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David S. Pellman, MD


  • Su X, Ohi R, Pellman D.Move in for the kill: motile microtubule regulators.Trends Cell Biol. 2012 Nov;22(11):567-75.
  • Buttery SM, Kono K, Stokasimov E, Pellman D.Regulation of the formin Bnr1 by septins anda MARK/Par1-family septin-associated kinase.Mol Biol Cell. 2012 Oct;23(20):4041-53.
  • Kono K, Saeki Y, Yoshida S, Tanaka K, Pellman D.Proteasomal degradation resolves competition between cell polarization and cellular wound healing.Cell. 2012 Jul 6;150(1):151-64.
  • Carter SL, Cibulskis K, Helman E, McKenna A, Shen H, Zack T, Laird PW, Onofrio RC, Winckler W, Weir BA, Beroukhim R, Pellman D, Levine DA, Lander ES, Meyerson M, Getz G.Absolute quantification of somatic DNA alterations in human cancer.Nat Biotechnol. 2012 May;30(5):413-21.
  • Varetti G, Pellman D."Two" much of a good thing: telomere damage-induced genome doubling drives tumorigenesis.Cancer Cell. 2012 Jun 12;21(6):712-4.
  • Storchová Z, Becker J, Talarek N, Kögelsberger S, Pellman D.Bub1, Sgo1 and Mps1 mediate a distinct pathway for chromosome bi-orientation in budding yeast.Mol Biol Cell. 2011 Mar 9.
  • Meyerson M, Pellman D.Cancer genomes evolve by pulverizing single chromosomes.Cell. 2011 Jan 7;144(1):9-10.
  • Breuer M, Kolano A, Kwon M, Li CC, Tsai TF, Pellman D, Brunet S, Verlhac MH.HURP permits MTOC sorting for robust meiotic spindle bipolarity, similar to extra centrosome clustering in cancer cells.J Cell Biol. 2010 Dec 27;191(7):1251-60.
  • Vinciguerra P, Godinho SA, Parmar K, Pellman D, D'Andrea AD.Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells.J Clin Invest. 2010 Nov 1;120(11):3834-42.
  • Pellman D.David Pellman: Grasping the geometry of cancer. [Interviewed by Caitlin Sedwick].J Cell Biol. 2010 Jul 12;190(1):4-5.
  • Kwiatkowski N, Jelluma N, Filippakopoulos P, Soundararajan M, Manak MS, Kwon M, Choi HG, Sim T, Deveraux QL, Rottmann S, Pellman D, Shah JV, Kops GJ, Knapp S, Gray NS.Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.Nat Chem Biol. 2010 May;6(5):359-68.
  • Tischfield MA, Baris HN, Wu C, Rudolph G, Van Maldergem L, He W, Chan WM, Andrews C, Demer JL, Robertson RL, Mackey DA, Ruddle JB, Bird TD, Gottlob I, Pieh C, Traboulsi EI, Pomeroy SL, Hunter DG, Soul JS, Newlin A, Sabol LJ, Doherty EJ, de Uzcátegui CE, de Uzcátegui N, Collins ML, Sener EC, Wabbels B, Hellebrand H, Meitinger T, de Berardinis T, Magli A, Schiavi C, Pastore-Trossello M, Koc F, Wong AM, Levin AV, Geraghty MT, Descartes M, Flaherty M, Jamieson RV, Møller HU, Meuthen I, Callen DF, Kerwin J, Lindsay S, Meindl A, Gupta ML, Pellman D, Engle EC.Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance.Cell. 2010 Jan 8;140(1):74-87.
  • Rhodes J, Amsterdam A, Sanda T, Moreau LA, McKenna K, Heinrichs S, Ganem NJ, Ho KW, Neuberg DS, Johnston A, Ahn Y, Kutok JL, Hromas R, Wray J, Lee C, Murphy C, Radtke I, Downing JR, Fleming MD, MacConaill LE, Amatruda JF, Gutierrez A, Galinsky I, Stone RM, Ross EA, Pellman DS, Kanki JP, Look AT.Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.Mol Cell Biol. 2009 Nov;29(21):5911-22.
