• Home
  • News
  • Calendar
  • About DF/HCC
  • Membership
  • Visitor Center

Kornelia Polyak, MD, PhD

Publications

  • Marusyk A, Tabassum DP, Altrock PM, Almendro V, Michor F, Polyak K.Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity.Nature. 2014 Jul 30.
    25079331
  • Yamamoto S, Wu Z, Russnes HG, Takagi S, Peluffo G, Vaske C, Zhao X, Moen Vollan HK, Maruyama R, Ekram MB, Sun H, Kim JH, Carver K, Zucca M, Feng J, Almendro V, Bessarabova M, Rueda OM, Nikolsky Y, Caldas C, Liu XS, Polyak K.JARID1B is a luminal lineage-driving oncogene in breast cancer.Cancer Cell. 2014 Jun 16;25(6):762-77.
    24937458
  • Godinho SA, Picone R, Burute M, Dagher R, Su Y, Leung CT, Polyak K, Brugge JS, Théry M, Pellman D.Oncogene-like induction of cellular invasion from centrosome amplification.Nature. 2014 Jun 5(7503):167-71.
    24739973
  • Zou MR, Cao J, Liu Z, Huh SJ, Polyak K, Yan Q.Histone Demethylase Jumonji AT-Rich Interactive Domain 1B (JARID1B) Controls Mammary Gland Development by Regulating Key Developmental and Lineage Specification Genes.J Biol Chem. 2014 May 6.
    24802759
  • Polyak K.Tumor Heterogeneity Confounds and Illuminates: A case for Darwinian tumor evolution.Nat Med. 2014 Apr 7;20(4):344-6.
    24710378
  • Polyak K, Marusyk A.Cancer: Clonal cooperation.Nature. 2014 Apr 3;508(7494):52-3.
    24695309
  • Hines WC, Su Y, Kuhn I, Polyak K, Bissell MJ.Sorting out the FACS: a devil in the details.Cell Rep. 2014 Mar 13;6(5):779-81.
    24630040
  • Almendro V, Kim HJ, Cheng YK, Gönen M, Itzkovitz S, Argani P, van Oudenaarden A, Sukumar S, Michor F, Polyak K.Genetic and phenotypic diversity in breast tumor metastases.Cancer Res. 2014 Mar 1;74(5):1338-48.
    24448237
  • Almendro V, Cheng YK, Randles A, Itzkovitz S, Marusyk A, Ametller E, Gonzalez-Farre X, Muñoz M, Russnes HG, Helland A, Rye IH, Borresen-Dale AL, Maruyama R, van Oudenaarden A, Dowsett M, Jones RL, Reis-Filho J, Gascon P, Gönen M, Michor F, Polyak K.Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity.Cell Rep. 2014 Feb 13;6(3):514-27.
    24462293
  • Chin YR, Yoshida T, Marusyk A, Beck AH, Polyak K, Toker A.Targeting Akt3 signaling in triple-negative breast cancer.Cancer Res. 2014 Feb 1;74(3):964-73.
    24335962
  • Timmerman LA, Holton T, Yuneva M, Louie RJ, Padró M, Daemen A, Hu M, Chan DA, Ethier SP, van 't Veer LJ, Polyak K, McCormick F, Gray JW.Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.Cancer Cell. 2013 Oct 14;24(4):450-65.
    24094812
  • McLaughlin SK, Olsen SN, Dake B, De Raedt T, Lim E, Bronson RT, Beroukhim R, Polyak K, Brown M, Kuperwasser C, Cichowski K.The RasGAP gene, RASAL2, is a tumor and metastasis suppressor.Cancer Cell. 2013 Sep 9;24(3):365-78.
    24029233
  • Steenbergen RD, Ongenaert M, Snellenberg S, Trooskens G, van der Meide WF, Pandey D, Bloushtain-Qimron N, Polyak K, Meijer CJ, Snijders PJ, Van Criekinge W.Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis.J Pathol. 2013 Sep;231(1):53-62.
