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David A. Frank, MD, PhD


  • Walker SR, Xiang M, Frank DA.Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer.Mol Cell Endocrinol. 2013 Mar 24.
  • Chmielecki J, Crago AM, Rosenberg M, O'Connor R, Walker SR, Ambrogio L, Auclair D, McKenna A, Heinrich MC, Frank DA, Meyerson M.Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.Nat Genet. 2013 Feb;45(2):131-2.
  • Nelson EA, Walker SR, Xiang M, Weisberg E, Bar-Natan M, Barrett R, Liu S, Kharbanda S, Christie AL, Nicolais M, Griffin JD, Stone RM, Kung AL, Frank DA.The STAT5 Inhibitor Pimozide Displays Efficacy in Models of Acute Myelogenous Leukemia Driven by FLT3 Mutations.Genes Cancer. 2012 Jul;3(7-8):503-11.
  • Greulich H, Kaplan B, Mertins P, Chen TH, Tanaka KE, Yun CH, Zhang X, Lee SH, Cho J, Ambrogio L, Liao R, Imielinski M, Banerji S, Berger AH, Lawrence MS, Zhang J, Pho NH, Walker SR, Winckler W, Getz G, Frank D, Hahn WC, Eck MJ, Mani DR, Jaffe JD, Carr SA, Wong KK, Meyerson M.Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14476-81.
  • Nelson EA, Walker SR, Weisberg E, Bar-Natan M, Barrett R, Gashin LB, Terrell S, Klitgaard JL, Santo L, Addorio MR, Ebert BL, Griffin JD, Frank DA.The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors.Blood. 2011 Mar 24;117(12):3421-9.
  • Morikawa T, Baba Y, Yamauchi M, Kuchiba A, Nosho K, Shima K, Tanaka N, Huttenhower C, Frank DA, Fuchs CS, Ogino S.STAT3 Expression, Molecular Features, Inflammation Patterns, and Prognosis in a Database of 724 Colorectal Cancers.Clin Cancer Res. 2011 Mar 15;17(6):1452-62.
  • Walker SR, Chaudhury M, Nelson EA, Frank DA.Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling.Mol Pharmacol. 2010 Nov;78(5):903-8.
  • Yoda A, Yoda Y, Chiaretti S, Bar-Natan M, Mani K, Rodig SJ, West N, Xiao Y, Brown JR, Mitsiades C, Sattler M, Kutok JL, DeAngelo DJ, Wadleigh M, Piciocchi A, Dal Cin P, Bradner JE, Griffin JD, Anderson KC, Stone RM, Ritz J, Foà R, Aster JC, Frank DA, Weinstock DM.Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):252-7.
  • Frank DA.STAT6 in PMBL: pathogenic or passenger?.Blood. 2009 Aug 6;114(6):1133-4.
  • Walker SR, Nelson EA, Zou L, Chaudhury M, Signoretti S, Richardson A, Frank DA.Reciprocal effects of STAT5 and STAT3 in breast cancer.Mol Cancer Res. 2009 Jun;7(6):966-76.
  • Sakamoto KM,Frank DA.CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy.Clin Cancer Res. 2009 Apr 15;15(8):2583-7.
  • Ikeuchi Y,Stegmuller J,Netherton S,Huynh MA,Masu M,Frank D,Bonni S,Bonni A.A SnoN-Ccd1 pathway promotes axonal morphogenesis in the mammalian brain.J Neurosci. 2009 Apr 1;29(13):4312-21.
  • Frank DA.Targeting transcription factors for cancer therapy.IDrugs. 2009 Jan;12(1):29-33. Review.
  • Nelson EA,Walker SR,Kepich A,Gashin LB,Hideshima T,Ikeda H,Chauhan D,Anderson KC,Frank DA.Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.Blood. 2008 Dec 15;112(13):5095-102.
  • de la Iglesia N,Konopka G,Lim KL,Nutt CL,Bromberg JF,Frank DA,Mischel PS,Louis DN,Bonni A.Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness.J Neurosci. 2008 Jun 4;28(23):5870-8.
  • Frank DA.Review: Prophylactic use of granulocyte colony-stimulating factor reduces febrile neutropenia and short-term mortality in cancer.ACP J Club. 2008 Jan-Feb;148(1):7.
  • Germain D, Frank DA.Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy.Clin Cancer Res. 2007 Oct 1;13(19):5665-9. Review.
  • Liddle FJ, Frank DA.STAT1 expression is not required for polyp formation in Min mice.Mol Carcinog. 2008 Feb;47(2):75-9.
