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Mikael J. Pittet, PhD

Publications

  • Cortez-Retamozo V, Engblom C, Pittet MJ.Remote control of macrophage production by cancer.Oncoimmunology. 2013 May 1;2(5):e24183.
    23762799
  • Squadrito ML, Etzrodt M, De Palma M, Pittet MJ.MicroRNA-mediated control of macrophages and its implications for cancer.Trends Immunol. 2013 Mar 12.
    23498847
  • Cortez-Retamozo V, Etzrodt M, Newton A, Ryan R, Pucci F, Sio SW, Kuswanto W, Rauch PJ, Chudnovskiy A, Iwamoto Y, Kohler R, Marinelli B, Gorbatov R, Wojtkiewicz G, Panizzi P, Mino-Kenudson M, Forghani R, Figueiredo JL, Chen JW, Xavier R, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ.Angiotensin II drives the production of tumor-promoting macrophages.Immunity. 2013 Feb 21;38(2):296-308.
    23333075
  • Pucci F, Pittet MJ.Molecular Pathways: Tumor-derived microvesicles and their interactions with immune cells in vivo.Clin Cancer Res. 2013 Feb 20.
    23426276
  • Lau KS, Cortez-Retamozo V, Philips SR, Pittet MJ, Lauffenburger DA, Haigis KM.Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNF-α-Induced Apoptosis in the Intestinal Epithelium.PLoS Biol. 2012 Sep;10(9):e1001393.
    23055830
  • Etzrodt M, Cortez-Retamozo V, Newton A, Zhao J, Ng A, Wildgruber M, Romero P, Wurdinger T, Xavier R, Geissmann F, Meylan E, Nahrendorf M, Swirski FK, Baltimore D, Weissleder R, Pittet MJ.Regulation of monocyte functional heterogeneity by miR-146a and Relb.Cell Rep. 2012 Apr 19;1(4):317-24.
    22545247
  • Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HW, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M.Myocardial infarction accelerates atherosclerosis.Nature. 2012 Jul 19;487(7407):325-9.
    22763456
  • Cortez-Retamozo V, Etzrodt M, Pittet MJ.Regulation of Macrophage and Dendritic Cell Responses by Their Lineage Precursors.Journal Of Innate Immunity. 2012 Mar 16.
    22433183
  • Cortez-Retamozo V, Etzrodt M, Newton A, Rauch PJ, Chudnovskiy A, Berger C, Ryan RJ, Iwamoto Y, Marinelli B, Gorbatov R, Forghani R, Novobrantseva TI, Koteliansky V, Figueiredo JL, Chen JW, Anderson DG, Nahrendorf M, Swirski FK, Weissleder R, Pittet MJ.Origins of tumor-associated macrophages and neutrophils.Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2491-6.
    22308361
  • Rauch PJ, Chudnovskiy A, Robbins CS, Weber GF, Etzrodt M, Hilgendorf I, Tiglao E, Figueiredo JL, Iwamoto Y, Theurl I, Gorbatov R, Waring MT, Chicoine AT, Mouded M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK.Innate response activator B cells protect against microbial sepsis.Science. 2012 Feb 3;335(6068):597-601.
    22245738
  • Robbins CS, Chudnovskiy A, Rauch PJ, Figueiredo JL, Iwamoto Y, Gorbatov R, Etzrodt M, Weber GF, Ueno T, van Rooijen N, Mulligan-Kehoe MJ, Libby P, Nahrendorf M, Pittet MJ, Weissleder R, Swirski FK.Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions.Circulation. 2012 Jan 17;125(2):364-74.
    22144566
  • Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW, Dutta P, Wei Y, Robbins C, Iwamoto Y, Sena B, Chudnovskiy A, Panizzi P, Keliher E, Higgins JM, Libby P, Moskowitz MA, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M.Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis.J Exp Med. 2012 Jan 16;209(1):123-37.
    22213805
  • Lee WW, Marinelli B, van der Laan AM, Sena BF, Gorbatov R, Leuschner F, Dutta P, Iwamoto Y, Ueno T, Begieneman MP, Niessen HW, Piek JJ, Vinegoni C, Pittet MJ, Swirski FK, Tawakol A, Di Carli M, Weissleder R, Nahrendorf M.PET/MRI of inflammation in myocardial infarction.J Am Coll Cardiol. 2012 Jan 10;59(2):153-63.