    23674368
  • Choudhury S, Almendro V, Merino VF, Wu Z, Maruyama R, Su Y, Martins FC, Fackler MJ, Bessarabova M, Kowalczyk A, Conway T, Beresford-Smith B, Macintyre G, Cheng YK, Lopez-Bujanda Z, Kaspi A, Hu R, Robens J, Nikolskaya T, Haakensen VD, Schnitt SJ, Argani P, Ethington G, Panos L, Grant M, Clark J, Herlihy W, Lin SJ, Chew G, Thompson EW, Greene-Colozzi A, Richardson AL, Rosson GD, Pike M, Garber JE, Nikolsky Y, Blum JL, Au A, Hwang ES, Tamimi RM, Michor F, Haviv I, Liu XS, Sukumar S, Polyak K.Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics.Cell Stem Cell. 2013 Jul 3;13(1):117-30.
    23770079
  • Pantel K, Diaz LA, Polyak K.Tracking tumor resistance using 'liquid biopsies'.Nat Med. 2013 Jun;19(6):676-7.
    23744147
  • Seo JH, Li Q, Fatima A, Eklund A, Szallasi Z, Polyak K, Richardson AL, Freedman ML.Deconvoluting complex tissues for expression quantitative trait locus-based analyses.Philos Trans R Soc Lond B Biol Sci. 2013;368(1620):20120363.
    23650637
  • Almendro V, Marusyk A, Polyak K.Cellular Heterogeneity and Molecular Evolution in Cancer.Annu Rev Pathol. 2012 Oct 22.
    23092187
  • Polyak K, Metzger Filho O.SnapShot: Breast Cancer.Cancer Cell. 2012 Oct 16;22(4):562-562.e1.
    23079664
  • Bhatia S, Frangioni JV, Hoffman RM, Iafrate AJ, Polyak K.The challenges posed by cancer heterogeneity.Nat Biotechnol. 2012 Jul;30(7):604-10.
    22781679
  • Polyak K.On using functional genetics to understand breast cancer biology.Cold Spring Harb Perspect Biol. 2012 Jul;4(7):a013516.
    22751154
  • Banerji S, Cibulskis K, Rangel-Escareno C, Brown KK, Carter SL, Frederick AM, Lawrence MS, Sivachenko AY, Sougnez C, Zou L, Cortes ML, Fernandez-Lopez JC, Peng S, Ardlie KG, Auclair D, Bautista-Piña V, Duke F, Francis J, Jung J, Maffuz-Aziz A, Onofrio RC, Parkin M, Pho NH, Quintanar-Jurado V, Ramos AH, Rebollar-Vega R, Rodriguez-Cuevas S, Romero-Cordoba SL, Schumacher SE, Stransky N, Thompson KM, Uribe-Figueroa L, Baselga J, Beroukhim R, Polyak K, Sgroi DC, Richardson AL, Jimenez-Sanchez G, Lander ES, Gabriel SB, Garraway LA, Golub TR, Melendez-Zajgla J, Toker A, Getz G, Hidalgo-Miranda A, Meyerson M.Sequence analysis of mutations and translocations across breast cancer subtypes.Nature. 2012 Jun 21;486(7403):405-9.
    22722202
  • Martins FC, De S, Almendro V, Gönen M, Park SY, Blum JL, Herlihy W, Ethington G, Schnitt SJ, Tung N, Garber JE, Fetten K, Michor F, Polyak K.Evolutionary pathways in BRCA1-associated breast tumors.Cancer Discovery. 2012 Jun;2(6):503-11.
    22628410
  • Marusyk A, Almendro V, Polyak K.Intra-tumour heterogeneity: a looking glass for cancer?.Nat Rev Cancer. 2012 May;12(5):323-34. Review.
    22513401
  • Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, Bloushtain-Qimron N, Kim JJ, Choudhury SA, Maruyama R, Wu Z, Gönen M, Mulvey LA, Bessarabova MO, Huh SJ, Silver SJ, Kim SY, Park SY, Lee HE, Anderson KS, Richardson AL, Nikolskaya T, Nikolsky Y, Liu XS, Root DE, Hahn WC, Frank DA, Polyak K.The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.J Clin Invest. 2011 Jul 1;121(7):2723-35.
