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Ralph Scully, MBBS, PhD

Publications

  • Willis NA, Chandramouly G, Huang B, Kwok A, Follonier C, Deng C, Scully R.BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks.Nature. 2014 Apr 28.
    24776801
  • Beck C, Boehler C, Barbat JG, Bonnet ME, Illuzzi G, Ronde P, Gauthier LR, Magroun N, Rajendran A, Lopez BS, Scully R, Boussin FD, Schreiber V, Dantzer F.PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways.Nucleic Acids Res. 2014 Mar 5.
    24598253
  • Chandramouly G, Kwok A, Huang B, Willis NA, Xie A, Scully R.BRCA1 and CtIP suppress long-tract gene conversion between sister chromatids.Nat Commun. 2013;4:2404.
    23994874
  • Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, Driggers EM, Zhang J, Bailey ST, Sharpless NE, Hayes DN, Patel NM, Janne PA, Bardeesy N, Engelman JA, Manning BD, Shaw RJ, Asara JM, Scully R, Kimmelman A, Byers LA, Gibbons DL, Wistuba II, Heymach JV, Kwiatkowski DJ, Kim WY, Kung AL, Gray NS, Root DE, Cantley LC, Wong KK.Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer.Cancer Discovery. 2013 Aug;3(8):870-9.
    23715154
  • Hartlerode AJ, Guan Y, Rajendran A, Ura K, Schotta G, Xie A, Shah JV, Scully R.Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks.PLoS ONE. 2012;7(11):e49211.
    23209566
  • Juvekar A, Burga LN, Hu H, Lunsford EP, Ibrahim YH, Balmañà J, Rajendran A, Papa A, Spencer K, Lyssiotis CA, Nardella C, Pandolfi PP, Baselga J, Scully R, Asara JM, Cantley LC, Wulf GM.Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer.Cancer Discovery. 2012 Nov;2(11):1048-63.
    22915751
  • Nguyen CL, Possemato R, Bauerlein EL, Xie A, Scully R, Hahn WC.Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts.Mol Cell Biol. 2012 Oct;32(19):3963-77.
    22851694
  • Hu Y, Scully R, Sobhian B, Xie A, Shestakova E, Livingston DM.RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci.Genes Dev. 2011 Apr 1;25(7):685-700.
    21406551
  • Hartlerode A, Odate S, Shim I, Brown J, Scully R.Cell Cycle-Dependent Induction of Homologous Recombination by a Tightly Regulated I-SceI Fusion Protein.PLoS ONE. 2011;6(3):e16501.
    21408059
  • Scully R.The spindle-assembly checkpoint, aneuploidy, and gastrointestinal cancer.N Engl J Med. 2010 Dec 30;363(27):2665-6.
    21190461
  • Xie A, Odate S, Chandramouly G, Scully R.H2AX post-translational modifications in the ionizing radiation response and homologous recombination.Cell Cycle. 2010 Sep;9(17):3602-10.
    20703100
  • Scully R.A histone code for DNA repair.Nat Rev Mol Cell Biol. 2010 Mar;11(3):164.
    20213875
  • Hartlerode AJ, Scully R.Mechanisms of double-strand break repair in somatic mammalian cells.Biochem J. 2009 Oct 15;423(2):157-68. Review.
    19772495
  • Xie A, Kwok A, Scully R.Role of mammalian Mre11 in classical and alternative nonhomologous end joining.Nat Struct Mol Biol. 2009 Aug;16(8):814-8.
    19633669
  • Nagaraju G,Hartlerode A,Kwok A,Chandramouly G,Scully R.XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversion between sister chromatids.Mol Cell Biol. 2009 Aug;29(15):4283-94.
    19470754
  • Oberdoerffer P,Michan S,McVay M,Mostoslavsky R,Vann J,Park SK,Hartlerode A,Stegmuller J,Hafner A,Loerch P,Wright SM,Mills KD,Bonni A,Yankner BA,Scully R,Prolla TA,Alt FW,Sinclair DA.SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.Cell. 2008 Nov 28;135(5):907-18.
    19041753
  • Lipshultz SE, Alvarez JA, Scully RE.Anthracycline associated cardiotoxicity in survivors of childhood cancer.Heart. 2008 Apr;94(4):525-33. Review.
    18347383
  • Xie A, Scully R.Hijacking the DNA damage response to enhance viral replication: gamma-herpesvirus 68 orf36 phosphorylates histone H2AX.Mol Cell. 2007 Jul 20;27(2):178-9. Review.
    17643367
  • Barry E, Alvarez JA, Scully RE, Miller TL, Lipshultz SE.Anthracycline-induced cardiotoxicity: course, pathophysiology, prevention and management.Expert Opin Pharmacother. 2007 Jun;8(8):1039-58. Review.
    17516870
  • Nagaraju G, Scully R.Minding the gap: The underground functions of BRCA1 and BRCA2 at stalled replication forks.DNA Repair (Amst). 2007 Jul 1;6(7):1018-31. Review.
