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David T. Scadden, MD

Publications

  • Roccaro AM, Sacco A, Maiso P, Azab AK, Tai YT, Reagan M, Azab F, Flores LM, Campigotto F, Weller E, Anderson KC, Scadden DT, Ghobrial IM.BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression.J Clin Invest. 2013 Apr 1;123(4):1542-55.
    23454749
  • Hoggatt J, Mohammad KS, Singh P, Hoggatt AF, Chitteti BR, Speth JM, Hu P, Poteat BA, Stilger KN, Ferraro F, Silberstein L, Wong FK, Farag SS, Czader M, Milne GL, Breyer RM, Serezani CH, Scadden DT, Guise TA, Srour EF, Pelus LM.Differential stem- and progenitor-cell trafficking by prostaglandin E2.Nature. 2013 Mar 21;495(7441):365-9.
    23485965
  • Pozzi S, Fulciniti M, Yan H, Vallet S, Eda H, Patel K, Santo L, Cirstea D, Hideshima T, Schirtzinge L, Kuhstoss S, Anderson KC, Munshi N, Scadden D, Kronenberg HM, Raje N.In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma.Bone. 2013 Apr;53(2):487-96.
    23333523
  • Brown K, Xie S, Qiu X, Mohrin M, Shin J, Liu Y, Zhang D, Scadden DT, Chen D.SIRT3 reverses aging-associated degeneration.Cell Rep. 2013 Feb 21;3(2):319-27.
    23375372
  • Yildirim E, Kirby JE, Brown DE, Mercier FE, Sadreyev RI, Scadden DT, Lee JT.Xist RNA is a potent suppressor of hematologic cancer in mice.Cell. 2013 Feb 14;152(4):727-42.
    23415223
  • Krause DS, Scadden DT, Preffer FI.The hematopoietic stem cell niche--home for friend and foe?.Cytometry. Part B, Clinical Cytometry.;84(1):7-20.
    23281119
  • Fulzele K, Krause DS, Panaroni C, Saini V, Barry KJ, Liu X, Lotinun S, Baron R, Bonewald L, Feng JQ, Chen M, Weinstein LS, Wu JY, Kronenberg HM, Scadden DT, Divieti Pajevic P.Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling.Blood. 2012 Nov 16.
    23160461
  • van Etten RA, Mauro M, Radich JP, Goldman JM, Saglio G, Jamieson C, Soverini S, Gambacorti-Passerini C, Hehlmann R, Martinelli G, Perrotti D, Scadden DT, Skorski T, Tefferi A, Mughal TI.Advances in the biology and therapy of chronic myeloid leukemia (CML): Proceedings from the 6(th) Post-ASH International CML and Myeloproliferative Neoplasms Workshop.Leuk Lymphoma. 2012 Nov 2.
    23121619
  • Guo S, Bai H, Megyola CM, Halene S, Krause DS, Scadden DT, Lu J.Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms.Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16636-41.
    23012470
  • Yusuf RZ, Scadden DT.Fate through Fat: Lipid Metabolism Determines Stem Cell Division Outcome.Cell Metab. 2012 Oct 3;16(4):411-3.
    23040066
  • Kalaitzidis D, Sykes SM, Wang Z, Punt N, Tang Y, Ragu C, Sinha AU, Lane SW, Souza AL, Clish CB, Anastasiou D, Gilliland DG, Scadden DT, Guertin DA, Armstrong SA.mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.Cell Stem Cell. 2012 Sep 7;11(3):429-39.
    22958934
  • Hoggatt J, Scadden DT.The stem cell niche: tissue physiology at a single cell level.J Clin Invest. 2012 Sep 4;122(9):3029-34.
    22945635
  • Demers M, Krause DS, Schatzberg D, Martinod K, Voorhees JR, Fuchs TA, Scadden DT, Wagner DD.Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis.Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13076-81.
    22826226
  • Scadden DT.Rethinking stroma: lessons from the blood.Cell Stem Cell. 2012 Jun 14;10(6):648-9.
    22704500
  • Yusuf RZ, Wang YH, Scadden DT.The secrets of the bone marrow niche: Metabolic priming for AML.Nat Med. 2012 Jun;18(6):865-7.
    22673998
  • Steinbicker AU, Sachidanandan C, Vonner AJ, Yusuf RZ, Deng DY, Lai CS, Rauwerdink KM, Winn JC, Saez B, Cook CM, Szekely BA, Roy CN, Seehra JS, Cuny GD, Scadden DT, Peterson RT, Bloch KD, Yu PB.Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation.Blood. 2011 Mar 10.
