M, Greenberg ME.A brain-specific microRNA regulates dendritic spine development.Nature. 2006 Jan 19;439(7074):283-9.
    16421561
  • Cowan CW, Shao YR, Sahin M, Shamah SM, Lin MZ, Greer PL, Gao S, Griffith EC, Brugge JS, Greenberg ME.Vav family GEFs link activated Ephs to endocytosis and axon guidance.Neuron. 2005 Apr 21;46(2):205-17.
    15848800
  • Sahin M, Greer PL, Lin MZ, Poucher H, Eberhart J, Schmidt S, Wright TM, Shamah SM, O'connell S, Cowan CW, Hu L, Goldberg JL, Debant A, Corfas G, Krull CE, Greenberg ME.Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse.Neuron. 2005 Apr 21;46(2):191-204.
    15848799
  • Hong EJ, West AE, Greenberg ME.Transcriptional control of cognitive development.Curr Opin Neurobiol. 2005 Feb;15(1):21-8.
    15721740
  • Tolias KF, Bikoff JB, Burette A, Paradis S, Harrar D, Tavazoie S, Weinberg RJ, Greenberg ME.The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines.Neuron. 2005 Feb 17;45(4):525-38.
    15721239
  • Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q.Mouse brain organization revealed through direct genome-scale TF expression analysis.Science. 2004 Dec 24;306(5705):2255-7.
    15618518
  • Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME.Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.Science. 2004 Mar 26;303(5666):2011-5.
    14976264
  • Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM, Datta SR, Greenberg ME, Licklider LJ, Lowell BB, Gygi SP, Korsmeyer SJ.BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.Nature. 2003 Aug 21;424(6951):952-6.
    12931191
  • Ranger AM, Zha J, Harada H, Datta SR, Danial NN, Gilmore AP, Kutok JL, Le Beau MM, Greenberg ME, Korsmeyer SJ.Bad-deficient mice develop diffuse large B cell lymphoma.Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9324-9.
    12876200
  • Datta SR, Ranger AM, Lin MZ, Sturgill JF, Ma YC, Cowan CW, Dikkes P, Korsmeyer SJ, Greenberg ME.Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis.Dev Cell. 2002 Nov;3(5):631-43.
    12431371
  • Zhu JW, Field SJ, Gore L, Thompson M, Yang H, Fujiwara Y, Cardiff RD, Greenberg M, Orkin SH, DeGregori J.E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.Mol Cell Biol. 2001 Dec;21(24):8547-64.
    11713289
  • Shamah SM, Lin MZ, Goldberg JL, Estrach S, Sahin M, Hu L, Bazalakova M, Neve RL, Corfas G, Debant A, Greenberg ME.EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin.Cell. 2001 Apr 20;105(2):233-44.
    11336673
  • Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME.Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms.Cell. 2001 Feb 9;104(3):365-76.
    11239394
  • Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME.Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a).Mol Cell Biol. 2001 Feb;21(3):952-65.
    11154281
  • Dalva MB, Takasu MA, Lin MZ, Shamah SM, Hu L, Gale NW, Greenberg ME.EphB receptors interact with NMDA receptors and regulate excitatory synapse formation.Cell. 2000 Dec 8;103(6):945-56.
    11136979
  • Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, Greenberg ME.14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation.Mol Cell. 2000 Jul;6(1):41-51.
    10949026
  • Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME.Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.Science. 1999 Nov 12;286(5443):1358-62.
    10558990
  • Mao Z, Bonni A, Xia F, Nadal-Vicens M, Greenberg ME.Neuronal activity-dependent cell survival mediated by transcription factor MEF2.Science. 1999 Oct 22;286(5440):785-90.
    10531066
  • Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME.Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.Cell. 1999 Mar 19;96(6):857-68.
    10102273
  • Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, Sekiguchi JM, Rathbun GA, Swat W, Wang J, Bronson RT, Malynn BA, Bryans M, Zhu C, Chaudhuri J, Davidson L, Ferrini R, Stamato T, Orkin SH, Greenberg ME, Alt FW.A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis.Cell. 1998 Dec 23;95(7):891-902.
