Jonathan A. Fletcher, MD

Publications

• Ou WB, Hubert C, Corson JM, Bueno R, Flynn DL, Sugarbaker DJ, Fletcher JA.Targeted inhibition of multiple receptor tyrosine kinases in mesothelioma.Neoplasia. 2011 Jan;13(1):12-22.
  21245936
• Mariño-Enríquez A, Ou WB, Weldon CB, Fletcher JA, Pérez-Atayde AR.ALK rearrangement in sickle cell trait-associated renal medullary carcinoma.Genes Chromosomes Cancer. 2011 Mar;50(3):146-53.
  21213368
• Janeway KA, Kim SY, Lodish M, Nosé V, Rustin P, Gaal J, Dahia PL, Liegl B, Ball ER, Raygada M, Lai AH, Kelly L, Hornick JL, , O'Sullivan M, de Krijger RR, Dinjens WN, Demetri GD, Antonescu CR, Fletcher JA, Helman L, Stratakis CA.Defects in succinate
  21173220
• Chi P, Chen Y, Zhang L, Guo X, Wongvipat J, Shamu T, Fletcher JA, Dewell S, Maki RG, Zheng D, Antonescu CR, Allis CD, Sawyers CL.ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours.Nature. 2010 Oct 14;467(7317):8
  20927104
• Ligon AH, Morton CC, Bieber FR, Fletcher JA, Giersch AB, Kantarci S, Leach N, Lee C, Sandstrom M, Weremowicz S, Xiao S, Dal Cin P.Reporting of diagnostic cytogenetic results.Curr Protoc Hum Genet. 2010 Oct;Appendix 1:1D.1-23.
  20891028
• Rossi S, Gasparotto D, Toffolatti L, Pastrello C, Gallina G, Marzotto A, Sartor C, Barbareschi M, Cantaloni C, Messerini L, Bearzi I, Arrigoni G, Mazzoleni G, Fletcher JA, Casali PG, Talamini R, Maestra R, Dei Tos AP.Molecular and clinicopathologic charac
  20861712
• Janeway KA, Zhu MJ, Barretina J, Perez-Atayde A, Demetri GD, Fletcher JA.Strong expression of IGF1R in pediatric gastrointestinal stromal tumors without IGF1R genomic amplification.Int J Cancer. 2010 Dec 1;127(11):2718-22.
  20162573
• Agoston AT, Liang CW, Richkind KE, Fletcher JA, Vargas SO.Trisomy 18 is a consistent cytogenetic feature in pilomatricoma.Mod Pathol. 2010 Aug;23(8):1147-50.
  20495544
• Weisberg E, Choi HG, Ray A, Barrett R, Zhang J, Sim T, Zhou W, Seeliger M, Cameron M, Azam M, Fletcher JA, Debiec-Rychter M, Mayeda M, Moreno D, Kung AL, Janne PA, Khosravi-Far R, Melo JV, Manley P, Adamia S, Wu C, Gray N, Griffin JD.Discovery of a small
  20299508
• Parkkila S, Lasota J, Fletcher JA, Ou WB, Kivelä AJ, Nuorva K, Parkkila AK, Ollikainen J, Sly WS, Waheed A, Pastorekova S, Pastorek J, Isola J, Miettinen M.Carbonic anhydrase II. A novel biomarker for gastrointestinal stromal tumors.Mod Pathol. 2010 May;
  20081808
• Sadow PM, Heinrich MC, Corless CL, Fletcher JA, Nosé V.Absence of BRAF, NRAS, KRAS, HRAS Mutations, and RET/PTC Gene Rearrangements Distinguishes Dominant Nodules in Hashimoto Thyroiditis from Papillary Thyroid Carcinomas.Endocr Pathol. 2010 Jun;21(2):73
  20012784
• Liegl-Atzwanger B, Fletcher JA, Fletcher CD.Gastrointestinal stromal tumors.Virchows Arch. 2010 Feb;456(2):111-27. Review.