    22222080
  • Keliher EJ, Yoo J, Nahrendorf M, Lewis JS, Marinelli B, Newton A, Pittet MJ, Weissleder R.89Zr-labeled dextran nanoparticles allow in vivo macrophage imaging.Bioconjug Chem. 2011 Dec 21;22(12):2383-9.
    22035047
  • Pittet MJ, Weissleder R.Intravital imaging.Cell. 2011 Nov 23;147(5):983-91. Review.
    22118457
  • Leuschner F, Dutta P, Gorbatov R, Novobrantseva TI, Donahoe JS, Courties G, Lee KM, Kim JI, Markmann JF, Marinelli B, Panizzi P, Lee WW, Iwamoto Y, Milstein S, Epstein-Barash H, Cantley W, Wong J, Cortez-Retamozo V, Newton A, Love K, Libby P, Pittet MJ, Swirski FK, Koteliansky V, Langer R, Weissleder R, Anderson DG, Nahrendorf M.Therapeutic siRNA silencing in inflammatory monocytes in mice.Nat Biotechnol. 2011 Oct 9.
    21983520
  • Pittet MJ, Swirski FK.Monocytes link atherosclerosis and cancer.Eur J Immunol. 2011 Sep;41(9):2519-22.
    21952809
  • Panizzi P, Nahrendorf M, Figueiredo JL, Panizzi J, Marinelli B, Iwamoto Y, Keliher E, Maddur AA, Waterman P, Kroh HK, Leuschner F, Aikawa E, Swirski FK, Pittet MJ, Hackeng TM, Fuentes-Prior P, Schneewind O, Bock PE, Weissleder R.In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation.Nat Med. 2011 Sep;17(9):1142-6.
    21857652
  • Da Silva N, Cortez-Retamozo V, Reinecker HC, Wildgruber M, Hill E, Brown D, Swirski FK, Pittet MJ, Breton S.A dense network of dendritic cells populates the murine epididymis.Reproduction. 2011 May;141(5):653-63.
    21310816
  • Nahrendorf M, Keliher E, Marinelli B, Leuschner F, Robbins CS, Gerszten RE, Pittet MJ, Swirski FK, Weissleder R.Detection of macrophages in aortic aneurysms by nanoparticle positron emission tomography-computed tomography.Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):750-7.
    21252070
  • Xia Y, Cortez-Retamozo V, Niederkofler V, Salie R, Chen S, Samad TA, Hong CC, Arber S, Vyas JM, Weissleder R, Pittet MJ, Lin HY.Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages.J Immunol. 2011 Feb 1;186(3):1369-76.
    21187450
  • Issadore D, Shao H, Chung J, Newton A, Pittet M, Weissleder R, Lee H.Self-assembled magnetic filter for highly efficient immunomagnetic separation.Lab Chip. 2011 Jan 7;11(1):147-51.
    20949198
  • Leuschner F, Panizzi P, Chico-Calero I, Lee WW, Ueno T, Cortez-Retamozo V, Waterman P, Gorbatov R, Marinelli B, Iwamoto Y, Chudnovskiy A, Figueiredo JL, Sosnovik DE, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M.Angiotensin-Converting Enzyme Inhibition Prevents the Release of Monocytes From Their Splenic Reservoir in Mice With Myocardial Infarction.Circ Res. 2010 Oct 7.
    20930148
  • Swirski FK, Wildgruber M, Ueno T, Figueiredo JL, Panizzi P, Iwamoto Y, Zhang E, Stone JR, Rodriguez E, Chen JW, Pittet MJ, Weissleder R, Nahrendorf M.Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice.J Clin Invest. 2010 Jul 1;120(7):2627-34.
    20577051
  • Nahrendorf M, Pittet MJ, Swirski FK.Monocytes: protagonists of infarct inflammation and repair after myocardial infarction.Circulation. 2010 Jun 8;121(22):2437-45. Review.
    20530020
  • Nahrendorf M, Keliher E, Marinelli B, Waterman P, Feruglio PF, Fexon L, Pivovarov M, Swirski FK, Pittet MJ, Vinegoni C, Weissleder R.Hybrid PET-optical imaging using targeted probes.Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7910-5.