  • Lynch RA, Etchin J, Battle TE, Frank DA.A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells.Cancer Res. 2007 Feb 1;67(3):1254-61.
  • Walker SR, Nelson EA, Frank DA.STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas.Oncogene. 2007 Jan 11;26(2):224-33.
  • Frank DA.STAT3 as a central mediator of neoplastic cellular transformation.Cancer Lett. 2007 Jun 28;251(2):199-210. Review.
  • Ishii Y, Pirkmaier A, Alvarez JV, Frank DA, Keselman I, Logothetis D, Mandeli J, O'Connell MJ, Waxman S, Germain D.Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model.J Natl Cancer Inst. 2006 Sep 6;98(17):1238-47.
  • Bhattacharjee A, Xu B, Frank DA, Feldman GM, Cathcart MK.Monocyte 15-lipoxygenase expression is regulated by a novel cytosolic signaling complex with protein kinase C delta and tyrosine-phosphorylated Stat3.J Immunol. 2006 Sep 15;177(6):3771-81.
  • Zorn E, Nelson EA, Mohseni M, Porcheray F, Kim H, Litsa D, Bellucci R, Raderschall E, Canning C, Soiffer RJ, Frank DA, Ritz J.IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT dependent mechanism and induces the expansion of these cells in vivo.Blood. 2006 Sep 1;108(5):1571-9.
  • Liddle FJ, Alvarez JV, Poli V, Frank DA.Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants.Biochemistry. 2006 May 2;45(17):5599-605.
  • Arbiser JL, Govindarajan B, Battle TE, Lynch R, Frank DA, Ushio-Fukai M, Perry BN, Stern DF, Bowden GT, Liu A, Klein E, Kolodziejski PJ, Eissa NT, Hossain CF, Nagle DG.Carbazole is a naturally occurring inhibitor of angiogenesis and inflammation isolated from antipsoriatic coal tar.J Invest Dermatol. 2006 Jun;126(6):1396-402.
  • Battle TE, Lynch RA, Frank DA.Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis.Cancer Res. 2006 Apr 1;66(7):3649-57.
  • Alvarez JV, Greulich H, Sellers WR, Meyerson M, Frank DA.Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor.Cancer Res. 2006 Mar 15;66(6):3162-8.
  • Isomoto H, Kobayashi S, Werneburg NW, Bronk SF, Guicciardi ME, Frank DA, Gores GJ.Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells.Hepatology. 2005 Dec;42(6):1329-38.
  • Greulich H, Chen TH, Feng W, Jänne PA, Alvarez JV, Zappaterra M, Bulmer SE, Frank DA, Hahn WC, Sellers WR, Meyerson M.Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants.PLoS Med. 2005 Oct 4;2(11):e313.
  • Kay NE, Bone ND, Lee YK, Jelinek DF, Leland P, Battle TE, Frank DA, Puri RK.A recombinant IL-4-Pseudomonas exotoxin inhibits protein synthesis and overcomes apoptosis resistance in human CLL B cells.Leuk Res. 2005 Sep;29(9):1009-18.
  • Battle TE, Arbiser J, Frank DA.The natural product Honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells.Blood. 2005 Jul 15;106(2):690-7.
  • Alvarez JV, Febbo PG, Ramaswamy S, Loda M, Richardson A, Frank DA.Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors.Cancer Res. 2005 Jun 15;65(12):5054-62.
  • Cerimele F, Battle T, Lynch R, Frank DA, Murad E, Cohen C, Macaron N, Sixbey J, Smith K, Watnick RS, Eliopoulos A, Shehata B, Arbiser JL.Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma.Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):175-9.
  • Nelson EA, Walker SR, Alvarez JV, Frank DA.Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification.J Biol Chem. 2004 Dec 24;279(52):54724-30.
  • Nelson EA, Walker SR, Alvarez JA, Frank DA.Identification of unique STAT5 targets by chromatin immunoprecipitation-based gene identification.J Biol Chem. 2004 Nov;In press:In press.
  • Yuan H, Liddle F, Mahajan S, Frank DA.IL-6 induced survival of colorectal carcinoma cells is inhibited by butyrate through downregulation of the IL-6 receptor.Carcinogenesis. 2004 Oct;In press:In press.
  • Yuan H, Liddle FJ, Mahajan S, Frank DA.IL-6-induced survival of colorectal carcinoma cells is inhibited by butyrate through down-regulation of the IL-6 receptor.Carcinogenesis. 2004 Nov;25(11):2247-55.
