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Vikas P. Sukhatme, MD, ScD


  • Xie H, Hanai JI, Ren JG, Kats L, Burgess K, Bhargava P, Signoretti S, Billiard J, Duffy KJ, Grant A, Wang X, Lorkiewicz PK, Schatzman S, Bousamra M, Lane AN, Higashi RM, Fan TW, Pandolfi PP, Sukhatme VP, Seth P.Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells.Cell Metab. 2014 Apr 9.
  • Daemen A, Griffith OL, Heiser LM, Wang NJ, Enache OM, Sanborn Z, Pepin F, Durinck S, Korkola JE, Griffith M, Hur JS, Huh N, Chung J, Cope L, Fackler MJ, Umbricht C, Sukumar S, Seth P, Sukhatme VP, Jakkula LR, Lu Y, Mills GB, Cho RJ, Collisson EA, van't Veer LJ, Spellman PT, Gray JW.Modeling precision treatment of breast cancer.Genome Biol. 2013;14(10):R110.
  • Husain Z, Seth P, Sukhatme VP.Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology.Oncoimmunology. 2013 Nov 1;2(11):e26383.
  • Chan B, Sukhatme VP.One-step purification of soluble recombinant human 6-phosphogluconate dehydrogenase from Escherichia coli.Protein Expr Purif. 2013 Nov;92(1):62-6.
  • Chan B, VanderLaan PA, Sukhatme VP.6-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met.Biochem Biophys Res Commun. 2013 Sep 20;439(2):247-51.
  • Husain Z, Huang Y, Seth P, Sukhatme VP.Tumor-derived lactate modifies antitumor immune response: effect on myeloid-derived suppressor cells and NK cells.J Immunol. 2013 Aug 1;191(3):1486-95.
  • Cerdeira AS, Rajakumar A, Royle CM, Lo A, Husain Z, Thadhani RI, Sukhatme VP, Karumanchi SA, Kopcow HD.Conversion of Peripheral Blood NK Cells to a Decidual NK-like Phenotype by a Cocktail of Defined Factors.J Immunol. 2013 Apr 15;190(8):3939-48.
  • Arnaout R, Buck TP, Roulette P, Sukhatme VP.Predicting the cost and pace of pharmacogenomic advances: an evidence-based study.Clin Chem. 2013 Apr;59(4):649-57.
  • Sun X, Han L, Seth P, Bian S, Li L, Csizmadia E, Junger WG, Schmelzle M, Usheva A, Tapper EB, Baffy G, Sukhatme VP, Wu Y, Robson SC.Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/Entpd1 null mice.Hepatology. 2012 Aug 1.
  • Sukhatme VP, Chan B.Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence.FEBS Lett. 2012 Jul 30;586(16):2389-95.
  • Wagner BK, Gilbert TJ, Hanai J, Imamura S, Bodycombe NE, Bon RS, Waldmann H, Clemons PA, Sukhatme VP, Mootha VK.A small-molecule screening strategy to identify suppressors of statin myopathy.ACS Chem Biol. 2011 Sep 16;6(9):900-4.
  • Hanai JI, Doro N, Sasaki AT, Kobayashi S, Cantley LC, Seth P, Sukhatme VP.Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-actiated protein kinase (MAPK) and phosphatidylinositol-3- kinase (PI3K)/AKT pathways.J Cell Physiol. 2011 Jun 17.
  • Seth P, Grant A, Tang J, Vinogradov E, Wang X, Lenkinski R, Sukhatme VP.On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate.Neoplasia. 2011 Jan;13(1):60-71.
  • Ren JG, Seth P, Everett P, Clish CB, Sukhatme VP.Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2.PLoS ONE. 2010;5(9).
  • Bullock AJ, Zhang L, AM O’Neill, Percy A, Sukhatme V, Mier JW, Atkins MB, Bhatt RS.Plasma angiopoietin-2 (ANG2) as an angiogenic biomarker in renal cell carcinoma (RCC).J Clin Oncology AACR Proceedings 2010.;28(15s).
  • Bhatt RS, Merchan J, Parker R, Wu HK, Zhang L, Seery V, Heymach JV, Atkins MB, McDermott D, Sukhatme VP.A phase 2 pilot trial of low-dose, continuous infusion, or "metronomic" paclitaxel and oral celecoxib in patients with metastatic melanoma.Cancer. 2010 Apr 1;116(7):1751-6.
  • Cao P,Hanai JI,Tanksale P,Imamura S,Sukhatme VP,Lecker SH.Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect.FASEB J. 2009 Sep;23(9):2844-54.
  • Boguski MS, Mandl KD, Sukhatme VP.Drug discovery. Repurposing with a difference.Science. 2009 Jun 12;324(5933):1394-5.
