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Christopher D. Fletcher, FRCPath, MBBS, MD

Publications

  • Wojcik JB, Bellizzi AM, Dal Cin P, Bredella MA, Fletcher CD, Hornicek FJ, Deshpande V, Hornick JL, Nielsen GP.Primary Sclerosing Epithelioid Fibrosarcoma of Bone: Analysis of a Series.Am J Surg Pathol. 2014 Jun 11.
    24921641
  • Mariño-Enríquez A, Fletcher CD.Round cell sarcomas - Biologically important refinements in subclassification.Int J Biochem Cell Biol. 2014 May 5.
    24801613
  • Wang Y, Marino-Enriquez A, Bennett RR, Zhu M, Shen Y, Eilers G, Lee JC, Henze J, Fletcher BS, Gu Z, Fox EA, Antonescu CR, Fletcher CD, Guo X, Raut CP, Demetri GD, van de Rijn M, Ordog T, Kunkel LM, Fletcher JA.Dystrophin is a tumor suppressor in human cancers with myogenic programs.Nat Genet. 2014 Jun;46(6):601-6.
    24793134
  • Sioletic S, Czaplinski J, Hu L, Fletcher JA, Fletcher CD, Wagner AJ, Loda M, Demetri GD, Sicinska ET, Snyder EL.c-Jun promotes cell migration and drives expression of the motility factor ENPP2 in soft tissue sarcomas.J Pathol. 2014 May 22.
    24852265
  • Charli-Joseph Y, Saggini A, Doyle LA, Fletcher CD, Weier J, Mirza S, Vemula S, Leboit PE.DNA copy number changes in tumors within the spectrum of cellular, atypical, and metastasizing fibrous histiocytoma.J Am Acad Dermatol. 2014 Apr 19.
    24755122
  • Specht K, Sung YS, Zhang L, Richter GH, Fletcher CD, Antonescu CR.Distinct transcriptional signature and immunoprofile of CIC-DUX4 fusion-positive round cell tumors compared to EWSR1-rearranged ewing sarcomas: Further evidence toward distinct pathologic entities.Genes Chromosomes Cancer. 2014 Apr 10.
    24723486
  • Le Loarer F, Zhang L, Fletcher CD, Ribeiro A, Singer S, Italiano A, Neuville A, Houlier A, Chibon F, Coindre JM, Antonescu CR.Consistent SMARCB1 homozygous deletions in epithelioid sarcoma and in a subset of myoepithelial carcinomas can be reliably detected by FISH in archival material.Genes Chromosomes Cancer. 2014 Jun;53(6):475-86.
    24585572
  • Vivero M, Doyle LA, Fletcher CD, Mertens F, Hornick JL.GRIA2 is a novel diagnostic marker for solitary fibrous tumour identified through gene expression profiling.Histopathology. 2014 Jan 23.
    24456377
  • Walther C, Tayebwa J, Lilljebjörn H, Magnusson L, Nilsson J, von Steyern FV, Øra I, Domanski HA, Fioretos T, Nord KH, Fletcher CD, Mertens F.A novel SERPINE1-FOSB fusion gene results in transcriptional up-regulation of FOSB in pseudomyogenic haemangioendothelioma.J Pathol. 2014 Apr;232(5):534-40.
    24374978
  • Doyle LA, Vivero M, Fletcher CD, Mertens F, Hornick JL.Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics.Mod Pathol. 2014 Mar;27(3):390-5.
    24030747
  • Fletcher CD, Kahl BS.Central nervous system involvement in diffuse large B-cell lymphoma: an analysis of risks and prevention strategies in the post-rituximab era.Leuk Lymphoma. 2014 Feb 24.
    24286262
  • Hettmer S, Teot LA, Kozakewich H, Werger AM, Davies KJ, Fletcher CD, Grier HE, Rodriguez-Galindo C, Wagers AJ.Myogenic Tumors in Nevoid Basal Cell Carcinoma Syndrome.J. Pediatr. Hematol. Oncol. 2014 Feb 10.
    24517962
  • Schaefer IM, Fletcher CD.Myxoid Variant of So-called Angiomatoid "Malignant Fibrous Histiocytoma": Clinicopathologic Characterization in a Series of 21 Cases.Am J Surg Pathol. 2014 Feb 5.
    24503754
  • Szuhai K, de Jong D, Leung WY, Fletcher CD, Hogendoorn PC.Transactivating mutation of the MYOD1 gene is a frequent event in adult spindle cell rhabdomyosarcoma.J Pathol. 2014 Feb;232(3):300-7.
    24272621
  • Jo VY, Fletcher CD.WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition.Pathology. 2014 Feb;46(2):95-104.
    24378391
  • Fletcher CD.Recently characterized soft tissue tumors that bring biologic insight.Mod Pathol. 2014 Jan;27 Suppl 1:S98-112.
    24384856
  • Doyle LA, Fletcher CD.Peripheral hemangioblastoma: clinicopathologic characterization in a series of 22 cases.Am J Surg Pathol. 2014 Jan;38(1):119-27.
