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William C. Aird, MD


  • Dharaneeswaran H, Abid MR, Yuan L, Dupuis D, Beeler DL, Spokes K, Janes L, Sciuto T, Kang PM, Jaminet SC, Dvorak A, Grant MA, Regan E, Aird WC.FoxO1-Mediated Activation of Akt Plays a Critical Role in Vascular Homeostasis.Circ Res. 2014 May 29.
  • Okada Y, Funahashi N, Tanaka T, Nishiyama Y, Yuan L, Shirakura K, Turjman AS, Kano Y, Naruse H, Suzuki A, Sakai M, Zhixia J, Kitajima K, Ishimoto K, Hino N, Kondoh M, Mukai Y, Nakagawa S, García-Cardeña G, Aird WC, Doi T.Endothelial Cell-Specific Expression of Roundabout 4 Is Regulated by Differential DNA Methylation of the Proximal Promoter.Arterioscler Thromb Vasc Biol. 2014 May 22.
  • Adams WJ, Zhang Y, Cloutier J, Kuchimanchi P, Newton G, Sehrawat S, Aird WC, Mayadas TN, Luscinskas FW, García-Cardeña G.Functional vascular endothelium derived from human induced pluripotent stem cells.Stem Cell Reports. 2013;1(2):105-13.
  • Zhang G, Yang L, Kim GS, Ryan K, Lu S, O'Donnell RK, Spokes K, Shapiro N, Aird WC, Kluk MJ, Yano K, Sanchez T.Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation.Blood. 2013 Jul 18;122(3):443-55.
  • Zaslavsky A, Chou ST, Schadler K, Lieberman A, Pimkin M, Kim YJ, Baek KH, Aird WC, Weiss MJ, Ryeom S.The calcineurin-NFAT pathway negatively regulates megakaryopoiesis.Blood. 2013 Apr 18;121(16):3205-15.
  • Yoshikawa M, Mukai Y, Okada Y, Tsumori Y, Tsunoda S, Tsutsumi Y, Aird WC, Yoshioka Y, Okada N, Doi T, Nakagawa S.Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody.Blood. 2013 Apr 4;121(14):2804-13.
  • Shirodkar AV, St Bernard R, Gavryushova A, Kop A, Knight BJ, Yan MS, Man HS, Sud M, Hebbel RP, Oettgen P, Aird WC, Marsden PA.A mechanistic role for DNA methylation in endothelial cell (EC)-enriched gene expression: relationship with DNA replication timing.Blood. 2013 Feb 28.
  • Tozawa H, Kanki Y, Suehiro JI, Tsutsumi S, Kohro T, Wada Y, Aburatani H, Aird WC, Kodama T, Minami T.Genome-wide approaches reveal functional IL-4 inducible STAT6 binding to the vascular cell adhesion molecule-1 promoter.Mol Cell Biol. 2011 Apr 4.
  • Liu J, Yuan L, Molema G, Regan E, Janes L, Beeler D, Spokes KC, Okada Y, Minami T, Oettgen P, Aird WC.Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletal muscle.Blood. 2011 Jan 6;117(1):342-51.
  • Wada Y, Li D, Merley A, Zukauskas A, Aird WC, Dvorak HF, Shih SC.A multi-gene transcriptional profiling approach to the discovery of cell signature markers.Cytotechnology. 2010 Oct 23.
  • Damrauer SM, Fisher MD, Wada H, Siracuse JJ, da Silva CG, Moon K, Csizmadia E, Maccariello ER, Patel VI, Studer P, Essayagh S, Aird WC, Daniel S, Ferran C.A20 inhibits post-angioplasty restenosis by blocking macrophage trafficking and decreasing adventitial neovascularization.Atherosclerosis. 2010 Aug;211(2):404-8.
  • Nassiri M, Liu J, Kulak S, Uwiera RR, Aird WC, Ballermann BJ, Jahroudi N.Repressors NFI and NFY participate in organ-specific regulation of von Willebrand factor promoter activity in transgenic mice.Arterioscler Thromb Vasc Biol. 2010 Jul;30(7):1423-9.
  • Aird WC, Kwaan HC.Under-recognized significance of endothelial heterogeneity: hemostasis, thrombosis, and beyond.Semin Thromb Hemost. 2010 Apr;36(3):225-6.
