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David T. Scadden, MD

Publications

  • Kfoury Y, Mercier F, Scadden DT.SnapShot: The Hematopoietic Stem Cell Niche.Cell. 2014 Jul 3;158(1):228-228.e1.
    24995988
  • Cho J, Yusuf R, Kook S, Attar E, Lee D, Park B, Cheng T, Scadden DT, Lee BC.Purinergic P2Y14 receptor modulates stress-induced hematopoietic stem/progenitor cell senescence.J Clin Invest. 2014 Jul 1;124(7):3159-71.
    24937426
  • Kharchenko PV, Silberstein L, Scadden DT.Bayesian approach to single-cell differential expression analysis.Nat Methods. 2014 May 18.
    24836921
  • Park D, Spencer JA, Lin CP, Scadden DT.Sequential In vivo Imaging of Osteogenic Stem/Progenitor Cells During Fracture Repair.Journal Of Visualized Experiments : Jo Ve. 2014(87).
    24894331
  • Kalaitzidis D, Scadden DT.Tic-TACs: refreshing hair growth.Cell. 2014 May 8;157(4):769-70.
    24813602
  • Spencer JA, Ferraro F, Roussakis E, Klein A, Wu J, Runnels JM, Zaher W, Mortensen LJ, Alt C, Turcotte R, Yusuf R, Côté D, Vinogradov SA, Scadden DT, Lin CP.Direct measurement of local oxygen concentration in the bone marrow of live animals.Nature. 2014 Apr 10;508(7495):269-73.
    24590072
  • Schajnovitz A, Scadden DT.Bone's dark side: mutated osteoblasts implicated in leukemia.Cell Res. 2014 Apr;24(4):383-4.
    24589711
  • Scadden DT.Nice Neighborhood: Emerging Concepts of the Stem Cell Niche.Cell. 2014 Mar 27;157(1):41-50.
    24679525
  • Li X, Romain RD, Park D, Scadden DT, Merchant JL, Arnaout MA.Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89.Stem Cells. 2014 Mar;32(3):791-801.
    24549639
  • Morrison SJ, Scadden DT.The bone marrow niche for haematopoietic stem cells.Nature. 2014 Jan 16;505(7483):327-34. Review.
    24429631
  • Catic A, Suh CY, Hill CT, Daheron L, Henkel T, Orford KW, Dombkowski DM, Liu T, Liu XS, Scadden DT.Genome-wide map of nuclear protein degradation shows NCoR1 turnover as a key to mitochondrial gene regulation.Cell. 2013 Dec 5;155(6):1380-95.
    24315104
  • Silberstein L, Scadden DT.Blood scent.Cell. 2013 Nov 21;155(5):981-2.
    24267883
  • Carlson AL, Fujisaki J, Wu J, Runnels JM, Turcotte R, Spencer JA, Celso CL, Scadden DT, Strom TB, Lin CP.Correction: Tracking Single Cells in Live Animals Using a Photoconvertible Near-Infrared Cell Membrane Label.PLoS ONE. 2013;8(11).
    24250779
  • Zhang H, Alberich-Jorda M, Amabile G, Yang H, Staber PB, Di Ruscio A, Diruscio A, Welner RS, Ebralidze A, Zhang J, Levantini E, Lefebvre V, Valk PJ, Delwel R, Hoogenkamp M, Nerlov C, Cammenga J, Saez B, Scadden DT, Bonifer C, Ye M, Tenen DG.Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia.Cancer Cell. 2013 Nov 11;24(5):575-88.
    24183681
  • Hartwell KA, Miller PG, Mukherjee S, Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M, Järås M, Puram R, Dancik V, Al-Shahrour F, Kindler T, Tothova Z, Chattopadhyay S, Hasaka T, Narayan R, Dai M, Huang C, Shterental S, Chu LP, Haydu JE, Shieh JH, Steensma DP, Munoz B, Bittker JA, Shamji AF, Clemons PA, Tolliday NJ, Carpenter AE, Gilliland DG, Stern AM, Moore MA, Scadden DT, Schreiber SL, Ebert BL, Golub TR.Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.Nat Chem Biol. 2013 Dec;9(12):840-8.
