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Rosalind A. Segal, MD, PhD

Publications

  • Persson L, Witt RM, Galligan M, Greer PL, Eisner A, Pazyra-Murphy MF, Datta SR, Segal RA.Shh-proteoglycan interactions regulate maturation of olfactory glomerular circuitry.Dev Neurobiol. 2014 Jun 10.
    24913191
  • Bergthold G, Bandopadhayay P, Bi WL, Ramkissoon L, Stiles C, Segal RA, Beroukhim R, Ligon KL, Grill J, Kieran MW.Pediatric low-grade gliomas: How modern biology reshapes the clinical field.Biochim Biophys Acta. 2014 Apr;1845(2):294-307.
    24589977
  • Cosker KE, Segal RA.Neuronal signaling through endocytosis.Cold Spring Harb Perspect Biol. 2014 Feb;6(2).
    24492712
  • Gruber Filbin M, Dabral SK, Pazyra-Murphy MF, Ramkissoon S, Kung AL, Pak E, Chung J, Theisen MA, Sun Y, Franchetti Y, Sun Y, Shulman DS, Redjal N, Tabak B, Beroukhim R, Wang Q, Zhao J, Dorsch M, Buonamici S, Ligon KL, Kelleher JF, Segal RA.Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities.Nat Med. 2013 Nov;19(11):1518-23.
    24076665
  • Witt RM, Hecht ML, Pazyra-Murphy MF, Cohen SM, Noti C, van Kuppevelt TH, Fuller M, Chan JA, Hopwood JJ, Seeberger PH, Segal RA.Heparan sulfate proteoglycans containing a glypican 5 core and 2-O-sulfo-iduronic acid function as Sonic Hedgehog co-receptors to promote proliferation.J Biol Chem. 2013 Sep 6;288(36):26275-88.
    23867465
  • Cosker KE, Pazyra-Murphy MF, Fenstermacher SJ, Segal RA.Target-derived neurotrophins coordinate transcription and transport of bclw to prevent axonal degeneration.J Neurosci. 2013 Mar 20;33(12):5195-207.
    23516285
  • Courchesne SL, Pazyra-Murphy MF, Lee DJ, Segal RA.Neuromuscular junction defects in mice with mutation of dynein heavy chain 1.PLoS ONE. 2011;6(2):e16753.
    21346813
  • Courchesne SL, Karch C, Pazyra-Murphy MF, Segal RA.Sensory neuropathy attributable to loss of Bcl-w.J Neurosci. 2011 Feb 2;31(5):1624-34.
    21289171
  • Cosker KE, Segal RA.The longer U(T)R, the further you go.Nat Neurosci. 2010 Mar;13(3):273-5.
    20177416
  • Gruber-Olipitz M, Segal RA.Live or let die: CCM2 provides the link.Neuron. 2009 Sep 10;63(5):559-60.
    19755097
  • Arimura N,Kimura T,Nakamuta S,Taya S,Funahashi Y,Hattori A,Shimada A,Menager C,Kawabata S,Fujii K,Iwamatsu A,Segal RA,Fukuda M,Kaibuchi K.Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27.Dev Cell. 2009 May;16(5):675-86.
    19460344
  • Pazyra-Murphy MF,Hans A,Courchesne SL,Karch C,Cosker KE,Heerssen HM,Watson FL,Kim T,Greenberg ME,Segal RA.A retrograde neuronal survival response: target-derived neurotrophins regulate MEF2D and bcl-w.J Neurosci. 2009 May 20;29(20):6700-9.
    19458239
  • Chan JA,Balasubramanian S,Witt RM,Nazemi KJ,Choi Y,Pazyra-Murphy MF,Walsh CO,Thompson M,Segal RA.Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses.Nat Neurosci. 2009 Apr;12(4):409-17.
    19287388
  • Pazyra-Murphy MF,Segal RA.Preparation and maintenance of dorsal root ganglia neurons in compartmented cultures.J Vis Exp. 2008(20).
    19078939
  • Ha J,Lo KW,Myers KR,Carr TM,Humsi MK,Rasoul BA,Segal RA,Pfister KK.A neuron-specific cytoplasmic dynein isoform preferentially transports TrkB signaling endosomes.J Cell Biol. 2008 Jun 16;181(6):1027-39.
    18559670
  • Zhou P, Porcionatto M, Pilapil M, Chen Y, Choi Y, Tolias KF, Bikoff JB, Hong EJ, Greenberg ME, Segal RA.Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors.Neuron. 2007 Jul 5;55(1):53-68.
