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Frederick W. Alt, PhD

Publications

  • Alt F, Almouzni G.Genome architecture and expression.Curr Opin Genet Dev. 2013 May 1.
    23642835
  • Rass E, Chandramouly G, Zha S, Alt FW, Xie A.Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells.J Biol Chem. 2013 Mar 8;288(10):7086-95.
    23355489
  • Gostissa M, Bianco JM, Malkin DJ, Kutok JL, Rodig SJ, Morse HC, Bassing CH, Alt FW.Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas.Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2934-9.
    23382223
  • Shi W, Bain AL, Schwer B, Al-Ejeh F, Smith C, Wong L, Chai H, Miranda MS, Ho U, Kawaguchi M, Miura Y, Finnie JW, Wall M, Heierhorst J, Wicking C, Spring KJ, Alt FW, Khanna KK.Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2.PLoS Genet. 2013 Feb;9(2):e1003298.
    23408915
  • Oksenych V, Kumar V, Liu X, Guo C, Schwer B, Zha S, Alt FW.Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2234-9.
    23345432
  • Selimyan R, Gerstein RM, Ivanova I, Precht P, Subrahmanyam R, Perlot T, Alt FW, Sen R.Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly.PLoS Biol. 2013 Jan;11(1):e1001475.
    23382652
  • Subrahmanyam R, Du H, Ivanova I, Chakraborty T, Ji Y, Zhang Y, Alt FW, Schatz DG, Sen R.Localized epigenetic changes induced by D(H) recombination restricts recombinase to DJ(H) junctions.Nat Immunol. 2012 Dec;13(12):1205-12.
    23104096
  • Wesemann DR, Portuguese AJ, Magee JM, Gallagher MP, Zhou X, Panchakshari RA, Alt FW.Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells.Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13745-50.
    22869756
  • Gostissa M, Alt FW, Chiarle R.Mechanisms that Promote and Suppress Chromosomal Translocations in Lymphocytes.Annu Rev Immunol. 2011 Apr 23;29:319-50.
    21219174
  • Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW.Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21790-4.
    21098266
  • Guo C, Alt FW, Giallourakis C.PAIRing for distal Igh locus V(D)J recombination.Immunity. 2011 Feb 25;34(2):139-41.
    21349424
  • Green MR, Monti S, Dalla-Favera R, Pasqualucci L, Walsh NC, Schmidt-Supprian M, Kutok JL, Rodig SJ, Neuberg DS, Rajewsky K, Golub TR, Alt FW, Shipp MA, Manis JP.Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program.Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2873-8.
    21282644
  • Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW.The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.Cell. 2011 Feb 4;144(3):353-63.
    21255825
  • Eccleston J, Yan C, Yuan K, Alt FW, Selsing E.Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining.J Immunol. 2011 Feb 15;186(4):2336-43.
    21242524
  • Zha S, Jiang W, Fujiwara Y, Patel H, Goff PH, Brush JW, Dubois RL, Alt FW.Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2028-33.
    21245310
  • Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW.ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks.Nature. 2011 Jan 13;469(7329):250-4.
    21160472
  • Giallourakis CC, Franklin A, Guo C, Cheng HL, Yoon HS, Gallagher M, Perlot T, Andzelm M, Murphy AJ, Macdonald LE, Yancopoulos GD, Alt FW.Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination.Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22207-12.
    21123744
  • Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E.SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.Cell Metab. 2010 Dec 1;12(6):654-61.
    21109197
  • Perlot T, Pawlitzky I, Manis JP, Zarrin AA, Brodeur PH, Alt FW.Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus.PLoS ONE. 2010;5(11):e13992.
    21085586
  • De Ravin SS, Cowen EW, Zarember KA, Whiting-Theobald NL, Kuhns DB, Sandler NG, Douek DC, Pittaluga S, Poliani PL, Lee YN, Notarangelo LD, Wang L, Alt FW, Kang EM, Milner JD, Niemela JE, Fontana-Penn M, Sinal SH, Malech HL.Hypomorphic Rag mutations can cause destructive midline granulomatous disease.Blood. 2010 Aug 26;116(8):1263-71.
    20489056
  • Zhang Y, Gostissa M, Hildebrand DG, Becker MS, Boboila C, Chiarle R, Lewis S, Alt FW.The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers.Adv Immunol. 2010;106:93-133.
    20728025
  • Walter JE, Rucci F, Patrizi L, Recher M, Regenass S, Paganini T, Keszei M, Pessach I, Lang PA, Poliani PL, Giliani S, Al-Herz W, Cowan MJ, Puck JM, Bleesing J, Niehues T, Schuetz C, Malech H, DeRavin SS, Facchetti F, Gennery AR, Andersson E, Kamani NR, Sekiguchi J, Alenezi HM, Chinen J, Dbaibo G, ElGhazali G, Fontana A, Pasic S, Detre C, Terhorst C, Alt FW, Notarangelo LD.Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency.J Exp Med. 2010 Jul 5;207(7):1541-54.