  20165865
• Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L, Greulich H, Reich M, Winckler W, Lawrence MS, Weir BA, Tanaka KE, Chiang DY, Bass AJ, Lo
  20164920
• Bauer S, Parry JA, Mühlenberg T, Brown MF, Seneviratne D, Chatterjee P, Chin A, Rubin BP, Kuan SF, Fletcher JA, Duensing S, Duensing A.Proapoptotic activity of bortezomib in gastrointestinal stromal tumor cells.Cancer Res. 2010 Jan 1;70(1):150-9.
  20028860
• Subramanian S, Thayanithy V, West RB, Lee CH, Beck AH, Zhu S, Downs-Kelly E, Montgomery K, Goldblum JR, Hogendoorn PC, Corless CL, Oliveira AM, Dry SM, Nielsen TO, Rubin BP, Fletcher JA, Fletcher CD, van de Rijn M.Genome-wide transcriptome analyses reveal
  19890883
• MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, Fiorentino M, Rubin MA, Polyak K, Chan J, Wang Y, Fletcher JA, Santagata S, Corso G, Roviello F, Shivdasan
  19924296
• Razis E, Selviaridis P, Labropoulos S, Norris JL, Zhu MJ, Song DD, Kalebic T, Torrens M, Kalogera-Fountzila A, Karkavelas G, Karanastasi S, Fletcher JA, Fountzilas G.Phase II study of neoadjuvant imatinib in glioblastoma: evaluation of clinical and molecu
  19789313
• Demetri GD, Heinrich MC, Fletcher JA, Fletcher CD, Van den Abbeele AD, Corless CL, Antonescu CR, George S, Morgan JA, Chen MH, Bello CL, Huang X, Cohen DP, Baum CM, Maki RG.Molecular target modulation, imaging, and clinical evaluation of gastrointestinal
  19737946
• Yen CC, Chen WM, Chen TH, Chen WY, Chen PC, Chiou HJ, Hung GY, Wu HT, Wei CJ, Shiau CY, Wu YC, Chao TC, Tzeng CH, Chen PM, Lin CH, Chen YJ, Fletcher JA.Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 delet
  19724913
• Mühlenberg T, Zhang Y, Wagner AJ, Grabellus F, Bradner J, Taeger G, Lang H, Taguchi T, Schuler M, Fletcher JA, Bauer S.Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.C
  19706776
• Factor RE, Dal Cin P, Fletcher JA, Cibas ES.Cytogenetics and fluorescence in situ hybridization as adjuncts to cytology in the diagnosis of malignant mesothelioma.Cancer Cytopathol. 2009 Aug 25;117(4):247-53.
  19536878
• Gunaratnam M,Swank S,Haider SM,Galesa K,Reszka AP,Beltran M,Cuenca F,Fletcher JA,Neidle S.Targeting Human Gastrointestinal Stromal Tumor Cells with a Quadruplex-Binding Small Molecule.J Med Chem. 2009 Jun 25;52(12):3774-83.
  19469547
• Snyder EL,Sandstrom DJ,Law K,Fiore C,Sicinska E,Brito J,Bailey D,Fletcher JA,Loda M,Rodig SJ,Dal Cin P,Fletcher CD.c-Jun amplification and overexpression are oncogenic in liposarcoma but not always sufficient to inhibit the adipocytic differentiation prog
  19449367
• Jiang X,Zhou J,Yuen NK,Corless CL,Heinrich MC,Fletcher JA,Demetri GD,Widlund HR,Fisher DE,Hodi FS.Imatinib targeting of KIT-mutant oncoprotein in melanoma.Clin Cancer Res. 2008 Dec 1;14(23):7726-32.