    17610817
  • Redjal N, Chan JA, Segal RA, Kung AL.CXCR4 inhibition synergizes with cytotoxic chemotherapy in gliomas.Clin Cancer Res. 2006 Nov 15;12(22):6765-71.
    17121897
  • Redjal N, Chan JA, Segal RA, Kung A.CXCR4 inhibtion syniergizes with cytotoxic chemotherapy in gliomas.J Am Diet Assoc. 2006 Summer;In Press:In Press.
  • Choi Y, Borghesani PR, Chan JA, Segal RA.Migration from a mitogenic niche promotes cell-cycle exit.J Neurosci. 2005 Nov 9;25(45):10437-45.
    16280582
  • Heerssen HM, Pazyra MF, Segal RA.Dynein motors transport activated Trks to promote survival of target-dependent neurons.Nat Neurosci. 2004 Jun;7(6):596-604.
    15122257
  • Rubin JB, Kung AL, Klein RS, Chan JA, Sun Y, Schmidt K, Kieran MW, Luster AD, Segal RA.A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13513-8.
    14595012
  • Kim JY, Nelson AL, Algon SA, Graves O, Sturla LM, Goumnerova LC, Rowitch DH, Segal RA, Pomeroy SL.Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice.Dev Biol. 2003 Nov 1;263(1):50-66.
    14568546
  • Carter AR, Berry EM, Segal RA.Regional expression of p75NTR contributes to neurotrophin regulation of cerebellar patterning.Mol Cell Neurosci. 2003 Jan;22(1):1-13.
    12595234
  • Wang KC, Kim JA, Sivasankaran R, Segal R, He Z.P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.Nature. 2002 Nov 7;420(6911):74-8.
    12422217
  • Bhattacharyya A, Watson FL, Pomeroy SL, Zhang YZ, Stiles CD, Segal RA.High-resolution imaging demonstrates dynein-based vesicular transport of activated Trk receptors.J Neurobiol. 2002 Jun 15;51(4):302-12.
    12150505
  • Kim JY, Koralnik IJ, LeFave M, Segal RA, Pfister LA, Pomeroy SL.Medulloblastomas and primitive neuroectodermal tumors rarely contain polyomavirus DNA sequences.Neuro-oncol. 2002 Jul;4(3):165-70.
    12084346
  • Rubin JB, Choi Y, Segal RA.Cerebellar proteoglycans regulate sonic hedgehog responses during development.Development. 2002 May;129(9):2223-32.
    11959830
  • Borghesani PR, Peyrin JM, Klein R, Rubin J, Carter AR, Schwartz PM, Luster A, Corfas G, Segal RA.BDNF stimulates migration of cerebellar granule cells.Development. 2002 Mar;129(6):1435-42.
    11880352
  • Carter AR, Chen C, Schwartz PM, Segal RA.Brain-derived neurotrophic factor modulates cerebellar plasticity and synaptic ultrastructure.J Neurosci. 2002 Feb 15;22(4):1316-27.
    11850459
  • Watson FL, Heerssen HM, Bhattacharyya A, Klesse L, Lin MZ, Segal RA.Neurotrophins use the Erk5 pathway to mediate a retrograde survival response.Nat Neurosci. 2001 Oct;4(10):981-8.
    11544482
  • Klein RS, Rubin JB, Gibson HD, DeHaan EN, Alvarez-Hernandez X, Segal RA, Luster AD.SDF-1 alpha induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells.Development. 2001 Jun;128(11):1971-81.
    11493520
  • Choi DY, Toledo-Aral JJ, Segal R, Halegoua S.Sustained signaling by phospholipase C-gamma mediates nerve growth factor-triggered gene expression.Mol Cell Biol. 2001 Apr;21(8):2695-705.
    11283249
  • O'Brien SP, Seipel K, Medley QG, Bronson R, Segal R, Streuli M.Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos.Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12074-8.
    11050238
  • Zhang Y, Moheban DB, Conway BR, Bhattacharyya A, Segal RA.Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation.J Neurosci. 2000 Aug 1;20(15):5671-8.
    10908605
  • Borghesani PR, Alt FW, Bottaro A, Davidson L, Aksoy S, Rathbun GA, Roberts TM, Swat W, Segal RA, Gu Y.Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice.Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3336-41.
    10716718
  • Watson FL, Heerssen HM, Moheban DB, Lin MZ, Sauvageot CM, Bhattacharyya A, Pomeroy SL, Segal RA.Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex.J Neurosci. 1999 Sep 15;19(18):7889-900.
    10479691
  • Watson FL, Porcionatto MA, Bhattacharyya A, Stiles CD, Segal RA.TrkA glycosylation regulates receptor localization and activity.J Neurobiol. 1999 May;39(2):323-36.
