Michael R. Hamblin, PhD

Publications

• Mroz P, Hamblin MR.The immunosuppressive side of PDT.Photochem Photobiol Sci. 2011 Mar 24.
  21437314
• Mroz P, Szokalska A, Wu MX, Hamblin MR.Photodynamic therapy of tumors can lead to development of systemic antigen-specific immune response.PLoS ONE. 2010;5(12):e15194.
  21179470
• Mroz P, Hashmi JT, Huang YY, Lange N, Hamblin MR.Stimulation of anti-tumor immunity by photodynamic therapy.Expert Rev Clin Immunol. 2011 Jan;7(1):75-91. Review.
  21162652
• Mroz P, Huang YY, Szokalska A, Zhiyentayev T, Janjua S, Nifli AP, Sherwood ME, Ruzié C, Borbas KE, Fan D, Krayer M, Balasubramanian T, Yang E, Kee HL, Kirmaier C, Diers JR, Bocian DF, Holten D, Lindsey JS, Hamblin MR.Stable synthetic bacteriochlorins ove
  20385618
• Hamblin MR.Introduction to experimental and clinical studies using low-level laser (light) therapy (LLLT).Lasers Surg Med. 2010 Aug;42(6):447-9.
  20662020
• Chen Z, Zhou S, Chen J, Deng Y, Luo Z, Chen H, Hamblin MR, Huang M.Pentalysine beta-carbonylphthalocyanine zinc: an effective tumor-targeting photosensitizer for photodynamic therapy.ChemMedChem. 2010 Jun 7;5(6):890-8.
  20458713
• Huang YY, Mroz P, Zhiyentayev T, Sharma SK, Balasubramanian T, Ruzié C, Krayer M, Fan D, Borbas KE, Yang E, Kee HL, Kirmaier C, Diers JR, Bocian DF, Holten D, Lindsey JS, Hamblin MR.In vitro photodynamic therapy and quantitative structure-activity relati
  20441223
• Park J, Mroz P, Hamblin MR, Yaroslavsky AN.Dye-enhanced multimodal confocal microscopy for noninvasive detection of skin cancers in mouse models.J Biomed Opt.;15(2):026023.
  20459268
• Mroz P,Bhaumik J,Dogutan DK,Aly Z,Kamal Z,Khalid L,Kee HL,Bocian DF,Holten D,Lindsey JS,Hamblin MR.Imidazole metalloporphyrins as photosensitizers for photodynamic therapy: Role of molecular charge, central metal and hydroxyl radical production.Cancer Let
  19346065
• Castano AP, Mroz P, Wu MX, Hamblin MR.Photodynamic therapy plus low-dose cyclophosphamide generates antitumor immunity in a mouse model.Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5495-500.
  18378905
• Garcez AS, Nuñez SC, Hamblin MR, Ribeiro MS.Antimicrobial effects of photodynamic therapy on patients with necrotic pulps and periapical lesion.J Endod. 2008 Feb;34(2):138-42.
  18215668
• Garcez AS, Nunez SC, Lage-Marques JL, Hamblin MR, Ribeiro MS.Photonic real-time monitoring of bacterial reduction in root canals by genetically engineered bacteria after chemomechanical endodontic therapy.Braz Dent J. 2007;18(3):202-7.
  18176710
• Tawakol A, Castano AP, Gad F, Zahra T, Bashian G, Migrino RQ, Ahmadi A, Stern J, Anatelli F, Chirico S, Shirazi A, Syed S, Fischman AJ, Muller JE, Hamblin MR.Intravascular detection of inflamed atherosclerotic plaques using a fluorescent photosensitizer t
  18167594
• Apidianakis Y, Mindrinos MN, Xiao W, Tegos GP, Papisov MI, Hamblin MR, Davis RW, Tompkins RG, Rahme LG.Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma.PLoS ONE. 2007;2(12):e1356.
  18159239
• Mroz P, Tegos GP, Gali H, Wharton T, Sarna T, Hamblin MR.Photodynamic therapy with fullerenes.Photochem Photobiol Sci. 2007 Nov;6(11):1139-49. Review.
  17973044
• Demidova-Rice TN, Salomatina EV, Yaroslavsky AN, Herman IM, Hamblin MR.Low-level light stimulates excisional wound healing in mice.Lasers Surg Med. 2007 Oct;39(9):706-15.
  17960752
• Mroz P, Pawlak A, Satti M, Lee H, Wharton T, Gali H, Sarna T, Hamblin MR.Functionalized fullerenes mediate photodynamic killing of cancer cells: Type I versus Type II photochemical mechanism.Free Radic Biol Med. 2007 Sep 1;43(5):711-9.