  • Friedberg JW, Dong DA, Li S, Kim H, Stephans K, Noonan K, Neuberg D, Gribben JG, Fisher DC, Freedman AS, Takvorian T, Jurgens R, Battle TE, Frank DA.Oral fludarabine has significant activity in patients with previously untreated chronic lymphocytic leukemia, and leads to increased STAT1 levels in vivo.Leuk Res. 2004 Feb;28(2):139-47.
  • Battle TE, Frank DA.STAT1 mediates differentiation of chronic lymphocytic leukemia cells in response to Bryostatin 1.Blood. 2003 Oct 15;102(8):3016-24.
  • Battle TE, Castro-Malaspina H, Gribben JG, Frank DA.Sustained complete remission of CLL associated with the use of a Chinese herbal extract: case report and mechanistic analysis.Leuk Res. 2003 Sep;27(9):859-63.
  • Battle TE, Wierda WG, Rassenti LZ, Zahrieh D, Neuberg D, Kipps TJ, Frank DA.In vivo activation of signal transducer and activator of transcription 1 after CD154 gene therapy for chronic lymphocytic leukemia is associated with clinical and immunologic response.Clin Cancer Res. 2003 Jun;9(6):2166-72.
  • Xu B, Bhattacharjee A, Roy B, Xu HM, Anthony D, Frank DA, Feldman GM, Cathcart MK.Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen-activated protein kinase-mediated serine 727 phosphorylation of Stat1 and Stat3.Mol Cell Biol. 2003 Jun;23(11):3918-28.
  • Frank DA.StAT signaling in cancer: insights into pathogenesis and treatment strategies.Cancer Treat Res. 2003;115:267-91.
  • Battle TE, Frank DA.The role of STATs in apoptosis.Curr Mol Med. 2002 Jun;2(4):381-92.
  • Vonderheide RH, Butler MO, Liu JF, Battle TE, Hirano N, Gribben JG, Frank DA, Schultze JL, Nadler LM.CD40 activation of carcinoma cells increases expression of adhesion and major histocompatibility molecules but fails to induce either CD80/CD86 expression or T cell alloreactivity.Int J Oncol. 2001 Oct;19(4):791-8.
  • Arbiser JL, Yeung R, Weiss SW, Arbiser ZK, Amin MB, Cohen C, Frank D, Mahajan S, Herron GS, Yang J, Onda H, Zhang HB, Bai X, Uhlmann E, Loehr A, Northrup H, Au P, Davis I, Fisher DE, Gutmann DH.The generation and characterization of a cell line derived from a sporadic renal angiomyolipoma: use of telomerase to obtain stable populations of cells from benign neoplasms.Am J Pathol. 2001 Aug;159(2):483-91.
  • Barber DL, Beattie BK, Mason JM, Nguyen MH, Yoakim M, Neel BG, D'Andrea AD, Frank DA.A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation.Blood. 2001 Apr 15;97(8):2230-7.
  • Mahajan S, Gollob JA, Ritz J, Frank DA.CD2 stimulation leads to the delayed and prolonged activation of STAT1 in T cells but not NK cells.Exp Hematol. 2001 Feb;29(2):209-20.
  • Frank DA, Meuse J, Hirsch D, Ibrahim JG, van den Abbeele AD.The treatment and outcome of cancer patients with thromboses on central venous catheters.J Thromb Thrombolysis. 2000 Dec;10(3):271-5.
  • Duarte RF, Frank DA.SCF and G-CSF lead to the synergistic induction of proliferation and gene expression through complementary signaling pathways.Blood. 2000 Nov 15;96(10):3422-30.
  • Gollob JA, Veenstra KG, Jyonouchi H, Kelly AM, Ferrieri P, Panka DJ, Altare F, Fieschi C, Casanova JL, Frank DA, Mier JW.Impairment of STAT activation by IL-12 in a patient with atypical mycobacterial and staphylococcal infections.J Immunol. 2000 Oct 1;165(7):4120-6.
  • Karras JG, McKay RA, Lu T, Pych J, Frank DA, Rothstein TL, Monia BP.STAT3 regulates the growth and immunoglobulin production of BCL(1) B cell lymphoma through control of cell cycle progression.Cell Immunol. 2000 Jun 15;202(2):124-35.
  • Lin TS, Mahajan S, Frank DA.STAT signaling in the pathogenesis and treatment of leukemias.Oncogene. 2000 May 15;19(21):2496-504.
