• Home
  • News
  • Calendar
  • About DF/HCC
  • Membership
  • Visitor Center

Alexander S. Guimaraes, MD, PhD


  • Kessler LG, Barnhart HX, Buckler AJ, Choudhury KR, Kondratovich MV, Toledano A, Guimaraes AR, Filice R, Zhang Z, Sullivan DC, .The emerging science of quantitative imaging biomarkers terminology and definitions for scientific studies and regulatory submissions.Statistical Methods in Medical Research. 2014 Jun 11.
  • Huang EP, Wang XF, Roy Choudhury K, McShane LM, Gönen M, Ye J, Buckler AJ, Kinahan PE, Reeves AP, Jackson EF, Guimaraes AR, Zahlmann G, .Meta-analysis of the technical performance of an imaging procedure: Guidelines and statistical methodology.Statistical Methods in Medical Research. 2014 May 28.
  • Agrawal MD, Pinho DF, Kulkarni NM, Hahn PF, Guimaraes AR, Sahani DV.Oncologic applications of dual-energy CT in the abdomen.Radiographics.;34(3):589-612.
  • Catalano OA, Rosen BR, Sahani DV, Hahn PF, Guimaraes AR, Vangel MG, Nicolai E, Soricelli A, Salvatore M.Clinical impact of PET/MR imaging in patients with cancer undergoing same-day PET/CT: initial experience in 134 patients--a hypothesis-generating exploratory study.Radiology. 2013 Dec;269(3):857-69.
  • Faris JE, Blaszkowsky LS, McDermott S, Guimaraes AR, Szymonifka J, Huynh MA, Ferrone CR, Wargo JA, Allen JN, Dias LE, Kwak EL, Lillemoe KD, Thayer SP, Murphy JE, Zhu AX, Sahani DV, Wo JY, Clark JW, Fernandez-Del Castillo C, Ryan DP, Hong TS.FOLFIRINOX in Locally Advanced Pancreatic Cancer: The Massachusetts General Hospital Cancer Center Experience.Oncologist. 2013 May 8.
  • Yuan Y, Andronesi OC, Bortfeld TR, Richter C, Wolf R, Guimaraes AR, Hong TS, Seco J.Feasibility study of in vivo MRI based dosimetric verification of proton end-of-range for liver cancer patients.Radiother Oncol. 2013 Mar;106(3):378-82.
  • Simmons LH, Guimaraes AR, Zukerberg LR.Case records of the Massachusetts General Hospital. Case 6-2013. A 54-year-old man with recurrent diarrhea.N Engl J Med. 2013 Feb 21;368(8):757-65.
  • Steele DJ, Kasmar AG, Guimaraes AR, Dekker JP.Case records of the Massachusetts General Hospital. Case 3-2013. A 72-year-old woman with abdominal pain and distention after peritoneal dialysis.N Engl J Med. 2013 Jan 24;368(4):375-85.
  • Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R.The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.Cell. 2012 Dec 7;151(6):1185-99.
  • Sahani DV, Bonaffini PA, Catalano OA, Guimaraes AR, Blake MA.State-of-the-art PET/CT of the pancreas: current role and emerging indications.Radiographics.;32(4):1133-58; discussion 1158-60.
  • Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Alemán JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR.The Phosphoinositide 3-Kinase Regulatory Subunit p85{alpha} Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling.Cancer Res. 2010 Jul 1;70(13):5305-15.
  • Guimaraes AR, Ross R, Figuereido JL, Waterman P, Weissleder R.MRI with Magnetic Nanoparticles Monitors Downstream Anti-Angiogenic Effects of mTOR Inhibition.Mol Imaging Biol. 2010 Jun 18.
  • Vallet S, Mukherjee S, Vaghela N, Hideshima T, Fulciniti M, Pozzi S, Santo L, Cirstea D, Patel K, Sohani AR, Guimaraes A, Xie W, Chauhan D, Schoonmaker JA, Attar E, Churchill M, Weller E, Munshi N, Seehra JS, Weissleder R, Anderson KC, Scadden DT, Raje N.Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5124-9.
  • Kirsch DG, Grimm J, Guimaraes AR, Wojtkiewicz GR, Perez BA, Santiago PM, Anthony NK, Forbes T, Doppke K, Weissleder R, Jacks T.Imaging primary lung cancers in mice to study radiation biology.Int J Radiat Oncol Biol Phys. 2010 Mar 15;76(4):973-7.
  • Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R.The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.Cell. 2010 Jan 22;140(2):280-93.
  • Baden LR, Digumarthy SR, Guimaraes AS, Branda JA.Case records of the Massachusetts General Hospital. Case 35-2009. A 60-year-old male renal-transplant recipient with renal insufficiency, diabetic ketoacidosis, and mental-status changes.N Engl J Med. 2009 Nov 12;361(20):1980-9.