  • Xie H,Valera VA,Merino MJ,Amato AM,Signoretti S,Linehan WM,Sukhatme VP,Seth P.LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer.Mol Cancer Ther. 2009 Mar;8(3):626-35.
  • Chan B,Sukhatme VP.Suppression of Tie-1 in endothelial cells in vitro induces a change in the genome-wide expression profile reflecting an inflammatory function.FEBS Lett. 2009 Mar 18;583(6):1023-8.
  • Wei F,Karihaloo A,Yu Z,Marlier A,Seth P,Shibazaki S,Wang T,Sukhatme VP,Somlo S,Cantley LG.Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo.Kidney Int. 2008 Nov;74(10):1310-8.
  • Chan B,Sukhatme VP.Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro.Thromb Res. 2009 Mar;123(5):745-52.
  • Bhatt RS, Landis DM, Zimmer M, Torregrossa J, Chen S, Sukhatme VP, Iliopoulos O, Balk S, Bubley GJ.Hypoxia-inducible factor-2alpha: effect on radiation sensitivity and differential regulation by an mTOR inhibitor.BJU Int. 2008 Aug;102(3):358-63.
  • Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP.Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules.Biochem Biophys Res Commun. 2008 Jul 4;371(3):475-9.
  • Zeidel M, Bonventre J, Forrest J, Sukhatme V.A national course for renal fellows: the origins of renal physiology.J Am Soc Nephrol. 2008 Apr;19(4):649-50.
  • Gallagher DC,Parikh SM,Balonov K,Miller A,Gautam S,Talmor D,Sukhatme VP.Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndrome.Shock. 2008 Jun;29(6):656-61.
  • Giuliano JS, Lahni PM, Harmon K, Wong HR, Doughty LA, Carcillo JA, Zingarelli B, Sukhatme VP, Parikh SM, Wheeler DS.Admission angiopoietin levels in children with septic shock.Shock. 2007 Dec;28(6):650-654.
  • Hanai J, Cao P, Tanksale P, Imamura S, Koshimizu E, Zhao J, Kishi S, Yamashita M, Phillips PS, Sukhatme VP, Lecker SH.The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity.J Clin Invest. 2007 Dec;117(12):3940-51.
  • Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP.Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo.J Biol Chem. 2007 Aug 17;282(33):23910-8.
  • Hakime A, Hines-Peralta A, Peddi H, Atkins MB, Sukhatme VP, Signoretti S, Regan M, Goldberg SN.Combination of radiofrequency ablation with antiangiogenic therapy for tumor ablation efficacy: study in mice.Radiology. 2007 Aug;244(2):464-70.
  • Yuan HT, Venkatesha S, Chan B, Deutsch U, Mammoto T, Sukhatme VP, Woolf AS, Karumanchi SA.Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival.FASEB J. 2007 Oct;21(12):3171-83.
  • Gallagher DC, Bhatt RS, Parikh SM, Patel P, Seery V, McDermott DF, Atkins MB, Sukhatme VP.Angiopoietin 2 is a potential mediator of high-dose interleukin 2-induced vascular leak.Clin Cancer Res. 2007 Apr 1;13(7):2115-20.
  • Atkins MB, Ernstoff MS, Figlin RA, Flaherty KT, George DJ, Kaelin WG, Kwon ED, Libermann TA, Linehan WM, McDermott DF, Ochoa AC, Pantuck AJ, Rini BI, Rosen MA, Sosman JA, Sukhatme VP, Vieweg JW, Wood CG, King L.Innovations and challenges in renal cell carcinoma: summary statement from the second cambridge conference.Clin Cancer Res. 2007 Jan 15;13(2):667s-70s. Review.
  • Bhatt RS, Seth P, Sukhatme VP.Biomarkers for monitoring antiangiogenic therapy.Clin Cancer Res. 2007 Jan 15;13(2 Pt 2):777s-780s. Review.
  • Mochida Y, Parisuthiman D, Kaku M, Hanai J, Sukhatme VP, Yamauchi M.Nephrocan, a novel member of the small leucine-rich repeat protein family, is an inhibitor of transforming growth factor-beta signaling.J Biol Chem. 2006 Nov 24;281(47):36044-51.
  • Venkatesha S, Hanai J, Seth P, Karumanchi SA, Sukhatme VP.Lipocalin 2 antagonizes the proangiogenic action of ras in transformed cells.Mol Cancer Res. 2006 Nov;4(11):821-9.
  • Hu G, Tang J, Zhang B, Lin Y, Hanai J, Galloway J, Bedell V, Bahary N, Han Z, Ramchandran R, Thisse B, Thisse C, Zon LI, Sukhatme VP.A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro.J Cell Sci. 2006 Oct 1;119(Pt 19):4117-26.