    9875844
  • Saudou F, Finkbeiner S, Devys D, Greenberg ME.Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.Cell. 1998 Oct 2;95(1):55-66.
    9778247
  • Brown JR, Nigh E, Lee RJ, Ye H, Thompson MA, Saudou F, Pestell RG, Greenberg ME.Fos family members induce cell cycle entry by activating cyclin D1.Mol Cell Biol. 1998 Sep;18(9):5609-19.
    9710644
  • Tao X, Finkbeiner S, Arnold DB, Shaywitz AJ, Greenberg ME.Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism.Neuron. 1998 Apr;20(4):709-26.
    9581763
  • Finkbeiner S, Tavazoie SF, Maloratsky A, Jacobs KM, Harris KM, Greenberg ME.CREB: a major mediator of neuronal neurotrophin responses.Neuron. 1997 Nov;19(5):1031-47.
    9390517
  • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.Cell. 1997 Oct 17;91(2):231-41.
    9346240
  • Bonni A, Sun Y, Nadal-Vicens M, Bhatt A, Frank DA, Rozovsky I, Stahl N, Yancopoulos GD, Greenberg ME.Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway.Science. 1997 Oct 17;278(5337):477-83.
    9334309
  • Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME.Regulation of neuronal survival by the serine-threonine protein kinase Akt.Science. 1997 Jan 31;275(5300):661-5.
    9005851
  • Xing J, Ginty DD, Greenberg ME.Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.Science. 1996 Aug 16;273(5277):959-63.
    8688081
  • Brown JR, Ye H, Bronson RT, Dikkes P, Greenberg ME.A defect in nurturing in mice lacking the immediate early gene fosB.Cell. 1996 Jul 26;86(2):297-309.
    8706134
  • Field SJ, Tsai FY, Kuo F, Zubiaga AM, Kaelin WG, Livingston DM, Orkin SH, Greenberg ME.E2F-1 functions in mice to promote apoptosis and suppress proliferation.Cell. 1996 May 17;85(4):549-61.
    8653790
  • Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME.Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis.Science. 1995 Nov 24;270(5240):1326-31.
    7481820
  • Frank DA, Greenberg ME.CREB: a mediator of long-term memory from mollusks to mammals.Cell. 1994 Oct 7;79(1):5-8.
    7923377
  • Rosen LB, Ginty DD, Weber MJ, Greenberg ME.Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras.Neuron. 1994 Jun;12(6):1207-21.
    8011335
  • Bading H, Ginty DD, Greenberg ME.Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways.Science. 1993 Apr 9;260(5105):181-6.
    8097060
  • Ginty DD, Kornhauser JM, Thompson MA, Bading H, Mayo KE, Takahashi JS, Greenberg ME.Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock.Science. 1993 Apr 9;260(5105):238-41.
    8097062
  • Bading H, Greenberg ME.Stimulation of protein tyrosine phosphorylation by NMDA receptor activation.Science. 1991 Aug 23;253(5022):912-4.
    1715095
  • Sheng M, Thompson MA, Greenberg ME.CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases.Science. 1991 Jun 7;252(5011):1427-30.
    1646483
  • Shyu AB, Belasco JG, Greenberg ME.Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.Genes Dev. 1991 Feb;5(2):221-31.
    1899842
  • Sheng M, McFadden G, Greenberg ME.Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB.Neuron. 1990 Apr;4(4):571-82.
    2157471
  • Rivera VM, Sheng M, Greenberg ME.The inner core of the serum response element mediates both the rapid induction and subsequent repression of c-fos transcription following serum stimulation.Genes Dev. 1990 Feb;4(2):255-68.
    2110922
  • Halazonetis TD, Georgopoulos K, Greenberg ME, Leder P.c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities.Cell. 1988 Dec 2;55(5):917-24.
    3142692
  • Greenberg ME, Ziff EB, Greene LA.Stimulation of neuronal acetylcholine receptors induces rapid gene transcription.Science. 1986 Oct 3;234(4772):80-3.
    3749894
  • Greenberg ME, Ziff EB.Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene.Nature. 1984 Oct 4-10;311(5985):433-8.
    6090941