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Tom A. Rapoport, PhD


  • Bauer BW, Shemesh T, Chen Y, Rapoport TA.A "Push and Slide" Mechanism Allows Sequence-Insensitive Translocation of Secretory Proteins by the SecA ATPase.Cell. 2014 Jun 5;157(6):1416-29.
  • Park E, Rapoport TA.Bacterial protein translocation requires only one copy of the SecY complex in vivo.J Cell Biol. 2012 Sep 3;198(5):881-93.
  • Liu TY, Bian X, Sun S, Hu X, Klemm RW, Prinz WA, Rapoport TA, Hu J.Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion.Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):E2146-54.
  • Bian X, Klemm RW, Liu TY, Zhang M, Sun S, Sui X, Liu X, Rapoport TA, Hu J.Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes.Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):3976-81.
  • Chen X, Tukachinsky H, Huang CH, Jao C, Chu YR, Tang HY, Mueller B, Schulman S, Rapoport TA, Salic A.Processing and turnover of the Hedgehog protein in the endoplasmic reticulum.J Cell Biol. 2011 Mar 7;192(5):825-38.
  • Shibata Y, Shemesh T, Prinz WA, Palazzo AF, Kozlov MM, Rapoport TA.Mechanisms determining the morphology of the peripheral ER.Cell. 2010 Nov 24;143(5):774-88.
  • Rapoport TA.A preliminary report on my life in science.Mol Biol Cell. 2010 Nov 15;21(22):3770-2.
  • Carvalho P, Stanley AM, Rapoport TA.Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p.Cell. 2010 Nov 12;143(4):579-91.
  • Schulman S, Wang B, Li W, Rapoport TA.Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners.Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15027-32.
  • Bauer BW, Rapoport TA.Mapping polypeptide interactions of the SecA ATPase during translocation.Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20800-5.
  • Li W, Schulman S, Dutton RJ, Boyd D, Beckwith J, Rapoport TA.Structure of a bacterial homologue of vitamin K epoxide reductase.Nature. 2010 Jan 28;463(7280):507-12.
  • Zimmer J, Rapoport TA.Conformational flexibility and peptide interaction of the translocation ATPase SecA.J Mol Biol. 2009 Dec 11;394(4):606-12.
  • Rapoport TA.Membrane Shape.Annu Rev Cell Dev Biol. 2009;25:329-54. Review.
  • Hu J, Shibata Y, Zhu PP, Voss C, Rismanchi N, Prinz WA, Rapoport TA, Blackstone C.A class of dynamin-like GTPases involved in the generation of the tubular ER network.Cell. 2009 Aug 7;138(3):549-61.
  • Erlandson KJ,Miller SB,Nam Y,Osborne AR,Zimmer J,Rapoport TA.A role for the two-helix finger of the SecA ATPase in protein translocation.Nature. 2008 Oct 16;455(7215):984-7.
  • Zimmer J,Nam Y,Rapoport TA.Structure of a complex of the ATPase SecA and the protein-translocation channel.Nature. 2008 Oct 16;455(7215):936-43.
  • Rapoport TA.Protein transport across the endoplasmic reticulum membrane.FEBS J. 2008 Sep;275(18):4471-8.
  • Menetret JF,Hegde RS,Aguiar M,Gygi SP,Park E,Rapoport TA,Akey CW.Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome.Structure. 2008 Jul;16(7):1126-37.
  • Shibata Y, Voss C, Rist JM, Hu J, Rapoport TA, Prinz WA, Voeltz GK.The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum.J Biol Chem. 2008 Jul 4;283(27):18892-904.
  • Erlandson KJ, Or E, Osborne AR, Rapoport TA.Analysis of polypeptide movement in the SecY channel during SecA-mediated protein translocation.J Biol Chem. 2008 Jun 6;283(23):15709-15.
  • Goder V, Carvalho P, Rapoport TA.The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p.FEBS Lett. 2008 May 14;582(11):1575-80.
  • Hu J, Shibata Y, Voss C, Shemesh T, Li Z, Coughlin M, Kozlov MM, Rapoport TA, Prinz WA.Membrane proteins of the endoplasmic reticulum induce high-curvature tubules.Science. 2008 Feb 29;319(5867):1247-50.
  • Burton BM, Marquis KA, Sullivan NL, Rapoport TA, Rudner DZ.The ATPase SpoIIIE transports DNA across fused septal membranes during sporulation in Bacillus subtilis.Cell. 2007 Dec 28;131(7):1301-12.
  • Menetret JF, Schaletzky J, Clemons WM Jr, Osborne AR, Skanland SS, Denison C, Gygi SP, Kirkpatrick DS, Park E, Ludtke SJ, Rapoport TA, Akey CW.Ribosome binding of a single copy of the SecY complex: implications for protein translocation.Mol Cell. 2007 Dec 28;28(6):1083-92.
  • Palazzo AF, Springer M, Shibata Y, Lee CS, Dias AP, Rapoport TA.The signal sequence coding region promotes nuclear export of mRNA.PLoS Biol. 2007 Dec;5(12):e322.
  • Rapoport TA.Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.Nature. 2007 Nov 29;450(7170):663-9. Review.
  • Ye J, Cho SH, Fuselier J, Li W, Beckwith J, Rapoport TA.Crystal structure of an unusual thioredoxin protein with a zinc finger domain.J Biol Chem. 2007 Nov 30;282(48):34945-51.
  • Or E, Rapoport T.Cross-linked SecA dimers are not functional in protein translocation.FEBS Lett. 2007 Jun 12;581(14):2616-20.
  • Carvalho P, Goder V, Rapoport TA.Distinct Ubiquitin-Ligase Complexes Define Convergent Pathways for the Degradation of ER Proteins.Cell. 2006 Jul 28;126(2):361-73.
  • Ye J, Osborne AR, Groll M, Rapoport TA.RecA-like motor ATPases--lessons from structures.Biochim Biophys Acta. 2004 Nov 4;1659(1):1-18.
  • Rapoport TA, Goder V, Heinrich SU, Matlack KE.Membrane-protein integration and the role of the translocation channel.Trends Cell Biol. 2004 Oct;14(10):568-75.
  • Ye Y, Shibata Y, Yun C, Ron D, Rapoport TA.A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol.Nature. 2004 Jun 24;429(6994):841-7.
  • Van den Berg B, Clemons WM, Collinson I, Modis Y, Hartmann E, Harrison SC, Rapoport TA.X-ray structure of a protein-conducting channel.Nature. 2004 Jan 1;427(6969):36-44.
  • Tsai B, Gilbert JM, Stehle T, Lencer W, Benjamin TL, Rapoport TA.Gangliosides are receptors for murine polyoma virus and SV40.EMBO J. 2003 Sep 1;22(17):4346-55.
  • Heinrich SU, Rapoport TA.Cooperation of transmembrane segments during the integration of a double-spanning protein into the ER membrane.EMBO J. 2003 Jul 15;22(14):3654-63.
  • Ye Y, Meyer HH, Rapoport TA.Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains.J Cell Biol. 2003 Jul 7;162(1):71-84.