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Xi He, PhD


  • Wang L, Shalek AK, Lawrence M, Ding R, Gaublomme JT, Pochet N, Stojanov P, Sougnez C, Shukla SA, Stevenson KE, Zhang W, Wong J, Sievers QL, MacDonald BT, Vartanov AR, Goldstein NR, Neuberg D, He X, Lander E, Hacohen N, Regev A, Getz G, Brown JR, Park H, Wu CJ.Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL.Blood. 2014 Aug 14(7):1089-98.
  • MacDonald BT, Hien A, Zhang X, Iranloye O, Virshup DM, Waterman ML, He X.Disulfide Bond Requirements for Active Wnt Ligands.J Biol Chem. 2014 May 19.
  • Zhang X, He X.PAF makes it EZ(H2) for β-catenin transactivation.Mol Cell. 2013 Oct 24;52(2):157-8.
  • Kim SE, Huang H, Zhao M, Zhang X, Zhang A, Semonov MV, MacDonald BT, Zhang X, Garcia Abreu J, Peng L, He X.Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies.Science. 2013 May 17;340(6134):867-70.
  • Xu Y, Xu C, Kato A, Tempel W, Abreu JG, Bian C, Hu Y, Hu D, Zhao B, Cerovina T, Diao J, Wu F, He HH, Cui Q, Clark E, Ma C, Barbara A, Veenstra GJ, Xu G, Kaiser UB, Liu XS, Sugrue SP, He X, Min J, Kato Y, Shi YG.Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development.Cell. 2012 Dec 7;151(6):1200-13.
  • MacDonald BT, He X.Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling.Cold Spring Harb Perspect Biol. 2012 Dec;4(12).
  • Macaulay IC, Thon JN, Tijssen MR, Steele BM, Macdonald BT, Meade G, Burns P, Rendon A, Salunkhe V, Murphy RP, Bennett C, Watkins NA, He X, Fitzgerald DJ, Italiano JE, Maguire PB.Canonical Wnt signaling in megakaryocytes regulates proplatelet formation.Blood. 2012 Nov 16.
  • Li Z, He X, Feng J.Dicer is essential for neuronal polarity.Int J Dev Neurosci. 2012 Nov;30(7):607-11.
  • Macdonald BT, He X.A finger on the pulse of Wnt receptor signaling.Cell Res. 2012 Oct;22(10):1410-2.
  • Bienz M, He X.Biochemistry. A lipid linchpin for Wnt-Fz docking.Science. 2012 Jul 6;337(6090):44-5.
  • Zhang X, Abreu JG, Yokota C, MacDonald BT, Singh S, Coburn KL, Cheong SM, Zhang MM, Ye QZ, Hang HC, Steen H, He X.Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.Cell. 2012 Jun 22;149(7):1565-77.
  • Peereboom DM, Supko JG, Carson KA, Batchelor T, Phuphanich S, Lesser G, Mikkelson T, Fisher J, Desideri S, He X, Grossman SA, .A phase I/II trial and pharmacokinetic study of ixabepilone in adult patients with recurrent high-grade gliomas.J. Neurooncol. 2010 Nov;100(2):261-8.
  • Xu W, He X.DEEP Insights through the DEP Domain.Structure. 2010 Oct 13;18(10):1223-5.
  • Lee G, Goretsky T, Managlia E, Dirisina R, Singh AP, Brown JB, May R, Yang GY, Ragheb JW, Evers BM, Weber CR, Turner JR, He XC, Katzman RB, Li L, Barrett TA.Phosphoinositide 3-Kinase Signaling Mediates beta-Catenin Activation in Intestinal Epithelial Stem and Progenitor Cells in Colitis.Gastroenterology. 2010 Sep;139(3):869-81, 881.e1-9.
  • Bird GH, Madani N, Perry AF, Princiotto AM, Supko JG, He X, Gavathiotis E, Sodroski JG, Walensky LD.Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic.Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14093-8.
  • Park K, He X, Lee HO, Hua X, Li Y, Wiest D, Kappes DJ.TCR-mediated ThPOK induction promotes development of mature (CD24-) gammadelta thymocytes.EMBO J. 2010 Jul 21;29(14):2329-41.
  • Zhang B, Abreu JG, Zhou K, Chen Y, Hu Y, Zhou T, He X, Ma JX.Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family.Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6900-5.