  • Merchan JR, Tang J, Hu G, Lin Y, Mutter W, Tong C, Karumanchi SA, Russell SJ, Sukhatme VP.Protease activity of urokinase and tumor progression in a syngeneic mammary cancer model.J Natl Cancer Inst. 2006 Jun 7;98(11):756-64.
  • Hines-Peralta A, Sukhatme V, Regan M, Signoretti S, Liu ZJ, Goldberg SN.Improved tumor destruction with arsenic trioxide and radiofrequency ablation in three animal models.Radiology. 2006 Jul;240(1):82-9.
  • Tang J, Hu G, Hanai J, Yadlapalli G, Lin Y, Zhang B, Galloway J, Bahary N, Sinha S, Thisse B, Thisse C, Jin JP, Zon LI, Sukhatme VP.A critical role for calponin 2 in vascular development.J Biol Chem. 2006 Mar 10;281(10):6664-72.
  • Seth P, Lin Y, Hanai J, Shivalingappa V, Duyao MP, Sukhatme VP.Magic roundabout, a tumor endothelial marker: expression and signaling.Biochem Biophys Res Commun. 2005 Jul 1;332(2):533-41.
  • Karumanchi SA, Maynard SE, Stillman IE, Epstein FH, Sukhatme VP.Preeclampsia: a renal perspective.Kidney Int. 2005 Jun;67(6):2101-13. Review.
  • Hanai J, Mammoto T, Seth P, Mori K, Karumanchi SA, Barasch J, Sukhatme VP.Lipocalin 2 diminishes invasiveness and metastasis of Ras-transformed cells.J Biol Chem. 2005 Apr 8;280(14):13641-7.
  • Merchan JR, Jayaram DR, Supko JG, He X, Bubley GJ, Sukhatme VP.Increased endothelial uptake of paclitaxel as a potential mechanism for its antiangiogenic effects: potentiation by Cox-2 inhibition.Int J Cancer. 2005 Jan 20;113(3):490-8.
  • Strom TB, Sukhatme VP.A refined understanding of immunosuppressives and cancer risk.Kidney Int. 2003 Mar;63(3):1160-1.
  • Merchan JR, Chan B, Kale S, Schnipper LE, Sukhatme VP.In vitro and in vivo induction of antiangiogenic activity by plasminogen activators and captopril.J Natl Cancer Inst. 2003 Mar 5;95(5):388-99.
  • Lin LF, Zhu G, Yoo JJ, Soker S, Sukhatme VP, Atala A.A system for the enhancement of adenovirus mediated gene transfer to uro-epithelium.J Urol. 2002 Aug;168(2):813-8.
  • Karumanchi SA, Jha V, Ramchandran R, Karihaloo A, Tsiokas L, Chan B, Dhanabal M, Hanai JI, Venkataraman G, Shriver Z, Keiser N, Kalluri R, Zeng H, Mukhopadhyay D, Chen RL, Lander AD, Hagihara K, Yamaguchi Y, Sasisekharan R, Cantley L, Sukhatme VP.Cell surface glypicans are low-affinity endostatin receptors.Mol Cell. 2001 Apr;7(4):811-22.
  • Karumanchi SA, Jiang L, Knebelmann B, Stuart-Tilley AK, Alper SL, Sukhatme VP.VHL tumor suppressor regulates Cl-/HCO3- exchange and Na+/H+ exchange activities in renal carcinoma cells.Physiol Genomics. 2001 Apr 2;5(3):119-28.
  • Hanna NN, Seetharam S, Mauceri HJ, Beckett MA, Jaskowiak NT, Salloum RM, Hari D, Dhanabal M, Ramchandran R, Kalluri R, Sukhatme VP, Kufe DW, Weichselbaum RR.Antitumor interaction of short-course endostatin and ionizing radiation.Cancer J. 2000 Sep-Oct;6(5):287-93.
  • Yokoyama Y, Green JE, Sukhatme VP, Ramakrishnan S.Effect of endostatin on spontaneous tumorigenesis of mammary adenocarcinoma in a transgenic mouse model.Cancer Res. 2000 Aug 15;60(16):4362-5.
  • Hari D, Beckett MA, Sukhatme VP, Dhanabal M, Nodzenski E, Lu H, Mauceri HJ, Kufe DW, Weichselbaum RR.Angiostatin induces mitotic cell death of proliferating endothelial cells.Mol Cell Biol Res Commun. 2000 May;3(5):277-82.
  • Colorado PC, Torre A, Kamphaus G, Maeshima Y, Hopfer H, Takahashi K, Volk R, Zamborsky ED, Herman S, Sarkar PK, Ericksen MB, Dhanabal M, Simons M, Post M, Kufe DW, Weichselbaum RR, Sukhatme VP, Kalluri R.Anti-angiogenic cues from vascular basement membrane collagen.Cancer Res. 2000 May 1;60(9):2520-6.
