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Robert Haddad, MD

Publications

  • Misiukiewicz KJ, Camille N, Tishler R, Haddad R, Limaye S, Posner M.Organ Preservation for Adenoid Cystic Carcinoma of the Larynx.Oncologist. 2013 Apr 24.
    23615699
  • Limaye SA, Posner MR, Krane JF, Fonfria M, Lorch JH, Dillon DA, Shreenivas AV, Tishler RB, Haddad RI.Trastuzumab for the treatment of salivary duct carcinoma.Oncologist. 2013;18(3):294-300.
    23429737
  • Hanna GJ, Haddad RI, Lorch JH.Induction chemotherapy for locoregionally advanced head and neck cancer: past, present, future?.Oncologist. 2013;18(3):288-93.
    23442306
  • Hanna J, Reimann JD, Haddad RI, Krane JF.Human papillomavirus-associated adenocarcinoma of the base of the tongue.Hum Pathol. 2013 Mar 1.
    23465278
  • Haddad R, O'Neill A, Rabinowits G, Tishler R, Khuri F, Adkins D, Clark J, Sarlis N, Lorch J, Beitler JJ, Limaye S, Riley S, Posner M.Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial.Lancet Oncol. 2013 Mar;14(3):257-64.
    23414589
  • Chau NG, Haddad RI.Vandetanib for the treatment of medullary thyroid cancer.Clin Cancer Res. 2013 Feb 1;19(3):524-9.
    23231950
  • Haigentz M, Kim M, Sarta C, Lin J, Keresztes RS, Culliney B, Gaba AG, Smith RV, Shapiro GI, Chirieac LR, Mariadason JM, Belbin TJ, Greally JM, Wright JJ, Haddad RI.Phase II trial of the histone deacetylase inhibitor romidepsin in patients with recurrent/metastatic head and neck cancer.Oral Oncol. 2012 Dec;48(12):1281-8.
    22748449
  • Shah SM, Drage MG, Lichtman AH, Haddad RI.Metastatic human papillomavirus-positive nasopharyngeal carcinoma with an unusual pattern of aggressive hematogenous spread.J Clin Oncol. 2012 Nov 10;30(32):e321-3.
    23008310
  • Rabinowits G, Haddad RI.Overcoming resistance to EGFR inhibitor in head and neck cancer: A review of the literature.Oral Oncol. 2012 Nov;48(11):1085-9.
    22840785
  • Liang C, Marsit CJ, McClean MD, Nelson HH, Christensen BC, Haddad RI, Clark JR, Wein RO, Grillone GA, Houseman EA, Halec G, Waterboer T, Pawlita M, Krane JF, Kelsey KT.Biomarkers of HPV in Head and Neck Squamous Cell Carcinoma.Cancer Res. 2012 Oct 1;72(19):5004-5013.
    22991304
  • Sher DJ, Posner MR, Tishler RB, Sarlis NJ, Haddad RI, Holupka EJ, Devlin PM.Relationship Between Radiation Treatment Time and Overall Survival After Induction Chemotherapy for Locally Advanced Head-and-Neck Carcinoma: A Subset Analysis of TAX 324.Int J Radiat Oncol Biol Phys. 2011 Feb 10.
    21300455
  • Lorch JH, Goloubeva O, Haddad RI, Cullen K, Sarlis N, Tishler R, Tan M, Fasciano J, Sammartino DE, Posner MR, .Induction chemotherapy with cisplatin and fluorouracil alone or in combination with docetaxel in locally advanced squamous-cell cancer of the head and neck: long-term results of the TAX 324 randomised phase 3 trial.Lancet Oncol. 2011 Feb;12(2):153-9.
    21233014
  • Cooley ME, Emmons KM, Haddad R, Wang Q, Posner M, Bueno R, Cohen TJ, Johnson BE.Patient-reported receipt of and interest in smoking-cessation interventions after a diagnosis of cancer.Cancer. 2011 Jan 10.