    17379580
  • Scully R, Xie A.In my end is my beginning: control of end resection and DSBR pathway 'choice' by cyclin-dependent kinases.Oncogene. 2005 Apr 18;24(17):2871-6.
    15838521
  • Xie A, Puget N, Shim I, Odate S, Jarzyna I, Bassing CH, Alt FW, Scully R.Control of sister chromatid recombination by histone H2AX.Mol Cell. 2004 Dec 22;16(6):1017-25.
    15610743
  • Puget N, Knowlton M, Scully R.Molecular analysis of sister chromatid recombination in mammalian cells.DNA Repair (Amst). 2005 Feb 3;4(2):149-61.
    15590323
  • Scully R, Xie A.BRCA1 and BRCA2 in breast cancer predisposition and recombination control.J Mammary Gland Biol Neoplasia. 2004 Jul;9(3):237-46.
    15557797
  • Scully R, Xie A, Nagaraju G.Molecular functions of BRCA1 in the DNA damage response.Cancer Biol Ther. 2004 Jun;3(6):521-7.
    15280660
  • Avni D, Yang H, Martelli F, Hofmann F, ElShamy WM, Ganesan S, Scully R, Livingston DM.Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage.Mol Cell. 2003 Sep;12(3):735-46.
    14527418
  • Scully R, Puget N.Hereditary breast and ovarian cancer genes.Methods Mol Biol. 2003;222:41-57.
    12710679
  • Eichhorn JH, Young RH, Clement PB, Scully RE.Mesodermal (mllerian) adenosarcoma of the ovary: a clinicopathologic analysis of 40 cases and a review of the literature.Am J Surg Pathol. 2002 Oct;26(10):1243-58.
    12360039
  • Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow SR, Fleming JC, Monroe BC, Ciccone DN, Yan C, Vlasakova K, Livingston DM, Ferguson DO, Scully R, Alt FW.Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX.Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8173-8.
    12034884
  • Scully R, Puget N.BRCA1 and BRCA2 in hereditary breast cancer.Biochimie. 2002 Jan;84(1):95-102.
    11900881
  • Scully R, Puget N, Vlasakova K.DNA polymerase stalling, sister chromatid recombination and the BRCA genes.Oncogene. 2000 Dec 11;19(53):6176-83.
    11156531
  • Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, Abraham RT.Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.Genes Dev. 2000 Dec 1;14(23):2989-3002.
    11114888
  • Scully R, Livingston DM.In search of the tumour-suppressor functions of BRCA1 and BRCA2.Nature. 2000 Nov 23;408(6811):429-32.
    11100717
  • Eid JE, Kung AL, Scully R, Livingston DM.p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion.Cell. 2000 Sep 15;102(6):839-48.
    11030627
  • Scully R, Ganesan S, Vlasakova K, Chen J, Socolovsky M, Livingston DM.Genetic analysis of BRCA1 function in a defined tumor cell line.Mol Cell. 1999 Dec;4(6):1093-9.
    10635334
  • Oliva E, Young RH, Clement PB, Scully RE.Myxoid and fibrous endometrial stromal tumors of the uterus: a report of 10 cases.Int J Gynecol Pathol. 1999 Oct;18(4):310-9.
    10542938
  • Chen JJ, Silver D, Cantor S, Livingston DM, Scully R.BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway.Cancer Res. 1999 Apr 1;59(7 Suppl):1752s-1756s.
    10197592
  • Wilson CA, Ramos L, Villaseor MR, Anders KH, Press MF, Clarke K, Karlan B, Chen JJ, Scully R, Livingston D, Zuch RH, Kanter MH, Cohen S, Calzone FJ, Slamon DJ.Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas.Nat Genet. 1999 Feb;21(2):236-40.
    9988281
  • Chen J, Silver DP, Walpita D, Cantor SB, Gazdar AF, Tomlinson G, Couch FJ, Weber BL, Ashley T, Livingston DM, Scully R.Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.Mol Cell. 1998 Sep;2(3):317-28.
    9774970
  • Scully R, Chen J, Ochs RL, Keegan K, Hoekstra M, Feunteun J, Livingston DM.Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage.Cell. 1997 Aug 8;90(3):425-35.
    9267023
  • Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD.BRCA1 is a component of the RNA polymerase II holoenzyme.Proc Natl Acad Sci U S A. 1997 May 27;94(11):5605-10.
    9159119
  • Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T, Livingston DM.Association of BRCA1 with Rad51 in mitotic and meiotic cells.Cell. 1997 Jan 24;88(2):265-75.
    9008167
  • Yao TP, Ku G, Zhou N, Scully R, Livingston DM.The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10626-31.
    8855229
  • Scully R, Ganesan S, Brown M, De Caprio JA, Cannistra SA, Feunteun J, Schnitt S, Livingston DM.Location of BRCA1 in human breast and ovarian cancer cells.Science. 1996 Apr 5;272(5258):123-6.
    8600523