    21393479
  • Vunjak-Novakovic G, Scadden DT.Biomimetic platforms for human stem cell research.Cell Stem Cell. 2011 Mar 4;8(3):252-61.
    21362565
  • Lo Celso C, Lin CP, Scadden DT.In vivo imaging of transplanted hematopoietic stem and progenitor cells in mouse calvarium bone marrow.Nat Protoc. 2011 Jan;6(1):1-14.
    21212779
  • Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusuf RZ, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park PJ, Shirihai OS, Scadden DT, Bardeesy N.The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.Nature. 2010 Dec 2;468(7324):659-63.
    21124451
  • Jeanson NT, Scadden DT.Vitamin D receptor (VDR) deletion leads to increased hematopoietic stem and progenitor cells residing in the spleen.Blood. 2010 Nov 18;116(20):4126-9.
    20664059
  • Guo S, Scadden DT.A microRNA regulating adult hematopoietic stem cells.Cell Cycle. 2010 Sep;9(18):3637-8.
    20855952
  • Méndez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, Scadden DT, Ma'ayan A, Enikolopov GN, Frenette PS.Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.Nature. 2010 Aug 12;466(7308):829-34.
    20703299
  • Guo S, Lu J, Schlanger R, Zhang H, Wang JY, Fox MC, Purton LE, Fleming HH, Cobb B, Merkenschlager M, Golub TR, Scadden DT.MicroRNA miR-125a controls hematopoietic stem cell number.Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14229-34.
    20616003
  • Lane AA, Scadden DT.Stem cells and DNA damage: persist or perish?.Cell. 2010 Aug 6;142(3):360-2.
    20691895
  • Lymperi S, Ferraro F, Scadden DT.The HSC niche concept has turned 31. Has our knowledge matured?.Ann N Y Acad Sci. 2010 Mar;1192(1):12-8. Review.
    20392212
  • Raaijmakers MH, Mukherjee S, Guo S, Zhang S, Kobayashi T, Schoonmaker JA, Ebert BL, Al-Shahrour F, Hasserjian RP, Scadden EO, Aung Z, Matza M, Merkenschlager M, Lin C, Rommens JM, Scadden DT.Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.Nature. 2010 Apr 8;464(7290):852-7.
    20305640
  • Vallet S, Mukherjee S, Vaghela N, Hideshima T, Fulciniti M, Pozzi S, Santo L, Cirstea D, Patel K, Sohani AR, Guimaraes A, Xie W, Chauhan D, Schoonmaker JA, Attar E, Churchill M, Weller E, Munshi N, Seehra JS, Weissleder R, Anderson KC, Scadden DT, Raje N.Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5124-9.
    20194748
  • Jones R,Capen DE,Jacobson M,Cohen KS,Scadden DT,Duda DG.VEGFR2PDGFRbeta circulating precursor cells participate in capillary restoration after hyperoxia acute lung injury (HALI).J Cell Mol Med. 2009 Sep;13(9B):3720-9.
    19426150
  • Curley MD, Therrien VA, Cummings CL, Sergent PA, Koulouris CR, Friel AM, Roberts DJ, Seiden MV, Scadden DT, Rueda BR, Foster R.CD133 expression defines a tumor initiating cell population in primary human ovarian cancer.Stem Cells. 2009 Dec;27(12):2875-83.
    19816957
  • Lane SW,Scadden DT,Gilliland DG.The leukemic stem cell niche - current concepts and therapeutic opportunities.Blood. 2009 Aug 6;114(6):1150-7. Review.
    19401558
  • Qiu J,Takagi Y,Harada J,Topalkara K,Wang Y,Sims JR,Zheng G,Huang P,Ling Y,Scadden DT,Moskowitz MA,Cheng T.p27Kip1 constrains proliferation of neural progenitor cells in adult brain under homeostatic and ischemic conditions.Stem Cells. 2009 Apr;27(4):920-7.
    19353520
  • Adams GB,Alley IR,Chung UI,Chabner KT,Jeanson NT,Lo Celso C,Marsters ES,Chen M,Weinstein LS,Lin CP,Kronenberg HM,Scadden DT.Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow.Nature. 2009 May 7;459(7243):103-7.
    19322176
  • Yusuf RZ,Scadden DT.Homing of hematopoietic cells to the bone marrow.J Vis Exp. 2009(25).
    19295497
  • Wu JY,Scadden DT,Kronenberg HM.Role of the osteoblast lineage in the bone marrow hematopoietic niches.J Bone Miner Res. 2009 May;24(5):759-64. Review.