    21225877
  • Sher DJ, Balboni TA, Haddad RI, Norris CM, Posner MR, Wirth LJ, Goguen LA, Annino D, Tishler RB.Efficacy and Toxicity of Chemoradiotherapy Using Intensity-Modulated Radiotherapy for Unknown Primary of Head and Neck.Int J Radiat Oncol Biol Phys. 2010 Dec 20.
    21177045
  • Tuttle RM, Ball DW, Byrd D, Dilawari RA, Doherty GM, Duh QY, Ehya H, Farrar WB, Haddad RI, Kandeel F, Kloos RT, Kopp P, Lamonica DM, Loree TR, Lydiatt WM, McCaffrey JC, Olson JA, Parks L, Ridge JA, Shah JP, Sherman SI, Sturgeon C, Waguespack SG, Wang TN, Wirth LJ, .Thyroid carcinoma.J Natl Compr Canc Netw. 2010 Nov;8(11):1228-74.
    21081783
  • Schoenfeld JD, Sher DJ, Norris CM, Haddad RI, Posner MR, Balboni TA, Tishler RB.Salivary Gland Tumors Treated With Adjuvant Intensity-Modulated Radiotherapy With or Without Concurrent Chemotherapy.Int J Radiat Oncol Biol Phys. 2010 Nov 12.
    21075557
  • Sher DJ, Haddad RI, Norris CM, Posner MR, Wirth LJ, Goguen LA, Annino D, Balboni T, Allen A, Tishler RB.Efficacy and toxicity of reirradiation using intensity-modulated radiotherapy for recurrent or second primary head and neck cancer.Cancer. 2010 Oct 15;116(20):4761-8.
    20572036
  • Weidong Lu , Posner MR, Wayne P, Rosenthal DS, Haddad RI.Acupuncture for dysphagia after chemoradiation therapy in head and neck cancer: a case series report.Integr Cancer Ther. 2010 Sep;9(3):284-90.
    20713374
  • Goguen LA, Chapuy CI, Sher DJ, Israel DA, Blinder RA, Norris CM, Tishler RB, Haddad RI, Annino DJ.Utilizing computed tomography as a road map for designing selective and superselective neck dissection after chemoradiotherapy.Otolaryngology Head And Neck Surgery : Official Journal Of American Academy Of Otolaryngology Head And Neck Surgery. 2010 Sep;143(3):367-74.
    20723773
  • Agoston ES, Robinson SJ, Mehra KK, Birch C, Semmel D, Mirkovic J, Haddad RI, Posner MR, Kindelberger D, Krane JF, Brodsky J, Crum CP.Polymerase chain reaction detection of HPV in squamous carcinoma of the oropharynx.Am J Clin Pathol. 2010 Jul;134(1):36-41.
    20551264
  • Robinson BG, Paz-Ares L, Krebs A, Vasselli J, Haddad R.Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer.J Clin Endocrinol Metab. 2010 Jun;95(6):2664-71.
    20371662
  • Tuttle RM, Ball DW, Byrd D, Daniels GH, Dilawari RA, Doherty GM, Duh QY, Ehya H, Farrar WB, Haddad RI, Kandeel F, Kloos RT, Kopp P, Lamonica DM, Loree TR, Lydiatt WM, McCaffrey J, Olson JA, Parks L, Ridge JA, Shah JP, Sherman SI, Sturgeon C, Waguespack SG, Wang TN, Wirth LJ.Medullary carcinoma.J Natl Compr Canc Netw. 2010 May;8(5):512-30.
    20495082
  • Goguen LA, Norris CM, Jaklitsch MT, Sullivan CA, Posner MR, Haddad RI, Tishler RB, Burke E, Annino DJ.Combined antegrade and retrograde esophageal dilation for head and neck cancer-related complete esophageal stenosis.Laryngoscope. 2010 Feb;120(2):261-6.
    19998421
  • Cullen KJ, Schumaker L, Nikitakis N, Goloubeva O, Tan M, Sarlis NJ, Haddad RI, Posner MR.beta-Tubulin-II expression strongly predicts outcome in patients receiving induction chemotherapy for locally advanced squamous carcinoma of the head and neck: a companion analysis of the TAX 324 trial.J Clin Oncol. 2009 Dec 20;27(36):6222-8.