    24145646
  • Antonescu CR, Sung YS, Chen CL, Zhang L, Chen HW, Singer S, Agaram NP, Sboner A, Fletcher CD.Novel ZC3H7B-BCOR, MEAF6-PHF1, and EPC1-PHF1 fusions in ossifying fibromyxoid tumors-molecular characterization shows genetic overlap with endometrial stromal sarcoma.Genes Chromosomes Cancer. 2014 Feb;53(2):183-93.
    24285434
  • Fletcher CD.The evolving classification of soft tissue tumours - an update based on the new 2013 WHO classification.Histopathology. 2014 Jan;64(1):2-11.
    24164390
  • Doyle LA, Fletcher CD.Predicting behavior of solitary fibrous tumor: are we getting closer to more accurate risk assessment?.Ann Surg Oncol. 2013 Dec;20(13):4055-6.
    24048700
  • Doyle LA, Hornick JL, Fletcher CD.PEComa of the gastrointestinal tract: clinicopathologic study of 35 cases with evaluation of prognostic parameters.Am J Surg Pathol. 2013 Dec;37(12):1769-82.
    24061520
  • Jo VY, Reith JD, Coindre JM, Fletcher CD.Paratesticular rhabdomyoma: a morphologically distinct sclerosing variant.Am J Surg Pathol. 2013 Nov;37(11):1737-42.
    23887159
  • Hettmer S, Teot LA, van Hummelen P, MacConaill L, Bronson RT, Dall'Osso C, Mao J, McMahon AP, Gruber PJ, Grier HE, Rodriguez-Galindo C, Fletcher CD, Wagers AJ.Mutations in Hedgehog pathway genes in fetal rhabdomyomas.J Pathol. 2013 Sep;231(1):44-52.
    23780909
  • Chen BJ, Chapuy B, Ouyang J, Sun HH, Roemer MG, Xu ML, Yu H, Fletcher CD, Freeman GJ, Shipp MA, Rodig SJ.PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignancies.Clin Cancer Res. 2013 Jul 1;19(13):3462-73.
    23674495
  • Antonescu CR, Le Loarer F, Mosquera JM, Sboner A, Zhang L, Chen CL, Chen HW, Pathan N, Krausz T, Dickson BC, Weinreb I, Rubin MA, Hameed M, Fletcher CD.Novel YAP1-TFE3 fusion defines a distinct subset of epithelioid hemangioendothelioma.Genes Chromosomes Cancer. 2013 Aug;52(8):775-84.
    23737213
  • Antonescu CR, Zhang L, Shao SY, Mosquera JM, Weinreb I, Katabi N, Fletcher CD.Frequent PLAG1 gene rearrangements in skin and soft tissue myoepithelioma with ductal differentiation.Genes Chromosomes Cancer. 2013 Apr 30.
    23630011
  • Kurek KC, Pansuriya TC, van Ruler MA, van den Akker B, Luks VL, Verbeke SL, Kozakewich HP, Sciot R, Lev D, Lazar AJ, Fletcher CD, Bovée JV.R132C IDH1 Mutations Are Found in Spindle Cell Hemangiomas and Not in Other Vascular Tumors or Malformations.Am J Pathol. 2013 May;182(5):1494-500.
    23485734
  • Jo VY, Antonescu CR, Zhang L, Dal Cin P, Hornick JL, Fletcher CD.Cutaneous syncytial myoepithelioma: clinicopathologic characterization in a series of 38 cases.Am J Surg Pathol. 2013 May;37(5):710-8.
    23588365
  • Al-Zaid T, Wang WL, Lopez-Terrada D, Lev D, Hornick JL, Hafeez Diwan A, Fletcher CD, Lazar AJ.Pleomorphic fibroma and dermal atypical lipomatous tumor: are they related?.J Cutan Pathol. 2013 Apr;40(4):379-84.
    23506010
  • Doyle LA, Fletcher CD.Metastasizing "benign" cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases.Am J Surg Pathol. 2013 Apr;37(4):484-95.
    23426120
  • Antonescu CR, Romeo S, Zhang L, Nafa K, Hornick JL, Nielsen GP, Mino-Kenudson M, Huang HY, Mosquera JM, Dei Tos PA, Fletcher CD.Dedifferentiation in gastrointestinal stromal tumor to an anaplastic KIT-negative phenotype: a diagnostic pitfall: morphologic and molecular characterization of 8 cases occurring either de novo or after imatinib therapy.Am J Surg Pathol. 2013 Mar;37(3):385-92.
    23348204
  • Sioletic S, Dal Cin P, Fletcher CD, Hornick JL.Well-differentiated and dedifferentiated liposarcomas with prominent myxoid stroma: analysis of 56 cases.Histopathology. 2012 Jun 18.
    23020289
  • de Feraudy S, Fletcher CD.Fibroblastic connective tissue nevus: a rare cutaneous lesion analyzed in a series of 25 cases.Am J Surg Pathol. 2012 Oct;36(10):1509-15.
    22892597
  • Doyle LA, Wang WL, Dal Cin P, Lopez-Terrada D, Mertens F, Lazar AJ, Fletcher CD, Hornick JL.MUC4 is a sensitive and extremely useful marker for sclerosing epithelioid fibrosarcoma: association with FUS gene rearrangement.Am J Surg Pathol. 2012 Oct;36(10):1444-51.