    19257832
  • Ali N,Karlsson C,Aspling M,Hu G,Hacohen N,Scadden DT,Larsson J.Forward RNAi screens in primary human hematopoietic stem/progenitor cells.Blood. 2009 Apr 16;113(16):3690-5.
    19188664
  • Scadden DT,Komaroff AL.Will stem cells finally deliver?.Newsweek. 2008 Dec 15;152(24):57-8.
    19105310
  • Raaijmakers MH,Scadden DT.Divided within: heterogeneity within adult stem cell pools.Cell. 2008 Dec 12;135(6):1006-8.
    19070570
  • Lo Celso C,Fleming HE,Wu JW,Zhao CX,Miake-Lye S,Fujisaki J,Cote D,Rowe DW,Lin CP,Scadden DT.Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche.Nature. 2009 Jan 1;457(7225):92-6.
    19052546
  • Wu JY,Purton LE,Rodda SJ,Chen M,Weinstein LS,McMahon AP,Scadden DT,Kronenberg HM.Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways.Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16976-81.
    18957542
  • Rodrigues NP,Boyd AS,Fugazza C,May GE,Guo Y,Tipping AJ,Scadden DT,Vyas P,Enver T.GATA-2 regulates granulocyte-macrophage progenitor cell function.Blood. 2008 Dec 15;112(13):4862-73.
    18840712
  • Larsson J,Ohishi M,Garrison B,Aspling M,Janzen V,Adams GB,Curto M,McClatchey AI,Schipani E,Scadden DT.Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture.Cell Stem Cell. 2008 Aug 7;3(2):221-7.
    18682243
  • Raaijmakers MH,Scadden DT.Evolving concepts on the microenvironmental niche for hematopoietic stem cells.Curr Opin Hematol. 2008 Jul;15(4):301-6. Review.
    18536566
  • Lu J, Guo S, Ebert BL, Zhang H, Peng X, Bosco J, Pretz J, Schlanger R, Wang JY, Mak RH, Dombkowski DM, Preffer FI, Scadden DT, Golub TR.MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors.Dev Cell. 2008 Jun;14(6):843-53.
    18539114
  • Janzen V,Fleming HE,Riedt T,Karlsson G,Riese MJ,Lo Celso C,Reynolds G,Milne CD,Paige CJ,Karlsson S,Woo M,Scadden DT.Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3.Cell Stem Cell. 2008 Jun 5;2(6):584-94.
    18522851
  • Fernandez L, Rodriguez S, Huang H, Chora A, Fernandes J, Mumaw C, Cruz E, Pollok K, Cristina F, Price JE, Ferkowicz MJ, Scadden DT, Clauss M, Cardoso AA, Carlesso N.Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation.Exp Hematol. 2008 May;36(5):545-558.
    18439488
  • Papayannopoulou T, Scadden DT.Stem-cell ecology and stem cells in motion.Blood. 2008 Apr 15;111(8):3923-30. Review.
    18398055
  • Craiu A, Scadden D.Flow electroporation with pulsed electric fields for purging tumor cells.Methods Mol Biol. 2008;423:301-10.
    18370208
  • Purton LE, Scadden DT.Limiting factors in murine hematopoietic stem cell assays.Cell Stem Cell. 2007 Sep 13;1(3):263-70. Review.
    18371361
  • Lo Celso C, Scadden DT.Stem cells remember their grade.Cell Stem Cell. 2007 Aug 16;1(2):132-4.
    18371344
  • Fleming HE, Janzen V, Lo Celso C, Guo J, Leahy KM, Kronenberg HM, Scadden DT.Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.Cell Stem Cell. 2008 Mar 6;2(3):274-83.
    18371452
  • Kim WJ, Okimoto RA, Purton LE, Goodwin M, Haserlat SM, Dayyani F, Sweetser DA, McClatchey AI, Bernard OA, Look AT, Bell DW, Scadden DT, Haber DA.Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.Blood. 2008 May 1;111(9):4716-22.
    18299447
  • Daley GQ, Scadden DT.Prospects for stem cell-based therapy.Cell. 2008 Feb 22;132(4):544-8.
    18295571
  • Friel AM, Sergent PA, Patnaude C, Szotek PP, Oliva E, Scadden DT, Seiden MV, Foster R, Rueda BR.Functional analyses of the cancer stem cell-like properties of human endometrial tumor initiating cells.Cell Cycle. 2008 Jan;7(2):242-9.