  19047099
• Heinrich MC,Maki RG,Corless CL,Antonescu CR,Harlow A,Griffith D,Town A,McKinley A,Ou WB,Fletcher JA,Fletcher CD,Huang X,Cohen DP,Baum CM,Demetri GD.Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in
  18955458
• Heinrich MC,Owzar K,Corless CL,Hollis D,Borden EC,Fletcher CD,Ryan CW,von Mehren M,Blanke CD,Rankin C,Benjamin RS,Bramwell VH,Demetri GD,Bertagnolli MM,Fletcher JA.Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase
  18955451
• French CA,Fletcher JA,Cibas ES,Caulfield C,Allard P,Kroll TG.Molecular detection of PPAR gamma rearrangements and thyroid carcinoma in preoperative fine-needle aspiration biopsies.Endocr Pathol. 2008 Fall;19(3):166-74.
  18688583
• Heinrich MC, Joensuu H, Demetri GD, Corless CL, Apperley J, Fletcher JA, Soulieres D, Dirnhofer S, Harlow A, Town A, McKinley A, Supple SG, Seymour J, Di Scala L, van Oosterom A, Herrmann R, Nikolova Z, McArthur AG.Phase II, Open-Label Study Evaluating th
  18451237
• French CA, Ramirez CL, Kolmakova J, Hickman TT, Cameron MJ, Thyne ME, Kutok JL, Toretsky JA, Tadavarthy AK, Kees UR, Fletcher JA, Aster JC.BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintai
  17934517
• Blanke CD, Demetri GD, von Mehren M, Heinrich MC, Eisenberg B, Fletcher JA, Corless CL, Fletcher CD, Roberts PJ, Heinz D, Wehre E, Nikolova Z, Joensuu H.Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate f
  18235121
• Janeway KA, Liegl B, Harlow A, Le C, Perez-Atayde A, Kozakewich H, Corless CL, Heinrich MC, Fletcher JA.Pediatric KIT wild-type and platelet-derived growth factor receptor alpha-wild-type gastrointestinal stromal tumors share KIT activation but not mechan
  17909012
• Zhu MJ, Ou WB, Fletcher CD, Cohen PS, Demetri GD, Fletcher JA.KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance.Oncogene. 2007 Sep 27;26(44):6386-95.
  17452978
• Desai J, Shankar S, Heinrich MC, Fletcher JA, Fletcher CD, Manola J, Morgan JA, Corless CL, George S, Tuncali K, Silverman SG, Van den Abbeele AD, van Sonnenberg E, Demetri GD.Clonal evolution of resistance to imatinib in patients with metastatic gastroin
  17875769
• Schmidt J, Derr V, Heinrich MC, Crum CP, Fletcher JA, Corless CL, Nose V.BRAF in papillary thyroid carcinoma of ovary (struma ovarii).Am J Surg Pathol. 2007 Sep;31(9):1337-43.
  17721188
• Grosso F, Jones RL, Demetri GD, Judson IR, Blay JY, Le Cesne A, Sanfilippo R, Casieri P, Collini P, Dileo P, Spreafico C, Stacchiotti S, Tamborini E, Tercero JC, Jimeno J, D'Incalci M, Gronchi A, Fletcher JA, Pilotti S, Casali PG.Efficacy of trabected
  17586092
• Huang J, Zhao YL, Li Y, Fletcher JA, Xiao S.Genomic and functional evidence for an ARID1A tumor suppressor role.Genes Chromosomes Cancer. 2007 Aug;46(8):745-50.
  17492758
• Bauer S, Duensing A, Demetri GD, Fletcher JA.KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway.Oncogene. 2007 Nov 29;26(54):7560-8.
  17546049
• Nucci MR, Drapkin R, Cin PD, Fletcher CD, Fletcher JA.Distinctive Cytogenetic Profile in Benign Metastasizing Leiomyoma: Pathogenetic Implications.Am J Surg Pathol. 2007 May;31(5):737-743.
  17460458
• Chang BS, Yang T, Cibas ES, Fletcher JA.An in vitro cytologic assay for evaluation of the KIT signaling pathway in gastrointestinal stromal tumors.Mod Pathol. 2007 May;20(5):579-83.