    20547827
  • Zha S, Bassing CH, Sanda T, Brush JW, Patel H, Goff PH, Murphy MM, Tepsuporn S, Gatti RA, Look AT, Alt FW.ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.J Exp Med. 2010 Jul 5;207(7):1369-80.
    20566716
  • Westerberg LS, Meelu P, Baptista M, Eston MA, Adamovich DA, Cotta-de-Almeida V, Seed B, Rosen MK, Vandenberghe P, Thrasher AJ, Klein C, Alt FW, Snapper SB.Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.J Exp Med. 2010 Jun 7;207(6):1145-52.
    20513746
  • Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV, Alt FW, Kahn CR, Verdin E.SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.Nature. 2010 Mar 4;464(7285):121-5.
    20203611
  • Zhang T, Franklin A, Boboila C, McQuay A, Gallagher MP, Manis JP, Khamlichi AA, Alt FW.Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions.Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3040-5.
    20133637
  • Rucci F, Notarangelo LD, Fazeli A, Patrizi L, Hickernell T, Paganini T, Coakley KM, Detre C, Keszei M, Walter JE, Feldman L, Cheng HL, Poliani PL, Wang JH, Balter BB, Recher M, Andersson EM, Zha S, Giliani S, Terhorst C, Alt FW, Yan CT.Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome.Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3024-9.
    20133615
  • Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW.Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70.Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3034-9.
    20133803
  • Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW.Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.J Exp Med. 2010 Feb 15;207(2):417-27.
    20142431
  • Gostissa M, Yan CT, Bianco JM, Cogné M, Pinaud E, Alt FW.Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.Nature. 2009 Dec 10;462(7274):803-7.
    20010689
  • Lee YN, Alt FW, Reyes J, Gleason M, Zarrin AA, Jung D.Differential utilization of T cell receptor TCR alpha/TCR delta locus variable region gene segments is mediated by accessibility.Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17487-92.
    19805067
  • Schwer B, Eckersdorff M, Li Y, Silva JC, Fermin D, Kurtev MV, Giallourakis C, Comb MJ, Alt FW, Lombard DB.Calorie restriction alters mitochondrial protein acetylation.Aging Cell. 2009 Sep;8(5):604-6.
    19594485
  • Zha S, Boboila C, Alt FW.Mre11: roles in DNA repair beyond homologous recombination.Nat Struct Mol Biol. 2009 Aug;16(8):798-800.
    19654615
  • Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW.Mechanisms promoting translocations in editing and switching peripheral B cells.Nature. 2009 Jul 9;460(7252):231-6.
    19587764
  • Callen E,Jankovic M,Wong N,Zha S,Chen HT,Difilippantonio S,Di Virgilio M,Heidkamp G,Alt FW,Nussenzweig A,Nussenzweig M.Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes.Mol Cell. 2009 May 15;34(3):285-97.
    19450527
  • Basu U,Franklin A,Schwer B,Cheng HL,Chaudhuri J,Alt FW.Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation.Biochem Soc Trans. 2009 Jun;37(Pt 3):561-8.
    19442251
  • Carpenter AC,Yang-Iott KS,Chao LH,Nuskey B,Whitlow S,Alt FW,Bassing CH.Assembled DJbeta complexes influence TCRbeta chain selection and peripheral Vbeta repertoire.J Immunol. 2009 May 1;182(9):5586-95.
    19380806
  • Schenten D,Kracker S,Esposito G,Franco S,Klein U,Murphy M,Alt FW,Rajewsky K.Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability.J Exp Med. 2009 Feb 16;206(2):477-90.
    19204108
  • Cheng HL,Vuong BQ,Basu U,Franklin A,Schwer B,Astarita J,Phan RT,Datta A,Manis J,Alt FW,Chaudhuri J.Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice.Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2717-22.
    19196992
  • Gostissa M,Ranganath S,Bianco JM,Alt FW.Chromosomal location targets different MYC family gene members for oncogenic translocations.Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2265-70.
    19174520
  • Van Gool F,Galli M,Gueydan C,Kruys V,Prevot PP,Bedalov A,Mostoslavsky R,Alt FW,De Smedt T,Leo O.Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.Nat Med. 2009 Feb;15(2):206-10.
    19151729
  • Giblin W,Chatterji M,Westfield G,Masud T,Theisen B,Cheng HL,DeVido J,Alt FW,Ferguson DO,Schatz DG,Sekiguchi J.Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.Blood. 2009 Mar 26;113(13):2965-75.
    19126872
  • Perlot T,Alt FW.Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.Adv Immunol. 2008;99:1-32.
    19117530
  • Wang JH,Alt FW,Gostissa M,Datta A,Murphy M,Alimzhanov MB,Coakley KM,Rajewsky K,Manis JP,Yan CT.Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching.J Exp Med. 2008 Dec 22;205(13):3079-90.