    18256549
  • Mukherjee S, Raje N, Schoonmaker JA, Liu JC, Hideshima T, Wein MN, Jones DC, Vallet S, Bouxsein ML, Pozzi S, Chhetri S, Seo YD, Aronson JP, Patel C, Fulciniti M, Purton LE, Glimcher LH, Lian JB, Stein G, Anderson KC, Scadden DT.Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice.J Clin Invest. 2008 Feb;118(2):491-504.
    18219387
  • Orford KW, Scadden DT.Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation.Nat Rev Genet. 2008 Feb;9(2):115-28. Review.
    18202695
  • Spitzer TR, Ambinder RF, Lee JY, Kaplan LD, Wachsman W, Straus DJ, Aboulafia DM, Scadden DT.Dose-reduced busulfan, cyclophosphamide, and autologous stem cell transplantation for human immunodeficiency virus-associated lymphoma: AIDS Malignancy Consortium study 020.Biol Blood Marrow Transplant. 2008 Jan;14(1):59-66.
    18158962
  • Au P, Daheron LM, Duda DG, Cohen KS, Tyrrell JA, Lanning RM, Fukumura D, Scadden DT, Jain RK.Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels.Blood. 2008 Feb 1;111(3):1302-5.
    17993613
  • Adams GB, Martin RP, Alley IR, Chabner KT, Cohen KS, Calvi LM, Kronenberg HM, Scadden DT.Corrigendum: Therapeutic targeting of a stem cell niche.Nat Biotechnol. 2007 Aug;25(8):944.
    17687371
  • Walkley CR, Olsen GH, Dworkin S, Fabb SA, Swann J, McArthur GA, Westmoreland SV, Chambon P, Scadden DT, Purton LE.A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency.Cell. 2007 Jun 15;129(6):1097-110.
    17574023
  • Duda DG, Cohen KS, Scadden DT, Jain RK.A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood.Nat Protoc. 2007;2(4):805-10.
    17446880
  • Scadden DT.The stem cell niche in health and leukemic disease.Best Pract Res Clin Haematol. 2007 Mar;20(1):19-27. Review.
    17336251
  • Bihl F, Narayan M, Chisholm JV, Henry LM, Suscovich TJ, Brown EE, Welzel TM, Kaufmann DE, Zaman TM, Dollard S, Martin JN, Wang F, Scadden DT, Kaye KM, Brander C.Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes.J Virol. 2007 May;81(9):4904-8.
    17329344
  • Wang ZZ, Au P, Chen T, Shao Y, Daheron LM, Bai H, Arzigian M, Fukumura D, Jain RK, Scadden DT.Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo.Nat Biotechnol. 2007 Mar;25(3):317-8.
    17322871
  • Adams GB, Martin RP, Alley IR, Chabner KT, Cohen KS, Calvi LM, Kronenberg HM, Scadden DT.Therapeutic targeting of a stem cell niche.Nat Biotechnol. 2007 Feb;25(2):238-43.
    17237769
  • Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK.AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.Cancer Cell. 2007 Jan;11(1):83-95.
    17222792
  • Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT.Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.Nature. 2006 Sep 28;443(7110):421-6.
    16957735
  • Fleming HE, Scadden DT.Embryonic stem cells make human T cells.Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12213-4.
    16894150
  • Scadden DT.The stem-cell niche as an entity of action.Nature. 2006 Jun 29;441(7097):1075-9. Review.
    16810242
  • Purton LE, Scadden DT.Osteoclasts eat stem cells out of house and home.Nat Med. 2006 Jun;12(6):610-1.
    16761001
  • Janzen V, Scadden DT.Stem cells: good, bad and reformable.Nature. 2006 May 25;441(7092):418-9.
    16724049
  • Duda DG, Cohen KS, di Tomaso E, Au P, Klein RJ, Scadden DT, Willett CG, Jain RK.Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy.J Clin Oncol. 2006 Mar 20;24(9):1449-53.
    16549839
  • Robertson P, Means TK, Luster AD, Scadden DT.CXCR4 and CCR5 mediate homing of primitive bone marrow-derived hematopoietic cells to the postnatal thymus.Exp Hematol. 2006 Mar;34(3):308-19.
    16543065
  • Flavell SW, Cowan CW, Kim TK, Greer PL, Lin Y, Paradis S, Griffith EC, Hu LS, Chen C, Greenberg ME.Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number.Science. 2006 Feb 17;311(5763):1008-12.
    16484497
  • Adams GB, Chabner KT, Alley IR, Olson DP, Szczepiorkowski ZM, Poznansky MC, Kos CH, Pollak MR, Brown EM, Scadden DT.Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor.Nature. 2006 Feb 2;439(7076):599-603.
