Kevin M. Haigis, PhD

Publications

• Lau KS, Juchheim AM, Cavaliere KR, Philips SR, Lauffenburger DA, Haigis KM.In Vivo Systems Analysis Identifies Spatial and Temporal Aspects of the Modulation of TNF-{alpha}-Induced Apoptosis and Proliferation by MAPKs.Sci Signal. 2011;4(165):ra16.
  21427409
• Haigis KM, Sweet-Cordero A.New insights into oncogenic stress.Nat Genet. 2011 Mar;43(3):177-8.
  21350495
• Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K.Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.Blood. 2011 Feb 10;117(6):2022-32.
  21163920
• Tanaka N, Huttenhower C, Nosho K, Baba Y, Shima K, Quackenbush J, Haigis KM, Giovannucci E, Fuchs CS, Ogino S.Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer.Am J Pathol. 2
  21037082
• Irahara N, Baba Y, Nosho K, Shima K, Yan L, Dias-Santagata D, Iafrate AJ, Fuchs CS, Haigis KM, Ogino S.NRAS mutations are rare in colorectal cancer.Diagn Mol Pathol. 2010 Sep;19(3):157-63.
  20736745
• Kreeger PK, Wang Y, Haigis KM, Lauffenburger DA.Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation.Integr Biol (Camb). 2010 Apr 7;2(4):202-8.
  20473400
• Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, Jeffords LB, Sodha P, Mercer KL, Cohen R, Takeuchi O, Korsmeyer SJ, Bronson RT, Kim CF, Haigis KM, Jain RK, Jacks T.p53 controls radiation-induced gastrointestinal syndrome in mice indepe
  20019247
• Lau KS, Haigis KM.Non-redundancy within the RAS oncogene family: insights into mutational disparities in cancer.Mol Cells. 2009 Oct;28(4):315-20. Review.
  19812895
• Kreeger PK, Mandhana R, Alford SK, Haigis KM, Lauffenburger DA.RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.Cancer Res.
  19789336
• Matharu KS, Mizoguchi E, Cotoner CA, Nguyen DD, Mingle B, Iweala OI, McBee ME, Stefka AT, Prioult G, Haigis KM, Bhan AK, Snapper SB, Murakami H, Schauer DB, Reinecker HC, Mizoguchi A, Nagler CR.Toll-like receptor 4-mediated regulation of spontaneous Helic
  19596011
• Morris EJ,Ji JY,Yang F,Di Stefano L,Herr A,Moon NS,Kwon EJ,Haigis KM,Naar AM,Dyson NJ.E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8.Nature. 2008 Sep 25;455(7212):552-6.
  18794899
• Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T.Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tum
  18372904
• Kissil JL, Walmsley MJ, Hanlon L, Haigis KM, Bender Kim CF, Sweet-Cordero A, Eckman MS, Tuveson DA, Capobianco AJ, Tybulewicz VL, Jacks T.Requirement for Rac1 in a K-ras induced lung cancer in the mouse.Cancer Res. 2007 Sep 1;67(17):8089-94.
  17804720
• Poutahidis T, Haigis KM, Rao VP, Nambiar PR, Taylor CL, Ge Z, Watanabe K, Davidson A, Horwitz BH, Fox JG, Erdman SE.Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma.Carcinogenesis. 2007
  17724375
• Kwong LN, Weiss KR, Haigis KM, Dove WF.Atm is a negative regulator of intestinal neoplasia.Oncogene. 2008 Feb 7;27(7):1013-8.
  17700532
• Kaiser S, Park YK, Franklin JL, Halberg RB, Yu M, Jessen WJ, Freudenberg J, Chen X, Haigis K, Jegga AG, Kong S, Sakthivel B, Xu H, Reichling T, Azhar M, Boivin GP, Roberts RB, Bissahoyo AC, Gonzales F, Bloom GC, Eschrich S, Carter SL, Aronow JE, Kleimeyer
  17615082
• Keller JW, Haigis KM, Franklin JL, Whitehead RH, Jacks T, Coffey RJ.Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex.Oncogene. 2007 May 10;26(21):3051-9.
  17130841
• Haigis K, Sage J, Glickman J, Shafer S, Jacks T.The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium.J Biol Chem. 2006 Jan 6;281(1):638-47.
  16258171
• Haigis KM, Hoff PD, White A, Shoemaker AR, Halberg RB, Dove WF.Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function.Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9769-73.
  15210940