    19917838
  • Haddad RI, Tishler RB, Norris C, Goguen L, Balboni TA, Costello R, Wirth L, Lorch J, Andreozzi B, Annino D, Posner MR.Phase I study of C-TPF in patients with locally advanced squamous cell carcinoma of the head and neck.J Clin Oncol. 2009 Sep 20;27(27):4448-53.
    19704061
  • Haddad R, Sonis S, Posner M, Wirth L, Costello R, Braschayko P, Allen A, Mahadevan A, Flynn J, Burke E, Li Y, Tishler RB.Randomized phase 2 study of concomitant chemoradiotherapy using weekly carboplatin/paclitaxel with or without daily subcutaneous amifostine in patients with locally advanced head and neck cancer.Cancer. 2009 Oct 1;115(19):4514-23.
    19634161
  • Settle K, Posner MR, Schumaker LM, Tan M, Suntharalingam M, Goloubeva O, Strome SE, Haddad RI, Patel SS, Cambell EV, Sarlis N, Lorch J, Cullen KJ.Racial survival disparity in head and neck cancer results from low prevalence of human papillomavirus infection in black oropharyngeal cancer patients.Cancer Prev Res (Phila Pa). 2009 Sep;2(9):776-81.
    19641042
  • Haddad RI.Re: Randomized trial of induction chemotherapy with cisplatin and 5-fluorouracil with or without docetaxel for larynx preservation.Journal of the National Cancer Institute. 2009 Aug 19;101(16):1157-8; author reply 1158.
    19567423
  • Haddad RI, Posner MR.Induction chemotherapy in head and neck cancer.J Clin Oncol. 2009 Aug 10;27(23):e52-3; author reply e54.
    19597015
  • Wirth LJ,Krane JF,Li Y,Othus M,Moran AE,Dorfman DM,Norris CM Jr,Goguen L,Posner MR,Haddad RI,Bertagnolli MM.A pilot surrogate endpoint biomarker study of celecoxib in oral premalignant lesions.Cancer Prev Res (Phila Pa). 2008 Oct;1(5):339-48.
    19138978
  • Lorch JH,Posner MR,Wirth LJ,Haddad RI.Seeking alternative biological therapies: the future of targeted molecular treatment.Oral Oncol. 2009 Apr-May;45(4-5):447-53. Review.
    19027348
  • Lorch JH,Posner MR,Wirth LJ,Haddad RI.Induction chemotherapy in locally advanced head and neck cancer: a new standard of care?.Hematol Oncol Clin North Am. 2008 Dec;22(6):1155-63, viii. Review.
    19010265
  • Caglar HB, Tishler RB, Othus M, Burke E, Li Y, Goguen L, Wirth LJ, Haddad RI, Norris CM, Court LE, Aninno DJ, Posner MR, Allen AM.Dose to Larynx Predicts for Swallowing Complications After Intensity-Modulated Radiotherapy.Int J Radiat Oncol Biol Phys. 2008 Nov 15;72(4):1110-8.
    18468812
  • Sirdah M, Tarazi I, Al Najjar E, Al Haddad R.Evaluation of the diagnostic reliability of different RBC indices and formulas in the differentiation of the beta-thalassaemia minor from iron deficiency in Palestinian population.Int J Lab Hematol. 2008 Aug;30(4):324-330.
    18445163
  • Haddad R, Crum C, Chen Z, Krane J, Posner M, Li Y, Burk R.HPV16 transmission between a couple with HPV-related head and neck cancer.Oral Oncol. 2008 Aug;44(8):812-5.
    18061523
  • Haddad R, Romero R, Gould BR, Tromp G, Gotsch F, Edwin SS, Zingg HH.Angiogenesis gene expression in mouse uterus during the common pathway of parturition.Am J Obstet Gynecol. 2008 May;198(5):539.e1-8.
    18455529
  • Resstel LB, de Andrade CR, Haddad R, Eberlin MN, de Oliveira AM, Correa FM.HYPERHOMOCYSTEINAEMIA-INDUCED CARDIOVASCULAR CHANGES IN RATS.Clin Exp Pharmacol Physiol. 2008 Apr 21.