  • Yoshida S, Bartolini S, Pellman D.Mechanisms for concentrating Rho1 during cytokinesis.Genes Dev. 2009 Apr 1;23(7):810-23.
  • Chandhok NS, Pellman D.A little CIN may cost a lot: revisiting aneuploidy and cancer.Curr Opin Genet Dev. 2009 Feb;19(1):74-81. Review.
  • Atkins BD, Yoshida S, Pellman D.Symmetry breaking: scaffold plays matchmaker for polarity signaling proteins.Curr Biol. 2008 Dec 23;18(24):R1130-2.
  • Kwon M, Godinho SA, Chandhok NS, Ganem NJ, Azioune A, Thery M, Pellman D.Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.Genes Dev. 2008 Aug 15;22(16):2189-203.
  • Kwon M, Godinho SA, Chandhok NS, Ganem NJ, Azioune A, Thery M, Pellman D.Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.Genes Dev..
  • Kono K, Nogami S, Abe M, Nishizawa M, Morishita S, Pellman D, Ohya Y.G1/S Cyclin-Dependent Kinase Regulates Small GTPase Rho1p through Phosphorylation of RhoGEF Tus1p in Saccharomyces cerevisiae.Mol Biol Cell. 2008 Apr;19(4):1763-71.
  • Austin KM, Gupta ML, Coats SA, Tulpule A, Mostoslavsky G, Balazs AB, Mulligan RC, Daley G, Pellman D, Shimamura A.Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome.J Clin Invest. 2008 Apr;118(4):1511-8.
  • Yoshida S, Pellman D.Plugging the GAP between cell polarity and cell cycle.EMBO Rep. 2008 Jan;9(1):39-41.
  • Ceol CJ, Pellman D, Zon LI.APC and colon cancer: two hits for one.Nat Med. 2007 Nov;13(11):1286-7.
  • Ganem NJ, Pellman D.Limiting the proliferation of polyploid cells.Cell. 2007 Nov 2;131(3):437-40. Review.
  • Schller U, Zhao Q, Godinho SA, Heine VM, Medema RH, Pellman D, Rowitch DH.Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors.Mol Cell Biol. 2007 Dec;27(23):8259-70.
  • Jallepalli PV, Pellman D.Cell biology. Aneuploidy in the balance.Science. 2007 Aug 17;317(5840):904-5.
  • Buttery SM, Yoshida S, Pellman D.Yeast formins Bni1 and Bnr1 utilize different modes of cortical interaction during the assembly of actin cables.Mol Biol Cell. 2007 May;18(5):1826-38.
  • Pellman D.Cell biology: aneuploidy and cancer.Nature. 2007 Mar 1;446(7131):38-9.
  • Ganem NJ, Storchova Z, Pellman D.Tetraploidy, aneuploidy and cancer.Curr Opin Genet Dev. 2007 Apr;17(2):157-62. Review.
  • Storchov Z, Breneman A, Cande J, Dunn J, Burbank K, O'Toole E, Pellman D.Genome-wide genetic analysis of polyploidy in yeast.Nature. 2006 Oct 5;443(7111):541-7.
  • Gupta ML, Carvalho P, Roof DM, Pellman D.Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle.Nat Cell Biol. 2006 Sep;8(9):913-23.
  • Yoshida S, Kono K, Lowery DM, Bartolini S, Yaffe MB, Ohya Y, Pellman D.Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis.Science. 2006 Jul 7;313(5783):108-11.
  • Yi C, McCarty JH, Troutman SA, Eckman MS, Bronson RT, Kissil JL.Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancer.Mol Cell Biol. 2005 Nov;25(22):10052-9.
  • Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT, Pellman D.Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells.Nature. 2005 Oct 13;437(7061):1043-7.
  • Yoshida S, Guillet M, Pellman D.MEN signaling: daughter bound pole must escape her mother to be fully active.Dev Cell. 2005 Aug;9(2):168-70.