  17396139
• Thomas RK, Baker AC, Debiasi RM, Winckler W, Laframboise T, Lin WM, Wang M, Feng W, Zander T, Macconnaill LE, Lee JC, Nicoletti R, Hatton C, Goyette M, Girard L, Majmudar K, Ziaugra L, Wong KK, Gabriel S, Beroukhim R, Peyton M, Barretina J, Dutt A, Emery
  17392811
• Liu Y, Tseng M, Perdreau SA, Rossi F, Antonescu C, Besmer P, Fletcher JA, Duensing S, Duensing A.Histone H2AX is a mediator of gastrointestinal stromal tumor cell apoptosis following treatment with imatinib mesylate.Cancer Res. 2007 Mar 15;67(6):2685-92.
  17363589
• Li Y, Chang Q, Rubin BP, Fletcher CD, Morgan TW, Mentzer SJ, Sugarbaker DJ, Fletcher JA, Xiao S.Insulin receptor activation in solitary fibrous tumours.J Pathol. 2007 Apr;211(5):550-4.
  17299733
• Thomas RK, Baker AC, Debiasi RM, Winckler W, Laframboise T, Lin WM, Wang M, Feng W, Zander T, MacConaill L, Lee JC, Nicoletti R, Hatton C, Goyette M, Girard L, Majmudar K, Ziaugra L, Wong KK, Gabriel S, Beroukhim R, Peyton M, Barretina J, Dutt A, Emery C,
  17293865
• Fletcher JA, Rubin BP.KIT mutations in GIST.Curr Opin Genet Dev. 2007 Feb;17(1):3-7. Review.
  17208434
• Bauer S, Yu LK, Demetri GD, Fletcher JA.Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor.Cancer Res. 2006 Sep 15;66(18):9153-61.
  16982758
• Heinrich MC, Corless CL, Blanke CD, Demetri GD, Joensuu H, Roberts PJ, Eisenberg BL, von Mehren M, Fletcher CD, Sandau K, McDougall K, Ou WB, Chen CJ, Fletcher JA.Molecular correlates of imatinib resistance in gastrointestinal stromal tumors.J Clin Oncol.
  16954519
• Rezk S, Wheelock L, Fletcher JA, Oliveira AM, Keuker CP, Newburger PE, Xu B, Woda BA, Miron PM.Acute lymphocytic leukemia with eosinophilia and unusual karyotype.Leuk Lymphoma. 2006 Jun;47(6):1176-9.
  16840218
• Rossi S, Ou W, Tang D, Bhattacharya N, Dei Tos A, Fletcher J, Loda M.Gastrointestinal stromal tumours overexpress fatty acid synthase.J Pathol. 2006 Jul;209(3):369-75.
  16583360
• Davis IJ, Kim JJ, Ozsolak F, Widlund HR, Rozenblatt-Rosen O, Granter SR, Du J, Fletcher JA, Denny CT, Lessnick SL, Linehan WM, Kung AL, Fisher DE.Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.Cancer Cell. 200
  16766266
• Heinrich MC, McArthur GA, Demetri GD, Joensuu H, Bono P, Herrmann R, Hirte H, Cresta S, Koslin DB, Corless CL, Dirnhofer S, van Oosterom AT, Nikolova Z, Dimitrijevic S, Fletcher JA.Clinical and molecular studies of the effect of imatinib on advanced aggre
  16505440
• Oliveira AM, Ross JS, Fletcher JA.Tumor suppressor genes in breast cancer: the gatekeepers and the caretakers.Am J Clin Pathol. 2005 Dec;124 Suppl:S16-28. Review.
  16468415
• Brock JE, Perez-Atayde AR, Kozakewich HP, Richkind KE, Fletcher JA, Vargas SO.Cytogenetic aberrations in perineurioma: variation with subtype.Am J Surg Pathol. 2005 Sep;29(9):1164-9.