    21633165
  • Maruyama R, Choudhury S, Kowalczyk A, Bessarabova M, Beresford-Smith B, Conway T, Kaspi A, Wu Z, Nikolskaya T, Merino VF, Lo PK, Liu XS, Nikolsky Y, Sukumar S, Haviv I, Polyak K.Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium.PLoS Genet. 2011 Apr;7(4):e1001369.
    21533021
  • Bessarabova M, Pustovalova O, Shi W, Serebriyskaya T, Ishkin A, Polyak K, Velculescu VE, Nikolskaya T, Nikolsky Y.Functional synergies yet distinct modulators affected by genetic alterations in common human cancers.Cancer Res. 2011 Mar 11.
    21398405
  • Polyak K, Garber J.Targeting the missing links for cancer therapy.Nat Med. 2011 Mar;17(3):283-4.
    21383736
  • Wu ZJ, Meyer CA, Choudhury S, Shipitsin M, Maruyama R, Bessarabova M, Nikolskaya T, Sukumar S, Schwartzman A, Liu JS, Polyak K, Liu XS.Gene expression profiling of human breast tissue samples using SAGE-Seq.Genome Res. 2010 Dec;20(12):1730-9.
    21045080
  • Maruyama R, Shipitsin M, Choudhury S, Wu Z, Protopopov A, Yao J, Lo PK, Bessarabova M, Ishkin A, Nikolsky Y, Liu XS, Sukumar S, Polyak K.Breast Cancer Special Feature: Altered antisense-to-sense transcript ratios in breast cancer.Proc Natl Acad Sci U S A. 2010 Nov 22.
    21098291
  • Michor F, Polyak K.The Origins and Implications of Intratumor Heterogeneity.Cancer Prev Res (Phila Pa). 2010 Nov;3(11):1361-4.
    20959519
  • Polyak K, Kalluri R.The Role of the Microenvironment in Mammary Gland Development and Cancer.Cold Spring Harb Perspect Biol. 2010 Nov;2(11):a003244.
    20591988
  • Polyak K.Molecular markers for the diagnosis and management of ductal carcinoma in situ.J Natl Cancer Inst Monogr. 2010;2010(41):210-3.
    20956832
  • Polyak K.Going small is the new big.Nat Methods. 2010 Aug;7(8):597, 599-600.
    20676079
  • Irie HY, Shrestha Y, Selfors LM, Frye F, Iida N, Wang Z, Zou L, Yao J, Lu Y, Epstein CB, Natesan S, Richardson AL, Polyak K, Mills GB, Hahn WC, Brugge JS.PTK6 regulates IGF-1-induced anchorage-independent survival.PLoS ONE. 2010;5(7):e11729.
    20668531
  • Miron A, Varadi M, Carrasco D, Li H, Luongo L, Kim HJ, Park SY, Cho EY, Lewis G, Kehoe S, Iglehart JD, Dillon D, Allred DC, Macconaill L, Gelman R, Polyak K.PIK3CA mutations in in situ and invasive breast carcinomas.Cancer Res. 2010 Jul 15;70(14):5674-8.
    20551053
  • Petersen OW, Polyak K.Stem cells in the human breast.Cold Spring Harb Perspect Biol. 2010 May 1;2(5):a003160. Review.
    20452965
  • Park SY, Gönen M, Kim HJ, Michor F, Polyak K.Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype.J Clin Invest. 2010 Feb 1;120(2):636-44.
    20101094
  • Park SY, Lee HE, Li H, Shipitsin M, Gelman R, Polyak K.Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer.Clin Cancer Res. 2010 Feb 1;16(3):876-87.
    20103682
  • Marusyk A, Polyak K.Tumor heterogeneity: causes and consequences.Biochim Biophys Acta. 2010 Jan;1805(1):105-17. Review.