  • Carvalho P, Pellman D.Mitotic spindle: laser microsurgery in yeast cells.Curr Biol. 2004 Sep 21;14(18):R748-50.
  • Andalis AA, Storchova Z, Styles C, Galitski T, Pellman D, Fink GR.Defects arising from whole-genome duplications in Saccharomyces cerevisiae.Genetics. 2004 Jul;167(3):1109-21.
  • Carvalho P, Gupta ML, Hoyt MA, Pellman D.Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation.Dev Cell. 2004 Jun;6(6):815-29.
  • Xu Y, Moseley JB, Sagot I, Poy F, Pellman D, Goode BL, Eck MJ.Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture.Cell. 2004 Mar 5;116(5):711-23.
  • Molk JN, Schuyler SC, Liu JY, Evans JG, Salmon ED, Pellman D, Bloom K.The differential roles of budding yeast Tem1p, Cdc15p, and Bub2p protein dynamics in mitotic exit.Mol Biol Cell. 2004 Apr;15(4):1519-32.
  • Storchova Z, Pellman D.From polyploidy to aneuploidy, genome instability and cancer.Nat Rev Mol Cell Biol. 2004 Jan;5(1):45-54.
  • Moseley JB, Sagot I, Manning AL, Xu Y, Eck MJ, Pellman D, Goode BL.A conserved mechanism for Bni1- and mDia1-induced actin assembly and dual regulation of Bni1 by Bud6 and profilin.Mol Biol Cell. 2004 Feb;15(2):896-907.
  • Carvalho P, Tirnauer JS, Pellman D.Surfing on microtubule ends.Trends Cell Biol. 2003 May;13(5):229-37.
  • Chestukhin A, Pfeffer C, Milligan S, DeCaprio JA, Pellman D.Processing, localization, and requirement of human separase for normal anaphase progression.Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4574-9.
  • Sheeman B, Carvalho P, Sagot I, Geiser J, Kho D, Hoyt MA, Pellman D.Determinants of S. cerevisiae dynein localization and activation: implications for the mechanism of spindle positioning.Curr Biol. 2003 Mar 4;13(5):364-72.
  • Schuyler SC, Liu JY, Pellman D.The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins.J Cell Biol. 2003 Feb 17;160(4):517-28.
  • Leader B, Lim H, Carabatsos MJ, Harrington A, Ecsedy J, Pellman D, Maas R, Leder P.Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes.Nat Cell Biol. 2002 Dec;4(12):921-8.
  • Sagot I, Rodal AA, Moseley J, Goode BL, Pellman D.An actin nucleation mechanism mediated by Bni1 and profilin.Nat Cell Biol. 2002 Aug;4(8):626-31.
  • Schuyler SC, Pellman D.Analysis of the size and shape of protein complexes from yeast.Methods Enzymol. 2002;351:150-68.
  • Lin H, de Carvalho P, Kho D, Tai CY, Pierre P, Fink GR, Pellman D.Polyploids require Bik1 for kinetochore-microtubule attachment.J Cell Biol. 2001 Dec 24;155(7):1173-84.
  • Sagot I, Klee SK, Pellman D.Yeast formins regulate cell polarity by controlling the assembly of actin cables.Nat Cell Biol. 2002 Jan;4(1):42-50.
  • Yarm F, Sagot I, Pellman D.The social life of actin and microtubules: interaction versus cooperation.Curr Opin Microbiol. 2001 Dec;4(6):696-702.
  • Lechler T, Jonsdottir GA, Klee SK, Pellman D, Li R.A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast.J Cell Biol. 2001 Oct 15;155(2):261-70.
  • Pellman D, Christman MF.Separase anxiety: dissolving the sister bond and more.Nat Cell Biol. 2001 Sep;3(9):E207-9.
  • Huang JN, Park I, Ellingson E, Littlepage LE, Pellman D.Activity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p.J Cell Biol. 2001 Jul 9;154(1):85-94.