  16096405
• Li FP, Fletcher JA, Heinrich MC, Garber JE, Sallan SE, Curiel-Lewandrowski C, Duensing A, van de Rijn M, Schnipper LE, Demetri GD.Familial gastrointestinal stromal tumor syndrome: phenotypic and molecular features in a kindred.J Clin Oncol. 2005 Apr 20;23
  15837988
• Labropoulos SV, Fletcher JA, Oliveira AM, Papadopoulos S, Razis ED.Sustained complete remission of metastatic dermatofibrosarcoma protuberans with imatinib mesylate.Anticancer Drugs. 2005 Apr;16(4):461-6.
  15746584
• Oliveira AM, Perez-Atayde AR, Dal Cin P, Gebhardt MC, Chen CJ, Neff JR, Demetri GD, Rosenberg AE, Bridge JA, Fletcher JA.Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD
  15735689
• McArthur GA, Demetri GD, van Oosterom A, Heinrich MC, Debiec-Rychter M, Corless CL, Nikolova Z, Dimitrijevic S, Fletcher JA.Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: Imatinib Target Explorat
  15681532
• Oliveira AM, Perez-Atayde AR, Inwards CY, Medeiros F, Derr V, Hsi BL, Gebhardt MC, Rosenberg AE, Fletcher JA.USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts
  15509545
• Price VE, Fletcher JA, Zielenska M, Cole W, Viero S, Manson DE, Stuart M, Pappo AS.Imatinib mesylate: an attractive alternative in young children with large, surgically challenging dermatofibrosarcoma protuberans.Pediatr Blood Cancer. 2005 May;44(5):511-5
  15503291
• Chen J, Deangelo DJ, Kutok JL, Williams IR, Lee BH, Wadleigh M, Duclos N, Cohen S, Adelsperger J, Okabe R, Coburn A, Galinsky I, Huntly B, Cohen PS, Meyer T, Fabbro D, Roesel J, Banerji L, Griffin JD, Xiao S, Fletcher JA, Stone RM, Gilliland DG.PKC412 inh
  15448205
• Duensing A, Joseph NE, Medeiros F, Smith F, Hornick JL, Heinrich MC, Corless CL, Demetri GD, Fletcher CD, Fletcher JA.Protein Kinase C theta (PKCtheta) expression and constitutive activation in gastrointestinal stromal tumors (GISTs).Cancer Res. 2004 Aug
  15289315
• Medeiros F, Corless CL, Duensing A, Hornick JL, Oliveira AM, Heinrich MC, Fletcher JA, Fletcher CD.KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications.Am J Surg Pathol. 2004 Jul;28(7):889-94.
  15223958
• Fletcher JA.Molecular biology and cytogenetics of soft tissue sarcomas: relevance for targeted therapies.Cancer Treat Res. 2004;120:99-116.
  15217220
• Fletcher JA.Role of KIT and platelet-derived growth factor receptors as oncoproteins.Semin Oncol. 2004 Apr;31(2 Suppl 6):4-11.
  15175998
• Rubin MA, Varambally S, Beroukhim R, Tomlins SA, Rhodes DR, Paris PL, Hofer MD, Storz-Schweizer M, Kuefer R, Fletcher JA, Hsi BL, Byrne JA, Pienta KJ, Collins C, Sellers WR, Chinnaiyan AM.Overexpression, amplification, and androgen regulation of TPD52 in
  15172988
• Panagopoulos I, Storlazzi CT, Fletcher CD, Fletcher JA, Nascimento A, Domanski HA, Wejde J, Brosjö O, Rydholm A, Isaksson M, Mandahl N, Mertens F.The chimeric FUS/CREB3l2 gene is specific for low-grade fibromyxoid sarcoma.Genes Chromosomes Cancer. 2004 Ju
  15139001
• Dahlén A, Fletcher CD, Mertens F, Fletcher JA, Perez-Atayde AR, Hicks MJ, Debiec-Rychter M, Sciot R, Wejde J, Wedin R, Mandahl N, Panagopoulos I.Activation of the GLI oncogene through fusion with the beta-actin gene (ACTB) in a group of distinctive pericy
  15111311
• Oliveira AM, Hsi BL, Weremowicz S, Rosenberg AE, Dal Cin P, Joseph N, Bridge JA, Perez-Atayde AR, Fletcher JA.USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst.Cancer Res. 2004 Mar 15;64(6):1920-3.
