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Markus H. Frank, M.D.


  • de Waard NE, Kolovou PE, McGuire SP, Cao J, Frank NY, Frank MH, Jager MJ, Ksander BR.Expression of Multidrug Resistance Transporter ABCB5 in a Murine Model of Human Conjunctival Melanoma.Ocul Oncol Pathol. 2015 Apr;1(3):182-189.
  • Gray ES, Reid A, Bowyer S, Calapre L, Siew K, Pearce R, Cowell L, Frank MH, Millward M, Ziman M.Circulating Melanoma Cell Subpopulations: Their Heterogeneity and Differential Responses to Treatment.J Invest Dermatol. 2015 Apr 1.
  • Frank MH, Frank NY.Restoring the cornea from limbal stem cells.Regen Med. 2015 Jan;10(1):1-4.
  • Lee CW, Zhan Q, Lezcano C, Frank MH, Huang J, Larson AR, Lin JY, Wan MT, Lin PI, Ma J, Kleffel S, Schatton T, Lian CG, Murphy GF.Nestin depletion induces melanoma matrix metalloproteinases and invasion.Lab Invest. 2014 Nov 3.
  • Wilson BJ, Saab KR, Ma J, Schatton T, Pütz P, Zhan Q, Murphy GF, Gasser M, Waaga-Gasser AM, Frank NY, Frank MH.ABCB5 Maintains Melanoma-Initiating Cells through a Proinflammatory Cytokine Signaling Circuit.Cancer Res. 2014 Aug 1;74(15):4196-207.
  • Ksander BR, Kolovou PE, Wilson BJ, Saab KR, Guo Q, Ma J, McGuire SP, Gregory MS, Vincent WJ, Perez VL, Cruz-Guilloty F, Kao WW, Call MK, Tucker BA, Zhan Q, Murphy GF, Lathrop KL, Alt C, Mortensen LJ, Lin CP, Zieske JD, Frank MH, Frank NY.ABCB5 is a limbal stem cell gene required for corneal development and repair.Nature. 2014 Jul 17;511(7509):353-7.
  • Volpicelli ER, Lezcano C, Zhan Q, Girouard SD, Kindelberger DW, Frank MH, Frank NY, Crum CP, Murphy GF.The multidrug-resistance transporter ABCB5 is expressed in human placenta.Int J Gynecol Pathol. 2014 Jan;33(1):45-51.
  • Murphy GF, Wilson BJ, Girouard SD, Frank NY, Frank MH.Stem cells and targeted approaches to melanoma cure.Mol Aspects Med. 2013 Oct 19.
  • Lin JY, Zhang M, Schatton T, Wilson BJ, Alloo A, Ma J, Qureshi AA, Frank NY, Han J, Frank MH.Genetically determined ABCB5 functionality correlates with pigmentation phenotype and melanoma risk.Biochem Biophys Res Commun. 2013 Jun 11.
  • Nedosekin DA, Sarimollaoglu M, Galanzha EI, Sawant R, Torchilin VP, Verkhusha VV, Ma J, Frank MH, Biris AS, Zharov VP.Synergy of photoacoustic and fluorescence flow cytometry of circulating cells with negative and positive contrasts.J Biophotonics. 2013 May;6(5):425-34.
  • Reid AL, Millward M, Pearce R, Lee M, Frank MH, Ireland A, Monshizadeh L, Rai T, Heenan P, Medic S, Kumarasinghe P, Ziman M.Markers of circulating tumour cells in the peripheral blood of patients with melanoma correlate with disease recurrence and progression.Br J Dermatol. 2013 Jan;168(1):85-92.
  • Cedeno-Laurent F, Opperman MJ, Barthel SR, Hays D, Schatton T, Zhan Q, He X, Matta KL, Supko JG, Frank MH, Murphy GF, Dimitroff CJ.Metabolic Inhibition of Galectin-1-Binding Carbohydrates Accentuates Antitumor Immunity.J Invest Dermatol. 2011 Dec 8.
  • Pendse SS, Briscoe DM, Frank MH.P-glycoprotein and alloimmune T-cell activation.Clinical And Applied Immunology Reviews. 2003 Jul;4(1):3-14.
  • Wilson BJ, Schatton T, Zhan Q, Gasser M, Ma J, Saab KR, Schanche R, Waaga-Gasser AM, Gold JS, Huang Q, Murphy GF, Frank MH, Frank NY.ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients.Cancer Res. 2011 Jun 7.
  • Wilson BJ, Schatton T, Frank MH, Frank NY.Colorectal Cancer Stem Cells: Biology and Therapeutic Implications.Current Colorectal Cancer Reports. 2011 Jun;7(2):128-135.
  • Ho J, Pandey P, Schatton T, Sims-Lucas S, Khalid M, Frank MH, Hartwig S, Kreidberg JA.The Pro-Apoptotic Protein Bim Is a MicroRNA Target in Kidney Progenitors.J Am Soc Nephrol. 2011 Jun;22(6):1053-63.
  • Laga AC, Zhan Q, Weishaupt C, Ma J, Frank MH, Murphy GF.SOX2 and nestin expression in human melanoma: an immunohistochemical and experimental study.Exp Dermatol. 2011 Apr;20(4):339-45.