    19064702
  • Oberdoerffer P,Michan S,McVay M,Mostoslavsky R,Vann J,Park SK,Hartlerode A,Stegmuller J,Hafner A,Loerch P,Wright SM,Mills KD,Bonni A,Yankner BA,Scully R,Prolla TA,Alt FW,Sinclair DA.SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.Cell. 2008 Nov 28;135(5):907-18.
    19041753
  • Basu U,Franklin A,Alt FW.Post-translational regulation of activation-induced cytidine deaminase.Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):667-73. Review.
    19010772
  • Basu U,Wang Y,Alt FW.Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase.Mol Cell. 2008 Oct 24;32(2):285-91.
    18951095
  • Bassing CH,Whitlow S,Mostoslovasky R,Yang-Iott K,Ranganath S,Alt FW.Vbeta cluster sequences reduce the frequency of primary Vbeta2 and Vbeta14 rearrangements.Eur J Immunol. 2008 Sep;38(9):2564-72.
    18792409
  • Li G,Alt FW,Cheng HL,Brush JW,Goff PH,Murphy MM,Franco S,Zhang Y,Zha S.Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination.Mol Cell. 2008 Sep 5;31(5):631-40.
    18775323
  • Takizawa M,Tolarova H,Li Z,Dubois W,Lim S,Callen E,Franco S,Mosaico M,Feigenbaum L,Alt FW,Nussenzweig A,Potter M,Casellas R.AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development.J Exp Med. 2008 Sep 1;205(9):1949-57.
    18678733
  • Zha S,Sekiguchi J,Brush JW,Bassing CH,Alt FW.Complementary functions of ATM and H2AX in development and suppression of genomic instability.Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9302-6.
    18599436
  • Walkley CR,Qudsi R,Sankaran VG,Perry JA,Gostissa M,Roth SI,Rodda SJ,Snay E,Dunning P,Fahey FH,Alt FW,McMahon AP,Orkin SH.Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease.Genes Dev. 2008 Jun 15;22(12):1662-76.
    18559481
  • Zarrin AA,Goff PH,Senger K,Alt FW.Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching.J Exp Med. 2008 Jul 7;205(7):1567-72.
    18541713
  • Franco S, Murphy MM, Li G, Borjeson T, Boboila C, Alt FW.DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination.J Exp Med. 2008 Mar 17;205(3):557-64.
    18316419
  • Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW, Finkel T.A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3374-9.
    18296641
  • Perlot T, Li G, Alt FW.Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions.Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3843-8.
    18292225
  • Ranganath S, Carpenter AC, Gleason M, Shaw AC, Bassing CH, Alt FW.Productive coupling of accessible Vbeta14 segments and DJbeta complexes determines the frequency of Vbeta14 rearrangement.J Immunol. 2008 Feb 15;180(4):2339-46.
    18250443
  • Lombard DB, Schwer B, Alt FW, Mostoslavsky R.SIRT6 in DNA repair, metabolism and ageing.J Intern Med. 2008 Feb;263(2):128-41.
    18226091
  • Takeyama K, Monti S, Manis JP, Cin PD, Getz G, Beroukhim R, Dutt S, Aster JC, Alt FW, Golub TR, Shipp MA.Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas.Oncogene. 2008 Jan 10;27(3):318-22.
    17637749
  • Zhang Y, Kwon S, Yamaguchi T, Cubizolles F, Rousseaux S, Kneissel M, Cao C, Li N, Cheng HL, Chua K, Lombard D, Mizeracki A, Matthias G, Alt FW, Khochbin S, Matthias P.Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.Mol Cell Biol. 2008 Mar;28(5):1688-701.
    18180281
  • Wuerffel R, Wang L, Grigera F, Manis J, Selsing E, Perlot T, Alt FW, Cogne M, Pinaud E, Kenter AL.S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.Immunity. 2007 Nov;27(5):711-22.
    17980632
  • Alt FW.From gene amplification to V(D)J recombination and back: a personal account of my early years in B cell biology.Eur J Immunol. 2007 Nov;37 Suppl 1:S138-47.
    17972338
  • Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, Dequiedt F, Haendeler J, Mione M, Dejana E, Alt FW, Zeiher AM, Dimmeler S.SIRT1 controls endothelial angiogenic functions during vascular growth.Genes Dev. 2007 Oct 15;21(20):2644-58.
    17938244
  • Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer B.Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.Mol Cell Biol. 2007 Dec;27(24):8807-14.
    17923681
  • Bassing CH, Ranganath S, Murphy M, Savic V, Gleason M, Alt FW.Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations.Blood. 2008 Feb 15;111(4):2163-9.
    17855626
  • Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW.IgH class switching and translocations use a robust non-classical end-joining pathway.Nature. 2007 Sep 27;449(7161):478-82.