  15026324
• Duensing A, Medeiros F, McConarty B, Joseph NE, Panigrahy D, Singer S, Fletcher CD, Demetri GD, Fletcher JA.Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs).Oncogene. 2004 May 13;23(22):3999-4006.
  15007386
• Kemmer K, Corless CL, Fletcher JA, McGreevey L, Haley A, Griffith D, Cummings OW, Wait C, Town A, Heinrich MC.KIT mutations are common in testicular seminomas.Am J Pathol. 2004 Jan;164(1):305-13.
  14695343
• Heinrich MC, Corless CL, Demetri GD, Blanke CD, von Mehren M, Joensuu H, McGreevey LS, Chen CJ, Van den Abbeele AD, Druker BJ, Kiese B, Eisenberg B, Roberts PJ, Singer S, Fletcher CD, Silberman S, Dimitrijevic S, Fletcher JA.Kinase mutations and imatinib
  14645423
• Davis IJ, Hsi BL, Arroyo JD, Vargas SO, Yeh YA, Motyckova G, Valencia P, Perez-Atayde AR, Argani P, Ladanyi M, Fletcher JA, Fisher DE.Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation.Proc Natl Acad Sc
  12719541
• Haralambieva E, Banham AH, Bastard C, Delsol G, Gaulard P, Ott G, Pileri S, Fletcher JA, Mason DY.Detection by the fluorescence in situ hybridization technique of MYC translocations in paraffin-embedded lymphoma biopsy samples.Br J Haematol. 2003 Apr;121(
  12670331
• French CA, Alexander EK, Cibas ES, Nose V, Laguette J, Faquin W, Garber J, Moore F, Fletcher JA, Larsen PR, Kroll TG.Genetic and biological subgroups of low-stage follicular thyroid cancer.Am J Pathol. 2003 Apr;162(4):1053-60.
  12651598
• Armstrong SA, Kung AL, Mabon ME, Silverman LB, Stam RW, Den Boer ML, Pieters R, Kersey JH, Sallan SE, Fletcher JA, Golub TR, Griffin JD, Korsmeyer SJ.Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classif
  12620411
• French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA.BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma.Cancer Res. 2003 Jan 15;63(2):304-7.
  12543779
• Heinrich MC, Corless CL, Duensing A, McGreevey L, Chen CJ, Joseph N, Singer S, Griffith DJ, Haley A, Town A, Demetri GD, Fletcher CD, Fletcher JA.PDGFRA activating mutations in gastrointestinal stromal tumors.Science. 2003 Jan 31;299(5607):708-10.
  12522257
• Chang Q, Li Y, White MF, Fletcher JA, Xiao S.Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: therapeutic implications.Cancer Res. 2002 Nov 1;62(21):6035-8.
  12414625
• Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD, Joen
  12181401
• Heinrich MC, Rubin BP, Longley BJ, Fletcher JA.Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations.Hum Pathol. 2002 May;33(5):484-95.
  12094373
• Vargas SO, Nosé V, Fletcher JA, Perez-Atayde AR.Gains of chromosome 8 are confined to mesenchymal components in pleuropulmonary blastoma.Pediatr Dev Pathol. 2001 Sep-Oct;4(5):434-45.
  11779045
• French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA.BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19).Am J Pathol. 2001 Dec;159(6):1987-92.
  11733348
• Rubin BP, Singer S, Tsao C, Duensing A, Lux ML, Ruiz R, Hibbard MK, Chen CJ, Xiao S, Tuveson DA, Demetri GD, Fletcher CD, Fletcher JA.KIT activation is a ubiquitous feature of gastrointestinal stromal tumors.Cancer Res. 2001 Nov 15;61(22):8118-21.