  • Frank NY, Schatton T, Kim S, Zhan Q, Wilson BJ, Ma J, Saab KR, Osherov V, Widlund HR, Gasser M, Waaga-Gasser AM, Kupper TS, Murphy GF, Frank MH.VEGFR-1 expressed by malignant melanoma initiating cells is required for tumor growth.Cancer Res. 2011 Jan 11.
  • Ma J, Lin JY, Alloo A, Wilson BJ, Schatton T, Zhan Q, Murphy GF, Waaga-Gasser AM, Gasser M, Hodi FS, Frank NY, Frank MH.Isolation of tumorigenic circulating melanoma cells.Biochem Biophys Res Commun. 2010 Nov 26;402(4):711-7.
  • Schatton T, Frank MH.The in vitro spheroid melanoma cell culture assay: cues on tumor initiation?.J Invest Dermatol. 2010 Jul;130(7):1769-71.
  • Izawa A, Schatton T, Frank NY, Ueno T, Yamaura K, Pendse SS, Margaryan A, Grimm M, Gasser M, Waaga-Gasser AM, Sayegh MH, Frank MH.A novel in vivo regulatory role of P-glycoprotein in alloimmunity.Biochem Biophys Res Commun. 2010 Apr 9;394(3):646-52.
  • Ma J, Frank MH.Tumor initiation in human malignant melanoma and potential cancer therapies.Anticancer Agents Med Chem. 2010 Feb 1;10(2):131-6. Review.
  • Schatton T, Schütte U, Frank NY, Zhan Q, Hoerning A, Robles SC, Zhou J, Hodi FS, Spagnoli GC, Murphy GF, Frank MH.Modulation of T-Cell Activation by Malignant Melanoma Initiating Cells.Cancer Res. 2010 Jan 15;70(2):697-708.
  • Frank NY, Schatton T, Frank MH.The therapeutic promise of the cancer stem cell concept.J Clin Invest. 2010 Jan;120(1):41-50. Review.
  • Schatton T, Frank MH.Antitumor immunity and cancer stem cells.Ann N Y Acad Sci. 2009 Sep;1176:154-69.
  • Schatton T, Frank NY, Frank MH.Identification and targeting of cancer stem cells.Bioessays. 2009 Oct;31(10):1038-49. Review.
  • Behjati S, Frank MH.The effects of tamoxifen on immunity.Curr Med Chem. 2009;16(24):3076-80. Review.
  • Frank NY,Frank MH.ABCB5 gene amplification in human leukemia cells.Leuk Res. 2009 Oct;33(10):1303-5.
  • Schatton T, Frank MH.Cancer stem cells and human malignant melanoma.Pigment Cell Melanoma Res. 2008 Feb;21(1):39-55. Review.
  • Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH.Identification of cells initiating human melanomas.Nature. 2008 Jan 17;451(7176):345-9.
  • Pendse SS, Behjati S, Schatton T, Izawa A, Sayegh MH, Frank MH.P-glycoprotein functions as a differentiation switch in antigen presenting cell maturation.Am J Transplant. 2006 Dec;6(12):2884-93.
  • Frank NY, Kho AT, Schatton T, Murphy GF, Molloy MJ, Zhan Q, Ramoni MF, Frank MH, Kohane IS, Gussoni E.Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin.J Cell Biol. 2006 Oct 9;175(1):99-110.
  • Lutz NW, Franks SE, Frank MH, Pomer S, Hull WE.Investigation of multidrug resistance in cultured human renal cell carcinoma cells by 31P-NMR spectroscopy and treatment survival assays.MAGMA. 2005 Jul;18(3):144-61.
  • Frank NY, Margaryan A, Huang Y, Schatton T, Waaga-Gasser AM, Gasser M, Sayegh MH, Sadee W, Frank MH.ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma.Cancer Res. 2005 May 15;65(10):4320-33.
  • Lapchak PH, Melter M, Pal S, Flaxenburg JA, Geehan C, Frank MH, Mukhopadhyay D, Briscoe DM.CD40-induced transcriptional activation of vascular endothelial growth factor involves a 68-bp region of the promoter containing a CpG island.Am J Physiol Renal Physiol. 2004 Sep;287(3):F512-20.
  • Frank MH, Sayegh MH.Immunomodulatory functions of mesenchymal stem cells.Lancet. 2004 May 1;363(9419):1411-2.
  • Frank NY, Pendse SS, Lapchak PH, Margaryan A, Shlain D, Doeing C, Sayegh MH, Frank MH.Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter.J Biol Chem. 2003 Nov 21;278(47):47156-65.
  • Pendse S, Sayegh MH, Frank MH.P-glycoprotein--a novel therapeutic target for immunomodulation in clinical transplantation and autoimmunity?.Curr Drug Targets. 2003 Aug;4(6):469-76.
  • Frank MH, Denton MD, Alexander SI, Khoury SJ, Sayegh MH, Briscoe DM.Specific MDR1 P-glycoprotein blockade inhibits human alloimmune T cell activation in vitro.J Immunol. 2001 Feb 15;166(4):2451-9.
  • Frank MH, Pomer S.Interferon alpha2b differentially affects proliferation of two human renal cell carcinoma cell lines differing in the P-glycoprotein-associated multidrug-resistant phenotype.J Cancer Res Clin Oncol. 1999;125(2):117-20.
  • Kellner H, Liegl U, Frank M, Zoller WG.[Reversible esophageal dysfunction as a side effect of levodopa].Bildgebung. 1996 Mar;63(1):48-50.