  17664135
• Castano AP, Dai T, Yaroslavsky I, Cohen R, Apruzzese WA, Smotrich MH, Hamblin MR.Low-level laser therapy for zymosan-induced arthritis in rats: Importance of illumination time.Lasers Surg Med. 2007 Jul;39(6):543-50.
  17659584
• Fuchs BB, Tegos GP, Hamblin MR, Mylonakis E.Susceptibility of Cryptococcus neoformans to photodynamic inactivation is associated with cell wall integrity.Antimicrob Agents Chemother. 2007 Aug;51(8):2929-36.
  17548495
• Tang HM, Hamblin MR, Yow CM.A comparative in vitro photoinactivation study of clinical isolates of multidrug-resistant pathogens.J Infect Chemother. 2007 Apr;13(2):87-91.
  17458675
• Møller-Kristensen M, Hamblin MR, Thiel S, Jensenius JC, Takahashi K.Burn injury reveals altered phenotype in mannan-binding lectin-deficient mice.J Invest Dermatol. 2007 Jun;127(6):1524-31.
  17363917
• Anatelli F, Mroz P, Liu Q, Yang C, Castano AP, Swietlik E, Hamblin MR.Macrophage-targeted photosensitizer conjugate delivered by intratumoral injection.Mol Pharm. 2006 Nov-Dec;3(6):654-64.
  17140253
• Garcez AS, Ribeiro MS, Tegos GP, Núñez SC, Jorge AO, Hamblin MR.Antimicrobial photodynamic therapy combined with conventional endodontic treatment to eliminate root canal biofilm infection.Lasers Surg Med. 2007 Jan;39(1):59-66.
  17066481
• Foley JW, Song X, Demidova TN, Jalil F, Jilal F, Hamblin MR.Synthesis and properties of benzo[a]phenoxazinium chalcogen analogues as novel broad-spectrum antimicrobial photosensitizers.J Med Chem. 2006 Aug 24;49(17):5291-9.
  16913718
• Castano AP, Mroz P, Hamblin MR.Photodynamic therapy and anti-tumour immunity.Nat Rev Cancer. 2006 Jul;6(7):535-45. Review.
  16794636
• Borbas KE, Mroz P, Hamblin MR, Lindsey JS.Bioconjugatable porphyrins bearing a compact swallowtail motif for water solubility.Bioconjug Chem. 2006 May-Jun;17(3):638-53.
  16704201
• Tegos GP, Demidova TN, Arcila-Lopez D, Lee H, Wharton T, Gali H, Hamblin MR.Cationic fullerenes are effective and selective antimicrobial photosensitizers.Chem Biol. 2005 Oct;12(10):1127-35.
  16242655
• Liu Q, Hamblin MR.Macrophage-targeted photodynamic therapy: scavenger receptor expression and activation state.Int J Immunopathol Pharmacol. 2005 Jul-Sep;18(3):391-402.
  16164823
• Demidova TN, Gad F, Zahra T, Francis KP, Hamblin MR.Monitoring photodynamic therapy of localized infections by bioluminescence imaging of genetically engineered bacteria.J Photochem Photobiol B. 2005 Oct 3;81(1):15-25.
  16040251
• Lambrechts SA, Demidova TN, Aalders MC, Hasan T, Hamblin MR.Photodynamic therapy for Staphylococcus aureus infected burn wounds in mice.Photochem Photobiol Sci. 2005 Jul;4(7):503-9.
  15986057
• Hamblin MR, Viveiros J, Yang C, Ahmadi A, Ganz RA, Tolkoff MJ.Helicobacter pylori accumulates photoactive porphyrins and is killed by visible light.Antimicrob Agents Chemother. 2005 Jul;49(7):2822-7.
  15980355
• Demidova TN, Hamblin MR.Effect of cell-photosensitizer binding and cell density on microbial photoinactivation.Antimicrob Agents Chemother. 2005 Jun;49(6):2329-35.
  15917529
• Ganz RA, Viveiros J, Ahmad A, Ahmadi A, Khalil A, Tolkoff MJ, Nishioka NS, Hamblin MR.Helicobacter pylori in patients can be killed by visible light.Lasers Surg Med. 2005 Apr;36(4):260-5.
  15791671
• Khadem J, Martino M, Anatelli F, Dana MR, Hamblin MR.Healing of perforating rat corneal incisions closed with photodynamic laser-activated tissue glue.Lasers Surg Med. 2004;35(4):304-11.
  15493025
• Demidova TN, Hamblin MR.Photodynamic therapy targeted to pathogens.Int J Immunopathol Pharmacol. 2004 Sep-Dec;17(3):245-54.
