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Kevin M. Haigis, PhD

Publications

  • Imamura Y, Lochhead P, Yamauchi M, Kuchiba A, Qian ZR, Liao X, Nishihara R, Jung S, Wu K, Nosho K, Wang YE, Peng S, Bass AJ, Haigis KM, Meyerhardt JA, Chan AT, Fuchs CS, Ogino S.Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review.Mol Cancer. 2014;13(1):135.
    24885062
  • Gierut JJ, Jacks TE, Haigis KM.Strategies to achieve conditional gene mutation in mice.Cold Spring Harb Protoc. 2014;2014(4).
    24692485
  • Gierut JJ, Jacks TE, Haigis KM.Whole-mount x-gal staining of mouse tissues.Cold Spring Harb Protoc. 2014;2014(4).
    24692489
  • Russo AL, Ryan DP, Borger DR, Wo JY, Szymonifka J, Liang WY, Kwak EL, Blaszkowsky LS, Clark JW, Allen JN, Zhu AX, Berger DL, Cusack JC, Mamon HJ, Haigis KM, Hong TS.Mutational and clinical predictors of pathologic complete response in the treatment of locally advanced rectal cancer.J Gastrointest Cancer. 2014 Mar;45(1):34-9.
    24006244
  • Gierut JJ, Jacks TE, Haigis KM.Producing and concentrating lenti-Cre for mouse infections.Cold Spring Harb Protoc. 2014 Mar;2014(3):304-6.
    24591688
  • Gierut JJ, Jacks TE, Haigis KM.In vivo delivery of lenti-Cre or adeno-Cre into mice using intranasal instillation.Cold Spring Harb Protoc. 2014 Mar;2014(3):307-9.
    24591689
  • Russo AL, Borger DR, Szymonifka J, Ryan DP, Wo JY, Blaszkowsky LS, Kwak EL, Allen JN, Wadlow RC, Zhu AX, Murphy JE, Faris JE, Dias-Santagata D, Haigis KM, Ellisen LW, Iafrate AJ, Hong TS.Mutational analysis and clinical correlation of metastatic colorectal cancer.Cancer. 2014 Feb 5.
    24500602
  • Kleiman LB, Krebs AM, Kim SY, Hong TS, Haigis KM.Comparative analysis of radiosensitizers for K-RAS mutant rectal cancers.PLoS ONE. 2013;8(12):e82982.
    24349411
  • Lau KS, Schrier SB, Gierut J, Lyons J, Lauffenburger DA, Haigis KM.Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α.Integr Biol (Camb). 2013 Nov;5(11):1355-65.
    24084984
  • Yang MH, Laurent G, Bause AS, Spang R, German N, Haigis MC, Haigis KM.HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS.Mol Cancer Res. 2013 Sep;11(9):1072-7.
    23723075
  • Xu J, Haigis KM, Firestone AJ, McNerney ME, Li Q, Davis E, Chen SC, Nakitandwe J, Downing J, Jacks T, Le Beau MM, Shannon K.Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation.Cancer Discovery. 2013 Sep;3(9):993-1001.
    23733505
  • Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM.Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice.Integr Biol (Camb). 2013 Jul 24;5(7):940-63.
    23685806
  • Wang Y, Velho S, Vakiani E, Peng S, Bass AJ, Chu GC, Gierut J, Bugni JM, Der CJ, Philips M, Solit DB, Haigis KM.Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression.Cancer Discovery. 2013 Mar;3(3):294-307.
    23274911
  • Mitra D, Luo X, Morgan A, Wang J, Hoang MP, Lo J, Guerrero CR, Lennerz JK, Mihm MC, Wargo JA, Robinson KC, Devi SP, Vanover JC, D'Orazio JA, McMahon M, Bosenberg MW, Haigis KM, Haber DA, Wang Y, Fisher DE.An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background.Nature. 2012 Nov 15;491(7424):449-53.
    23123854
  • Imamura Y, Morikawa T, Liao X, Lochhead P, Kuchiba A, Yamauchi M, Qian ZR, Nishihara R, Meyerhardt JA, Haigis KM, Fuchs CS, Ogino S.Specific mutations in KRAS codons 12 and 13, and patient prognosis in 1075 BRAF wild-type colorectal cancers.Clin Cancer Res. 2012 Sep 1;18(17):4753-63.
    22753589
  • Lau KS, Zhang T, Kendall KR, Lauffenburger D, Gray NS, Haigis KM.BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner.PLoS ONE. 2012;7(7):e41343.
    22815993
  • Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM.Regulation of RAS oncogenicity by acetylation.Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10843-8.