    24161946
  • Sykes SM, Scadden DT.Modeling human hematopoietic stem cell biology in the mouse.Semin Hematol. 2013 Apr;50(2):92-100.
    24216169
  • Krause DS, Fulzele K, Catic A, Sun CC, Dombkowski D, Hurley MP, Lezeau S, Attar E, Wu JY, Lin HY, Divieti-Pajevic P, Hasserjian RP, Schipani E, Van Etten RA, Scadden DT.Differential regulation of myeloid leukemias by the bone marrow microenvironment.Nat Med. 2013 Nov;19(11):1513-7.
    24162813
  • Cutler C, Multani P, Robbins D, Kim HT, Le T, Hoggatt J, Pelus LM, Desponts C, Chen YB, Rezner B, Armand P, Koreth J, Glotzbecker B, Ho VT, Alyea E, Isom M, Kao G, Armant M, Silberstein L, Hu P, Soiffer RJ, Scadden DT, Ritz J, Goessling W, North TE, Mendlein J, Ballen K, Zon LI, Antin JH, Shoemaker DD.Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.Blood. 2013 Oct 24;122(17):3074-81.
    23996087
  • Carlson AL, Fujisaki J, Wu J, Runnels JM, Turcotte R, Celso CL, Scadden DT, Strom TB, Lin CP.Tracking single cells in live animals using a photoconvertible near-infrared cell membrane label.PLoS ONE. 2013;8(8):e69257.
    23990881
  • Samuel R, Daheron L, Liao S, Vardam T, Kamoun WS, Batista A, Buecker C, Schäfer R, Han X, Au P, Scadden DT, Duda DG, Fukumura D, Jain RK.Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells.Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12774-9.
    23861493
  • Miller PG, Al-Shahrour F, Hartwell KA, Chu LP, Järås M, Puram RV, Puissant A, Callahan KP, Ashton J, McConkey ME, Poveromo LP, Cowley GS, Kharas MG, Labelle M, Shterental S, Fujisaki J, Silberstein L, Alexe G, Al-Hajj MA, Shelton CA, Armstrong SA, Root DE, Scadden DT, Hynes RO, Mukherjee S, Stegmaier K, Jordan CT, Ebert BL.In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling.Cancer Cell. 2013 Jul 8;24(1):45-58.
    23770013
  • Roccaro AM, Sacco A, Maiso P, Azab AK, Tai YT, Reagan M, Azab F, Flores LM, Campigotto F, Weller E, Anderson KC, Scadden DT, Ghobrial IM.BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression.J Clin Invest. 2013 Apr 1;123(4):1542-55.
    23454749
  • Ruiz-Riol M, Mothe B, Gandhi RT, Bhardwaj N, Scadden DT, Sanchez-Merino V, Brander C.Influenza, but not HIV-specific CTL epitopes, elicits delayed-type hypersensitivity (DTH) reactions in HIV-infected patients.Eur J Immunol. 2013 Mar 15.
    23504637
  • Hoggatt J, Mohammad KS, Singh P, Hoggatt AF, Chitteti BR, Speth JM, Hu P, Poteat BA, Stilger KN, Ferraro F, Silberstein L, Wong FK, Farag SS, Czader M, Milne GL, Breyer RM, Serezani CH, Scadden DT, Guise TA, Srour EF, Pelus LM.Differential stem- and progenitor-cell trafficking by prostaglandin E2.Nature. 2013 Mar 21;495(7441):365-9.
    23485965
  • Pozzi S, Fulciniti M, Yan H, Vallet S, Eda H, Patel K, Santo L, Cirstea D, Hideshima T, Schirtzinge L, Kuhstoss S, Anderson KC, Munshi N, Scadden D, Kronenberg HM, Raje N.In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma.Bone. 2013 Apr;53(2):487-96.