    20385821
  • Panizzi P, Swirski FK, Figueiredo JL, Waterman P, Sosnovik DE, Aikawa E, Libby P, Pittet M, Weissleder R, Nahrendorf M.Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis.J Am Coll Cardiol. 2010 Apr 13;55(15):1629-38.
    20378083
  • Vinegoni C, Fumene Feruglio P, Cortez-Retamozo V, Razansky D, Medoff BD, Ntziachristos V, Sbarbati A, Pittet M, Weissleder R.Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography.Opt Lett. 2010 Apr 1;35(7):1088-90.
    20364226
  • Swirski FK,Weissleder R,Pittet MJ.Heterogeneous In Vivo Behavior of Monocyte Subsets in Atherosclerosis.Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1424-32. Review.
    19372462
  • Nahrendorf M, Waterman P, Thurber G, Groves K, Rajopadhye M, Panizzi P, Marinelli B, Aikawa E, Pittet MJ, Swirski FK, Weissleder R.Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors.Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1444-51.
    19608968
  • Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ.Identification of splenic reservoir monocytes and their deployment to inflammatory sites.Science. 2009 Jul 31;325(5940):612-6.
    19644120
  • Wildgruber M,Lee H,Chudnovskiy A,Yoon TJ,Etzrodt M,Pittet MJ,Nahrendorf M,Croce K,Libby P,Weissleder R,Swirski FK.Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors.PLoS ONE. 2009;4(5):e5663.
    19461894
  • Leimgruber A,Berger C,Cortez-Retamozo V,Etzrodt M,Newton AP,Waterman P,Figueiredo JL,Kohler RH,Elpek N,Mempel TR,Swirski FK,Nahrendorf M,Weissleder R,Pittet MJ.Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle.Neoplasia. 2009 May;11(5):459-68, 2 p following 468.
    19412430
  • Pittet MJ.Behavior of immune players in the tumor microenvironment.Curr Opin Oncol. 2009 Jan;21(1):53-9. Review.
    19125019
  • Cortez-Retamozo V,Swirski FK,Waterman P,Yuan H,Figueiredo JL,Newton AP,Upadhyay R,Vinegoni C,Kohler R,Blois J,Smith A,Nahrendorf M,Josephson L,Weissleder R,Pittet MJ.Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation.J Clin Invest. 2008 Dec;118(12):4058-66.
    19033674
  • Libby P,Nahrendorf M,Pittet MJ,Swirski FK.Diversity of denizens of the atherosclerotic plaque: not all monocytes are created equal.Circulation. 2008 Jun 24;117(25):3168-70. Review.
    18574058
  • Shaw SY,Westly EC,Pittet MJ,Subramanian A,Schreiber SL,Weissleder R.Perturbational profiling of nanomaterial biologic activity.Proc Natl Acad Sci U S A. 2008 May 27;105(21):7387-92.
    18492802
  • Magnusson FC,Liblau RS,von Boehmer H,Pittet MJ,Lee JW,Turley SJ,Khazaie K.Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity.Gastroenterology. 2008 Apr;134(4):1028-37.
    18395084
  • Weissleder R, Pittet MJ.Imaging in the era of molecular oncology.Nature. 2008 Apr 3;452(7187):580-9. Review.
    18385732
  • Pittet MJ, Mempel TR.Regulation of T-cell migration and effector functions: insights from in vivo imaging studies.Immunol Rev. 2008 Feb;221:107-29. Review.
    18275478
  • Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ.The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.J Exp Med. 2007 Nov 26;204(12):3037-47.
    18025128
  • Swirski FK, Berger CR, Figueiredo JL, Mempel TR, von Andrian UH, Pittet MJ, Weissleder R.A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses.PLoS ONE. 2007;2(10):e1075.
    17957257
  • Tam JM, Upadhyay R, Pittet MJ, Weissleder R, Mahmood U.Improved in vivo whole-animal detection limits of green fluorescent protein-expressing tumor lines by spectral fluorescence imaging.Mol Imaging. 2007 Jul-Aug;6(4):269-76.
    17711782
  • Pittet MJ, Grimm J, Berger CR, Tamura T, Wojtkiewicz G, Nahrendorf M, Romero P, Swirski FK, Weissleder R.In vivo imaging of T cell delivery to tumors after adoptive transfer therapy.Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12457-61.