  11719439
• Vargas SO, French CA, Faul PN, Fletcher JA, Davis IJ, Dal Cin P, Perez-Atayde AR.Upper respiratory tract carcinoma with chromosomal translocation 15;19: evidence for a distinct disease entity of young patients with a rapidly fatal course.Cancer. 2001 Sep
  11571733
• Gisselsson D, Hibbard MK, Dal Cin P, Sciot R, Hsi BL, Kozakewich HP, Fletcher JA.PLAG1 alterations in lipoblastoma: involvement in varied mesenchymal cell types and evidence for alternative oncogenic mechanisms.Am J Pathol. 2001 Sep;159(3):955-62.
  11549588
• Steele-Perkins G, Fang W, Yang XH, Van Gele M, Carling T, Gu J, Buyse IM, Fletcher JA, Liu J, Bronson R, Chadwick RB, de la Chapelle A, Zhang X, Speleman F, Huang S.Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyl
  11544182
• Tuveson DA, Willis NA, Jacks T, Griffin JD, Singer S, Fletcher CD, Fletcher JA, Demetri GD.STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications.Oncogene. 2001 Aug 16;20(36):5054-8.
  11526490
• Argani P, Antonescu CR, Illei PB, Lui MY, Timmons CF, Newbury R, Reuter VE, Garvin AJ, Perez-Atayde AR, Fletcher JA, Beckwith JB, Bridge JA, Ladanyi M.Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: a distinctive tumo
  11438465
• Tuveson DA, Fletcher JA.Signal transduction pathways in sarcoma as targets for therapeutic intervention.Curr Opin Oncol. 2001 Jul;13(4):249-55.
  11429482
• Koontz JI, Soreng AL, Nucci M, Kuo FC, Pauwels P, van Den Berghe H, Cin PD, Fletcher JA, Sklar J.Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors.Proc Natl Acad Sci U S A. 2001 May 22;98(11):6348-53.
  11371647
• Lee C, Gisselsson D, Jin C, Nordgren A, Ferguson DO, Blennow E, Fletcher JA, Morton CC.Limitations of chromosome classification by multicolor karyotyping.Am J Hum Genet. 2001 Apr;68(4):1043-7.
  11222105
• Aguiar RC, Yakushijin Y, Kharbanda S, Salgia R, Fletcher JA, Shipp MA.BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration.Blood. 2000 Dec 15;96(13):4328-34.
  11110709
• Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E.NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.Genes Dev. 2000 Sep 15;14(18):2283-97.
  10995386
• Kroll TG, Sarraf P, Pecciarini L, Chen CJ, Mueller E, Spiegelman BM, Fletcher JA.PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected].Science. 2000 Aug 25;289(5483):1357-60.
  10958784
• Xiao S, McCarthy JG, Aster JC, Fletcher JA.ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain.Blood. 2000 Jul 15;96(2):699-704.
  10887137
• Lux ML, Rubin BP, Biase TL, Chen CJ, Maclure T, Demetri G, Xiao S, Singer S, Fletcher CD, Fletcher JA.KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors.Am J Pathol. 2000 Mar;156(3):791-5.
  10702394
• Morgan JA, Yin Y, Borowsky AD, Kuo F, Nourmand N, Koontz JI, Reynolds C, Soreng L, Griffin CA, Graeme-Cook F, Harris NL, Weisenburger D, Pinkus GS, Fletcher JA, Sklar J.Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymph
  10626814
• Rubin BP, Fletcher JA, Renshaw AA.Clear cell sarcoma of soft parts: report of a case primary in the kidney with cytogenetic confirmation.Am J Surg Pathol. 1999 May;23(5):589-94.
  10328092
• Millis K, Weybright P, Campbell N, Fletcher JA, Fletcher CD, Cory DG, Singer S.Classification of human liposarcoma and lipoma using ex vivo proton NMR spectroscopy.Magn Reson Med. 1999 Feb;41(2):257-67.
  10080272
• Davison JM, Morgan TW, Hsi BL, Xiao S, Fletcher JA.Subtracted, unique-sequence, in situ hybridization: experimental and diagnostic applications.Am J Pathol. 1998 Nov;153(5):1401-9.