  • Alam HB, Fricchione GL, Guimaraes AS, Zukerberg LR.Case records of the Massachusetts General Hospital. Case 31-2009. A 26-year-old man with abdominal distention and shock.N Engl J Med. 2009 Oct 8;361(15):1487-96.
  • Boland GW,Guimaraes AS,Mueller PR.The evolving radiology landscape: the importance of effective leadership.Eur Radiol. 2009 Oct;19(10):2321-5.
  • Ross RW, Zietman AL, Xie W, Coen JJ, Dahl DM, Shipley WU, Kaufman DS, Islam T, Guimaraes AR, Weissleder R, Harisinghani M.Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy.Clin Imaging.;33(4):301-5.
  • Jeong JH,Wang Z,Guimaraes AS,Ouyang X,Figueiredo JL,Ding Z,Jiang S,Guney I,Kang GH,Shin E,Hahn WC,Loda MF,Abate-Shen C,Weissleder R,Chin L.BRAF activation initiates but does not maintain invasive prostate adenocarcinoma.PLoS ONE. 2008;3(12):e3949.
  • Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, Lightbown A, Simendinger J, Li T, Padera RF, Garca-Echeverra C, Weissleder R, Mahmood U, Cantley LC, Wong KK.Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.Nat Med. 2008 Dec;14(12):1351-6.
  • Guimaraes AR,Rakhlin E,Weissleder R,Thayer SP.Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model.Pancreas. 2008 Nov;37(4):440-4.
  • Boland GW,Guimaraes AS,Mueller PR.The radiologist's conundrum: benefits and costs of increasing CT capacity and utilization.Eur Radiol. 2009 Jan;19(1):9-11; discussion 12.
  • Boland GW, Guimaraes AS, Mueller PR.Radiology report turnaround: expectations and solutions.Eur Radiol. 2008 Jul;18(7):1326-8.
  • Martins AH, Alves JM, Trujillo CA, Schwindt TT, Barnabe GF, Motta FL, Guimaraes AO, Casarini DE, Mello LE, Pesquero JB, Ulrich H.Kinin-B2 receptor expression and activity during differentiation of embryonic rat neurospheres.Cytometry A. 2008 Apr;73(4):361-8.
  • Guimaraes AR, Tabatabei S, Dahl D, McDougal WS, Weissleder R, Harisinghani MG.Pilot study evaluating use of lymphotrophic nanoparticle-enhanced magnetic resonance imaging for assessing lymph nodes in renal cell cancer.Urology. 2008 Apr;71(4):708-12.
  • Costa Raiol LC, Figueira Silva EC, Mendes da Fonseca D, Leal MF, Guimaraes AC, Calcagno DQ, Khayat AS, Assumpcao PP, de Arruda Cardoso Smith M, Burbano RR.Interrelationship between MYC gene numerical aberrations and protein expression in individuals from northern Brazil with early gastric adenocarcinoma.Cancer Genet Cytogenet. 2008 Feb;181(1):31-5.
  • Gomes CC, Drummond SN, Guimaraes AL, Andrade CI, Mesquita RA, Gomez RS.P21/ WAF1 and cyclin D1 variants and oral squamous cell carcinoma.J Oral Pathol Med. 2008 Mar;37(3):151-6.
  • Harisinghani M, Ross RW, Guimaraes AR, Weissleder R.Utility of a new bolus-injectable nanoparticle for clinical cancer staging.Neoplasia. 2007 Dec;9(12):1160-5.
  • Guimaraes AR, Wain JC, Mark EJ, Wittram C.Mucinous cystadenoma of the lung.AJR Am J Roentgenol. 2004 Aug;183(2):282.
  • Guimaraes AR, Baker JR, Jenkins BG, Lee PL, Weisskoff RM, Rosen BR, Gonzlez RG.Echoplanar chemical shift imaging.Magn Reson Med. 1999 May;41(5):877-82.
  • Guimaraes AR, Melcher JR, Talavage TM, Baker JR, Ledden P, Rosen BR, Kiang NY, Fullerton BC, Weisskoff RM.Imaging subcortical auditory activity in humans.Hum Brain Mapp. 1998;6(1):33-41.
  • Tracey I, Hamberg LM, Guimaraes AR, Hunter G, Chang I, Navia BA, Gonzlez RG.Increased cerebral blood volume in HIV-positive patients detected by functional MRI.Neurology. 1998 Jun;50(6):1821-6.
  • Stern CE, Corkin S, Gonzlez RG, Guimaraes AR, Baker JR, Jennings PJ, Carr CA, Sugiura RM, Vedantham V, Rosen BR.The hippocampal formation participates in novel picture encoding: evidence from functional magnetic resonance imaging.Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8660-5.
  • Tracey I, Carr CA, Guimaraes AR, Worth JL, Navia BA, Gonzlez RG.Brain choline-containing compounds are elevated in HIV-positive patients before the onset of AIDS dementia complex: A proton magnetic resonance spectroscopic study.Neurology. 1996 Mar;46(3):783-8.