    19931353
  • MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, Fiorentino M, Rubin MA, Polyak K, Chan J, Wang Y, Fletcher JA, Santagata S, Corso G, Roviello F, Shivdasani R, Kieran MW, Ligon KL, Stiles CD, Hahn WC, Meyerson ML, Garraway LA.Profiling critical cancer gene mutations in clinical tumor samples.PLoS ONE. 2009;4(11):e7887.
    19924296
  • Zhang Q, Gu J, Li L, Liu J, Luo B, Cheung HW, Boehm JS, Ni M, Geisen C, Root DE, Polyak K, Brown M, Richardson AL, Hahn WC, Kaelin WG, Bommi-Reddy A.Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase.Cancer Cell. 2009 Nov 6;16(5):413-24.
    19878873
  • Campbell I, Polyak K, Haviv I.Clonal mutations in the cancer-associated fibroblasts: the case against genetic coevolution.Cancer Res. 2009 Sep 1;69(17):6765-8; discussion 6769.
    19706773
  • Snyder EL,Bailey D,Shipitsin M,Polyak K,Loda M.Identification of CD44v6(+)/CD24- breast carcinoma cells in primary human tumors by quantum dot-conjugated antibodies.Lab Invest. 2009 Aug;89(8):857-66.
    19488035
  • Polyak K,Weinberg RA.Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits.Nat Rev Cancer. 2009 Apr;9(4):265-73. Review.
    19262571
  • Bloushtain-Qimron N,Yao J,Shipitsin M,Maruyama R,Polyak K.Epigenetic patterns of embryonic and adult stem cells.Cell Cycle. 2009 Mar 15;8(6):809-17.
    19229128
  • Hu M,Peluffo G,Chen H,Gelman R,Schnitt S,Polyak K.Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast.Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3372-7.
    19218449
  • Haviv I,Polyak K,Qiu W,Hu M,Campbell I.Origin of carcinoma associated fibroblasts.Cell Cycle. 2009 Feb 15;8(4):589-95. Review.
    19182519
  • Marotta LL,Polyak K.Cancer stem cells: a model in the making.Curr Opin Genet Dev. 2009 Feb;19(1):44-50. Review.
    19167210
  • Polyak K,Haviv I,Campbell IG.Co-evolution of tumor cells and their microenvironment.Trends Genet. 2009 Jan;25(1):30-8. Review.
    19054589
  • Hu M,Polyak K.Molecular characterisation of the tumour microenvironment in breast cancer.Eur J Cancer. 2008 Dec;44(18):2760-5. Review.
    19026532
  • Nikolsky Y,Sviridov E,Yao J,Dosymbekov D,Ustyansky V,Kaznacheev V,Dezso Z,Mulvey L,Macconaill LE,Winckler W,Serebryiskaya T,Nikolskaya T,Polyak K.Genome-wide functional synergy between amplified and mutated genes in human breast cancer.Cancer Res. 2008 Nov 15;68(22):9532-40.
    19010930
  • Cao D,Polyak K,Halushka MK,Nassar H,Kouprina N,Iacobuzio-Donahue C,Wu X,Sukumar S,Hicks J,De Marzo A,Argani P.Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9.Breast Cancer Res. 2008;10(5):R91.
    18954444
  • Bloushtain-Qimron N,Yao J,Snyder EL,Shipitsin M,Campbell LL,Mani SA,Hu M,Chen H,Ustyansky V,Antosiewicz JE,Argani P,Halushka MK,Thomson JA,Pharoah P,Porgador A,Sukumar S,Parsons R,Richardson AL,Stampfer MR,Gelman RS,Nikolskaya T,Nikolsky Y,Polyak K.Cell type-specific DNA methylation patterns in the human breast.Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14076-81.
    18780791
  • Kleer CG,Bloushtain-Qimron N,Chen YH,Carrasco D,Hu M,Yao J,Kraeft SK,Collins LC,Sabel MS,Argani P,Gelman R,Schnitt SJ,Krop IE,Polyak K.Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression.Clin Cancer Res. 2008 Sep 1;14(17):5357-67.