  • Wilbanks AM, Mahajan S, Frank DA, Druker BJ, Gilliland DG, Carroll M.TEL/PDGFbetaR fusion protein activates STAT1 and STAT5: a common mechanism for transformation by tyrosine kinase fusion proteins.Exp Hematol. 2000 May;28(5):584-93.
  • Wang KS, Frank DA, Ritz J.Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4.Blood. 2000 May 15;95(10):3183-90.
  • Sillaber C, Gesbert F, Frank DA, Sattler M, Griffin JD.STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells.Blood. 2000 Mar 15;95(6):2118-25.
  • Turkson J, Bowman T, Adnane J, Zhang Y, Djeu JY, Sekharam M, Frank DA, Holzman LB, Wu J, Sebti S, Jove R.Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein.Mol Cell Biol. 1999 Nov;19(11):7519-28.
  • Frank DA.STAT signaling in the pathogenesis and treatment of cancer.Mol Med. 1999 Jul;5(7):432-56.
  • Ho JM, Beattie BK, Squire JA, Frank DA, Barber DL.Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling.Blood. 1999 Jun 15;93(12):4354-64.
  • Smith D, Buckle GJ, Hafler DA, Frank DA, Höllsberg P.HTLV-I-infected T cells evade the antiproliferative action of IFN-beta.Virology. 1999 May 10;257(2):314-21.
  • Frank DA, Mahajan S, Ritz J.Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling.Nat Med. 1999 Apr;5(4):444-7.
  • Gollob JA, Schnipper CP, Murphy EA, Ritz J, Frank DA.The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation.J Immunol. 1999 Apr 15;162(8):4472-81.
  • Wang KS, Ritz J, Frank DA.IL-2 induces STAT4 activation in primary NK cells and NK cell lines, but not in T cells.J Immunol. 1999 Jan 1;162(1):299-304.
  • Gollob JA, Schnipper CP, Orsini E, Murphy E, Daley JF, Lazo SB, Frank DA, Neuberg D, Ritz J.Characterization of a novel subset of CD8(+) T cells that expands in patients receiving interleukin-12.J Clin Invest. 1998 Aug 1;102(3):561-75.
  • Gollob JA, Murphy EA, Mahajan S, Schnipper CP, Ritz J, Frank DA.Altered interleukin-12 responsiveness in Th1 and Th2 cells is associated with the differential activation of STAT5 and STAT1.Blood. 1998 Feb 15;91(4):1341-54.
  • Frank DA, Mahajan S, Ritz J.B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues.J Clin Invest. 1997 Dec 15;100(12):3140-8.
  • Karras JG, Wang Z, Huo L, Frank DA, Rothstein TL.Induction of STAT protein signaling through the CD40 receptor in B lymphocytes: distinct STAT activation following surface Ig and CD40 receptor engagement.J Immunol. 1997 Nov 1;159(9):4350-5.
  • Bonni A, Sun Y, Nadal-Vicens M, Bhatt A, Frank DA, Rozovsky I, Stahl N, Yancopoulos GD, Greenberg ME.Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway.Science. 1997 Oct 17;278(5337):477-83.
  • Karras JG, Wang Z, Huo L, Howard RG, Frank DA, Rothstein TL.Signal transducer and activator of transcription-3 (STAT3) is constitutively activated in normal, self-renewing B-1 cells but only inducibly expressed in conventional B lymphocytes.J Exp Med. 1997 Mar 17;185(6):1035-42.
  • Arbiser JL, Moses MA, Fernandez CA, Ghiso N, Cao Y, Klauber N, Frank D, Brownlee M, Flynn E, Parangi S, Byers HR, Folkman J.Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways.Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):861-6.
  • Karras JG, Huo L, Wang Z, Frank DA, Zimmet JM, Rothstein TL.Delayed tyrosine phosphorylation and nuclear expression of STAT1 following antigen receptor stimulation of B lymphocytes.J Immunol. 1996 Sep 15;157(6):2299-309.
  • Carlesso N, Frank DA, Griffin JD.Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.J Exp Med. 1996 Mar 1;183(3):811-20.
  • Inhorn RC, Carlesso N, Durstin M, Frank DA, Griffin JD.Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750.Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8665-9.
  • Sattler M, Durstin MA, Frank DA, Okuda K, Kaushansky K, Salgia R, Griffin JD.The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases.Exp Hematol. 1995 Aug;23(9):1040-8.
  • Bonni A, Frank DA, Schindler C, Greenberg ME.Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus.Science. 1993 Dec 3;262(5139):1575-9.