    22982887
  • Gebre-Medhin S, Nord KH, Möller E, Mandahl N, Magnusson L, Nilsson J, Jo VY, Vult von Steyern F, Brosjö O, Larsson O, Domanski HA, Sciot R, Debiec-Rychter M, Fletcher CD, Mertens F.Recurrent rearrangement of the PHF1 gene in ossifying fibromyxoid tumors.Am J Pathol. 2012 Sep;181(3):1069-77.
    22796436
  • Volpicelli ER, Fletcher CD.Desmin and CD34 positivity in cellular fibrous histiocytoma: an immunohistochemical analysis of 100 cases.J Cutan Pathol. 2012 Aug;39(8):747-52.
    22775584
  • Evans AG, French CA, Cameron MJ, Fletcher CD, Jackman DM, Lathan CS, Sholl LM.Pathologic characteristics of NUT midline carcinoma arising in the mediastinum.Am J Surg Pathol. 2012 Aug;36(8):1222-7.
    22790861
  • Chen BJ, Mariño-Enríquez A, Fletcher CD, Hornick JL.Loss of retinoblastoma protein expression in spindle cell/pleomorphic lipomas and cytogenetically related tumors: an immunohistochemical study with diagnostic implications.Am J Surg Pathol. 2012 Aug;36(8):1119-28.
    22790852
  • Saab ST, Hornick JL, Fletcher CD, Olson SJ, Coffin CM.IgG4 plasma cells in inflammatory myofibroblastic tumor: inflammatory marker or pathogenic link?.Mod Pathol. 2011 Apr;24(4):606-12.
    21297584
  • Doyle LA, Möller E, Cin PD, Fletcher CD, Mertens F, Hornick JL.MUC4 Is a Highly Sensitive and Specific Marker for Low-grade Fibromyxoid Sarcoma.Am J Surg Pathol. 2011 Mar 15.
    21415703
  • Mills AM, Beck AH, Montgomery KD, Zhu SX, Espinosa I, Lee CH, Subramanian S, Fletcher CD, van de Rijn M, West RB.Expression of subtype-specific group 1 leiomyosarcoma markers in a wide variety of sarcomas by gene expression analysis and immunohistochemistry.Am J Surg Pathol. 2011 Apr;35(4):583-9.
    21412072
  • Kraft S, Fletcher CD.Atypical intradermal smooth muscle neoplasms: clinicopathologic analysis of 84 cases and a reappraisal of cutaneous "leiomyosarcoma".Am J Surg Pathol. 2011 Apr;35(4):599-607.
    21358302
  • Carneiro A, Bendahl PO, Engellau J, Domanski HA, Fletcher CD, Rissler P, Rydholm A, Nilbert M.A prognostic model for soft tissue sarcoma of the extremities and trunk wall based on size, vascular invasion, necrosis, and growth pattern.Cancer. 2011 Mar 15;117(6):1279-87.
    21381015
  • Verbeke SL, Bertoni F, Bacchini P, Sciot R, Fletcher CD, Kroon HM, Hogendoorn PC, Bovée JV.Distinct histological features characterize primary angiosarcoma of bone.Histopathology. 2011 Jan;58(2):254-64.
    21323951
  • Hornick JL, Fletcher CD.Pseudomyogenic hemangioendothelioma: a distinctive, often multicentric tumor with indolent behavior.Am J Surg Pathol. 2011 Feb;35(2):190-201.
    21263239
  • Nese N, Martignoni G, Fletcher CD, Gupta R, Pan CC, Kim H, Ro JY, Hwang IS, Sato K, Bonetti F, Pea M, Amin MB, Hes O, Svec A, Kida M, Vankalakunti M, Berel D, Rogatko A, Gown AM, Amin MB.Pure epithelioid PEComas (so-called epithelioid angiomyolipoma) of the kidney: A clinicopathologic study of 41 cases: detailed assessment of morphology and risk stratification.Am J Surg Pathol. 2011 Feb;35(2):161-76.
    21263237
  • Mariño-Enríquez A, Wang WL, Roy A, Lopez-Terrada D, Lazar AJ, Fletcher CD, Coffin CM, Hornick JL.Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of inflammatory myofibroblastic tumor with nuclear membrane or perinuclear ALK.Am J Surg Pathol. 2011 Jan;35(1):135-44.
    21164297
  • Carneiro A, Bendahl PO, Engellau J, Domanski HA, Fletcher CD, Rissler P, Rydholm A, Nilbert M.A prognostic model for soft tissue sarcoma of the extremities and trunk wall based on size, vascular invasion, necrosis, and growth pattern.Cancer. 2010 Nov 8.
    21061335
  • Yamashita K, Fletcher CD.PEComa Presenting in Bone: Clinicopathologic Analysis of 6 Cases and Literature Review.Am J Surg Pathol. 2010 Nov;34(11):1622-9.
    20975340
  • Antonescu CR, Zhang L, Chang NE, Pawel BR, Travis W, Katabi N, Edelman M, Rosenberg AE, Nielsen GP, Dal Cin P, Fletcher CD.EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene.Genes Chromosomes Cancer. 2010 Dec;49(12):1114-24.
    20815032
  • Dewaele B, Floris G, Finalet-Ferreiro J, Fletcher CD, Coindre JM, Guillou L, Hogendoorn PC, Wozniak A, Vanspauwen V, Schöffski P, Marynen P, Vandenberghe P, Sciot R, Debiec-Rychter M.Coactivated platelet-derived growth factor receptor {alpha} and epidermal growth factor receptor are potential therapeutic targets in intimal sarcoma.Cancer Res. 2010 Sep 15;70(18):7304-14.