    17640914
  • Pittet MJ, Swirski FK, Reynolds F, Josephson L, Weissleder R.Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles.Nat Protoc. 2006;1(1):73-9.
    17406214
  • Nahrendorf M, Sosnovik DE, Waterman P, Swirski FK, Pande AN, Aikawa E, Figueiredo JL, Pittet MJ, Weissleder R.Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct.Circ Res. 2007 Apr 27;100(8):1218-25.
    17379832
  • Romero P, Zippelius A, Kurth I, Pittet MJ, Touvrey C, Iancu EM, Corthesy P, Devevre E, Speiser DE, Rufer N.Four functionally distinct populations of human effector-memory CD8+ T lymphocytes.J Immunol. 2007 Apr 1;178(7):4112-9.
    17371966
  • Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, Pittet MJ.Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata.J Clin Invest. 2007 Jan;117(1):195-205.
    17200719
  • Mempel TR, Pittet MJ, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Andrian UH.Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation.Immunity. 2006 Jul;25(1):129-41.
    16860762
  • Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R.Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease.Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10340-5.
    16801531
  • Tréhin R, Figueiredo JL, Pittet MJ, Weissleder R, Josephson L, Mahmood U.Fluorescent nanoparticle uptake for brain tumor visualization.Neoplasia. 2006 Apr;8(4):302-11.
    16756722
  • Pittet MJ, Gati A, Le Gal FA, Bioley G, Guillaume P, de Smedt M, Plum J, Speiser DE, Cerottini JC, Dietrich PY, Romero P, Zippelius A.Ex vivo characterization of allo-MHC-restricted T cells specific for a single MHC-peptide complex.J Immunol. 2006 Feb 15;176(4):2330-6.
    16455990
  • Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K.Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo.Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):419-24.
    15623559
  • Meidenbauer N,Zippelius A,Pittet MJ,Laumer M,Vogl S,Heymann J,Rehli M,Seliger B,Schwarz S,Le Gal FA,Dietrich PY,Andreesen R,Romero P,Mackensen A.High frequency of functionally active Melan-a-specific T cells in a patient with progressive immunoproteasome-deficient melanoma.Cancer Res. 2004 Sep 1;64(17):6319-26.
    15342421
  • Speiser DE,Pittet MJ,Guillaume P,Lubenow N,Hoffman E,Cerottini JC,Romero P.Ex vivo analysis of human antigen-specific CD8+ T-cell responses: quality assessment of fluorescent HLA-A2 multimer and interferon-gamma ELISPOT assays for patient immune monitoring.J Immunother. 2004 Jul-Aug;27(4):298-308.
    15235391
  • Liénard D, Rimoldi D, Marchand M, Dietrich PY, van Baren N, Geldhof C, Batard P, Guillaume P, Ayyoub M, Pittet MJ, Zippelius A, Fleischhauer K, Lejeune F, Cerottini JC, Romero P, Speiser DE.Ex vivo detectable activation of Melan-A-specific T cells correlating with inflammatory skin reactions in melanoma patients vaccinated with peptides in IFA.Cancer Immun. 2004 May 19;4:4.
    15149168
  • Zippelius A, Batard P, Rubio-Godoy V, Bioley G, Liénard D, Lejeune F, Rimoldi D, Guillaume P, Meidenbauer N, Mackensen A, Rufer N, Lubenow N, Speiser D, Cerottini JC, Romero P, Pittet MJ.Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance.Cancer Res. 2004 Apr 15;64(8):2865-73.
    15087405
  • Movassagh M, Spatz A, Davoust J, Lebecque S, Romero P, Pittet M, Rimoldi D, Liénard D, Gugerli O, Ferradini L, Robert C, Avril MF, Zitvogel L, Angevin E.Selective accumulation of mature DC-Lamp+ dendritic cells in tumor sites is associated with efficient T-cell-mediated antitumor response and control of metastatic dissemination in melanoma.Cancer Res. 2004 Mar 15;64(6):2192-8.
    15026362
  • Speiser DE, Pittet MJ, Rimoldi D, Guillaume P, Luescher IF, Liénard D, Lejeune F, Cerottini JC, Romero P.Evaluation of melanoma vaccines with molecularly defined antigens by ex vivo monitoring of tumor-specific T cells.Semin Cancer Biol. 2003 Dec;13(6):461-72.