    16382241
  • Duda DG, Cohen KS, Kozin SV, Perentes JY, Fukumura D, Scadden DT, Jain RK.Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors.Blood. 2006 Apr 1;107(7):2774-6.
    16339405
  • Dong HY, Scadden DT, de Leval L, Tang Z, Isaacson PG, Harris NL.Plasmablastic lymphoma in HIV-positive patients: an aggressive Epstein-Barr virus-associated extramedullary plasmacytic neoplasm.Am J Surg Pathol. 2005 Dec;29(12):1633-41.
    16327436
  • Willett CG, Boucher Y, Duda DG, di Tomaso E, Munn LL, Tong RT, Kozin SV, Petit L, Jain RK, Chung DC, Sahani DV, Kalva SP, Cohen KS, Scadden DT, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Shellito PC, Mino-Kenudson M, Lauwers GY.Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients.J Clin Oncol. 2005 Nov 1;23(31):8136-9.
    16258121
  • Woodberry T, Suscovich TJ, Henry LM, August M, Waring MT, Kaur A, Hess C, Kutok JL, Aster JC, Wang F, Scadden DT, Brander C.AlphaEbeta7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population.J Immunol. 2005 Oct 1;175(7):4355-62.
    16177076
  • Zhang J, Attar E, Cohen K, Crumpacker C, Scadden D.Silencing p21(Waf1/Cip1/Sdi1) expression increases gene transduction efficiency in primitive human hematopoietic cells.Gene Ther. 2005 Oct;12(19):1444-52.
    15877047
  • Rodrigues NP, Janzen V, Forkert R, Dombkowski DM, Boyd AS, Orkin SH, Enver T, Vyas P, Scadden DT.Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem cell homeostasis.Blood. 2005 Jul 15;106(2):477-84.
    15811962
  • Sipkins DA, Wei X, Wu JW, Runnels JM, Ct D, Means TK, Luster AD, Scadden DT, Lin CP.In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment.Nature. 2005 Jun 16;435(7044):969-73.
    15959517
  • Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK.Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo.Nat Med. 2005 Jun;11(6):678-82.
    15880117
  • Stier S, Ko Y, Forkert R, Lutz C, Neuhaus T, Grnewald E, Cheng T, Dombkowski D, Calvi LM, Rittling SR, Scadden DT.Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size.J Exp Med. 2005 Jun 6;201(11):1781-91.
    15928197
  • Kaplan LD, Lee JY, Ambinder RF, Sparano JA, Cesarman E, Chadburn A, Levine AM, Scadden DT.Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial 010.Blood. 2005 Sep 1;106(5):1538-43.
    15914552
  • Mosam A, Cassol E, Page T, Bodasing U, Cassol S, Dawood H, Friedland GH, Scadden DT, Aboobaker J, Jordaan JP, Lalloo UG, Esterhuizen TM, Coovadia HM.Generic antiretroviral efficacy in AIDS-associated Kaposi's sarcoma in sub-Saharan Africa.AIDS. 2005 Mar 4;19(4):441-3.
    15750399
  • Fangman JJ, Scadden DT.Anemia in HIV-infected adults: epidemiology, pathogenesis, and clinical management.Curr Hematol Rep. 2005 Mar;4(2):95-102.
    15720957
  • Craiu A, Saito Y, Limon A, Eppich HM, Olson DP, Rodrigues N, Adams GB, Dombkowski D, Richardson P, Schlossman R, Choi PS, Grogins J, O'Connor PG, Cohen K, Attar EC, Freshman J, Rich R, Mangano JA, Gribben JG, Anderson KC, Scadden DT.Flowing cells through pulsed electric fields efficiently purges stem cell preparations of contaminating myeloma cells while preserving stem cell function.Blood. 2005 Mar 1;105(5):2235-8.
    15292069
  • Suscovich TJ, Paulose-Murphy M, Harlow JD, Chen Y, Thomas SY, Mellott TJ, Walker BD, Scadden DT, Zeichner S, Brander C.Defective immune function of primary effusion lymphoma cells is associated with distinct KSHV gene expression profiles.Leuk Lymphoma. 2004 Jun;45(6):1223-38.
    15360006
  • Scadden DT.Cancer stem cells refined.Nat Immunol. 2004 Jul;5(7):701-3.
    15224098
  • Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK.Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.Nat Med. 2004 Feb;10(2):145-7.
    14745444
  • Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC, Martin RP, Schipani E, Divieti P, Bringhurst FR, Milner LA, Kronenberg HM, Scadden DT.Osteoblastic cells regulate the haematopoietic stem cell niche.Nature. 2003 Oct 23;425(6960):841-6.