    10235685
  • Kim JY, Sutton ME, Lu DJ, Cho TA, Goumnerova LC, Goritchenko L, Kaufman JR, Lam KK, Billet AL, Tarbell NJ, Wu J, Allen JC, Stiles CD, Segal RA, Pomeroy SL.Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas.Cancer Res. 1999 Feb 1;59(3):711-9.
    9973222
  • Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson RT, Springer TA.Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9448-53.
    9689100
  • Schwartz PM, Levy RL, Borghesani PR, Segal RA.Cerebellar pathology in BDNF -/- mice: the classic view of neurotrophins is changing.Mol Psychiatry. 1998 Mar;3(2):116-20.
    9577835
  • Pomeroy SL, Sutton ME, Goumnerova LC, Segal RA.Neurotrophins in cerebellar granule cell development and medulloblastoma.J Neurooncol. 1997 Dec;35(3):347-52.
    9440031
  • Schwartz PM, Borghesani PR, Levy RL, Pomeroy SL, Segal RA.Abnormal cerebellar development and foliation in BDNF-/- mice reveals a role for neurotrophins in CNS patterning.Neuron. 1997 Aug;19(2):269-81.
    9292718
  • Bhattacharyya A, Watson FL, Bradlee TA, Pomeroy SL, Stiles CD, Segal RA.Trk receptors function as rapid retrograde signal carriers in the adult nervous system.J Neurosci. 1997 Sep 15;17(18):7007-16.
    9278536
  • Cabelli RJ, Shelton DL, Segal RA, Shatz CJ.Blockade of endogenous ligands of trkB inhibits formation of ocular dominance columns.Neuron. 1997 Jul;19(1):63-76.
    9247264
  • Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME.Regulation of neuronal survival by the serine-threonine protein kinase Akt.Science. 1997 Jan 31;275(5300):661-5.
    9005851
  • Segal RA, Rua L, Schwartz P.Neurotrophins and programmed cell death during cerebellar development.Adv Neurol. 1997;72:79-86.
    8993686
  • Nachmanoff DB, Segal RA, Dawson DM, Brown RB, De Girolami U.Hereditary ataxia with sensory neuronopathy: Biemond's ataxia.Neurology. 1997 Jan;48(1):273-5.
    9008534
  • Segal RA, Bhattacharyya A, Rua LA, Alberta JA, Stephens RM, Kaplan DR, Stiles CD.Differential utilization of Trk autophosphorylation sites.J Biol Chem. 1996 Aug 16;271(33):20175-81.
    8702742
  • Segal RA, Greenberg ME.Intracellular signaling pathways activated by neurotrophic factors.Annu Rev Neurosci. 1996;19:463-89.
    8833451
  • Segal RA, Pomeroy SL, Stiles CD.Axonal growth and fasciculation linked to differential expression of BDNF and NT3 receptors in developing cerebellar granule cells.J Neurosci. 1995 Jul;15(7 Pt 1):4970-81.
    7623126
  • Segal RA, Goumnerova LC, Kwon YK, Stiles CD, Pomeroy SL.Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma.Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12867-71.
    7809137
  • Segal RA, Takahashi H, McKay RD.Changes in neurotrophin responsiveness during the development of cerebellar granule neurons.Neuron. 1992 Dec;9(6):1041-52.
    1463606
  • Segal RA, Chapman C, Barlow J.Monozygotic twins with seizures. Shared characteristics.Arch Neurol. 1991 Oct;48(10):1041-5.
    1929896
  • Segal RA, Luck DJ.Phosphorylation in isolated Chlamydomonas axonemes: a phosphoprotein may mediate the Ca2+-dependent photophobic response.J Cell Biol. 1985 Nov;101(5 Pt 1):1702-12.
    4055893
  • Segal RA, Huang B, Ramanis Z, Luck DJ.Mutant strains of Chlamydomonas reinhardtii that move backwards only.J Cell Biol. 1984 Jun;98(6):2026-34.
    6725408
  • Hsieh P, Segal R, Chen LB.Studies of fibronectin matrices in living cells with fluoresceinated gelatin.J Cell Biol. 1980 Oct;87(1):14-22.
    6998987
  • Chen LB, Murray A, Segal RA, Bushnell A, Walsh ML.Studies on intercellular LETS glycoprotein matrices.Cell. 1978 Jun;14(2):377-91.
    667946
  • Krueger JG, Segal RA, Moyer RC.Differences in the responsiveness of splenic, lymph node, and peripheral blood lymphoid cells to tumor membrane extracts.Cancer Res. 1977 Jan;37(1):320-2.
    830419