    15001165
  • Zippelius A, Bioley G, Le Gal FA, Rufer N, Brandes M, Batard P, De Smedt M, Plum J, Speiser DE, Cerottini JC, Dietrich PY, Romero P, Pittet MJ.Human thymus exports naive CD8 T cells that can home to nonlymphoid tissues.J Immunol. 2004 Mar 1;172(5):2773-7.
    14978076
  • Pittet MJ, Rubio-Godoy V, Bioley G, Guillaume P, Batard P, Speiser D, Luescher I, Cerottini JC, Romero P, Zippelius A.Alpha 3 domain mutants of peptide/MHC class I multimers allow the selective isolation of high avidity tumor-reactive CD8 T cells.J Immunol. 2003 Aug 15;171(4):1844-9.
    12902485
  • Rufer N, Zippelius A, Batard P, Pittet MJ, Kurth I, Corthesy P, Cerottini JC, Leyvraz S, Roosnek E, Nabholz M, Romero P.Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions.Blood. 2003 Sep 1;102(5):1779-87.
    12750165
  • Dietrich PY, Le Gal FA, Dutoit V, Pittet MJ, Trautman L, Zippelius A, Cognet I, Widmer V, Walker PR, Michielin O, Guillaume P, Connerotte T, Jotereau F, Coulie PG, Romero P, Cerottini JC, Bonneville M, Valmori D.Prevalent role of TCR alpha-chain in the selection of the preimmune repertoire specific for a human tumor-associated self-antigen.J Immunol. 2003 May 15;170(10):5103-9.
    12734356
  • Ayyoub M, Zippelius A, Pittet MJ, Rimoldi D, Valmori D, Cerottini JC, Romero P, Lejeune F, Liénard D, Speiser DE.Activation of human melanoma reactive CD8+ T cells by vaccination with an immunogenic peptide analog derived from Melan-A/melanoma antigen recognized by T cells-1.Clin Cancer Res. 2003 Feb;9(2):669-77.
    12576434
  • Schnyder B, Lahm H, Pittet M, Schnyder-Candrian S.Mono- or dual-phosphorylation of akt kinase is regulated by distinct receptors that involve the common insulin receptor substrate.J Recept Signal Transduct Res. 2002 Feb-Nov;22(1-4):213-28.
    12503617
  • Romero P, Pittet M, Dutoit V, Zippelius A, Liénard D, Lejeune F, Guillaume P, Rimoldi D, Valmori D, Speiser DE, Cerottini JC.Therapeutic cancer vaccines based on molecularly defined human tumor antigens.Vaccine. 2002 Dec 19;20 Suppl 4:A2-7.
    12477422
  • Romero P, Valmori D, Pittet MJ, Zippelius A, Rimoldi D, Lévy F, Dutoit V, Ayyoub M, Rubio-Godoy V, Michielin O, Guillaume P, Batard P, Luescher IF, Lejeune F, Liénard D, Rufer N, Dietrich PY, Speiser DE, Cerottini JC.Antigenicity and immunogenicity of Melan-A/MART-1 derived peptides as targets for tumor reactive CTL in human melanoma.Immunol Rev. 2002 Oct;188:81-96.
    12445283
  • Dutoit V, Rubio-Godoy V, Pittet MJ, Zippelius A, Dietrich PY, Legal FA, Guillaume P, Romero P, Cerottini JC, Houghten RA, Pinilla C, Valmori D.Degeneracy of antigen recognition as the molecular basis for the high frequency of naive A2/Melan-a peptide multimer(+) CD8(+) T cells in humans.J Exp Med. 2002 Jul 15;196(2):207-16.
    12119345
  • Pittet MJ, Zippelius A, Valmori D, Speiser DE, Cerottini JC, Romero P.Melan-A/MART-1-specific CD8 T cells: from thymus to tumor.Trends Immunol. 2002 Jul;23(7):325-8.
    12103339
  • Valmori D, Dutoit V, Schnuriger V, Quiquerez AL, Pittet MJ, Guillaume P, Rubio-Godoy V, Walker PR, Rimoldi D, Liénard D, Cerottini JC, Romero P, Dietrich PY.Vaccination with a Melan-A peptide selects an oligoclonal T cell population with increased functional avidity and tumor reactivity.J Immunol. 2002 Apr 15;168(8):4231-40.