    23333523
  • Brown K, Xie S, Qiu X, Mohrin M, Shin J, Liu Y, Zhang D, Scadden DT, Chen D.SIRT3 reverses aging-associated degeneration.Cell Rep. 2013 Feb 21;3(2):319-27.
    23375372
  • Yildirim E, Kirby JE, Brown DE, Mercier FE, Sadreyev RI, Scadden DT, Lee JT.Xist RNA is a potent suppressor of hematologic cancer in mice.Cell. 2013 Feb 14;152(4):727-42.
    23415223
  • Krause DS, Scadden DT, Preffer FI.The hematopoietic stem cell niche--home for friend and foe?.Cytometry. Part B, Clinical Cytometry.;84(1):7-20.
    23281119
  • Fulzele K, Krause DS, Panaroni C, Saini V, Barry KJ, Liu X, Lotinun S, Baron R, Bonewald L, Feng JQ, Chen M, Weinstein LS, Wu JY, Kronenberg HM, Scadden DT, Divieti Pajevic P.Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling.Blood. 2012 Nov 16.
    23160461
  • van Etten RA, Mauro M, Radich JP, Goldman JM, Saglio G, Jamieson C, Soverini S, Gambacorti-Passerini C, Hehlmann R, Martinelli G, Perrotti D, Scadden DT, Skorski T, Tefferi A, Mughal TI.Advances in the biology and therapy of chronic myeloid leukemia (CML): Proceedings from the 6(th) Post-ASH International CML and Myeloproliferative Neoplasms Workshop.Leuk Lymphoma. 2012 Nov 2.
    23121619
  • Guo S, Bai H, Megyola CM, Halene S, Krause DS, Scadden DT, Lu J.Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms.Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16636-41.
    23012470
  • Yusuf RZ, Scadden DT.Fate through Fat: Lipid Metabolism Determines Stem Cell Division Outcome.Cell Metab. 2012 Oct 3;16(4):411-3.
    23040066
  • Kalaitzidis D, Sykes SM, Wang Z, Punt N, Tang Y, Ragu C, Sinha AU, Lane SW, Souza AL, Clish CB, Anastasiou D, Gilliland DG, Scadden DT, Guertin DA, Armstrong SA.mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.Cell Stem Cell. 2012 Sep 7;11(3):429-39.
    22958934
  • Hoggatt J, Scadden DT.The stem cell niche: tissue physiology at a single cell level.J Clin Invest. 2012 Sep 4;122(9):3029-34.
    22945635
  • Demers M, Krause DS, Schatzberg D, Martinod K, Voorhees JR, Fuchs TA, Scadden DT, Wagner DD.Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis.Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13076-81.
    22826226
  • Scadden DT.Rethinking stroma: lessons from the blood.Cell Stem Cell. 2012 Jun 14;10(6):648-9.
    22704500
  • Yusuf RZ, Wang YH, Scadden DT.The secrets of the bone marrow niche: Metabolic priming for AML.Nat Med. 2012 Jun;18(6):865-7.
    22673998
  • Krause DS, Scadden DT.Deconstructing the complexity of a microenvironmental niche.Cell. 2012 Mar 30;149(1):16-7.
    22464318
  • Mosam A, Shaik F, Uldrick TS, Esterhuizen T, Friedland GH, Scadden DT, Aboobaker J, Coovadia HM.A randomized controlled trial of HAART versus HAART and chemotherapy in therapy-naïve patients with HIV-associated Kaposi sarcoma in South Africa.J Acquir Immune Defic Syndr. 2012 Mar 19.
    22395672
  • Park D, Spencer JA, Koh BI, Kobayashi T, Fujisaki J, Clemens TL, Lin CP, Kronenberg HM, Scadden DT.Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration.Cell Stem Cell. 2012 Mar 2;10(3):259-72.
    22385654