    17713479
  • Fraenkel S, Mostoslavsky R, Novobrantseva TI, Pelanda R, Chaudhuri J, Esposito G, Jung S, Alt FW, Rajewsky K, Cedar H, Bergman Y.Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus.Nat Immunol. 2007 Jul;8(7):715-22.
    17546032
  • Wu C, Ranganath S, Gleason M, Woodman BB, Borjeson TM, Alt FW, Bassing CH.Restriction of endogenous T cell antigen receptor beta rearrangements to Vbeta14 through selective recombination signal sequence modifications.Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4002-7.
    17360467
  • Zha S, Alt FW, Cheng HL, Brush JW, Li G.Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4518-23.
    17360556
  • Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P.Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha.EMBO J. 2007 Apr 4;26(7):1913-23.
    17347648
  • Basu U, Chaudhuri J, Phan RT, Datta A, Alt FW.Regulation of activation induced deaminase via phosphorylation.Adv Exp Med Biol. 2007;596:129-37. Review.
    17338181
  • Zarrin AA, Del Vecchio C, Tseng E, Gleason M, Zarin P, Tian M, Alt FW.Antibody class switching mediated by yeast endonuclease-generated DNA breaks.Science. 2007 Jan 19;315(5810):377-81.
    17170253
  • Mostoslavsky G, Fabian AJ, Rooney S, Alt FW, Mulligan RC.Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer.Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16406-11.
    17062750
  • Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L.SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.Cell. 2006 Sep 8;126(5):941-54.
    16959573
  • Franco S, Alt FW, Manis JP.Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations.DNA Repair (Amst). 2006 Sep 8;5(9-10):1030-41. Review.
    16934538
  • Aifantis I, Bassing CH, Garbe AI, Sawai K, Alt FW, von Boehmer H.The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells.J Exp Med. 2006 Jun 12;203(6):1543-50.
    16754716
  • Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli AP, Tepsuporn S, Hall G, Mulligan R, Fox E, Bronson R, De Girolami U, Lee C, Alt FW.XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice.Proc Natl Acad Sci U S A. 2006 May 9;103(19):7378-83.
    16670198
  • Jung D, Giallourakis C, Mostoslavsky R, Alt FW.Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus.Annu Rev Immunol. 2006;24:541-70. Review.
    16551259
  • Morales JC, Franco S, Murphy MM, Bassing CH, Mills KD, Adams MM, Walsh NC, Manis JP, Rassidakis GZ, Alt FW, Carpenter PB.53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3310-5.
    16492765
  • Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW.Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.Cell. 2006 Jan 27;124(2):315-29.
    16439206
  • Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW.H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.Mol Cell. 2006 Jan 20;21(2):201-14.
    16427010
  • O'neil J, Calvo J, McKenna K, Krishnamoorthy V, Aster JC, Bassing CH, Alt FW, Kelliher M, Look AT.Activating Notch1 mutations in mouse models of T-ALL.Blood. 2006 Jan 15;107(2):781-5.
    16166587
  • Schelonka RL, Ivanov II, Jung DH, Ippolito GC, Nitschke L, Zhuang Y, Gartland GL, Pelkonen J, Alt FW, Rajewsky K, Schroeder HW.A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune function.J Immunol. 2005 Nov 15;175(10):6624-32.
    16272317
  • Basu U, Chaudhuri J, Alpert C, Dutt S, Ranganath S, Li G, Schrum JP, Manis JP, Alt FW.The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.Nature. 2005 Nov 24;438(7067):508-11.
    16251902
  • Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW.DNA repair, genome stability, and aging.Cell. 2005 Feb 25;120(4):497-512.
    15734682
  • Dudley DD, Chaudhuri J, Bassing CH, Alt FW.Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences.Adv Immunol. 2005;86:43-112.
    15705419
  • Rooney S, Alt FW, Sekiguchi J, Manis JP.Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development.Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2471-5.
    15699324
  • Zarrin AA, Tian M, Wang J, Borjeson T, Alt FW.Influence of switch region length on immunoglobulin class switch recombination.Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2466-70.
    15684074
  • Kang J, Ferguson D, Song H, Bassing C, Eckersdorff M, Alt FW, Xu Y.Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression.Mol Cell Biol. 2005 Jan;25(2):661-70.
    15632067
  • Nussenzweig MC, Alt FW.Antibody diversity: one enzyme to rule them all.Nat Med. 2004 Dec;10(12):1304-5.
    15580255
  • Mostoslavsky R, Alt FW, Rajewsky K.The lingering enigma of the allelic exclusion mechanism.Cell. 2004 Sep 3;118(5):539-44.
    15339659
  • Chaudhuri J, Khuong C, Alt FW.Replication protein A interacts with AID to promote deamination of somatic hypermutation targets.Nature. 2004 Aug 26;430(7003):992-8.