  15461858
• Demidova TN, Hamblin MR.Macrophage-targeted photodynamic therapy.Int J Immunopathol Pharmacol. 2004 May-Aug;17(2):117-26.
  15171812
• Gad F, Zahra T, Hasan T, Hamblin MR.Effects of growth phase and extracellular slime on photodynamic inactivation of gram-positive pathogenic bacteria.Antimicrob Agents Chemother. 2004 Jun;48(6):2173-8.
  15155218
• Shi L, Takahashi K, Dundee J, Shahroor-Karni S, Thiel S, Jensenius JC, Gad F, Hamblin MR, Sastry KN, Ezekowitz RA.Mannose-binding Lectin-deficient Mice Are Susceptible to Infection with Staphylococcus aureus.J Exp Med. 2004 May 17;199(10):1379-90.
  15148336
• Gad F, Zahra T, Francis KP, Hasan T, Hamblin MR.Targeted photodynamic therapy of established soft-tissue infections in mice.Photochem Photobiol Sci. 2004 May;3(5):451-8.
  15122362
• Hamblin MR, Hasan T.Photodynamic therapy: a new antimicrobial approach to infectious disease?.Photochem Photobiol Sci. 2004 May;3(5):436-50.
  15122361
• Hamblin MR, Miller JL, Rizvi I, Loew HG, Hasan T.Pegylation of charged polymer-photosensitiser conjugates: effects on photodynamic efficacy.Br J Cancer. 2003 Sep 1;89(5):937-43.
  12942129
• Hamblin MR, Zahra T, Contag CH, McManus AT, Hasan T.Optical monitoring and treatment of potentially lethal wound infections in vivo.J Infect Dis. 2003 Jun 1;187(11):1717-25.
  12751029
• Kodama T, Doukas AG, Hamblin MR.Delivery of ribosome-inactivating protein toxin into cancer cells with shock waves.Cancer Lett. 2003 Jan 10;189(1):69-75.
  12445679
• Hamblin MR, O'Donnell DA, Murthy N, Rajagopalan K, Michaud N, Sherwood ME, Hasan T.Polycationic photosensitizer conjugates: effects of chain length and Gram classification on the photodynamic inactivation of bacteria.J Antimicrob Chemother. 2002 Jun;4
  12039886
• Hamblin MR, Miller JL, Rizvi I, Ortel B.Degree of substitution of chlorin(e6) conjugated to charged poly-L-lysine chains affects their cellular uptake, localization and phototoxicity towards macrophages and cancer cells.J Am Diet Assoc. 2002 Apr 01;10:139
• Kodama T, Doukas AG, Hamblin MR.Shock wave-mediated molecular delivery into cells.Biochim Biophys Acta. 2002 Jan 30;1542(1-3):186-94.
  11853891
• Hamblin MR, O'Donnell DA, Murthy N, Contag CH, Hasan T.Rapid control of wound infections by targeted photodynamic therapy monitored by in vivo bioluminescence imaging.Photochem Photobiol. 2002 Jan;75(1):51-7.
  11837327
• Hamblin MR, Miller JL, Rizvi I, Ortel B, Maytin EV, Hasan T.Pegylation of a chlorin(e6) polymer conjugate increases tumor targeting of photosensitizer.Cancer Res. 2001 Oct 1;61(19):7155-62.
  11585749
• Soukos NS, Hamblin MR, Keel S, Fabian RL, Deutsch TF, Hasan T.Epidermal growth factor receptor-targeted immunophotodiagnosis and photoimmunotherapy of oral precancer in vivo.Cancer Res. 2001 Jun 1;61(11):4490-6.
  11389080
• Hamblin MR, Del Governatore M, Rizvi I, Hasan T.Biodistribution of charged 17.1A photoimmunoconjugates in a murine model of hepatic metastasis of colorectal cancer.Br J Cancer. 2000 Dec;83(11):1544-51.
  11076666
• Hamblin MR, Miller JL, Ortel B.Scavenger-receptor targeted photodynamic therapy.Photochem Photobiol. 2000 Oct;72(4):533-40.
  11045726
• Kodama T, Hamblin MR, Doukas AG.Cytoplasmic molecular delivery with shock waves: importance of impulse.Biophys J. 2000 Oct;79(4):1821-32.
  11023888
• Del Governatore M, Hamblin MR, Shea CR, Rizvi I, Molpus KG, Tanabe KK, Hasan T.Experimental photoimmunotherapy of hepatic metastases of colorectal cancer with a 17.1A chlorin(e6) immunoconjugate.Cancer Res. 2000 Aug 1;60(15):4200-5.