  • Yokoyama Y, Dhanabal M, Griffioen AW, Sukhatme VP, Ramakrishnan S.Synergy between angiostatin and endostatin: inhibition of ovarian cancer growth.Cancer Res. 2000 Apr 15;60(8):2190-6.
  • McDonald GA, Zhu G, Li Y, Kovesdi I, Wickham TJ, Sukhatme VP.Efficient adenoviral gene transfer to kidney cortical vasculature utilizing a fiber modified vector.J Gene Med. 1999 Mar-Apr;1(2):103-10.
  • Kamphaus GD, Colorado PC, Panka DJ, Hopfer H, Ramchandran R, Torre A, Maeshima Y, Mier JW, Sukhatme VP, Kalluri R.Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth.J Biol Chem. 2000 Jan 14;275(2):1209-15.
  • Cohen HT, Zhou M, Welsh AM, Zarghamee S, Scholz H, Mukhopadhyay D, Kishida T, Zbar B, Knebelmann B, Sukhatme VP.An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association.Biochem Biophys Res Commun. 1999 Dec 9;266(1):43-50.
  • Lu H, Dhanabal M, Volk R, Waterman MJ, Ramchandran R, Knebelmann B, Segal M, Sukhatme VP.Kringle 5 causes cell cycle arrest and apoptosis of endothelial cells.Biochem Biophys Res Commun. 1999 May 19;258(3):668-73.
  • Dhanabal M, Volk R, Ramchandran R, Simons M, Sukhatme VP.Cloning, expression, and in vitro activity of human endostatin.Biochem Biophys Res Commun. 1999 May 10;258(2):345-52.
  • Ananth S, Knebelmann B, Grüning W, Dhanabal M, Walz G, Stillman IE, Sukhatme VP.Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma.Cancer Res. 1999 May 1;59(9):2210-6.
  • Dhanabal M, Ramchandran R, Waterman MJ, Lu H, Knebelmann B, Segal M, Sukhatme VP.Endostatin induces endothelial cell apoptosis.J Biol Chem. 1999 Apr 23;274(17):11721-6.
  • Ramchandran R, Dhanabal M, Volk R, Waterman MJ, Segal M, Lu H, Knebelmann B, Sukhatme VP.Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin.Biochem Biophys Res Commun. 1999 Feb 24;255(3):735-9.
  • Cook J, Krishnan S, Ananth S, Sells SF, Shi Y, Walther MM, Linehan WM, Sukhatme VP, Weinstein MH, Rangnekar VM.Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma.Oncogene. 1999 Feb 4;18(5):1205-8.
  • Dhanabal M, Ramchandran R, Volk R, Stillman IE, Lombardo M, Iruela-Arispe ML, Simons M, Sukhatme VP.Endostatin: yeast production, mutants, and antitumor effect in renal cell carcinoma.Cancer Res. 1999 Jan 1;59(1):189-97.
  • Gorski DH, Mauceri HJ, Salloum RM, Gately S, Hellman S, Beckett MA, Sukhatme VP, Soff GA, Kufe DW, Weichselbaum RR.Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin.Cancer Res. 1998 Dec 15;58(24):5686-9.
  • Mauceri HJ, Hanna NN, Beckett MA, Gorski DH, Staba MJ, Stellato KA, Bigelow K, Heimann R, Gately S, Dhanabal M, Soff GA, Sukhatme VP, Kufe DW, Weichselbaum RR.Combined effects of angiostatin and ionizing radiation in antitumour therapy.Nature. 1998 Jul 16;394(6690):287-91.
  • Knebelmann B, Ananth S, Cohen HT, Sukhatme VP.Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor.Cancer Res. 1998 Jan 15;58(2):226-31.
  • Drummond IA, Goodyer P, Sukhatme VP.Immortal, developmentally arrested human fetal kidney cell lines created by retroviral expression of human papilloma virus E6 and E7.Exp Nephrol. 1997 Sep-Oct;5(5):390-8.
  • Mukhopadhyay D, Knebelmann B, Cohen HT, Ananth S, Sukhatme VP.The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity.Mol Cell Biol. 1997 Sep;17(9):5629-39.
  • Tsiokas L, Kim E, Arnould T, Sukhatme VP, Walz G.Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2.Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6965-70.
  • Cohen HT, Bossone SA, Zhu G, McDonald GA, Sukhatme VP.Sp1 is a critical regulator of the Wilms' tumor-1 gene.J Biol Chem. 1997 Jan 31;272(5):2901-13.
  • Mukhopadhyay D, Tsiokas L, Sukhatme VP.Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression.Cancer Res. 1995 Dec 15;55(24):6161-5.
  • Mukhopadhyay D, Tsiokas L, Zhou XM, Foster D, Brugge JS, Sukhatme VP.Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation.Nature. 1995 Jun 15;375(6532):577-81.