    15273694
  • Bassing CH, Alt FW.The cellular response to general and programmed DNA double strand breaks.DNA Repair (Amst). 2004 Aug-Sep;3(8-9):781-96.
    15279764
  • Senoo M, Manis JP, Alt FW, McKeon F.p63 and p73 are not required for the development and p53-dependent apoptosis of T cells.Cancer Cell. 2004 Jul;6(1):85-9.
    15261144
  • Rooney S, Chaudhuri J, Alt FW.The role of the non-homologous end-joining pathway in lymphocyte development.Immunol Rev. 2004 Aug;200:115-31.
    15242400
  • Chaudhuri J, Alt FW.Class-switch recombination: interplay of transcription, DNA deamination and DNA repair.Nat Rev Immunol. 2004 Jul;4(7):541-52.
    15229473
  • Mills KD, Ferguson DO, Essers J, Eckersdorff M, Kanaar R, Alt FW.Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability.Genes Dev. 2004 Jun 1;18(11):1283-92.
    15175260
  • Couëdel C, Mills KD, Barchi M, Shen L, Olshen A, Johnson RD, Nussenzweig A, Essers J, Kanaar R, Li GC, Alt FW, Jasin M.Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells.Genes Dev. 2004 Jun 1;18(11):1293-304.
    15175261
  • Giallourakis C, Alt FW, Bassing CH.V(D)J recombinational accessibility-heading in the opposite direction?.Nat Immunol. 2004 Jun;5(6):561-2.
    15164012
  • Mostoslavsky R, Alt FW.Receptor revision in T cells: an open question?.Trends Immunol. 2004 Jun;25(6):276-9.
    15145316
  • Manis JP, Morales JC, Xia Z, Kutok JL, Alt FW, Carpenter PB.53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.Nat Immunol. 2004 May;5(5):481-7.
    15077110
  • Bassing CH, Alt FW.Molecular biology: case of mistaken identity.Nature. 2004 Mar 4;428(6978):29-31.
    14999268
  • Tian M, Jones DA, Smith M, Shinkura R, Alt FW.Deficiency in the nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV irradiation.Mol Cell Biol. 2004 Mar;24(6):2237-42.
    14993263
  • Rooney S, Sekiguchi J, Whitlow S, Eckersdorff M, Manis JP, Lee C, Ferguson DO, Alt FW.Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells.Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2410-5.
    14983023
  • Dedeoglu F, Horwitz B, Chaudhuri J, Alt FW, Geha RS.Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB.Int Immunol. 2004 Mar;16(3):395-404.
    14978013
  • Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME.Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.Science. 2004 Mar 26;303(5666):2011-5.
    14976264
  • Jung D, Alt FW.Unraveling V(D)J recombination; insights into gene regulation.Cell. 2004 Jan 23;116(2):299-311.
    14744439
  • Tian M, Shinkura R, Shinkura N, Alt FW.Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF.Mol Cell Biol. 2004 Feb;24(3):1200-5.
    14729965
  • Bassing CH, Alt FW.H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity.Cell Cycle. 2004 Feb;3(2):149-53.
    14712078
  • Theunissen JW, Kaplan MI, Hunt PA, Williams BR, Ferguson DO, Alt FW, Petrini JH.Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice.Mol Cell. 2003 Dec;12(6):1511-23.
    14690604
  • Pivniouk VI, Snapper SB, Kettner A, Alenius H, Laouini D, Falet H, Hartwig J, Alt FW, Geha RS.Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells.Int Immunol. 2003 Dec;15(12):1431-40.
    14645152
  • Exley MA, Bigley NJ, Cheng O, Shaulov A, Tahir SM, Carter QL, Garcia J, Wang C, Patten K, Stills HF, Alt FW, Snapper SB, Balk SP.Innate immune response to encephalomyocarditis virus infection mediated by CD1d.Immunology. 2003 Dec;110(4):519-26.
    14632651
  • Fujikawa K, Miletic AV, Alt FW, Faccio R, Brown T, Hoog J, Fredericks J, Nishi S, Mildiner S, Moores SL, Brugge J, Rosen FS, Swat W.Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells.J Exp Med. 2003 Nov 17;198(10):1595-608.
    14623913
  • Dudley DD, Sekiguchi J, Zhu C, Sadofsky MJ, Whitlow S, DeVido J, Monroe RJ, Bassing CH, Alt FW.Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.J Exp Med. 2003 Nov 3;198(9):1439-50.
    14581608
  • Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P, Bronson R, Appella E, Alt FW, Chua KF.Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice.Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10794-9.
    12960381
  • Bassing CH, Suh H, Ferguson DO, Chua KF, Manis J, Eckersdorff M, Gleason M, Bronson R, Lee C, Alt FW.Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors.Cell. 2003 Aug 8;114(3):359-70.