  10945630
• Molpus KL, Hamblin MR, Rizvi I, Hasan T.Intraperitoneal photoimmunotherapy of ovarian carcinoma xenografts in nude mice using charged photoimmunoconjugates.Gynecol Oncol. 2000 Mar;76(3):397-404.
  10684717
• Del Governatore M, Hamblin MR, Piccinini EE, Ugolini G, Hasan T.Targeted photodestruction of human colon cancer cells using charged 17.1A chlorin e6 immunoconjugates.Br J Cancer. 2000 Jan;82(1):56-64.
  10638967
• Khadem J, Veloso AA, Tolentino F, Hasan T, Hamblin MR.Photodynamic tissue adhesion with chlorin(e6) protein conjugates.Invest Ophthalmol Vis Sci. 1999 Dec;40(13):3132-7.
  10586934
• Hamblin MR, Rajadhyaksha M, Momma T, Soukos NS, Hasan T.In vivo fluorescence imaging of the transport of charged chlorin e6 conjugates in a rat orthotopic prostate tumour.Br J Cancer. 1999 Sep;81(2):261-8.
  10496351
• Duska LR, Hamblin MR, Miller JL, Hasan T.Combination photoimmunotherapy and cisplatin: effects on human ovarian cancer ex vivo.J Natl Cancer Inst. 1999 Sep 15;91(18):1557-63.
  10491432
• Momma T, Hamblin MR, Wu HC, Hasan T.Photodynamic therapy of orthotopic prostate cancer with benzoporphyrin derivative: local control and distant metastasis.Cancer Res. 1998 Dec 1;58(23):5425-31.
  9850075
• Soukos NS, Ximenez-Fyvie LA, Hamblin MR, Socransky SS, Hasan T.Targeted antimicrobial photochemotherapy.Antimicrob Agents Chemother. 1998 Oct;42(10):2595-601.
  9756761
• Momma T, Hamblin MR, Hasan T.Hormonal modulation of the accumulation of 5-aminolevulinic acid-induced protoporphyrin and phototoxicity in prostate cancer cells.Int J Cancer. 1997 Sep 17;72(6):1062-9.
  9378541
• Soukos NS, Hamblin MR, Hasan T.The effect of charge on cellular uptake and phototoxicity of polylysine chlorin(e6) conjugates.Photochem Photobiol. 1997 Apr;65(4):723-9.
  9114750
• Duska LR, Hamblin MR, Bamberg MP, Hasan T.Biodistribution of charged F(ab')2 photoimmunoconjugates in a xenograft model of ovarian cancer.Br J Cancer. 1997;75(6):837-44.
  9062404
• Hamblin MR, Miller JL, Hasan T.Effect of charge on the interaction of site-specific photoimmunoconjugates with human ovarian cancer cells.Cancer Res. 1996 Nov 15;56(22):5205-10.
  8912858
• Molpus KL, Kato D, Hamblin MR, Lilge L, Bamberg M, Hasan T.Intraperitoneal photodynamic therapy of human epithelial ovarian carcinomatosis in a xenograft murine model.Cancer Res. 1996 Mar 1;56(5):1075-82.
  8640764
• Hamblin MR, Newman EL.Photosensitizer targeting in photodynamic therapy. II. Conjugates of haematoporphyrin with serum lipoproteins.J Photochem Photobiol B. 1994 Nov;26(2):147-57.
  7815189
• Hamblin MR, Newman EL.Photosensitizer targeting in photodynamic therapy. I. Conjugates of haematoporphyrin with albumin and transferrin.J Photochem Photobiol B. 1994 Oct;26(1):45-56.
  7799139
• Hamblin MR, Newman EL.On the mechanism of the tumour-localising effect in photodynamic therapy.J Photochem Photobiol B. 1994 Apr;23(1):3-8.
  8021748
• Hamblin MR, Flora JS, Potter BV.myo-Inositol phosphorothioates, phosphatase-resistant analogues of myo-inositol phosphates. Synthesis of DL-myo-inositol 1,4-bisphosphate and DL-myo-inositol 1,4-bisphosphorothioate.Biochem J. 1987 Sep 15;246(3):771-4.
  3689330
• Hamblin MR, Cummins JH, Potter BV.Mung bean (Phaseolus aureus) nuclease. A mechanistic investigation of the DNA-cleavage reaction using a dinucleoside phosphorothioate.Biochem J. 1987 Feb 1;241(3):827-33.
  3036076
• Hamblin MR, Potter BV.E. coli Ada regulatory protein repairs the SP diastereoisomer of alkylated DNA.FEBS Lett. 1985 Sep 23;189(2):315-7.
  2995122