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Lee Josephson, PhD


  • Chen HH, Yuan H, Cho H, Sosnovik DE, Josephson L.
    Cytoprotective nanoparticles by conjugation of a polyhis tagged annexin V to a nanoparticle drug.
    Nanoscale. 2015 Feb 14;7(6):2255-9.
  • Habibollahi P, Waldron T, Heidari P, Sung Cho H, Alcantara D, Josephson L, Wang TC, Rustgi AK, Mahmood U.
    Fluorescent nanoparticle imaging allows noninvasive evaluation of immune cell modulation in esophageal dysplasia.
    Molecular Imaging. 2014 May 1;13(3):1-11.
  • Guo Y, Yuan H, Claudio NM, Kura S, Shakerdge N, Mempel TR, Bacskai BJ, Josephson L.
    PEG-Like Nanoprobes: Multimodal, Pharmacokinetically and Optically Tunable Nanomaterials.
    PLoS ONE. 2014;9(4):e95406.
  • Guo Y, Yuan H, Cho H, Kuruppu D, Jokivarsi K, Agarwal A, Shah K, Josephson L.
    High efficiency diffusion molecular retention tumor targeting.
    PLoS ONE. 2013;8(3):e58290.
  • Buckle T, Kuil J, van den Berg NS, Bunschoten A, Lamb HJ, Yuan H, Josephson L, Jonkers J, Borowsky AD, van Leeuwen FW.
    Use of a single hybrid imaging agent for integration of target validation with in vivo and ex vivo imaging of mouse tumor lesions resembling human DCIS.
    PLoS ONE. 2013;8(1):e48324.
  • Blois J, Smith A, Josephson L.
    The slow cell death response when screening chemotherapeutic agents.
    Cancer Chemother Pharmacol. 2010 Dec 31.
  • Sheth RA, Josephson L, Mahmood U.
    Evaluation and clinically relevant applications of a fluorescent imaging analog to fluorodeoxyglucose positron emission tomography.
    J Biomed Opt.;14(6):064014.
  • Garanger E, Blois J, Hilderbrand SA, Shao F, Josephson L.
    Divergent oriented synthesis for the design of reagents for protein conjugation.
    J Comb Chem.;12(1):57-64.
  • Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A.
    Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure.
    Circ Cardiovasc Imaging. 2009 Nov;2(6):468-75.
  • Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL, Dai G, Reynolds F, Rosenzweig A, Weissleder R, Josephson L.
    Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia.
    Circ Cardiovasc Imaging. 2009 Nov;2(6):460-7.
  • Smith RA, Yuan H, Weissleder R, Cantley LC, Josephson L.
    A wortmannin-cetuximab as a double drug.
    Bioconjug Chem. 2009 Nov;20(11):2185-9.
  • Stangenberg L, Ellson C, Cortez-Retamozo V, Ortiz-Lopez A, Yuan H, Blois J, Smith RA, Yaffe MB, Weissleder R, Benoist C, Mathis D, Josephson L, Mahmood U.
    Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function.
    Arthritis Rheum. 2009 Aug;60(8):2314-24.
  • Garanger E, Hilderbrand SA, Blois JT, Sosnovik DE, Weissleder R, Josephson L.
    A DNA-binding Gd chelate for the detection of cell death by MRI.
    Chem Commun (Camb). 2009 Aug 7(29):4444-6.
  • Yuan H, Pupo MT, Blois J, Smith A, Weissleder R, Clardy J, Josephson L.
    A stabilized demethoxyviridin derivative inhibits PI3 kinase.
    Bioorg Med Chem Lett. 2009 Aug 1;19(15):4223-7.
  • Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, Josephson L.
    The antiproliferative cytostatic effects of a self-activating viridin prodrug.
    Mol Cancer Ther. 2009 Jun;8(6):1666-75.
  • Koh I,Hong R,Weissleder R,Josephson L.
    Nanoparticle-target interactions parallel antibody-protein interactions.
    Anal Chem. 2009 May 1;81(9):3618-22.
  • Garanger E,Weissleder R,Josephson L.
    A multifunctional single-attachment-point reagent for controlled protein biotinylation.
    Bioconjug Chem. 2009 Jan;20(1):170-3.
  • Cortez-Retamozo V,Swirski FK,Waterman P,Yuan H,Figueiredo JL,Newton AP,Upadhyay R,Vinegoni C,Kohler R,Blois J,Smith A,Nahrendorf M,Josephson L,Weissleder R,Pittet MJ.
    Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation.
    J Clin Invest. 2008 Dec;118(12):4058-66.
  • Cortez-Retamozo V,Swirski FK,Waterman P,Yuan H,Figueiredo JL,Newton AP,Upadhyay R,Vinegoni C,Kohler R,Blois J,Smith A,Nahrendorf M,Josephson L,Weissleder R,Pittet MJ.
    Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation.
    J Clin Invest. 2008 Nov 6.
  • Perez JM,Grimm J,Josephson L,Weissleder R.
    Integrated nanosensors to determine levels and functional activity of human telomerase.
    Neoplasia. 2008 Oct;10(10):1066-72.
  • Gee MS,Upadhyay R,Bergquist H,Alencar H,Reynolds F,Maricevich M,Weissleder R,Josephson L,Mahmood U.
    Human breast cancer tumor models: molecular imaging of drug susceptibility and dosing during HER2/neu-targeted therapy.
    Radiology. 2008 Sep;248(3):925-35.
  • Blois J,Yuan H,Smith A,Pacold ME,Weissleder R,Cantley LC,Josephson L.
    Slow self-activation enhances the potency of viridin prodrugs.
    J Med Chem. 2008 Aug 14;51(15):4699-707.
  • Taktak S, Sosnovik D, Cima MJ, Weissleder R, Josephson L.
    Multiparameter magnetic relaxation switch assays.
    Anal Chem. 2007 Dec 1;79(23):8863-9.
  • Kim GY, Josephson L, Langer R, Cima MJ.
    Magnetic relaxation switch detection of human chorionic gonadotrophin.
    Bioconjug Chem. 2007 Nov-Dec;18(6):2024-8.
  • Gee MS, Upadhyay R, Bergquist H, Weissleder R, Josephson L, Mahmood U.
    Multiparameter noninvasive assessment of treatment susceptibility, drug target inhibition and tumor response guides cancer treatment.
    Int J Cancer. 2007 Dec 1;121(11):2492-500.
  • Weissleder R, Kelly K, Sun EY, Shtatland T, Josephson L.
    Cell-specific targeting of nanoparticles by multivalent attachment of small molecules.
    Nat Biotechnol. 2005 Nov;23(11):1418-23.
  • Schellingerhout D, Josephson L.
    Molecular imaging of cell-based therapies.
    Neuroimaging Clin N Am. 2004 May;14(2):331-42.
  • Schellenberger EA, Weissleder R, Josephson L.
    Optimal modification of annexin V with fluorescent dyes.
    Chembiochem. 2004 Mar 5;5(3):271-4.
  • Kircher MF, Mahmood U, King RS, Weissleder R, Josephson L.
    A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation.
    Cancer Res. 2003 Dec 1;63(23):8122-5.
  • Kircher MF, Allport JR, Graves EE, Love V, Josephson L, Lichtman AH, Weissleder R.
    In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors.
    Cancer Res. 2003 Oct 15;63(20):6838-46.
  • Josephson L, Mahmood U, Wunderbaldinger P, Tang Y, Weissleder R.
    Pan and sentinel lymph node visualization using a near-infrared fluorescent probe.
    Mol Imaging. 2003 Jan;2(1):18-23.