    12914700
  • Yan C, Martinez-Quiles N, Eden S, Shibata T, Takeshima F, Shinkura R, Fujiwara Y, Bronson R, Snapper SB, Kirschner MW, Geha R, Rosen FS, Alt FW.WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility.EMBO J. 2003 Jul 15;22(14):3602-12.
    12853475
  • Mills KD, Ferguson DO, Alt FW.The role of DNA breaks in genomic instability and tumorigenesis.Immunol Rev. 2003 Aug;194:77-95.
    12846809
  • Manis JP, Alt FW.Novel antibody switching defects in human patients.J Clin Invest. 2003 Jul;112(1):19-22.
    12840053
  • Mostoslavsky R, Alt FW, Bassing CH.Chromatin dynamics and locus accessibility in the immune system.Nat Immunol. 2003 Jul;4(7):603-6.
    12830134
  • Ferguson DO, Sekiguchi JM, Frank KM, Gao Y, Sharpless NE, Gu Y, Manis J, DePinho RA, Alt FW.The interplay between nonhomologous end-joining and cell cycle checkpoint factors in development, genomic stability, and tumorigenesis.Cold Spring Harb Symp Quant Biol. 2000;65:395-403.
    12760055
  • Enzler T, Gillessen S, Manis JP, Ferguson D, Fleming J, Alt FW, Mihm M, Dranoff G.Deficiencies of GM-CSF and interferon gamma link inflammation and cancer.J Exp Med. 2003 May 5;197(9):1213-9.
    12732663
  • Chaudhuri J, Tian M, Khuong C, Chua K, Pinaud E, Alt FW.Transcription-targeted DNA deamination by the AID antibody diversification enzyme.Nature. 2003 Apr 17;422(6933):726-30.
    12692563
  • Shinkura R, Tian M, Smith M, Chua K, Fujiwara Y, Alt FW.The influence of transcriptional orientation on endogenous switch region function.Nat Immunol. 2003 May;4(5):435-41.
    12679811
  • Rooney S, Alt FW, Lombard D, Whitlow S, Eckersdorff M, Fleming J, Fugmann S, Ferguson DO, Schatz DG, Sekiguchi J.Defective DNA repair and increased genomic instability in Artemis-deficient murine cells.J Exp Med. 2003 Mar 3;197(5):553-65.
    12615897
  • Bassing CH, Tillman RE, Woodman BB, Canty D, Monroe RJ, Sleckman BP, Alt FW.T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes.Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2598-603.
    12604775
  • Swat W, Xavier R, Mizoguchi A, Mizoguchi E, Fredericks J, Fujikawa K, Bhan AK, Alt FW.Essential role for Vav1 in activation, but not development, of gammadelta T cells.Int Immunol. 2003 Feb;15(2):215-21.
    12578851
  • Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA.Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.Nature. 2003 Feb 6;421(6923):643-8.
    12540856
  • Zinkel SS, Ong CC, Ferguson DO, Iwasaki H, Akashi K, Bronson RT, Kutok JL, Alt FW, Korsmeyer SJ.Proapoptotic BID is required for myeloid homeostasis and tumor suppression.Genes Dev. 2003 Jan 15;17(2):229-39.
    12533511
  • Akamatsu Y, Monroe R, Dudley DD, Elkin SK, Gartner F, Talukder SR, Takahama Y, Alt FW, Bassing CH, Oettinger MA.Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice.Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1209-14.
    12531919
  • Wu C, Bassing CH, Jung D, Woodman BB, Foy D, Alt FW.Dramatically increased rearrangement and peripheral representation of Vbeta14 driven by the 3'Dbeta1 recombination signal sequence.Immunity. 2003 Jan;18(1):75-85.
    12530977
  • Manis JP, Michaelson JS, Birshtein BK, Alt FW.Elucidation of a downstream boundary of the 3' IgH regulatory region.Mol Immunol. 2003 Jan;39(12):753-60.
    12531286
  • Jung D, Bassing CH, Fugmann SD, Cheng HL, Schatz DG, Alt FW.Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells.Immunity. 2003 Jan;18(1):65-74.
    12530976
  • Rooney S, Sekiguchi J, Zhu C, Cheng HL, Manis J, Whitlow S, DeVido J, Foy D, Chaudhuri J, Lombard D, Alt FW.Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice.Mol Cell. 2002 Dec;10(6):1379-90.
    12504013
  • Gervers M, Nolte I, Alt F, Hauschild G, Meyer-Lindenberg A, Fehr M.[Complications after implantation of a modular total hip prostheses compared with fixed head prostheses].Berl Munch Tierarztl Wochenschr. 2002 Nov-Dec;115(11-12):412-9.
    12481646
  • Zimmermann S, Alt F, Messerschmidt J, von Bohlen A, Taraschewski H, Sures B.Biological availability of traffic-related platinum-group elements (palladium, platinum, and rhodium) and other metals to the zebra mussel (Dreissena polymorpha) in water containing road dust.Environ Toxicol Chem. 2002 Dec;21(12):2713-8.