    14574413
  • Lee BC, Cheng T, Adams GB, Attar EC, Miura N, Lee SB, Saito Y, Olszak I, Dombkowski D, Olson DP, Hancock J, Choi PS, Haber DA, Luster AD, Scadden DT.P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells.Genes Dev. 2003 Jul 1;17(13):1592-604.
    12842911
  • Stier S, Cheng T, Forkert R, Lutz C, Dombkowski DM, Zhang JL, Scadden DT.Ex vivo targeting of p21Cip1/Waf1 permits relative expansion of human hematopoietic stem cells.Blood. 2003 Aug 15;102(4):1260-6.
    12702511
  • Scadden DT.AIDS-related malignancies.Annu Rev Med. 2003;54:285-303.
    12525676
  • Adams GB, Chabner KT, Foxall RB, Weibrecht KW, Rodrigues NP, Dombkowski D, Fallon R, Poznansky MC, Scadden DT.Heterologous cells cooperate to augment stem cell migration, homing, and engraftment.Blood. 2003 Jan 1;101(1):45-51.
    12393569
  • Preffer FI, Dombkowski D, Sykes M, Scadden D, Yang YG.Lineage-negative side-population (SP) cells with restricted hematopoietic capacity circulate in normal human adult blood: immunophenotypic and functional characterization.Stem Cells. 2002;20(5):417-27.
    12351812
  • Brander C, Raje N, O'Connor PG, Davies F, Davis J, Chauhan D, Hideshima T, Martin J, Osmond D, Kedes DH, Walker BD, Scadden DT, Anderson KC.Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma.Blood. 2002 Jul 15;100(2):698-700.
    12091368
  • Stier S, Cheng T, Dombkowski D, Carlesso N, Scadden DT.Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome.Blood. 2002 Apr 1;99(7):2369-78.
    11895769
  • Donato JL, Ko J, Kutok JL, Cheng T, Shirakawa T, Mao XQ, Beach D, Scadden DT, Sayegh MH, Adra CN.Human HTm4 is a hematopoietic cell cycle regulator.J Clin Invest. 2002 Jan;109(1):51-8.
    11781350
  • Cheng T, Shen H, Rodrigues N, Stier S, Scadden DT.Transforming growth factor beta 1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21(Cip1/Waf1) or p27(Kip1).Blood. 2001 Dec 15;98(13):3643-9.
    11739168
  • Brander C, O'Connor P, Suscovich T, Jones NG, Lee Y, Kedes D, Ganem D, Martin J, Osmond D, Southwood S, Sette A, Walker BD, Scadden DT.Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein.J Infect Dis. 2001 Jul 15;184(2):119-26.
    11424007
  • Poznansky MC, Olszak IT, Foxall RB, Piascik A, Adams GB, Evans RH, Cheng T, Scadden DT.Tissue source dictates lineage outcome of human fetal CD34(+)CD38(-) cells.Exp Hematol. 2001 Jun;29(6):766-74.
    11378272
  • Ratner L, Lee J, Tang S, Redden D, Hamzeh F, Herndier B, Scadden D, Kaplan L, Ambinder R, Levine A, Harrington W, Grochow L, Flexner C, Tan B, Straus D,.Chemotherapy for human immunodeficiency virus-associated non-Hodgkin's lymphoma in combination with highly active antiretroviral therapy.J Clin Oncol. 2001 Apr 15;19(8):2171-8.
    11304769
  • Ellisen LW, Carlesso N, Cheng T, Scadden DT, Haber DA.The Wilms tumor suppressor WT1 directs stage-specific quiescence and differentiation of human hematopoietic progenitor cells.EMBO J. 2001 Apr 17;20(8):1897-909.
    11296223
  • Shen H, Cheng T, Olszak I, Garcia-Zepeda E, Lu Z, Herrmann S, Fallon R, Luster AD, Scadden DT.CXCR-4 desensitization is associated with tissue localization of hemopoietic progenitor cells.J Immunol. 2001 Apr 15;166(8):5027-33.
    11290783
  • Cohen K, Scadden DT.Non-Hodgkin's lymphoma: pathogenesis, clinical presentation, and treatment.Cancer Treat Res. 2001;104:201-30.
    11191128
  • O'Connor PG, Scadden DT.AIDS oncology.Infect Dis Clin North Am. 2000 Dec;14(4):945-65, vii.
    11144646
  • Cheng T, Rodrigues N, Dombkowski D, Stier S, Scadden DT.Stem cell repopulation efficiency but not pool size is governed by p27(kip1).Nat Med. 2000 Nov;6(11):1235-40.