    18430058
  • Haddad R, Khan R, Takahashi YK, Mori K, Harel D, Sobel N.A metric for odorant comparison.Nat Methods. 2008 May;5(5):425-9.
    18376403
  • Tarazi IS, Sirdah MM, El Jeadi H, Al Haddad RM.Does cigarette smoking affect the diagnostic reliability of hemoglobin alpha 2 delta 2 (HbA2)?.J Clin Lab Anal. 2008;22(2):119-22.
    18348310
  • Pennell NA, Daniels GH, Haddad RI, Ross DS, Evans T, Wirth LJ, Fidias PH, Temel JS, Gurubhagavatula S, Heist RS, Clark JR, Lynch TJ.A Phase II Study of Gefitinib in Patients with Advanced Thyroid Cancer.Thyroid. 2008 Mar;18(3):317-23.
    17985985
  • Haddad R, Milagre HM, Catharino RR, Eberlin MN.Easy ambient sonic-spray ionization mass spectrometry combined with thin-layer chromatography.Anal Chem. 2008 Apr 15;80(8):2744-50.
    18331004
  • Roussan DA, Haddad R, Khawaldeh G.Molecular survey of avian respiratory pathogens in commercial broiler chicken flocks with respiratory diseases in Jordan.Poult Sci. 2008 Mar;87(3):444-8.
    18281569
  • Biselli JM, Goloni-Bertollo EM, Zampieri BL, Haddad R, Eberlin MN, Pavarino-Bertelli EC.Genetic polymorphisms involved in folate metabolism and elevated plasma concentrations of homocysteine: maternal risk factors for Down syndrome in Brazil.Genet Mol Res. 2008;7(1):33-42.
    18273817
  • Haddad R, Carmel L, Sobel N, Harel D.Predicting the receptive range of olfactory receptors.PLoS Comput Biol. 2008 Feb;4(2):e18.
    18248088
  • Haddad R, Annino D, Tishler RB.Multidisciplinary approach to cancer treatment: focus on head and neck cancer.Dent Clin North Am. 2008 Jan;52(1):1-17, vii. Review.
    18154862
  • Posner MR, Haddad RI.Novel agents for the treatment of mucositis.J Support Oncol. 2007 Oct;5(9 Suppl 4):33-9. Review.
    18046996
  • Posner MR, Hershock DM, Blajman CR, Mickiewicz E, Winquist E, Gorbounova V, Tjulandin S, Shin DM, Cullen K, Ervin TJ, Murphy BA, Raez LE, Cohen RB, Spaulding M, Tishler RB, Roth B, Viroglio Rdel C, Venkatesan V, Romanov I, Agarwala S, Harter KW, Dugan M, Cmelak A, Markoe AM, Read PW, Steinbrenner L, Colevas AD, Norris CM Jr, Haddad RI.Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer.N Engl J Med. 2007 Oct 25;357(17):1705-15.
    17960013
  • Chambers MS, Jones CU, Biel MA, Weber RS, Hodge KM, Chen Y, Holland JM, Ship JA, Vitti R, Armstrong I, Garden AS, Haddad R.Open-label, long-term safety study of cevimeline in the treatment of postirradiation xerostomia.Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1369-76.
    17855005
  • Muņoz AA, Haddad RI, Woo SB, Bhattacharyya N.Behavior of oral squamous cell carcinoma in subjects with prior lichen planus.Otolaryngol Head Neck Surg. 2007 Mar;136(3):401-4.
    17321867
  • Allen AM, Haddad RI, Tishler RB.Retropharyngeal nodes in hypopharynx cancer on positron emission tomography.J Clin Oncol. 2007 Feb 10;25(5):599-601.
    17290070
  • Haddad RM, Kennedy CC, Caples SM, Tracz MJ, Boloņa ER, Sideras K, Uraga MV, Erwin PJ, Montori VM.Testosterone and cardiovascular risk in men: a systematic review and meta-analysis of randomized placebo-controlled trials.Mayo Clin Proc. 2007 Jan;82(1):29-39. Review.