    12463569
  • Klein C, Nguyen D, Liu CH, Mizoguchi A, Bhan AK, Miki H, Takenawa T, Rosen FS, Alt FW, Mulligan RC, Snapper SB.Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice.Blood. 2003 Mar 15;101(6):2159-66.
    12433691
  • Yang XF, Ye Q, Press B, Han RZ, Bassing CH, Sleckman BP, Alt FW, Cantor H.Analysis of the complex genomic structure of Bcl-x and its relationship to Bcl-x(gamma) expression after CD28-dependent costimulation.Mol Immunol. 2002 Sep;39(1-2):45-55.
    12213327
  • Merget R, Kulzer R, Kniffka A, Alt F, Breitstadt R, Bruening T.Platinum concentrations in sera of catalyst production workers are not predictive of platinum salt allergy.Int J Hyg Environ Health. 2002 Jul;205(5):347-51.
    12173532
  • Solymar DC, Agarwal S, Bassing CH, Alt FW, Rao A.A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells.Immunity. 2002 Jul;17(1):41-50.
    12150890
  • Dudley DD, Manis JP, Zarrin AA, Kaylor L, Tian M, Alt FW.Internal IgH class switch region deletions are position-independent and enhanced by AID expression.Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9984-9.
    12114543
  • Ye Q, Press B, Kissler S, Yang XF, Lu L, Bassing CH, Sleckman BP, Jansson M, Panoutsakopoulou V, Trimble LA, Alt FW, Cantor H.T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice.J Exp Med. 2002 Jul 1;196(1):87-95.
    12093873
  • Zhu C, Mills KD, Ferguson DO, Lee C, Manis J, Fleming J, Gao Y, Morton CC, Alt FW.Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.Cell. 2002;109:811-821.
  • Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow SR, Fleming JC, Monroe BC, Ciccone DN, Yan C, Vlasakova K, Livingston DM, Ferguson DO, Scully R, Alt FW.Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX.Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8173-8.
    12034884
  • Chua KF, Alt FW, Manis JP.The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks.J Exp Med. 2002 May 6;195(9):F37-41.
    11994429
  • Bassing CH, Swat W, Alt FW.The mechanism and regulation of chromosomal V(D)J recombination.Cell. 2002 Apr;109 Suppl:S45-55.
    11983152
  • Manis JP, Dudley D, Kaylor L, Alt FW.IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells.Immunity. 2002 Apr;16(4):607-17.
    11970883
  • Inlay M, Alt FW, Baltimore D, Xu Y.Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation.Nat Immunol. 2002 May;3(5):463-8.
    11967540
  • Fujikawa K, Inoue Y, Sakai M, Koyama Y, Nishi S, Funada R, Alt FW, Swat W.Vav3 is regulated during the cell cycle and effects cell division.Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4313-8.
    11917103
  • Krawczyk C, Oliveira-dos-Santos A, Sasaki T, Griffiths E, Ohashi PS, Snapper S, Alt F, Penninger JM.Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells.Immunity. 2002 Mar;16(3):331-43.
    11911819
  • Shibata T, Takeshima F, Chen F, Alt FW, Snapper SB.Cdc42 facilitates invasion but not the actin-based motility of Shigella.Curr Biol. 2002 Feb 19;12(4):341-5.
    11864577
  • Manis JP, Tian M, Alt FW.Mechanism and control of class-switch recombination.Trends Immunol. 2002 Jan;23(1):31-9.
    11801452
  • Sekiguchi JA, Whitlow S, Alt FW.Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs.Mol Cell. 2001 Dec;8(6):1383-90.
    11779512
  • Sharpless NE, Ferguson DO, O'Hagan RC, Castrillon DH, Lee C, Farazi PA, Alson S, Fleming J, Morton CC, Frank K, Chin L, Alt FW, DePinho RA.Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions.Mol Cell. 2001 Dec;8(6):1187-96.
    11779495
  • Malynn BA, Shaw AC, Young F, Stewart V, Alt FW.Truncated immunoglobulin Dmu causes incomplete developmental progression of RAG-deficient pro-B cells.Mol Immunol. 2002 Jan;38(7):547-56.
    11750656
  • Tsitsikov EN, Laouini D, Dunn IF, Sannikova TY, Davidson L, Alt FW, Geha RS.TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice.Immunity. 2001 Oct;15(4):647-57.
    11672546
  • Ferguson DO, Alt FW.DNA double strand break repair and chromosomal translocation: lessons from animal models.Oncogene. 2001 Sep 10;20(40):5572-9.
    11607810
  • Snapper SB, Takeshima F, Antón I, Liu CH, Thomas SM, Nguyen D, Dudley D, Fraser H, Purich D, Lopez-Ilasaca M, Klein C, Davidson L, Bronson R, Mulligan RC, Southwick F, Geha R, Goldberg MB, Rosen FS, Hartwig JH, Alt FW.N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.Nat Cell Biol. 2001 Oct;3(10):897-904.