  • Schuyler SC, Pellman D.Microtubule "plus-end-tracking proteins": The end is just the beginning.Cell. 2001 May 18;105(4):421-4.
  • Pellman D.Cancer. A CINtillating new job for the APC tumor suppressor.Science. 2001 Mar 30;291(5513):2555-6.
  • Jnsson ZO, Dhar SK, Narlikar GJ, Auty R, Wagle N, Pellman D, Pratt RE, Kingston R, Dutta A.Rvb1p and Rvb2p are essential components of a chromatin remodeling complex that regulates transcription of over 5% of yeast genes.J Biol Chem. 2001 May 11;276(19):16279-88.
  • Schuyler SC, Pellman D.Search, capture and signal: games microtubules and centrosomes play.J Cell Sci. 2001 Jan;114(Pt 2):247-55.
  • Lee L, Tirnauer JS, Li J, Schuyler SC, Liu JY, Pellman D.Positioning of the mitotic spindle by a cortical-microtubule capture mechanism.Science. 2000 Mar 24;287(5461):2260-2.
  • Tirnauer JS, O'Toole E, Berrueta L, Bierer BE, Pellman D.Yeast Bim1p promotes the G1-specific dynamics of microtubules.J Cell Biol. 1999 May 31;145(5):993-1007.
  • Berrueta L, Tirnauer JS, Schuyler SC, Pellman D, Bierer BE.The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain.Curr Biol. 1999 Apr 22;9(8):425-8.
  • Lee L, Klee SK, Evangelista M, Boone C, Pellman D.Control of mitotic spindle position by the Saccharomyces cerevisiae formin Bni1p.J Cell Biol. 1999 Mar 8;144(5):947-61.
  • D'Andrea A, Pellman D.Deubiquitinating enzymes: a new class of biological regulators.Crit Rev Biochem Mol Biol. 1998;33(5):337-52.
  • Berrueta L, Kraeft SK, Tirnauer JS, Schuyler SC, Chen LB, Hill DE, Pellman D, Bierer BE.The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules.Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10596-601.
  • DeZwaan TM, Ellingson E, Pellman D, Roof DM.Kinesin-related KIP3 of Saccharomyces cerevisiae is required for a distinct step in nuclear migration.J Cell Biol. 1997 Sep 8;138(5):1023-40.
  • Juang YL, Huang J, Peters JM, McLaughlin ME, Tai CY, Pellman D.APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle.Science. 1997 Feb 28;275(5304):1311-4.
  • Pellman D, Bagget M, Tu YH, Fink GR, Tu H.Two microtubule-associated proteins required for anaphase spindle movement in Saccharomyces cerevisiae.J Cell Biol. 1995 Sep;130(6):1373-85.
  • Loeb JD, Schlenstedt G, Pellman D, Kornitzer D, Silver PA, Fink GR.The yeast nuclear import receptor is required for mitosis.Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7647-51.
  • Pellman D, McLaughlin ME, Fink GR.TATA-dependent and TATA-independent transcription at the HIS4 gene of yeast.Nature. 1990 Nov 1;348(6296):82-5.
  • Stoeckle MY, Sugano S, Hampe A, Vashistha A, Pellman D, Hanafusa H.78-kilodalton glucose-regulated protein is induced in Rous sarcoma virus-transformed cells independently of glucose deprivation.Mol Cell Biol. 1988 Jul;8(7):2675-80.
  • Pellman D, Garber EA, Cross FR, Hanafusa H.An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins.Nature. 1985 Mar 28-Apr 3;314(6009):374-7.
  • Pellman D, Garber EA, Cross FR, Hanafusa H.Fine structural mapping of a critical NH2-terminal region of p60src.Proc Natl Acad Sci U S A. 1985 Mar;82(6):1623-7.
  • Cross FR, Garber EA, Pellman D, Hanafusa H.A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation.Mol Cell Biol. 1984 Sep;4(9):1834-42.