  • Liu C, He X.Destruction of a Destructor: A New Avenue for Cancer Therapeutics Targeting the Wnt Pathway.Journal Of Molecular Cell Biology. 2010 Apr;2(2):70-3.
  • Zhong H, Zou H, Semenov MV, Moshinsky D, He X, Huang H, Li S, Quan J, Yang Z, Lin S.Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling.Mol Biosyst. 2009 Nov;5(11):1356-60.
  • MacDonald BT, Tamai K, He X.Wnt/beta-catenin signaling: components, mechanisms, and diseases.Dev Cell. 2009 Jul;17(1):9-26. Review.
  • Wu G,Huang H,Garcia Abreu J,He X.Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6.PLoS ONE. 2009;4(3):e4926.
  • Zhu AX,Ready N,Clark JW,Safran H,Amato A,Salem N,Pace S,He X,Zvereva N,Lynch TJ,Ryan DP,Supko JG.Phase I and pharmacokinetic study of gimatecan given orally once a week for 3 of 4 weeks in patients with advanced solid tumors.Clin Cancer Res. 2009 Jan 1;15(1):374-81.
  • Miech C,Pauer HU,He X,Schwarz TL.Presynaptic local signaling by a canonical wingless pathway regulates development of the Drosophila neuromuscular junction.J Neurosci. 2008 Oct 22;28(43):10875-84.
  • Choi YJ,Di Nardo A,Kramvis I,Meikle L,Kwiatkowski DJ,Sahin M,He X.Tuberous sclerosis complex proteins control axon formation.Genes Dev. 2008 Sep 15;22(18):2485-95.
  • Blakeley JO,Olson J,Grossman SA,He X,Weingart J,Supko JG.Effect of blood brain barrier permeability in recurrent high grade gliomas on the intratumoral pharmacokinetics of methotrexate: a microdialysis study.J Neurooncol. 2009 Jan;91(1):51-8.
  • He X,Fan HY,Garlick JD,Kingston RE.Diverse regulation of SNF2h chromatin remodeling by noncatalytic subunits.Biochemistry. 2008 Jul 8;47(27):7025-33.
  • Macdonald BT, Yokota C, Tamai K, Zeng X, He X.Wnt signal amplification: activity, cooperativity and regulation of multiple intracellular PPPSP motifs in the Wnt coreceptor LRP6.J Biol Chem. 2008 Jun 6;283(23):16115-23.
  • Semenov MV,Zhang X,He X.DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation.J Biol Chem. 2008 Aug 1;283(31):21427-32.
  • He X, Park K, Wang H, He X, Zhang Y, Hua X, Li Y, Kappes DJ.CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus.Immunity. 2008 Mar;28(3):346-58.
  • Huang H, He X.Wnt/beta-catenin signaling: new (and old) players and new insights.Curr Opin Cell Biol. 2008 Apr;20(2):119-25. Review.
  • Miao XS,Song P,Savage RE,Zhong C,Yang RY,Kizer D,Wu H,Volckova E,Ashwell MA,Supko JG,He X,Chan TC.Identification of the in vitro metabolites of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (ARQ 501; beta-lapachone) in whole blood.Drug Metab Dispos. 2008 Apr;36(4):641-8.
  • He X.Cilia put a brake on Wnt signalling.Nat Cell Biol. 2008 Jan;10(1):11-3.
  • Semenov MV, Habas R, Macdonald BT, He X.SnapShot: Noncanonical Wnt Signaling Pathways.Cell. 2007 Dec 28;131(7):1378.
  • Macdonald BT, Semenov MV, He X.SnapShot: Wnt/beta-catenin signaling.Cell. 2007 Dec 14;131(6):1204.
  • Zeng X, Huang H, Tamai K, Zhang X, Harada Y, Yokota C, Almeida K, Wang J, Doble B, Woodgett J, Wynshaw-Boris A, Hsieh JC, He X.Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.Development. 2008 Jan;135(2):367-75.
  • Habas R, He X.Cell signaling: moving to a Wnt-Rap.Curr Biol. 2007 Jun 19;17(12):R474-7.
  • Akingbemi BT,Braden TD,Kemppainen BW,Hancock KD,Sherrill JD,Cook SJ,He X,Supko JG.Exposure to phytoestrogens in the perinatal period affects androgen secretion by testicular Leydig cells in the adult rat.Endocrinology. 2007 Sep;148(9):4475-88.
