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Shiv S. Pillai, PhD, MBBS

Publications

  • Wallace ZS, Mattoo H, Carruthers M, Mahajan VS, Della Torre E, Lee H, Kulikova M, Deshpande V, Pillai S, Stone JH.Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4 concentrations.Ann Rheum Dis. 2014 May 9.
    24817416
  • Mattoo H, Mahajan VS, Della-Torre E, Sekigami Y, Carruthers M, Wallace ZS, Deshpande V, Stone JH, Pillai S.De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease.J Allergy Clin Immunol. 2014 May 6.
    24815737
  • Della-Torre E, Mattoo H, Mahajan VS, Deshpande V, Krause D, Song P, Pillai S, Stone JH.IgG4-related midline destructive lesion.Ann Rheum Dis. 2014 Mar 20.
    24651619
  • Mahajan VS, Mattoo H, Deshpande V, Pillai SS, Stone JH.IgG4-related disease.Annu Rev Pathol. 2014;9:315-47. Review.
    24111912
  • Ahmad M, Mahajan VS, Mattoo H, Stone JH, Pillai S.Individuals with IgG4-related disease do not have an increased frequency of the K409 variant of IgG4 that compromises Fab-arm exchange.J Rheumatol. 2014 Jan;41(1):185-7.
    24382929
  • Pillai S.Rethinking mechanisms of autoimmune pathogenesis.J Autoimmun. 2013 Sep;45:97-103. Review.
    23809879
  • Pillai S.Love the one you're with: the HIV, B cell and TFH cell triangle.Nat Med. 2013 Apr;19(4):401-2.
    23558623
  • Chellappa V, Taylor KN, Pedrick K, Donado C, Netravali IA, Haider K, Cariappa A, Dalomba NF, Pillai S.M89V Sialic acid Acetyl Esterase (SIAE) and all other non-synonymous common variants of this gene are catalytically normal.PLoS ONE. 2013;8(1):e53453.
    23308225
  • Surolia I, Pirnie SP, Chellappa V, Taylor KN, Cariappa A, Moya J, Liu H, Bell DW, Driscoll DR, Diederichs S, Haider K, Netravali I, Le S, Elia R, Dow E, Lee A, Freudenberg J, De Jager PL, Chretien Y, Varki A, Macdonald ME, Gillis T, Behrens TW, Bloch D, Collier D, Korzenik J, Podolsky DK, Hafler D, Murali M, Sands B, Stone JH, Gregersen PK, Pillai S.Functionally defective germline variants of sialic acid acetylesterase in autoimmunity.Nature. 2010 Jul 8;466(7303):243-7.
    20555325
  • Pillai S, Cariappa A.The follicular versus marginal zone B lymphocyte cell fate decision.Nat Rev Immunol. 2009 Nov;9(11):767-77. Review.
    19855403
  • Pillai S, Cariappa A, Pirnie SP.Esterases and autoimmunity: the sialic acid acetylesterase pathway and the regulation of peripheral B cell tolerance.Trends Immunol. 2009 Oct;30(10):488-93. Review.
    19766537
  • Brainard DM,Seung E,Frahm N,Cariappa A,Bailey CC,Hart WK,Shin HS,Brooks SF,Knight HL,Eichbaum Q,Yang YG,Sykes M,Walker BD,Freeman GJ,Pillai S,Westmoreland SV,Brander C,Luster AD,Tager AM.Induction of robust cellular and humoral virus-specific adaptive immune responses in HIV-infected humanized BLT mice.J Virol. 2009 Jul;83(14):7305-21.
    19420076
  • Cariappa A, Takematsu H, Liu H, Diaz S, Haider K, Boboila C, Kalloo G, Connole M, Shi HN, Varki N, Varki A, Pillai S.B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase.J Exp Med. 2009 Jan 16;206(1):125-38.
    19103880
  • Pillai S, Cariappa A.The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow-derived B lymphocytes.Immunol Cell Biol. 2009 Jan;87(1):16-9. Review.
    19030017
  • Kosakovsky Pond SL, Poon AF, Zarate S, Smith DM, Little SJ, Pillai SK, Ellis RJ, Wong JK, Leigh Brown AJ, Richman DD, Frost SD.Estimating selection pressures on HIV-1 using phylogenetic likelihood models.Stat Med. 2008 Oct 15;27(23):4779-89.
    18381707
  • White JH, Chiano M, Wigglesworth M, Geske R, Riley J, White N, Hall S, Zhu G, Maurio F, Savage T, Anderson W, Cordy J, Ducceschi M, Vestbo J, Pillai SG.Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation.Hum Mol Genet. 2008 Jul 1;17(13):1890-903.
    18344558
  • Leadbetter EA,Brigl M,Illarionov P,Cohen N,Luteran MC,Pillai S,Besra GS,Brenner MB.NK T cells provide lipid antigen-specific cognate help for B cells.Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8339-44.
    18550809
  • Allman D, Pillai S.Peripheral B cell subsets.Curr Opin Immunol. 2008 Apr;20(2):149-57. Review.
    18434123
  • Shimomura Y, Ogawa A, Kawada M, Sugimoto K, Mizoguchi E, Shi HN, Pillai S, Bhan AK, Mizoguchi A.A unique B2 B cell subset in the intestine.J Exp Med. 2008 Jun 9;205(6):1343-55.