    20685895
  • Frau DV, Erdas E, Caria P, Ambu R, Dettori T, Faa G, Fletcher CD, Vanni R.Deep fibrous histiocytoma with a clonal karyotypic alteration: molecular cytogenetic characterization of a t(16;17)(p13.3;q21.3).Cancer Genet Cytogenet. 2010 Oct 1;202(1):17-21.
    20804915
  • de Feraudy S, Fletcher CD.Intradermal nodular fasciitis: a rare lesion analyzed in a series of 24 cases.Am J Surg Pathol. 2010 Sep;34(9):1377-81.
    20716998
  • Mariño-Enríquez A, Fletcher CD, Dal Cin P, Hornick JL.Dedifferentiated liposarcoma with "homologous" lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria.Am J Surg Pathol. 2010 Aug;34(8):1122-31.
    20588177
  • Chen E, Fletcher CD, Nucci MR.Meningothelial proliferations in mature cystic teratoma of the ovary: evidence for the common presence of cranially derived tissues paralleling anterior embryonic plate development. An analysis of 25 consecutive cases.Am J Surg Pathol. 2010 Jul;34(7):1014-8.
    20534997
  • Verbeke SL, Fletcher CD, Alberghini M, Daugaard S, Flanagan AM, Parratt T, Kroon HM, Hogendoorn PC, Bovée JV.A reappraisal of hemangiopericytoma of bone; analysis of cases reclassified as synovial sarcoma and solitary fibrous tumor of bone.Am J Surg Pathol. 2010 Jun;34(6):777-83.
    20421780
  • Chen E, Fletcher CD.Cellular Angiofibroma With Atypia or Sarcomatous Transformation: Clinicopathologic Analysis of 13 Cases.Am J Surg Pathol. 2010 May;34(5):707-14.
    20305534
  • Rubin BP, Cooper K, Fletcher CD, Folpe AL, Gannon FH, Hunt JL, Lazar AJ, Montag AG, Peabody TD, Pollock RE, Reith JD, Qualman SJ, Rosenberg AE, Weiss SW, Krausz T, .Protocol for the examination of specimens from patients with tumors of soft tissue.Arch Pathol Lab Med. 2010 Apr;134(4):e31-9.
    20367297
  • Liegl-Atzwanger B, Fletcher JA, Fletcher CD.Gastrointestinal stromal tumors.Virchows Arch. 2010 Feb;456(2):111-27. Review.
    20165865
  • Wagner AJ, Malinowska-Kolodziej I, Morgan JA, Qin W, Fletcher CD, Vena N, Ligon AH, Antonescu CR, Ramaiya NH, Demetri GD, Kwiatkowski DJ, Maki RG.Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors.J Clin Oncol. 2010 Feb 10;28(5):835-40.
    20048174
  • Raut CP, Wang Q, Manola J, Morgan JA, George S, Wagner AJ, Butrynski JE, Fletcher CD, Demetri GD, Bertagnolli MM.Cytoreductive surgery in patients with metastatic gastrointestinal stromal tumor treated with sunitinib malate.Ann Surg Oncol. 2010 Feb;17(2):407-15.
    19898902
  • Hornick JL, Bundock EA, Fletcher CD.Hybrid schwannoma/perineurioma: clinicopathologic analysis of 42 distinctive benign nerve sheath tumors.Am J Surg Pathol. 2009 Oct;33(10):1554-61.
    19623031
  • Rubin BP, Blanke CD, Demetri GD, Dematteo RP, Fletcher CD, Goldblum JR, Lasota J, Lazar A, Maki RG, Miettinen M, Noffsinger A, Washington MK, Krausz T, .Protocol for the examination of specimens from patients with gastrointestinal stromal tumor.Arch Pathol Lab Med. 2010 Feb;134(2):165-70.
    20121601
  • Subramanian S, Thayanithy V, West RB, Lee CH, Beck AH, Zhu S, Downs-Kelly E, Montgomery K, Goldblum JR, Hogendoorn PC, Corless CL, Oliveira AM, Dry SM, Nielsen TO, Rubin BP, Fletcher JA, Fletcher CD, van de Rijn M.Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours.J Pathol. 2010 Jan;220(1):58-70.
    19890883
  • Trufant JW, Brenn T, Fletcher CD, Virata AR, Cook DL, Bosenberg MW.Melanotic schwannoma arising in association with nevus of Ota: 2 cases suggesting a shared mechanism.Am J Dermatopathol. 2009 Dec;31(8):808-13.
    19786855
  • DelBove J, Kuwahara Y, Mora-Blanco EL, Godfrey V, Funkhouser WK, Fletcher CD, Van Dyke T, Roberts CW, Weissman BE.Inactivation of SNF5 cooperates with p53 loss to accelerate tumor formation in Snf5(+/-);p53(+/-) mice.Mol Carcinog. 2009 Dec;48(12):1139-48.
