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Philip Leder, M.D.


  • Leder P.Retrospective. Marshall Warren Nirenberg (1927-2010).Science. 2010 Feb 19;327(5968):972.
  • Ravi D, Wiles AM, Bhavani S, Ruan J, Leder P, Bishop AJ.A network of conserved damage survival pathways revealed by a genomic RNAi screen.PLoS Genet. 2009 Jun;5(6):e1000527.
  • Zhou F,Leder P,Zuniga A,Dettenhofer M.Formin1 disruption confers oligodactylism and alters Bmp signaling.Hum Mol Genet. 2009 Jul 1;18(13):2472-82.
  • Babbe H,McMenamin J,Hobeika E,Wang J,Rodig SJ,Reth M,Leder P.Genomic instability resulting from Blm deficiency compromises development, maintenance, and function of the B cell lineage.J Immunol. 2009 Jan 1;182(1):347-60.
  • Leder P.An interview with...Philip Leder. Interview by Errol C. Friedberg.Nat Rev Mol Cell Biol. 2008 Nov;9(11):830.
  • Li X,Ito M,Zhou F,Youngson N,Zuo X,Leder P,Ferguson-Smith AC.A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints.Dev Cell. 2008 Oct;15(4):547-57.
  • Dettenhofer M,Zhou F,Leder P.Formin 1-isoform IV deficient cells exhibit defects in cell spreading and focal adhesion formation.PLoS ONE. 2008;3(6):e2497.
  • Leder A, McMenamin J, Zhou F, Moran JL, Beier DR, Leder P.Genome-wide SNP analysis of Tg.AC transgenic mice reveals an oncogenic collaboration between v-Ha-ras and Ink4a, which is absent in p53 deficiency.Oncogene. 2008 Apr 10;27(17):2456-65.
  • Li X, Leder P.Identifying genes preferentially expressed in undifferentiated embryonic stem cells.BMC Cell Biol. 2007;8:37.
  • Lu J, Ruhf ML, Perrimon N, Leder P.A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression.Proc Natl Acad Sci U S A. 2007 May 29;104(22):9381-6.
  • Babbe H, Chester N, Leder P, Reizis B.The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage.Mol Cell Biol. 2007 Mar;27(5):1947-59.
  • Chester N, Babbe H, Pinkas J, Manning C, Leder P.Mutation of the murine Bloom's syndrome gene produces global genome destabilization.Mol Cell Biol. 2006 Sep;26(17):6713-26.
  • Fantin VR, Leder P.Mitochondriotoxic compounds for cancer therapy.Oncogene. 2006 Aug 7;25(34):4787-97. Review.
  • Fantin VR, St-Pierre J, Leder P.Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance.Cancer Cell. 2006 Jun;9(6):425-34.
  • Zhou F, Leder P, Martin SS.Formin-1 protein associates with microtubules through a peptide domain encoded by exon-2.Exp Cell Res. 2006 Apr 15;312(7):1119-26.
  • Ridgeway AG, McMenamin J, Leder P.P53 levels determine outcome during beta-catenin tumor initiation and metastasis in the mammary gland and male germ cells.Oncogene. 2006 Jun 15;25(25):3518-27.
  • Martin SS, Ridgeway AG, Pinkas J, Lu Y, Reginato MJ, Koh EY, Michelman M, Daley GQ, Brugge JS, Leder P.A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth.Oncogene. 2004 Jun 3;23(26):4641-5.
  • Leader B, Lim H, Carabatsos MJ, Harrington A, Ecsedy J, Pellman D, Maas R, Leder P.Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes.Nat Cell Biol. 2002 Dec;4(12):921-8.
  • Fantin VR, Berardi MJ, Scorrano L, Korsmeyer SJ, Leder P.A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.Cancer Cell. 2002 Jul;2(1):29-42.
  • Michaelson JS, Leder P.beta-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland.Oncogene. 2001 Aug 23;20(37):5093-9.
  • Weinstein EJ, Grimm S, Leder P.The oncogene heregulin induces apoptosis in breast epithelial cells and tumors.Oncogene. 1998 Oct 22;17(16):2107-13.
  • Kelliher MA, Grimm S, Ishida Y, Kuo F, Stanger BZ, Leder P.The death domain kinase RIP mediates the TNF-induced NF-kappaB signal.Immunity. 1998 Mar;8(3):297-303.
  • Amundadottir LT, Leder P.Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes.Oncogene. 1998 Feb 12;16(6):737-46.
  • Wang YA, Elson A, Leder P.Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice.Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14590-5.
  • Lane TF, Leder P.Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice.Oncogene. 1997 Oct;15(18):2133-44.
  • Westphal CH, Leder P.Transposon-generated 'knock-out' and 'knock-in' gene-targeting constructs for use in mice.Curr Biol. 1997 Jul 1;7(7):530-3.
  • Westphal CH, Schmaltz C, Rowan S, Elson A, Fisher DE, Leder P.Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints.Cancer Res. 1997 May 1;57(9):1664-7.
  • Kitsberg DI, Leder P.Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice.Oncogene. 1996 Dec 19;13(12):2507-15.
  • Krane IM, Leder P.NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice.Oncogene. 1996 Apr 18;12(8):1781-8.
  • Deng C, Wynshaw-Boris A, Zhou F, Kuo A, Leder P.Fibroblast growth factor receptor 3 is a negative regulator of bone growth.Cell. 1996 Mar 22;84(6):911-21.
  • Lane TF, Deng C, Elson A, Lyu MS, Kozak CA, Leder P.Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice.Genes Dev. 1995 Nov 1;9(21):2712-22.
  • Deng C, Zhang P, Harper JW, Elledge SJ, Leder P.Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.Cell. 1995 Aug 25;82(4):675-84.
  • Elson A, Deng C, Campos-Torres J, Donehower LA, Leder P.The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice.Oncogene. 1995 Jul 6;11(1):181-90.
  • Lee FS, Lane TF, Kuo A, Shackleford GM, Leder P.Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice.Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2268-72.
  • Morrison BW, Moorman JR, Kowdley GC, Kobayashi YM, Jones LR, Leder P.Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes.J Biol Chem. 1995 Feb 3;270(5):2176-82.
  • Morrison BW, Leder P.neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors.Oncogene. 1994 Dec;9(12):3417-26.