    18519649
  • Pilcher CD, Wong JK, Pillai SK.Inferring HIV transmission dynamics from phylogenetic sequence relationships.PLoS Med. 2008 Mar 18;5(3):e69.
    18351799
  • Benatuil L, Kaye J, Cretin N, Godwin JG, Cariappa A, Pillai S, Iacomini J.Ig knock-in mice producing anti-carbohydrate antibodies: breakthrough of B cells producing low affinity anti-self antibodies.J Immunol. 2008 Mar 15;180(6):3839-48.
    18322191
  • Cariappa A, Boboila C, Moran ST, Liu H, Shi HN, Pillai S.The recirculating B cell pool contains two functionally distinct, long-lived, posttransitional, follicular B cell populations.J Immunol. 2007 Aug 15;179(4):2270-81.
    17675488
  • Moran ST, Cariappa A, Liu H, Muir B, Sgroi D, Boboila C, Pillai S.Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes.J Immunol. 2007 Jul 1;179(1):195-200.
    17579038
  • Moran ST, Cariappa A, Liu H, Boboila C, Shi HN, Holland PM, Peschon JJ, Pillai S.Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations.Mol Immunol. 2006 Apr;43(10):1694-9.
    16256200
  • Cariappa A, Mazo IB, Chase C, Shi HN, Liu H, Li Q, Rose H, Leung H, Cherayil BJ, Russell P, von Andrian U, Pillai S.Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes.Immunity. 2005 Oct;23(4):397-407.
    16226505
  • Pillai S.Two lymphoid roads diverge--but does antigen bade B cells to take the road less traveled?.Immunity. 2005 Sep;23(3):242-4.
    16169496
  • Cavanagh LL, Bonasio R, Mazo IB, Halin C, Cheng G, van der Velden AW, Cariappa A, Chase C, Russell P, Starnbach MN, Koni PA, Pillai S, Weninger W, von Andrian UH.Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells.Nat Immunol. 2005 Oct;6(10):1029-37.
    16155571
  • Cariappa A, Shoham T, Liu H, Levy S, Boucheix C, Pillai S.The CD9 tetraspanin is not required for the development of peripheral B cells or for humoral immunity.J Immunol. 2005 Sep 1;175(5):2925-30.
    16116178
  • Pillai S, Cariappa A, Moran ST.Marginal zone B cells.Annu Rev Immunol. 2005;23:161-96.
    15771569
  • Pillai S.Birth pangs: the stressful origins of lymphocytes.J Clin Invest. 2005 Feb;115(2):224-7.
    15690077
  • Pillai S, Cariappa A, Moran ST.Positive selection and lineage commitment during peripheral B-lymphocyte development.Immunol Rev. 2004 Feb;197:206-18.
    14962197
  • Cariappa A, Chen L, Haider K, Tang M, Nebelitskiy E, Moran ST, Pillai S.A catalytically inactive form of protein kinase C-associated kinase/receptor interacting protein 4, a protein kinase C beta-associated kinase that mediates NF-kappa B activation, interferes with early B cell development.J Immunol. 2003 Aug 15;171(4):1875-80.
    12902489
  • Moran ST, Haider K, Ow Y, Milton P, Chen L, Pillai S.Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner.J Biol Chem. 2003 Jun 13;278(24):21526-33.
    12676934
  • Cariappa A, Tang M, Parng C, Nebelitskiy E, Carroll M, Georgopoulos K, Pillai S.The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21.Immunity. 2001 May;14(5):603-15.
    11371362
  • Chen L, Haider K, Ponda M, Cariappa A, Rowitch D, Pillai S.Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase.J Biol Chem. 2001 Jun 15;276(24):21737-44.
    11278382
  • Cariappa A, Liou HC, Horwitz BH, Pillai S.Nuclear factor kappa B is required for the development of marginal zone B lymphocytes.J Exp Med. 2000 Oct 16;192(8):1175-82.
    11034607
  • Chaudhuri S, Cariappa A, Tang M, Bell D, Haber DA, Isselbacher KJ, Finkelstein D, Forcione D, Pillai S.Genetic susceptibility to breast cancer: HLA DQB*03032 and HLA DRB1*11 may represent protective alleles.Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11451-4.
    11027344
  • Ho SC, Chaudhuri S, Bachhawat A, McDonald K, Pillai S.Accelerated proteasomal degradation of membrane Ig heavy chains.J Immunol. 2000 May 1;164(9):4713-9.
    10779777
  • Pillai S.The chosen few? Positive selection and the generation of naive B lymphocytes.Immunity. 1999 May;10(5):493-502.
    10367895
  • Cariappa A, Kim TJ, Pillai S.Accelerated emigration of B lymphocytes in the Xid mouse.J Immunol. 1999 Apr 15;162(8):4417-23.
    10201977
  • Wang JH, Avitahl N, Cariappa A, Friedrich C, Ikeda T, Renold A, Andrikopoulos K, Liang L, Pillai S, Morgan BA, Georgopoulos K.Aiolos regulates B cell activation and maturation to effector state.Immunity. 1998 Oct;9(4):543-53.
    9806640