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Donald R. Senger, PhD


  • Hoang MV, Nagy JA, Senger DR.Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1.Blood. 2011 Feb 3;117(5):1751-60.
  • Hoang MV, Nagy JA, Senger DR.Cdc42-mediated inhibition of GSK-3β improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis.Microvasc Res. 2010 Sep 16.
  • Hoang MV, Nagy JA, Fox JE, Senger DR.Moderation of calpain activity promotes neovascular integration and lumen formation during VEGF-induced pathological angiogenesis.PLoS ONE. 2010;5(10):e13612.
  • Hoang MV, Smith LE, Senger DR.Calpain inhibitors reduce retinal hypoxia in ischemic retinopathy by improving neovascular architecture and functional perfusion.Biochim Biophys Acta. 2010 Sep 8.
  • Hoang MV, Smith LE, Senger DR.Moderate GSK-3β inhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy.Angiogenesis. 2010 Sep;13(3):269-77.
  • Senger DR.Vascular endothelial growth factor: much more than an angiogenesis factor.Mol Biol Cell. 2010 Feb;21(3):377-9.
  • Davis GE, Senger DR.Extracellular matrix mediates a molecular balance between vascular morphogenesis and regression.Curr Opin Hematol. 2008 May;15(3):197-203. Review.
  • Wu Y, Lun X, Zhou H, Wang L, Sun B, Bell JC, Barrett JW, McFadden G, Biegel JA, Senger DL, Forsyth PA.Oncolytic efficacy of recombinant vesicular stomatitis virus and myxoma virus in experimental models of rhabdoid tumors.Clin Cancer Res. 2008 Feb 15;14(4):1218-27.
  • Lun XQ, Zhou H, Alain T, Sun B, Wang L, Barrett JW, Stanford MM, McFadden G, Bell J, Senger DL, Forsyth PA.Targeting human medulloblastoma: oncolytic virotherapy with myxoma virus is enhanced by rapamycin.Cancer Res. 2007 Sep 15;67(18):8818-27.
  • Johnston AL, Lun X, Rahn JJ, Liacini A, Wang L, Hamilton MG, Parney IF, Hempstead BL, Robbins SM, Forsyth PA, Senger DL.The p75 neurotrophin receptor is a central regulator of glioma invasion.PLoS Biol. 2007 Aug;5(8):e212.
  • Alain T, Kim TS, Lun X, Liacini A, Schiff LA, Senger DL, Forsyth PA.Proteolytic disassembly is a critical determinant for reovirus oncolysis.Mol Ther. 2007 Aug;15(8):1512-21.
  • Nagy JA, Senger DR.VEGF-A, cytoskeletal dynamics, and the pathological vascular phenotype.Exp Cell Res. 2006 Mar 10;312(5):538-48.
  • Davis GE, Senger DR.Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization.Circ Res. 2005 Nov 25;97(11):1093-107.
  • Hoang MV, Senger DR.In vivo and in vitro models of Mammalian angiogenesis.Methods Mol Biol. 2005;294:269-85.
  • Liu Y, Senger DR.Matrix-specific activation of Src and Rho initiates capillary morphogenesis of endothelial cells.FASEB J. 2004 Mar;18(3):457-68.
  • Hoang MV, Whelan MC, Senger DR.Rho activity critically and selectively regulates endothelial cell organization during angiogenesis.Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1874-9.