  • Aird WC.Proximate and evolutionary causation of endothelial heterogeneity.Semin Thromb Hemost. 2010 Apr;36(3):276-85. Review.
  • Suehiro JI, Hamakubo T, Kodama T, Aird WC, Minami T.Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3.Blood. 2010 Mar 25;115(12):2520-32.
  • Jin E, Liu J, Suehiro J, Yuan L, Okada Y, Nikolova-Krstevski V, Yano K, Janes L, Beeler D, Spokes KC, Li D, Regan E, Shih SC, Oettgen P, Minami T, Aird WC.Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo.Blood. 2009 Dec 24;114(27):5557-66.
  • Song H, Suehiro J, Kanki Y, Kawai Y, Inoue K, Daida H, Yano K, Ohhashi T, Oettgen P, Aird WC, Kodama T, Minami T.Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells.J Biol Chem. 2009 Oct 16;284(42):29109-24.
  • Minami T, Yano K, Miura M, Kobayashi M, Suehiro J, Reid PC, Hamakubo T, Ryeom S, Aird WC, Kodama T.The Down syndrome critical region gene 1 short variant promoters direct vascular bed-specific gene expression during inflammation in mice.J Clin Invest. 2009 Aug;119(8):2257-70.
  • Baek KH,Zaslavsky A,Lynch RC,Britt C,Okada Y,Siarey RJ,Lensch MW,Park IH,Yoon SS,Minami T,Korenberg JR,Folkman J,Daley GQ,Aird WC,Galdzicki Z,Ryeom S.Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1.Nature. 2009 Jun 25;459(7250):1126-30.
  • Seguin C, Abid MR, Spokes KC, Schoots IG, Brkovic A, Sirois MG, Aird WC.Priming effect of homocysteine on inducible vascular cell adhesion molecule-1 expression in endothelial cells.Biomed Pharmacother.;62(6):395-400.
  • Aird WC.Endothelium in health and disease.Pharmacol Rep. 2008 Jan-Feb;60(1):139-43. Review.
  • Lee CW, Lin CC, Luo SF, Lee HC, Lee IT, Aird WC, Hwang TL, Yang CM.Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells.Mol Pharmacol. 2008 May;73(5):1454-64.
  • Abid MR, Spokes KC, Shih SC, Aird WC.NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways.J Biol Chem. 2007 Nov 30;282(48):35373-85.
  • Hawkins BJ, Solt LA, Chowdhury I, Kazi AS, Abid MR, Aird WC, May MJ, Foskett JK, Madesh M.G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence.Mol Cell Biol. 2007 Nov;27(21):7582-93.
  • Shapiro NI, Yano K, Okada H, Fischer C, Howell M, Spokes KC, Ngo L, Angus DC, Aird WC.A PROSPECTIVE, OBSERVATIONAL STUDY OF SOLUBLE FLT-1 AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN SEPSIS.Shock. 2007 Aug 16;Publish Ahead of Print.
  • Hwa C, Aird WC.The history of the capillary wall: doctors, discoveries, and debates.Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2667-79.
  • Aird WC.Vascular bed-specific thrombosis.J Thromb Haemost. 2007 Jul;5 Suppl 1:283-91. Review.
  • Feng J, Yano K, Monahan-Earley R, Morgan ES, Dvorak AM, Sellke FW, Aird WC.Vascular bed-specific endothelium-dependent vasomomotor relaxation in the hagfish, Myxine glutinosa.Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R894-900.
  • Okada Y, Yano K, Jin E, Funahashi N, Kitayama M, Doi T, Spokes K, Beeler DL, Shih SC, Okada H, Danilov TA, Maynard E, Minami T, Oettgen P, Aird WC.A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium.Circ Res. 2007 Jun 22;100(12):1712-22.
  • Sternberg DW, Aird W, Neuberg D, Thompson L, MacNeill K, Amrein P, Shulman LN.Treatment of patients with recurrent and primary refractory acute myelogenous leukemia using mitoxantrone and intermediate-dose cytarabine: a pharmacologically based regimen.Cancer. 2000 May 1;88(9):2037-41.