    11062534
  • Scadden DT.Epstein-Barr virus, the CNS, and AIDS-related lymphomas: as close as flame to smoke.J Clin Oncol. 2000 Oct 1;18(19):3323-4.
    11013270
  • Evans RH, Scadden DT.Haematological aspects of HIV infection.Baillieres Best Pract Res Clin Haematol. 2000 Jun;13(2):215-30.
    10942622
  • Brander C, Suscovich T, Lee Y, Nguyen PT, O'Connor P, Seebach J, Jones NG, van Gorder M, Walker BD, Scadden DT.Impaired CTL recognition of cells latently infected with Kaposi's sarcoma-associated herpes virus.J Immunol. 2000 Aug 15;165(4):2077-83.
    10925292
  • Poznansky MC, Evans RH, Foxall RB, Olszak IT, Piascik AH, Hartman KE, Brander C, Meyer TH, Pykett MJ, Chabner KT, Kalams SA, Rosenzweig M, Scadden DT.Efficient generation of human T cells from a tissue-engineered thymic organoid.Nat Biotechnol. 2000 Jul;18(7):729-34.
    10888839
  • Poznansky MC, Olszak IT, Foxall R, Evans RH, Luster AD, Scadden DT.Active movement of T cells away from a chemokine.Nat Med. 2000 May;6(5):543-8.
    10802710
  • Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R.Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells.Nat Biotechnol. 2000 Apr;18(4):410-4.
    10748521
  • Gill PS, Tulpule A, Espina BM, Cabriales S, Bresnahan J, Ilaw M, Louie S, Gustafson NF, Brown MA, Orcutt C, Winograd B, Scadden DT.Paclitaxel is safe and effective in the treatment of advanced AIDS-related Kaposi's sarcoma.J Clin Oncol. 1999 Jun;17(6):1876-83.
    10561228
  • Adams GB, McMullen M, Turner S, Olszak IT, Scadden DT, McClure MO, Poznansky MC.Isolation and transduction of CD34+ cells from small quantities of peripheral blood from HIV-1-infected patients not treated with hemopoietic growth factors.J Acquir Immune Defic Syndr. 1999 May 1;21(1):1-8.
    10235508
  • Nikolic B, Gardner JP, Scadden DT, Arn JS, Sachs DH, Sykes M.Normal development in porcine thymus grafts and specific tolerance of human T cells to porcine donor MHC.J Immunol. 1999 Mar 15;162(6):3402-7.
    10092795
  • Carlesso N, Aster JC, Sklar J, Scadden DT.Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics.Blood. 1999 Feb 1;93(3):838-48.
    9920832
  • Shen H, Cheng T, Preffer FI, Dombkowski D, Tomasson MH, Golan DE, Yang O, Hofmann W, Sodroski JG, Luster AD, Scadden DT.Intrinsic human immunodeficiency virus type 1 resistance of hematopoietic stem cells despite coreceptor expression.J Virol. 1999 Jan;73(1):728-37.
    9847379
  • Gardner JP, Rosenzweig M, Marks DF, Harper D, Gaynor K, Fallon RJ, Wall DA, Johnson RP, Scadden DT.T-lymphopoietic capacity of cord blood-derived CD34+ progenitor cells.Exp Hematol. 1998 Sep;26(10):991-9.
    9728935
  • Radomska HS, Huettner CS, Zhang P, Cheng T, Scadden DT, Tenen DG.CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors.Mol Cell Biol. 1998 Jul;18(7):4301-14.
    9632814
  • Gardner JP, Zhu H, Colosi PC, Kurtzman GJ, Scadden DT.Robust, but transient expression of adeno-associated virus-transduced genes during human T lymphopoiesis.Blood. 1997 Dec 15;90(12):4854-64.
    9389702
  • Franken M, Estabrooks A, Cavacini L, Sherburne B, Wang F, Scadden DT.Epstein-Barr virus-driven gene therapy for EBV-related lymphomas.Nat Med. 1996 Dec;2(12):1379-82.
    8946840
  • Cheng T, Shen H, Giokas D, Gere J, Tenen DG, Scadden DT.Temporal mapping of gene expression levels during the differentiation of individual primary hematopoietic cells.Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13158-63.
    8917561
  • Scadden DT, Pickus O, Hammer SM, Stretcher B, Bresnahan J, Gere J, McGrath J, Agosti JM.Lack of in vivo effect of granulocyte-macrophage colony-stimulating factor on human immunodeficiency virus type 1.AIDS Res Hum Retroviruses. 1996 Aug 10;12(12):1151-9.