    19676100
  • Raut CP, Nucci MR, Wang Q, Manola J, Bertagnolli MM, Demetri GD, Morgan JA, Muto MG, Fletcher CD, George S.Predictive value of FIGO and AJCC staging systems in patients with uterine leiomyosarcoma.Eur J Cancer. 2009 Nov;45(16):2818-24.
    19647426
  • Demetri GD, Heinrich MC, Fletcher JA, Fletcher CD, Van den Abbeele AD, Corless CL, Antonescu CR, George S, Morgan JA, Chen MH, Bello CL, Huang X, Cohen DP, Baum CM, Maki RG.Molecular target modulation, imaging, and clinical evaluation of gastrointestinal stromal tumor patients treated with sunitinib malate after imatinib failure.Clin Cancer Res. 2009 Sep 15;15(18):5902-9.
    19737946
  • Young LR,Franz DN,Nagarkatte P,Fletcher CD,Wikenheiser-Brokamp KA,Galsky MD,Corbridge TC,Lam AP,Gelfand MJ,McCormack FX.Utility of FDG-PET in Sporadic and Tuberous Sclerosis Associated Lymphangioleiomyomatosis.Chest. 2009 Sep;136(3):926-33.
    19349386
  • Mosquera JM, Fletcher CD.Expanding the spectrum of malignant progression in solitary fibrous tumors: a study of 8 cases with a discrete anaplastic component--is this dedifferentiated SFT?.Am J Surg Pathol. 2009 Sep;33(9):1314-21.
    19718788
  • Willems SM, Mohseny AB, Balog C, Sewrajsing R, Briaire-de Bruijn IH, Knijnenburg J, Cleton-Jansen AM, Sciot R, Fletcher CD, Deelder AM, Szuhai K, Hensbergen PJ, Hogendoorn PC.Cellular/intramuscular myxoma and grade I myxofibrosarcoma are characterized by distinct genetic alterations and specific composition of their extracellular matrix.J Cell Mol Med. 2009 Jul;13(7):1291-301.
    19320777
  • Snyder EL,Sandstrom DJ,Law K,Fiore C,Sicinska E,Brito J,Bailey D,Fletcher JA,Loda M,Rodig SJ,Dal Cin P,Fletcher CD.c-Jun amplification and overexpression are oncogenic in liposarcoma but not always sufficient to inhibit the adipocytic differentiation programme.J Pathol. 2009 Jul;218(3):292-300.
    19449367
  • Hornick JL,Dal Cin P,Fletcher CD.Loss of INI1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma.Am J Surg Pathol. 2009 Apr;33(4):542-50.
    19033866
  • Liegl B,Hornick JL,Corless CL,Fletcher CD.Monoclonal antibody DOG1.1 shows higher sensitivity than KIT in the diagnosis of gastrointestinal stromal tumors, including unusual subtypes.Am J Surg Pathol. 2009 Mar;33(3):437-46.
    19011564
  • Heinrich MC,Maki RG,Corless CL,Antonescu CR,Harlow A,Griffith D,Town A,McKinley A,Ou WB,Fletcher JA,Fletcher CD,Huang X,Cohen DP,Baum CM,Demetri GD.Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor.J Clin Oncol. 2008 Nov 20;26(33):5352-9.
    18955458
  • Heinrich MC,Owzar K,Corless CL,Hollis D,Borden EC,Fletcher CD,Ryan CW,von Mehren M,Blanke CD,Rankin C,Benjamin RS,Bramwell VH,Demetri GD,Bertagnolli MM,Fletcher JA.Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III Trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group.J Clin Oncol. 2008 Nov 20;26(33):5360-7.
    18955451
  • Liegl B,Hornick JL,Antonescu CR,Corless CL,Fletcher CD.Rhabdomyosarcomatous differentiation in gastrointestinal stromal tumors after tyrosine kinase inhibitor therapy: a novel form of tumor progression.Am J Surg Pathol. 2009 Feb;33(2):218-26.
    18830121
  • Nascimento AF,Raut CP,Fletcher CD.Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic.Am J Surg Pathol. 2008 Dec;32(12):1896-904.
    18813119
  • Liegl B,Fletcher CD.Ischemic fasciitis: analysis of 44 cases indicating an inconsistent association with immobility or debilitation.Am J Surg Pathol. 2008 Oct;32(10):1546-52.
    18724246
  • Bertagnolli MM,Morgan JA,Fletcher CD,Raut CP,Dileo P,Gill RR,Demetri GD,George S.Multimodality treatment of mesenteric desmoid tumours.Eur J Cancer. 2008 Nov;44(16):2404-10.
    18706807
  • Rouhani P,Fletcher CD,Devesa SS,Toro JR.Cutaneous soft tissue sarcoma incidence patterns in the U.S. : an analysis of 12,114 cases.Cancer. 2008 Aug 1;113(3):616-27.
    18618615
  • Hallor KH,Teixeira MR,Fletcher CD,Bizarro S,Staaf J,Domanski HA,von Steyern FV,Panagopoulos I,Mandahl N,Mertens F.Heterogeneous genetic profiles in soft tissue myoepitheliomas.Mod Pathol. 2008 Nov;21(11):1311-9.
    18604193
  • Liegl B,Bennett MW,Fletcher CD.Microcystic/reticular schwannoma: a distinct variant with predilection for visceral locations.Am J Surg Pathol. 2008 Jul;32(7):1080-7.