    18765527
  • Hu M, Polyak K.Microenvironmental regulation of cancer development.Curr Opin Genet Dev. 2008 Feb;18(1):27-34. Review.
    18282701
  • Mani SA,Guo W,Liao MJ,Eaton EN,Ayyanan A,Zhou AY,Brooks M,Reinhard F,Zhang CC,Shipitsin M,Campbell LL,Polyak K,Brisken C,Yang J,Weinberg RA.The epithelial-mesenchymal transition generates cells with properties of stem cells.Cell. 2008 May 16;133(4):704-15.
    18485877
  • Hu M, Yao J, Carroll DK, Weremowicz S, Chen H, Carrasco D, Richardson A, Violette S, Nikolskaya T, Nikolsky Y, Bauerlein EL, Hahn WC, Gelman RS, Allred C, Bissell MJ, Schnitt S, Polyak K.Regulation of in situ to invasive breast carcinoma transition.Cancer Cell. 2008 May;13(5):394-406.
    18455123
  • Qiu W, Hu M, Sridhar A, Opeskin K, Fox S, Shipitsin M, Trivett M, Thompson ER, Ramakrishna M, Gorringe KL, Polyak K, Haviv I, Campbell IG.No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas.Nat Genet. 2008 May;40(5):650-5.
    18408720
  • Campbell IG, Qiu W, Polyak K, Haviv I.Breast-cancer stromal cells with TP53 mutations.N Engl J Med. 2008 Apr 10;358(15):1634-5; author reply 1636.
    18403774
  • Shipitsin M, Polyak K.The cancer stem cell hypothesis: in search of definitions, markers, and relevance.Lab Invest. 2008 May;88(5):459-63. Review.
    18379567
  • Paruchuri V, Prasad A, McHugh K, Bhat HK, Polyak K, Ganju RK.S100A7-downregulation inhibits epidermal growth factor-induced signaling in breast cancer cells and blocks osteoclast formation.PLoS ONE. 2008;3(3):e1741.
    18320059
  • Blackshaw S, Croix BS, Polyak K, Kim JB, Cai L.Serial analysis of gene expression (SAGE): experimental method and data analysis.Curr Protoc Mol Biol. 2007 Oct;Chapter 25:Unit 25B.6.
    18265400
  • Polyak K.Is breast tumor progression really linear?.Clin Cancer Res. 2008 Jan 15;14(2):339-41.
    18223205
  • Zhao X, Goswami M, Pokhriyal N, Ma H, Du H, Yao J, Victor TA, Polyak K, Sturgis CD, Band H, Band V.Cyclooxygenase-2 expression during immortalization and breast cancer progression.Cancer Res. 2008 Jan 15;68(2):467-75.
    18199541
  • Polyak K.Breast cancer: origins and evolution.J Clin Invest. 2007 Nov;117(11):3155-63. Review.
    17975657
  • Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, Silliman N, Szabo S, Dezso Z, Ustyanksky V, Nikolskaya T, Nikolsky Y, Karchin R, Wilson PA, Kaminker JS, Zhang Z, Croshaw R, Willis J, Dawson D, Shipitsin M, Willson JK, Sukumar S, Polyak K, Park BH, Pethiyagoda CL, Pant PV, Ballinger DG, Sparks AB, Hartigan J, Smith DR, Suh E, Papadopoulos N, Buckhaults P, Markowitz SD, Parmigiani G, Kinzler KW, Velculescu VE, Vogelstein B.The genomic landscapes of human breast and colorectal cancers.Science. 2007 Nov 16;318(5853):1108-13.
    17932254
  • Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA.Mesenchymal stem cells within tumour stroma promote breast cancer metastasis.Nature. 2007 Oct 4;449(7162):557-63.
    17914389
  • Polyak K.Breast cancer stem cells: a case of mistaken identity?.Stem Cell Rev. 2007 Jun;3(2):107-9. Review.