    8844019
  • Gill PS, Wernz J, Scadden DT, Cohen P, Mukwaya GM, von Roenn JH, Jacobs M, Kempin S, Silverberg I, Gonzales G, Rarick MU, Myers AM, Shepherd F, Sawka C, Pike MC, Ross ME.Randomized phase III trial of liposomal daunorubicin versus doxorubicin, bleomycin, and vincristine in AIDS-related Kaposi's sarcoma.J Clin Oncol. 1996 Aug;14(8):2353-64.
    8708728
  • Rosenzweig M, Marks DF, Zhu H, Hempel D, Mansfield KG, Sehgal PK, Kalams S, Scadden DT, Johnson RP.In vitro T lymphopoiesis of human and rhesus CD34+ progenitor cells.Blood. 1996 May 15;87(10):4040-8.
    8639759
  • Freedman AR, Zhu H, Levine JD, Kalams S, Scadden DT.Generation of human T lymphocytes from bone marrow CD34+ cells in vitro.Nat Med. 1996 Jan;2(1):46-51.
    8564838
  • Berardi AC, Wang A, Abraham J, Scadden DT.Basic fibroblast growth factor mediates its effects on committed myeloid progenitors by direct action and has no effect on hematopoietic stem cells.Blood. 1995 Sep 15;86(6):2123-9.
    7662960
  • Columbyova L, Loda M, Scadden DT.Thrombopoietin receptor expression in human cancer cell lines and primary tissues.Cancer Res. 1995 Aug 15;55(16):3509-12.
    7627956
  • Scadden DT, Levine JD, Bresnahan J, Gere J, McGrath J, Wang Z, Resta DJ, Young D, Hammer SM.In vivo effects of interleukin 3 in HIV type 1-infected patients with cytopenia.AIDS Res Hum Retroviruses. 1995 Jun;11(6):731-40.
    7576933
  • Berardi AC, Wang A, Levine JD, Lopez P, Scadden DT.Functional isolation and characterization of human hematopoietic stem cells.Science. 1995 Jan 6;267(5194):104-8.
    7528940
  • Price P, Johnson RP, Scadden DT, Jassoy C, Rosenthal T, Kalams S, Walker BD.Cytotoxic CD8+ T lymphocytes reactive with human immunodeficiency virus-1 produce granulocyte/macrophage colony-stimulating factor and variable amounts of interleukins 2, 3, and 4 following stimulation with the cognate epitope.Clin Immunol Immunopathol. 1995 Jan;74(1):100-6.
    7527747
  • Bennett BD, Wang Z, Kuang WJ, Wang A, Groopman JE, Goeddel DV, Scadden DT.Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily.J Biol Chem. 1994 May 13;269(19):14211-8.
    8188704
  • Mark MR, Scadden DT, Wang Z, Gu Q, Goddard A, Godowski PJ.rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain.J Biol Chem. 1994 Apr 8;269(14):10720-8.
    7511603
  • Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT.Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene.Gene. 1994 Jan 28;138(1-2):247-51.
    7510261
  • Scadden DT, Wang Z, Groopman JE.Quantitation of plasma human immunodeficiency virus type 1 RNA by competitive polymerase chain reaction.J Infect Dis. 1992 Jun;165(6):1119-23.
    1583331
  • Scadden DT, Bering HA, Levine JD, Bresnahan J, Evans L, Epstein C, Groopman JE.GM-CSF as an alternative to dose modification of the combination zidovudine and interferon-alpha in the treatment of AIDS-associated Kaposi's sarcoma.Am J Clin Oncol. 1991;14 Suppl 1:S40-4.
    2048563
  • Scadden DT, Zeira M, Woon A, Wang Z, Schieve L, Ikeuchi K, Lim B, Groopman JE.Human immunodeficiency virus infection of human bone marrow stromal fibroblasts.Blood. 1990 Jul 15;76(2):317-22.
    1695109
  • Scadden DT, Fuller B, Cunningham JM.Human cells infected with retrovirus vectors acquire an endogenous murine provirus.J Virol. 1990 Jan;64(1):424-7.
    2152828
  • Groopman JE, Molina JM, Scadden DT.Hematopoietic growth factors. Biology and clinical applications.N Engl J Med. 1989 Nov 23;321(21):1449-59.
    2682244
  • Molina JM, Scadden DT, Byrn R, Dinarello CA, Groopman JE.Production of tumor necrosis factor alpha and interleukin 1 beta by monocytic cells infected with human immunodeficiency virus.J Clin Invest. 1989 Sep;84(3):733-7.
    2474573