    18520439
  • Hornick JL, Fletcher CD.Sclerosing PEComa: Clinicopathologic Analysis of a Distinctive Variant With a Predilection for the Retroperitoneum.Am J Surg Pathol. 2008 Apr;32(4):493-501.
    18223480
  • Liegl B, Hornick JL, Fletcher CD.Primary Cutaneous PEComa: Distinctive Clear Cell Lesions of Skin.Am J Surg Pathol. 2008 Apr;32(4):608-14.
    18277881
  • Fletcher CD.Undifferentiated sarcomas: what to do? And does it matter? A surgical pathology perspective.Ultrastruct Pathol. 2008 Mar-Apr;32(2):31-6.
    18446665
  • Gleason BC, Fletcher CD.Deep "benign" fibrous histiocytoma: clinicopathologic analysis of 69 cases of a rare tumor indicating occasional metastatic potential.Am J Surg Pathol. 2008 Mar;32(3):354-62.
    18300816
  • Blanke CD, Demetri GD, von Mehren M, Heinrich MC, Eisenberg B, Fletcher JA, Corless CL, Fletcher CD, Roberts PJ, Heinz D, Wehre E, Nikolova Z, Joensuu H.Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT.J Clin Oncol. 2008 Feb 1;26(4):620-5.
    18235121
  • Blanke CD, Rankin C, Demetri GD, Ryan CW, von Mehren M, Benjamin RS, Raymond AK, Bramwell VH, Baker LH, Maki RG, Tanaka M, Hecht JR, Heinrich MC, Fletcher CD, Crowley JJ, Borden EC.Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033.J Clin Oncol. 2008 Feb 1;26(4):626-32.
    18235122
  • Rossi S, Szuhai K, Ijszenga M, Tanke HJ, Zanatta L, Sciot R, Fletcher CD, Dei Tos AP, Hogendoorn PC.EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma.Clin Cancer Res. 2007 Dec 15;13(24):7322-8.
    18094413
  • Gleason BC, Fletcher CD.Myoepithelial carcinoma of soft tissue in children: an aggressive neoplasm analyzed in a series of 29 cases.Am J Surg Pathol. 2007 Dec;31(12):1813-24.
    18043035
  • Hahn HP, Fletcher CD.Primary mediastinal liposarcoma: clinicopathologic analysis of 24 cases.Am J Surg Pathol. 2007 Dec;31(12):1868-74.
    18043041
  • Calonje E, Fletcher CD, Mentzel T.Congenital hand lesion.Am J Dermatopathol. 2007 Dec;29(6):588-90.
    18032962
  • Zhu MJ, Ou WB, Fletcher CD, Cohen PS, Demetri GD, Fletcher JA.KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance.Oncogene. 2007 Sep 27;26(44):6386-95.
    17452978
  • Desai J, Shankar S, Heinrich MC, Fletcher JA, Fletcher CD, Manola J, Morgan JA, Corless CL, George S, Tuncali K, Silverman SG, Van den Abbeele AD, van Sonnenberg E, Demetri GD.Clonal evolution of resistance to imatinib in patients with metastatic gastrointestinal stromal tumors.Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5398-405.
    17875769
  • Antonescu CR, Dal Cin P, Nafa K, Teot LA, Surti U, Fletcher CD, Ladanyi M.EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma.Genes Chromosomes Cancer. 2007 Dec;46(12):1051-60.
    17724745
  • Reimann JD, Fletcher CD.Myxoid dermatofibrosarcoma protuberans: a rare variant analyzed in a series of 23 cases.Am J Surg Pathol. 2007 Sep;31(9):1371-7.
    17721193
  • Nascimento AF, Fletcher CD.The controversial nosology of benign nerve sheath tumors: neurofilament protein staining demonstrates intratumoral axons in many sporadic schwannomas.Am J Surg Pathol. 2007 Sep;31(9):1363-70.
    17721192
  • Demetri GD, Benjamin RS, Blanke CD, Blay JY, Casali P, Choi H, Corless CL, Debiec-Rychter M, DeMatteo RP, Ettinger DS, Fisher GA, Fletcher CD, Gronchi A, Hohenberger P, Hughes M, Joensuu H, Judson I, Le Cesne A, Maki RG, Morse M, Pappo AS, Pisters PW, Raut CP, Reichardt P, Tyler DS, Van den Abbeele AD, von Mehren M, Wayne JD, Zalcberg J.NCCN Task Force report: management of patients with gastrointestinal stromal tumor (GIST)--update of the NCCN clinical practice guidelines.J Natl Compr Canc Netw. 2007 Jul;5 Suppl 2:S1-29; quiz S30. Review.
    17624289
  • Drake TA, Braun J, Marchevsky A, Kohane IS, Fletcher C, Chueh H, Beckwith B, Berkowicz D, Kuo F, Zeng QT, Balis U, Holzbach A, McMurry A, Gee CE, McDonald CJ, Schadow G, Davis M, Hattab EM, Blevins L, Hook J, Becich M, Crowley RS, Taube SE, Berman J,.A system for sharing routine surgical pathology specimens across institutions: the Shared Pathology Informatics Network.Hum Pathol. 2007 Aug;38(8):1212-25.