    22711838
  • Lau KS, Juchheim AM, Cavaliere KR, Philips SR, Lauffenburger DA, Haigis KM.In Vivo Systems Analysis Identifies Spatial and Temporal Aspects of the Modulation of TNF-{alpha}-Induced Apoptosis and Proliferation by MAPKs.Sci Signal. 2011;4(165):ra16.
    21427409
  • Haigis KM, Sweet-Cordero A.New insights into oncogenic stress.Nat Genet. 2011 Mar;43(3):177-8.
    21350495
  • Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K.Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.Blood. 2011 Feb 10;117(6):2022-32.
    21163920
  • Tanaka N, Huttenhower C, Nosho K, Baba Y, Shima K, Quackenbush J, Haigis KM, Giovannucci E, Fuchs CS, Ogino S.Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer.Am J Pathol. 2010 Dec;177(6):2731-40.
    21037082
  • Irahara N, Baba Y, Nosho K, Shima K, Yan L, Dias-Santagata D, Iafrate AJ, Fuchs CS, Haigis KM, Ogino S.NRAS mutations are rare in colorectal cancer.Diagn Mol Pathol. 2010 Sep;19(3):157-63.
    20736745
  • Kreeger PK, Wang Y, Haigis KM, Lauffenburger DA.Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation.Integr Biol (Camb). 2010 Apr 7;2(4):202-8.
    20473400
  • Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, Jeffords LB, Sodha P, Mercer KL, Cohen R, Takeuchi O, Korsmeyer SJ, Bronson RT, Kim CF, Haigis KM, Jain RK, Jacks T.p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.Science. 2010 Jan 29;327(5965):593-6.
    20019247
  • Lau KS, Haigis KM.Non-redundancy within the RAS oncogene family: insights into mutational disparities in cancer.Mol Cells. 2009 Oct;28(4):315-20. Review.
    19812895
  • Kreeger PK, Mandhana R, Alford SK, Haigis KM, Lauffenburger DA.RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.Cancer Res. 2009 Oct 15;69(20):8191-9.
    19789336
  • Matharu KS, Mizoguchi E, Cotoner CA, Nguyen DD, Mingle B, Iweala OI, McBee ME, Stefka AT, Prioult G, Haigis KM, Bhan AK, Snapper SB, Murakami H, Schauer DB, Reinecker HC, Mizoguchi A, Nagler CR.Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice.Gastroenterology. 2009 Oct;137(4):1380-90.e1-3.
    19596011
  • Morris EJ,Ji JY,Yang F,Di Stefano L,Herr A,Moon NS,Kwon EJ,Haigis KM,Naar AM,Dyson NJ.E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8.Nature. 2008 Sep 25;455(7212):552-6.
    18794899
  • Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T.Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.Nat Genet. 2008 May;40(5):600-8.
    18372904
  • Kissil JL, Walmsley MJ, Hanlon L, Haigis KM, Bender Kim CF, Sweet-Cordero A, Eckman MS, Tuveson DA, Capobianco AJ, Tybulewicz VL, Jacks T.Requirement for Rac1 in a K-ras induced lung cancer in the mouse.Cancer Res. 2007 Sep 1;67(17):8089-94.
    17804720
  • Poutahidis T, Haigis KM, Rao VP, Nambiar PR, Taylor CL, Ge Z, Watanabe K, Davidson A, Horwitz BH, Fox JG, Erdman SE.Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma.Carcinogenesis. 2007 Dec;28(12):2614-23.
    17724375
  • Kwong LN, Weiss KR, Haigis KM, Dove WF.Atm is a negative regulator of intestinal neoplasia.Oncogene. 2008 Feb 7;27(7):1013-8.
    17700532
  • Kaiser S, Park YK, Franklin JL, Halberg RB, Yu M, Jessen WJ, Freudenberg J, Chen X, Haigis K, Jegga AG, Kong S, Sakthivel B, Xu H, Reichling T, Azhar M, Boivin GP, Roberts RB, Bissahoyo AC, Gonzales F, Bloom GC, Eschrich S, Carter SL, Aronow JE, Kleimeyer J, Kleimeyer M, Ramaswamy V, Settle SH, Boone B, Levy S, Graff JM, Doetschman T, Groden J, Dove WF, Threadgill DW, Yeatman TJ, Coffey RJ Jr, Aronow BJ.Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer.Genome Biol. 2007 Jul 5;8(7):R131.
    17615082
  • Keller JW, Haigis KM, Franklin JL, Whitehead RH, Jacks T, Coffey RJ.Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex.Oncogene. 2007 May 10;26(21):3051-9.
    17130841
  • Haigis K, Sage J, Glickman J, Shafer S, Jacks T.The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium.J Biol Chem. 2006 Jan 6;281(1):638-47.
    16258171
  • Haigis KM, Hoff PD, White A, Shoemaker AR, Halberg RB, Dove WF.Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function.Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9769-73.
    15210940