    17285783
  • Haddad R, Wirth L, Posner M.Emerging drugs for head and neck cancer.Expert Opin Emerg Drugs. 2006 Sep;11(3):461-7. Review.
    16939385
  • Sonis S, Haddad R, Posner M, Watkins B, Fey E, Morgan TV, Mookanamparambil L, Ramoni M.Gene expression changes in peripheral blood cells provide insight into the biological mechanisms associated with regimen-related toxicities in patients being treated for head and neck cancers.Oral Oncol. 2007 Mar;43(3):289-300.
    16920386
  • Haddad R, Tishler R, Wirth L, Norris CM, Goguen L, Sullivan C, O'Donnell L, Li Y, Posner M.Rate of pathologic complete responses to docetaxel, cisplatin, and fluorouracil induction chemotherapy in patients with squamous cell carcinoma of the head and neck.Arch Otolaryngol Head Neck Surg. 2006 Jun;132(6):678-81.
    16785415
  • Goguen LA, Posner MR, Norris CM, Tishler RB, Wirth LJ, Annino DJ, Gagne A, Sullivan CA, Sammartino DE, Haddad RI.Dysphagia after sequential chemoradiation therapy for advanced head and neck cancer.Otolaryngol Head Neck Surg. 2006 Jun;134(6):916-22.
    16730530
  • Goguen LA, Posner MR, Tishler RB, Wirth LJ, Norris CM, Annino DJ, Sullivan CA, Li Y, Haddad RI.Examining the need for neck dissection in the era of chemoradiation therapy for advanced head and neck cancer.Arch Otolaryngol Head Neck Surg. 2006 May;132(5):526-31.
    16702569
  • Tishler RB, Posner MR, Norris CM, Mahadevan A, Sullivan C, Goguen L, Wirth LJ, Costello R, Case M, Stowell S, Sammartino D, Busse PM, Haddad RI.Concurrent weekly docetaxel and concomitant boost radiation therapy in the treatment of locally advanced squamous cell cancer of the head and neck.Int J Radiat Oncol Biol Phys. 2006 Jul 15;65(4):1036-44.
    16682134
  • Haddad RI, Posner MR, Busse PM, Norris CM, Goguen LA, Wirth LJ, Blinder R, Krane JF, Tishler RB.Chemoradiotherapy for adenoid cystic carcinoma: preliminary results of an organ sparing approach.Am J Clin Oncol. 2006 Apr;29(2):153-7.
    16601434
  • Haddad R.Current and future directions in the treatment of squamous cell carcinoma of the head and neck: multidisciplinary symposium on head and neck cancer.Expert Opin Ther Targets. 2006 Apr;10(2):333-6.
    16548781
  • Haddad R, Allen A, Wirth L, Tishler R, Posner M.Integrating novel agents into the curative treatment of head and neck cancer.Expert Rev Anticancer Ther. 2006 Feb;6(2):157-9.
    16445367
  • Wirth LJ, Haddad RI, Lindeman NI, Zhao X, Lee JC, Joshi VA, Norris CM, Posner MR.Phase I study of gefitinib plus celecoxib in recurrent or metastatic squamous cell carcinoma of the head and neck.J Clin Oncol. 2005 Oct 1;23(28):6976-81.
    16172459
  • Sullivan CA, Haddad RI, Tishler RB, Mahadevan A, Krane JF.Chemoradiation-induced cell loss in human submandibular glands.Laryngoscope. 2005 Jun;115(6):958-64.
    15933500
  • Haddad R, Mahadevan A, Posner MR, Sullivan C.Long term survival with adjuvant carboplatin, paclitaxel, and radiation therapy in anaplastic thyroid cancer.Am J Clin Oncol. 2005 Feb;28(1):104.
    15685044
  • Gokhale AS, Haddad RI, Cavacini LA, Wirth L, Weeks L, Hallar M, Faucher J, Posner MR.Serum concentrations of interleukin-8, vascular endothelial growth factor, and epidermal growth factor receptor in patients with squamous cell cancer of the head and neck.Oral Oncol. 2005 Jan;41(1):70-6.
    15598588