    17490722
  • Nucci MR, Drapkin R, Cin PD, Fletcher CD, Fletcher JA.Distinctive Cytogenetic Profile in Benign Metastasizing Leiomyoma: Pathogenetic Implications.Am J Surg Pathol. 2007 May;31(5):737-743.
    17460458
  • Hornick JL, Fletcher CD.The role of KIT in the management of patients with gastrointestinal stromal tumors.Hum Pathol. 2007 May;38(5):679-87. Review.
    17437861
  • Coffin CM, Hornick JL, Fletcher CD.Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases.Am J Surg Pathol. 2007 Apr;31(4):509-20.
    17414097
  • Li Y, Chang Q, Rubin BP, Fletcher CD, Morgan TW, Mentzer SJ, Sugarbaker DJ, Fletcher JA, Xiao S.Insulin receptor activation in solitary fibrous tumours.J Pathol. 2007 Apr;211(5):550-4.
    17299733
  • Demetri GD, van Oosterom AT, Garrett CR, Blackstein ME, Shah MH, Verweij J, McArthur G, Judson IR, Heinrich MC, Morgan JA, Desai J, Fletcher CD, George S, Bello CL, Huang X, Baum CM, Casali PG.Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial.Lancet. 2006 Oct 14;368(9544):1329-38.
    17046465
  • Heinrich MC, Corless CL, Blanke CD, Demetri GD, Joensuu H, Roberts PJ, Eisenberg BL, von Mehren M, Fletcher CD, Sandau K, McDougall K, Ou WB, Chen CJ, Fletcher JA.Molecular correlates of imatinib resistance in gastrointestinal stromal tumors.J Clin Oncol. 2006 Oct 10;24(29):4764-74.
    16954519
  • Raut CP, Posner M, Desai J, Morgan JA, George S, Zahrieh D, Fletcher CD, Demetri GD, Bertagnolli MM.Surgical Management of Advanced Gastrointestinal Stromal Tumors After Treatment With Targeted Systemic Therapy Using Kinase Inhibitors.J Clin Oncol. 2006 May 20;24(15):2325-2331.
    16710031
  • Carrasco DR, Fenton T, Sukhdeo K, Protopopova M, Enos M, You MJ, Divicio D, Nogueira C, Stommel J, Pinkus GS, Fletcher C, Hornick JL, Cavenee WK, Furnari FB, Depinho RA.The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans.Cancer Cell. 2006 May;9(5):379-90.
    16697958
  • Hirsch MS, Dal Cin P, Fletcher CD.ALK expression in pseudosarcomatous myofibroblastic proliferations of the genitourinary tract.Histopathology. 2006 Apr;48(5):569-78.
    16623783
  • Carter MR, Hornick JL, Lester S, Fletcher CD.Spindle Cell (Sarcomatoid) Carcinoma of the Breast: A Clinicopathologic and Immunohistochemical Analysis of 29 Cases.Am J Surg Pathol. 2006 Mar;30(3):300-309.
    16538049
  • Hornick JL, Fletcher CD.Intraarticular nodular fasciitis--a rare lesion: clinicopathologic analysis of a series.Am J Surg Pathol. 2006 Feb;30(2):237-41.
    16434899
  • Plaza JA, Wakely PE, Moran C, Fletcher CD, Suster S.Sclerosing paraganglioma: report of 19 cases of an unusual variant of neuroendocrine tumor that may be mistaken for an aggressive malignant neoplasm.Am J Surg Pathol. 2006 Jan;30(1):7-12.
    16330936
  • George S, Hornick JL, Bertagnolli MM, Fletcher CD, Demetri GD.Current management of metastatic gastrointestinal stromal tumor: a case report.Clin Adv Hematol Oncol. 2003 Jan;1(1):63-4; discussion 65.
    16227963
  • Brenn T, Fletcher CD.Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases.Am J Surg Pathol. 2005 Aug;29(8):983-96.
    16006792
  • Lazar AJ, Fletcher CD.Primitive nonneural granular cell tumors of skin: clinicopathologic analysis of 13 cases.Am J Surg Pathol. 2005 Jul;29(7):927-34.
    15958858
  • Hornick JL, Fletcher CD.Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases.Am J Surg Pathol. 2005 Jul;29(7):859-65.
    15958849
  • Hornick JL, Fletcher CD.Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features.Am J Surg Pathol. 2005 Jul;29(7):845-58.
    15958848
  • Hornick JL, Fletcher CD.Intraabdominal cystic lymphangiomas obscured by marked superimposed reactive changes: clinicopathological analysis of a series.Hum Pathol. 2005 Apr;36(4):426-32.
    15892005
  • Patton EE, Widlund HR, Kutok JL, Kopani KR, Amatruda JF, Murphey RD, Berghmans S, Mayhall EA, Traver D, Fletcher CD, Aster JC, Granter SR, Look AT, Lee C, Fisher DE, Zon LI.BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.Curr Biol. 2005 Feb 8;15(3):249-54.
    15694309
  • Mertens F, Fletcher CD, Antonescu CR, Coindre JM, Colecchia M, Domanski HA, Downs-Kelly E, Fisher C, Goldblum JR, Guillou L, Reid R, Rosai J, Sciot R, Mandahl N, Panagopoulos I.Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene.Lab Invest. 2005 Mar;85(3):408-15.