    17873341
  • Campbell LL, Polyak K.Breast tumor heterogeneity: cancer stem cells or clonal evolution?.Cell Cycle. 2007 Aug;6(19):2332-8. Review.
    17786053
  • Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Roberts TM, Lander ES, Polyak K, Hahn WC.Integrative genomic approaches identify IKBKE as a breast cancer oncogene.Cell. 2007 Jun 15;129(6):1065-79.
    17574021
  • Hu M, Polyak K.Serial analysis of gene expression.Nat Protoc. 2006;1(4):1743-60.
    17487157
  • Hu M, Yao J, Polyak K.Methylation-specific digital karyotyping.Nat Protoc. 2006;1(3):1406-11.
    17406428
  • Shipitsin M, Campbell LL, Argani P, Weremowicz S, Bloushtain-Qimron N, Yao J, Nikolskaya T, Serebryiskaya T, Beroukhim R, Hu M, Halushka MK, Sukumar S, Parker LM, Anderson KS, Harris LN, Garber JE, Richardson AL, Schnitt SJ, Nikolsky Y, Gelman RS, Polyak K.Molecular definition of breast tumor heterogeneity.Cancer Cell. 2007 Mar;11(3):259-73.
    17349583
  • Polyak K.The p27Kip1 tumor suppressor gene: Still a suspect or proven guilty?.Cancer Cell. 2006 Nov;10(5):352-4.
    17097557
  • Polyak K, Hu M.Do myoepithelial cells hold the key for breast tumor progression?.J Mammary Gland Biol Neoplasia. 2005 Jul;10(3):231-47. Review.
    16807803
  • Yao J, Weremowicz S, Feng B, Gentleman RC, Marks JR, Gelman R, Brennan C, Polyak K.Combined cDNA array comparative genomic hybridization and serial analysis of gene expression analysis of breast tumor progression.Cancer Res. 2006 Apr 15;66(8):4065-78.
    16618726
  • Porter D, Yao J, Polyak K.SAGE and related approaches for cancer target identification.Drug Discov Today. 2006 Feb;11(3-4):110-8. Review.
    16533708
  • Polyak K.Pregnancy and breast cancer: the other side of the coin.Cancer Cell. 2006 Mar;9(3):151-3. Review.
    16530699
  • Polyak K, Hahn WC.Roots and stems: stem cells in cancer.Nat Med. 2006 Mar;12(3):296-300.
    16520777
  • Krop I, Mrz A, Carlsson H, Li X, Bloushtain-Qimron N, Hu M, Gelman R, Sabel MS, Schnitt S, Ramaswamy S, Kleer CG, Enerbck C, Polyak K.A putative role for psoriasin in breast tumor progression.Cancer Res. 2005 Dec 15;65(24):11326-34.
    16357139
  • Krop I, Parker MT, Bloushtain-Qimron N, Porter D, Gelman R, Sasaki H, Maurer M, Terry MB, Parsons R, Polyak K.HIN-1, an inhibitor of cell growth, invasion, and AKT activation.Cancer Res. 2005 Nov 1;65(21):9659-69.
    16266985
  • Hu M, Yao J, Cai L, Bachman KE, van den Brle F, Velculescu V, Polyak K.Distinct epigenetic changes in the stromal cells of breast cancers.Nat Genet. 2005 Aug;37(8):899-905.
    16007089
  • Krop I, Player A, Tablante A, Taylor-Parker M, Lahti-Domenici J, Fukuoka J, Batra SK, Papadopoulos N, Richards WG, Sugarbaker DJ, Wright RL, Shim J, Stamey TA, Sellers WR, Loda M, Meyerson M, Hruban R, Jen J, Polyak K.Frequent HIN-1 Promoter Methylation and Lack of Expression in Multiple Human Tumor Types.Mol Cancer Res. 2004 Sep;2(9):489-94.
