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Li Chai, MD


  • Ueno S, Lu J, He J, Li A, Zhang X, Ritz J, Silberstein LE, Chai L.Aberrant expression of SALL4 in acute B cell lymphoblastic leukemia: Mechanism, function, and implication for a potential novel therapeutic target.Exp Hematol. 2014 Apr;42(4):307-316.e8.
  • Wang F, Guo Y, Chen Q, Yang Z, Ning N, Zhang Y, Xu Y, Xu X, Tong C, Chai L, Cui W.Stem cell factor SALL4, a potential prognostic marker for myelodysplastic syndromes.J Hematol Oncol. 2013;6(1):73.
  • Li A, Yang Y, Gao C, Lu J, Jeong HW, Liu BH, Tang P, Yao X, Neuberg D, Huang G, Tenen DG, Chai L.A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis.J Clin Invest. 2013 Oct 1;123(10):4195-207.
  • Yong KJ, Chai L, Tenen DG.Oncofetal gene SALL4 in aggressive hepatocellular carcinoma.N Engl J Med. 2013 Sep 19;369(12):1171-2.
  • He J, Zhang W, Zhou Q, Zhao T, Song Y, Chai L, Li Y.Low-expression of microRNA-107 inhibits cell apoptosis in glioma by upregulation of SALL4.Int J Biochem Cell Biol. 2013 Sep;45(9):1962-73.
  • Yong KJ, Gao C, Lim JS, Yan B, Yang H, Dimitrov T, Kawasaki A, Ong CW, Wong KF, Lee S, Ravikumar S, Srivastava S, Tian X, Poon RT, Fan ST, Luk JM, Dan YY, Salto-Tellez M, Chai L, Tenen DG.Oncofetal gene SALL4 in aggressive hepatocellular carcinoma.N Engl J Med. 2013 Jun 13;368(24):2266-76.
  • Liang OD, Lu J, Nombela-Arrieta C, Zhong J, Zhao L, Pivarnik G, Mondal S, Chai L, Silberstein LE, Luo HR.Deficiency of lipid phosphatase SHIP enables long-term reconstitution of hematopoietic inductive bone marrow microenvironment.Dev Cell. 2013 May 28;25(4):333-49.
  • Gao C, Dimitrov T, Yong KJ, Tatetsu H, Jeong HW, Luo HR, Bradner JE, Tenen DG, Chai L.Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex.Blood. 2013 Feb 21;121(8):1413-21.
  • Gao C, Kong NR, Li A, Tatetu H, Ueno S, Yang Y, He J, Yang J, Ma Y, Kao GS, Tenen DG, Chai L.SALL4 is a key transcription regulator in normal human hematopoiesis.Transfusion. 2012 Aug 31.
  • Lu J, Sun Y, Nombela-Arrieta C, Du KP, Park SY, Chai L, Walkley C, Luo HR, Silberstein LE.Fak depletion in both hematopoietic and nonhematopoietic niche cells leads┬áto┬áhematopoietic stem cell expansion.Exp Hematol. 2012 Apr;40(4):307-317.e3.
  • Hobbs RM, Fagoonee S, Papa A, Webster K, Altruda F, Nishinakamura R, Chai L, Pandolfi PP.Functional Antagonism between Sall4 and Plzf Defines Germline Progenitors.Cell Stem Cell. 2012 Mar 2;10(3):284-98.
  • Gao C, Kong NR, Chai L.The role of stem cell factor SALL4 in leukemogenesis.Crit Rev Oncog. 2011;16(1-2):117-27. Review.
  • Chai L.The role of HSAL (SALL) genes in proliferation and differentiation in normal hematopoiesis and leukemogenesis.Transfusion. 2011 Nov;51 Suppl 4:87S-93S.
  • Jeong HW, Cui W, Yang Y, Lu J, He J, Li A, Song D, Guo Y, Liu BH, Chai L.SALL4, a stem cell factor, affects the side population by regulation of the ATP-binding cassette drug transport genes.PLoS ONE. 2011;6(4):e18372.
  • Yang J, Gao C, Chai L, Ma Y.A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells.PLoS ONE. 2010;5(5):e10766.
  • Yu H, Li Y, Gao C, Fabien L, Jia Y, Lu J, Silberstein LE, Pinkus GS, Ye K, Chai L, Luo HR.Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN.Leukemia. 2010 May;24(5):1077-80.
  • Lu J,Jeong H,Kong N,Yang Y,Carroll J,Luo HR,Silberstein LE,Yupoma,Chai L.Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex.PLoS ONE. 2009;4(5):e5577.
  • Le Y,Xu L,Lu J,Fang J,Nardi V,Chai L,Silberstein LE.FAK silencing inhibits leukemogenesis in BCR/ABL-transformed hematopoietic cells.Am J Hematol. 2009 May;84(5):273-8.
  • Yang J,Chai L,Fowles TC,Alipio Z,Xu D,Fink LM,Ward DC,Ma Y.Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells.Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19756-61.
  • Yang J,Chai L,Gao C,Fowles TC,Alipio Z,Dang H,Xu D,Fink LM,Ward DC,Ma Y.SALL4 is a key regulator of survival and apoptosis in human leukemic cells.Blood. 2008 Aug 1;112(3):805-13.
  • Jia Y, Loison F, Hattori H, Li Y, Erneux C, Park SY, Gao C, Chai L, Silberstein LE, Schurmans S, Luo HR.Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis.Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4739-44.
  • Yang J, Chai L, Liu F, Fink LM, Lin P, Silberstein LE, Amin HM, Ward DC, Ma Y.Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells.Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10494-9.
  • Ma Y, Cui W, Yang J, Qu J, Di C, Amin HM, Lai R, Ritz J, Krause DS, Chai L.SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice.Blood. 2006 Oct 15;108(8):2726-35.
  • Cui W, Kong NR, Ma Y, Amin HM, Lai R, Chai L.Differential expression of the novel oncogene, SALL4, in lymphoma, plasma cell myeloma, and acute lymphoblastic leukemia.Mod Pathol. 2006 Dec;19(12):1585-92.
  • Zhang J, Tam WL, Tong GQ, Wu Q, Chan HY, Soh BS, Lou Y, Yang J, Ma Y, Chai L, Ng HH, Lufkin T, Robson P, Lim B.Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1.Nat Cell Biol. 2006 Oct;8(10):1114-23.
  • Chai L,Yang J,Di C,Cui W,Kawakami K,Lai R,Ma Y.Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development.J Biol Chem. 2006 Jul 14;281(28):18918-26.
  • Herzog EL,Chai L,Krause DS.Plasticity of marrow-derived stem cells.Blood. 2003 Nov 15;102(10):3483-93.