    15640831
  • Berghmans S, Murphey RD, Wienholds E, Neuberg D, Kutok JL, Fletcher CD, Morris JP, Liu TX, Schulte-Merker S, Kanki JP, Plasterk R, Zon LI, Look AT.tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):407-12.
    15630097
  • Iwasa Y, Fletcher CD.Distinctive prepubertal vulval fibroma: a hitherto unrecognized mesenchymal tumor of prepubertal girls: analysis of 11 cases.Am J Surg Pathol. 2004 Dec;28(12):1601-8.
    15577679
  • Hornick JL, Bosenberg MW, Mentzel T, McMenamin ME, Oliveira AM, Fletcher CD.Pleomorphic liposarcoma: clinicopathologic analysis of 57 cases.Am J Surg Pathol. 2004 Oct;28(10):1257-67.
    15371941
  • Hornick JL, Jaffe ES, Fletcher CD.Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy.Am J Surg Pathol. 2004 Sep;28(9):1133-44.
    15316312
  • Medeiros F, Corless CL, Duensing A, Hornick JL, Oliveira AM, Heinrich MC, Fletcher JA, Fletcher CD.KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications.Am J Surg Pathol. 2004 Jul;28(7):889-94.
    15223958
  • Dahln A, Fletcher CD, Mertens F, Fletcher JA, Perez-Atayde AR, Hicks MJ, Debiec-Rychter M, Sciot R, Wejde J, Wedin R, Mandahl N, Panagopoulos I.Activation of the GLI oncogene through fusion with the beta-actin gene (ACTB) in a group of distinctive pericytic neoplasms: pericytoma with t(7;12).Am J Pathol. 2004 May;164(5):1645-53.
    15111311
  • Johnson BE, Fischer T, Fischer B, Dunlop D, Rischin D, Silberman S, Kowalski MO, Sayles D, Dimitrijevic S, Fletcher C, Hornick J, Salgia R, Le Chevalier T.Phase II study of imatinib in patients with small cell lung cancer.Clin Cancer Res. 2003 Dec 1;9(16 Pt 1):5880-7.
    14676110
  • Hornick JL, Fletcher CD.Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters.Am J Surg Pathol. 2003 Sep;27(9):1183-96.
    12960802
  • Heinrich MC, Corless CL, Duensing A, McGreevey L, Chen CJ, Joseph N, Singer S, Griffith DJ, Haley A, Town A, Demetri GD, Fletcher CD, Fletcher JA.PDGFRA activating mutations in gastrointestinal stromal tumors.Science. 2003 Jan 31;299(5607):708-10.
    12522257
  • Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD, Joensuu H.Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors.N Engl J Med. 2002 Aug 15;347(7):472-80.
    12181401
  • Rubin BP, Singer S, Tsao C, Duensing A, Lux ML, Ruiz R, Hibbard MK, Chen CJ, Xiao S, Tuveson DA, Demetri GD, Fletcher CD, Fletcher JA.KIT activation is a ubiquitous feature of gastrointestinal stromal tumors.Cancer Res. 2001 Nov 15;61(22):8118-21.
    11719439
  • Tuveson DA, Willis NA, Jacks T, Griffin JD, Singer S, Fletcher CD, Fletcher JA, Demetri GD.STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications.Oncogene. 2001 Aug 16;20(36):5054-8.
    11526490
  • Granter SR, Weilbaecher KN, Quigley C, Fletcher CD, Fisher DE.Clear cell sarcoma shows immunoreactivity for microphthalmia transcription factor: further evidence for melanocytic differentiation.Mod Pathol. 2001 Jan;14(1):6-9.
    11211309
  • Nucci MR, Young RH, Fletcher CD.Cellular pseudosarcomatous fibroepithelial stromal polyps of the lower female genital tract: an underrecognized lesion often misdiagnosed as sarcoma.Am J Surg Pathol. 2000 Feb;24(2):231-40.
    10680891
  • Fletcher CD, Dal Cin P, de Wever I, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Sciot R, Tallini G, van den Berghe H, Vanni R, Willn H.Correlation between clinicopathological features and karyotype in spindle cell sarcomas. A report of 130 cases from the CHAMP study group.Am J Pathol. 1999 Jun;154(6):1841-7.
    10362810
  • Demetri GD, Fletcher CD, Mueller E, Sarraf P, Naujoks R, Campbell N, Spiegelman BM, Singer S.Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma.Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3951-6.
    10097144
  • Millis K, Weybright P, Campbell N, Fletcher JA, Fletcher CD, Cory DG, Singer S.Classification of human liposarcoma and lipoma using ex vivo proton NMR spectroscopy.Magn Reson Med. 1999 Feb;41(2):257-67.
    10080272
  • Dei Tos AP, Piccinin S, Doglioni C, Vukosavljevic T, Mentzel T, Boiocchi M, Fletcher CD.Molecular aberrations of the G1-S checkpoint in myxoid and round cell liposarcoma.Am J Pathol. 1997 Dec;151(6):1531-9.
    9403703
  • Guillou L, Wadden C, Coindre JM, Krausz T, Fletcher CD."Proximal-type" epithelioid sarcoma, a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistochemical, and ultrastructural study of a series.Am J Surg Pathol. 1997 Feb;21(2):130-46.
    9042279