  • Donne AJ, Hampson L, He XT, Rothera MP, Homer JJ, Hampson IN.The effect of cidofovir on cellular HPV E6 level, a possible early therapeutic indicator for respiratory papillomatosis therapies.Clin Otolaryngol. 2007 Jun;32(3):230.
  • Harada Y, Yokota C, Habas R, Slusarski DC, He X.Retinoic acid-inducible G protein-coupled receptors bind to frizzled receptors and may activate non-canonical Wnt signaling.Biochem Biophys Res Commun. 2007 Jul 13;358(4):968-75.
  • Wei Q, Yokota C, Semenov MV, Doble B, Woodgett J, He X.R-spondin1 Is a High Affinity Ligand for LRP6 and Induces LRP6 Phosphorylation and beta-Catenin Signaling.J Biol Chem. 2007 May 25;282(21):15903-11.
  • Yu A, Rual JF, Tamai K, Harada Y, Vidal M, He X, Kirchhausen T.Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling.Dev Cell. 2007 Jan;12(1):129-41.
  • Semenov MV, He X.LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST.J Biol Chem. 2006 Dec 15;281(50):38276-84.
  • He X.Unwinding a path to nuclear beta-catenin.Cell. 2006 Oct 6;127(1):40-2.
  • Li Y, Lu W, He X, Bu G.Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd.FEBS Lett. 2006 Oct 2;580(22):5423-8.
  • Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, Guan KL.TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth.Cell. 2006 Sep 8;126(5):955-68.
  • He X, Chen MG, Lin GX, Ma Q.Arsenic induces NAD(P)H:quinone oxidoreductase I by disrupting the NRF2/KEAP1/CUL3 complex and recruiting NRF2/MAF to are enhancer.J Biol Chem. 2006 Aug 18;281(33):23620-31.
  • Yang J, Zhang W, Evans PM, Chen X, He X, Liu C.Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells.J Biol Chem. 2006 Jun 30;281(26):17751-7.
  • He X, Axelrod JD.A WNTer wonderland in Snowbird.Development. 2006 Jul;133(14):2597-603.
  • Wu G, He X.Threonine 41 in beta-catenin serves as a key phosphorylation relay residue in beta-catenin degradation.Biochemistry. 2006 Apr 25;45(16):5319-23.
  • Zhang W, Chen X, Kato Y, Evans PM, Yuan S, Yang J, Rychahou PG, Yang VW, He X, Evers BM, Liu C.Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression.Mol Cell Biol. 2006 Mar;26(6):2055-64.
  • Habas R, He X.Activation of Rho and Rac by Wnt/frizzled signaling.Methods Enzymol. 2006;406:500-11.
  • Klein A, He X, Roche M, Mallett A, Duska L, Supko JG, Seiden MV.Prolonged stabilization of platinum-resistant ovarian cancer in a single patient consuming a fermented soy therapy.Gynecol Oncol. 2006 Jan;100(1):205-9.
  • Eder JP, Ryan DP, Appleman L, Zhu AX, Puchalski T, He X, Sonnichsen DS, Cooper M, Wright J, Clark JW, Supko JG.Phase I clinical trial of the farnesyltransferase inhibitor BMS-214662 administered as a weekly 24 h continuous intravenous infusion in patients with advanced solid tumors.Cancer Chemother Pharmacol. 2006 Jul;58(1):107-116.
  • Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R, Okamura H, Woodgett J, He X.A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation.Nature. 2005 Dec 8;438(7069):873-7.
  • Merchan JR, Jayaram DR, Supko JG, He X, Bubley GJ, Sukhatme VP.Increased endothelial uptake of paclitaxel as a potential mechanism for its antiangiogenic effects: potentiation by Cox-2 inhibition.Int J Cancer. 2005 Jan 20;113(3):490-8.
  • Kato Y, Shi Y, He X.Neuralization of the Xenopus embryo by inhibition of p300/ CREB-binding protein function.J Neurosci. 1999 Nov 1;19(21):9364-73.
  • Liu C, Kato Y, Zhang Z, Do VM, Yankner BA, He X.beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation.Proc Natl Acad Sci U S A. 1999 May 25;96(11):6273-8.
  • He X, Saint-Jeannet JP, Wang Y, Nathans J, Dawid I, Varmus H.A member of the Frizzled protein family mediating axis induction by Wnt-5A.Science. 1997 Mar 14;275(5306):1652-4.