    11584271
  • Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH.Plasma cell differentiation requires the transcription factor XBP-1.Nature. 2001 Jul 19;412(6844):300-7.
    11460154
  • Sekiguchi J, Ferguson DO, Chen HT, Yang EM, Earle J, Frank K, Whitlow S, Gu Y, Xu Y, Nussenzweig A, Alt FW.Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development.Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3243-8.
    11248063
  • de Alboran IM, O'Hagan RC, Gärtner F, Malynn B, Davidson L, Rickert R, Rajewsky K, DePinho RA, Alt FW.Analysis of C-MYC function in normal cells via conditional gene-targeted mutation.Immunity. 2001 Jan;14(1):45-55.
    11163229
  • Gärtner F, Alt FW, Monroe RJ, Seidl KJ.Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice.J Exp Med. 2000 Dec 18;192(12):1745-54.
    11120771
  • Tian M, Alt FW.RNA editing meets DNA shuffling.Nature. 2000 Sep 7;407(6800):31, 33.
    10993058
  • O'Hagan RC, Ohh M, David G, de Alboran IM, Alt FW, Kaelin WG, DePinho RA.Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression.Genes Dev. 2000 Sep 1;14(17):2185-91.
    10970882
  • Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, Zhu C, Artandi SE, Rudolph KL, Gottlieb GJ, Chin L, Alt FW, DePinho RA.Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation.Nat Genet. 2000 Sep;26(1):85-8.
    10973255
  • Moores SL, Selfors LM, Fredericks J, Breit T, Fujikawa K, Alt FW, Brugge JS, Swat W.Vav family proteins couple to diverse cell surface receptors.Mol Cell Biol. 2000 Sep;20(17):6364-73.
    10938113
  • Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C, Manis JP, Horner J, DePinho RA, Alt FW.DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway.Mol Cell. 2000 Jun;5(6):993-1002.
    10911993
  • Chen F, Ma L, Parrini MC, Mao X, Lopez M, Wu C, Marks PW, Davidson L, Kwiatkowski DJ, Kirchhausen T, Orkin SH, Rosen FS, Mayer BJ, Kirschner MW, Alt FW.Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability.Curr Biol. 2000 Jun 29;10(13):758-65.
    10898977
  • Bauch A, Alt FW, Crabtree GR, Snapper SB.The cytoskeleton in lymphocyte signaling.Adv Immunol. 2000;75:89-114.
    10879282
  • Sleckman BP, Bassing CH, Hughes MM, Okada A, D'Auteuil M, Wehrly TD, Woodman BB, Davidson L, Chen J, Alt FW.Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments.Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7975-80.
    10869424
  • Bassing CH, Alt FW, Hughes MM, D'Auteuil M, Wehrly TD, Woodman BB, Gärtner F, White JM, Davidson L, Sleckman BP.Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.Nature. 2000 Jun 1;405(6786):583-6.
    10850719
  • Malynn BA, de Alboran IM, O'Hagan RC, Bronson R, Davidson L, DePinho RA, Alt FW.N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation.Genes Dev. 2000 Jun 1;14(11):1390-9.
    10837031
  • Messerschmidt J, von Bohlen A, Alt F, Klockenkämper R.Separation and enrichment of palladium and gold in biological and environmental samples, adapted to the determination by total reflection X-ray fluorescence.Analyst. 2000 Mar;125(3):397-9.
    10829339
  • Sleckman BP, Khan WN, Xu W, Bassing CH, Malynn BA, Copeland NG, Bardon CG, Breit TM, Davidson L, Oltz EM, Jenkins NA, Berman JE, Alt FW.Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene.Mol Cell Biol. 2000 Jun;20(12):4405-10.
    10825203
  • Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA, Alt FW.The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations.Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6630-3.
    10823907
  • Tian M, Alt FW.Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro.J Biol Chem. 2000 Aug 4;275(31):24163-72.
    10811812
  • Gao Y, Ferguson DO, Xie W, Manis JP, Sekiguchi J, Frank KM, Chaudhuri J, Horner J, DePinho RA, Alt FW.Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development.Nature. 2000 Apr 20;404(6780):897-900.
    10786799
  • Gietema JA, Meinardi MT, Messerschmidt J, Gelevert T, Alt F, Uges DR, Sleijfer DT.Circulating plasma platinum more than 10 years after cisplatin treatment for testicular cancer.Lancet. 2000 Mar 25;355(9209):1075-6.
    10744098
  • Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, Hasty P, Chun J, Alt FW.Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice.Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2668-73.
    10716994
  • Borghesani PR, Alt FW, Bottaro A, Davidson L, Aksoy S, Rathbun GA, Roberts TM, Swat W, Segal RA, Gu Y.Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice.Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3336-41.
    10716718