    11937585
  • Speiser DE, Liénard D, Pittet MJ, Batard P, Rimoldi D, Guillaume P, Cerottini JC, Romero P.In vivo activation of melanoma-specific CD8(+) T cells by endogenous tumor antigen and peptide vaccines. A comparison to virus-specific T cells.Eur J Immunol. 2002 Mar;32(3):731-41.
    11870617
  • Kerre TC, De Smet G, De Smedt M, Zippelius A, Pittet MJ, Langerak AW, De Bosscher J, Offner F, Vandekerckhove B, Plum J.Adapted NOD/SCID model supports development of phenotypically and functionally mature T cells from human umbilical cord blood CD34(+) cells.Blood. 2002 Mar 1;99(5):1620-6.
    11861276
  • Zippelius A, Pittet MJ, Batard P, Rufer N, de Smedt M, Guillaume P, Ellefsen K, Valmori D, Liénard D, Plum J, MacDonald HR, Speiser DE, Cerottini JC, Romero P.Thymic selection generates a large T cell pool recognizing a self-peptide in humans.J Exp Med. 2002 Feb 18;195(4):485-94.
    11854361
  • Speiser DE, Colonna M, Ayyoub M, Cella M, Pittet MJ, Batard P, Valmori D, Guillaume P, Liénard D, Cerottini JC, Romero P.The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells.J Immunol. 2001 Dec 1;167(11):6165-70.
    11714776
  • Pittet MJ, Speiser DE, Valmori D, Rimoldi D, Liénard D, Lejeune F, Cerottini JC, Romero P.Ex vivo analysis of tumor antigen specific CD8+ T cell responses using MHC/peptide tetramers in cancer patients.Int Immunopharmacol. 2001 Jul;1(7):1235-47.
    11460305
  • Pittet MJ, Zippelius A, Speiser DE, Assenmacher M, Guillaume P, Valmori D, Liénard D, Lejeune F, Cerottini JC, Romero P.Ex vivo IFN-gamma secretion by circulating CD8 T lymphocytes: implications of a novel approach for T cell monitoring in infectious and malignant diseases.J Immunol. 2001 Jun 15;166(12):7634-40.
    11390521
  • Pittet MJ, Speiser DE, Liénard D, Valmori D, Guillaume P, Dutoit V, Rimoldi D, Lejeune F, Cerottini JC, Romero P.Expansion and functional maturation of human tumor antigen-specific CD8+ T cells after vaccination with antigenic peptide.Clin Cancer Res. 2001 Mar;7(3 Suppl):796s-803s.
    11300475
  • Speiser DE, Migliaccio M, Pittet MJ, Valmori D, Liénard D, Lejeune F, Reichenbach P, Guillaume P, Lüscher I, Cerottini JC, Romero P.Human CD8(+) T cells expressing HLA-DR and CD28 show telomerase activity and are distinct from cytolytic effector T cells.Eur J Immunol. 2001 Feb;31(2):459-66.
    11180110
  • Valmori D, Dutoit V, Liénard D, Rimoldi D, Pittet MJ, Champagne P, Ellefsen K, Sahin U, Speiser D, Lejeune F, Cerottini JC, Romero P.Naturally occurring human lymphocyte antigen-A2 restricted CD8+ T-cell response to the cancer testis antigen NY-ESO-1 in melanoma patients.Cancer Res. 2000 Aug 15;60(16):4499-506.
    10969798
  • Romero P, Pittet MJ, Valmori D, Speiser DE, Cerundolo V, Liénard D, Lejeune F, Cerottini JC.Immune monitoring in cancer immunotherapy.Ernst Schering Res Found Workshop. 2000(30):75-97.
    10943317
  • Pittet MJ, Speiser DE, Valmori D, Cerottini JC, Romero P.Cutting edge: cytolytic effector function in human circulating CD8+ T cells closely correlates with CD56 surface expression.J Immunol. 2000 Feb 1;164(3):1148-52.
    10640724
  • Speiser DE, Pittet MJ, Valmori D, Dunbar R, Rimoldi D, Liénard D, MacDonald HR, Cerottini JC, Cerundolo V, Romero P.In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes.J Exp Med. 1999 Sep 20;190(6):775-82.
    10499916
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