  9811331
• Rubin BP, Chen CJ, Morgan TW, Xiao S, Grier HE, Kozakewich HP, Perez-Atayde AR, Fletcher JA.Congenital mesoblastic nephroma t(12;15) is associated with ETV6-NTRK3 gene fusion: cytogenetic and molecular relationship to congenital (infantile) fibrosarcoma.A
  9811336
• Jones D, Ballestas ME, Kaye KM, Gulizia JM, Winters GL, Fletcher J, Scadden DT, Aster JC.Primary-effusion lymphoma and Kaposi's sarcoma in a cardiac-transplant recipient.N Engl J Med. 1998 Aug 13;339(7):444-9.
  9700178
• Xiao S, Nalabolu SR, Aster JC, Ma J, Abruzzo L, Jaffe ES, Stone R, Weissman SM, Hudson TJ, Fletcher JA.FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome.Nat Genet. 1998 Jan;18(1):84-7.
  9425908
• Xiao S, Lux ML, Reeves R, Hudson TJ, Fletcher JA.HMGI(Y) activation by chromosome 6p21 rearrangements in multilineage mesenchymal cells from pulmonary hamartoma.Am J Pathol. 1997 Mar;150(3):901-10.
  9060828
• Tontonoz P, Singer S, Forman BM, Sarraf P, Fletcher JA, Fletcher CD, Brun RP, Mueller E, Altiok S, Oppenheim H, Evans RM, Spiegelman BM.Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor g
  8990192
• Hoffer FA, Chung T, Diller L, Kozakewich H, Fletcher JA, Shamberger RC.Percutaneous biopsy for prognostic testing of neuroblastoma.Radiology. 1996 Jul;200(1):213-6.
  8657913
• Xiao S, Li D, Corson JM, Vijg J, Fletcher JA.Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma.Cancer Res. 1995 Jul 15;55(14):2968-71.
  7606711
• Naeem R, Singer S, Fletcher JA.Translocation t(8;13)(p11;q11-12) in stem cell leukemia/lymphoma of T-cell and myeloid lineages.Genes Chromosomes Cancer. 1995 Feb;12(2):148-51.
  7535088
• Weremowicz S, Kozakewich HP, Haber D, Park S, Morton CC, Fletcher JA.Identification of genetically aberrant cell lineages in Wilms' tumors.Genes Chromosomes Cancer. 1994 May;10(1):40-8.
  7519872
• Fletcher JA, Kozakewich HP, Schoenberg ML, Morton CC.Cytogenetic findings in pediatric adipose tumors: consistent rearrangement of chromosome 8 in lipoblastoma.Genes Chromosomes Cancer. 1993 Jan;6(1):24-9.
  7680218
• Fletcher JA, Pinkus GS, Donovan K, Naeem R, Sugarbaker DJ, Mentzer S, Pinkus JL, Longtine J.Clonal rearrangement of chromosome band 6p21 in the mesenchymal component of pulmonary chondroid hamartoma.Cancer Res. 1992 Nov 15;52(22):6224-8.
  1423265
• Fletcher JA, Pinkus JL, Lage JM, Morton CC, Pinkus GS.Clonal 6p21 rearrangement is restricted to the mesenchymal component of an endometrial polyp.Genes Chromosomes Cancer. 1992 Oct;5(3):260-3.
  1384681
• Fletcher JA, Henkle C, Atkins L, Rosenberg AE, Morton CC.Trisomy 5 and trisomy 7 are nonrandom aberrations in pigmented villonodular synovitis: confirmation of trisomy 7 in uncultured cells.Genes Chromosomes Cancer. 1992 Apr;4(3):264-6.
  1382569
• Fletcher JA, Kozakewich HP, Hoffer FA, Lage JM, Weidner N, Tepper R, Pinkus GS, Morton CC, Corson JM.Diagnostic relevance of clonal cytogenetic aberrations in malignant soft-tissue tumors.N Engl J Med. 1991 Feb 14;324(7):436-42.
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