    15383627
  • Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H, Porter D, Hu M, Chin L, Richardson A, Schnitt S, Sellers WR, Polyak K.Molecular characterization of the tumor microenvironment in breast cancer.Cancer Cell. 2004 Jul;6(1):17-32.
    15261139
  • Burstein HJ, Polyak K, Wong JS, Lester SC, Kaelin CM.Ductal carcinoma in situ of the breast.N Engl J Med. 2004 Apr 1;350(14):1430-41.
    15070793
  • Polyak K.Breast cancer gene discovery.Expert Rev Mol Med. 2002 Aug 15;2002:1-18.
    14987381
  • Porter D, Polyak K.Cancer target discovery using SAGE.Expert Opin Ther Targets. 2003 Dec;7(6):759-69.
    14640911
  • Porter D, Weremowicz S, Chin K, Seth P, Keshaviah A, Lahti-Domenici J, Bae YK, Monitto CL, Merlos-Suarez A, Chan J, Hulette CM, Richardson A, Morton CC, Marks J, Duyao M, Hruban R, Gabrielson E, Gelman R, Polyak K.A neural survival factor is a candidate oncogene in breast cancer.Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10931-6.
    12953101
  • Krop I, Maguire P, Lahti-Domenici J, Lodeiro G, Richardson A, Johannsdottir HK, Nevanlinna H, Borg A, Gelman R, Barkardottir RB, Lindblom A, Polyak K.Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors.Cancer Res. 2003 May 1;63(9):2024-7.
    12727813
  • Porter D, Lahti-Domenici J, Keshaviah A, Bae YK, Argani P, Marks J, Richardson A, Cooper A, Strausberg R, Riggins GJ, Schnitt S, Gabrielson E, Gelman R, Polyak K.Molecular markers in ductal carcinoma in situ of the breast.Mol Cancer Res. 2003 Mar;1(5):362-75.
    12651909
  • Seth P, Porter D, Lahti-Domenici J, Geng Y, Richardson A, Polyak K.Cellular and molecular targets of estrogen in normal human breast tissue.Cancer Res. 2002 Aug 15;62(16):4540-4.
    12183401
  • Seth P, Krop I, Porter D, Polyak K.Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression).Oncogene. 2002 Jan 24;21(5):836-43.
    11850811
  • Polyak K.Molecular alterations in ductal carcinoma in situ of the breast.Curr Opin Oncol. 2002 Jan;14(1):92-6.
    11790987
  • Enerbck C, Porter DA, Seth P, Sgroi D, Gaudet J, Weremowicz S, Morton CC, Schnitt S, Pitts RL, Stampl J, Barnhart K, Polyak K.Psoriasin expression in mammary epithelial cells in vitro and in vivo.Cancer Res. 2002 Jan 1;62(1):43-7.
    11782356
  • Polyak K.On the birth of breast cancer.Biochim Biophys Acta. 2001 Nov 30;1552(1):1-13.
    11781111
  • Porter DA, Krop IE, Nasser S, Sgroi D, Kaelin CM, Marks JR, Riggins G, Polyak K.A SAGE (serial analysis of gene expression) view of breast tumor progression.Cancer Res. 2001 Aug 1;61(15):5697-702.
    11479200
  • Krop IE, Sgroi D, Porter DA, Lunetta KL, LeVangie R, Seth P, Kaelin CM, Rhei E, Bosenberg M, Schnitt S, Marks JR, Pagon Z, Belina D, Razumovic J, Polyak K.HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells.Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9796-801.
    11481438
  • Polyak K, Riggins GJ.Gene discovery using the serial analysis of gene expression technique: implications for cancer research.J Clin Oncol. 2001 Jun 1;19(11):2948-58.
    11387368
  • Seth P, Lunetta KL, Bell DW, Gray H, Nasser SM, Rhei E, Kaelin CM, Iglehart DJ, Marks JR, Garber JE, Haber DA, Polyak K.Phenol sulfotransferases: hormonal regulation, polymorphism, and age of onset of breast cancer.Cancer Res. 2000 Dec 15;60(24):6859-63.
    11156380