Irene M. Ghobrial, MD

Publications

• Sacco A, Aujay M, Morgan B, Azab AK, Maiso P, Liu Y, Zhang Y, Azab F, Ngo HT, Issa GC, Quang P, Roccaro AM, Ghobrial IM.Carfilzomib-Dependent Selective Inhibition of the Chymotrypsin-like Activity of the Proteasome Leads to Antitumor Activity in Waldenstr
  21355079
• Leleu X, Koulieris E, Maltezas D, Itzykson R, Xie W, Manier S, Dulery R, Boyle E, Gauthier J, Poulain S, Tatiana T, Panayiotidis P, Bradwell AR, Harding S, Leblond V, Kyrtsonis MC, Ghobrial IM.Novel M-Component Based Biomarkers in Waldenström's Macr
  21454223
• Sacco A, Maiso P, Azab A, Azab F, Zhang Y, Liu Y, Ngo HT, Morgan B, Quang P, Issa G, Ghobrial IM, Roccaro AM.Key Role of MicroRNAs in Waldenström's Macroglobulinemia Pathogenesis.Clin Lymphoma Myeloma Leuk. 2011 Feb 1;11(1):109-11.
  21454206
• Ghobrial IM, Zhang Y, Liu Y, Ngo H, Azab F, Sacco A, Azab A, Maiso P, Morgan B, Quang P, Issa G, Roccaro A.The Bone Marrow Niche in Waldenström's Macroglobulinemia.Clin Lymphoma Myeloma Leuk. 2011 Feb 1;11(1):118-20.
  21454209
• Leleu XP, Xie W, Bagshaw M, Banwait R, Leduc R, Roper N, Weller E, Ghobrial IM.The Role of Serum Immunoglobulin Free Light Chain (sFLC) in response and progression in Waldenstrom Macroglobulinemia (WM).Clin Cancer Res. 2011 Mar 17.
  21415221
• Ghobrial IM, Weller E, Vij R, Munshi NC, Banwait R, Bagshaw M, Schlossman R, Leduc R, Chuma S, Kunsman J, Laubach J, Jakubowiak AJ, Maiso P, Roccaro A, Armand P, Dollard A, Warren D, Harris B, Poon T, Sam A, Rodig S, Anderson KC, Richardson PG.Weekly bort
  21345726
• Sacco A, Roccaro A, Ghobrial IM.Role of dual PI3/Akt and mTOR inhibition in Waldenstrom's Macroglobulinemia.Oncotarget. 2010 Nov;1(7):578-82.
  21317453
• Runnels JM, Carlson AL, Pitsillides C, Thompson B, Wu J, Spencer JA, Kohler JM, Azab A, Moreau AS, Rodig SJ, Kung AL, Anderson KC, Ghobrial IM, Lin CP.Optical techniques for tracking multiple myeloma engraftment, growth, and response to therapy.J Biomed O
  21280893
• Calvo KR, Landgren O, Roccaro AM, Ghobrial IM.Role of microRNAs from monoclonal gammopathy of undetermined significance to multiple myeloma.Semin Hematol. 2011 Jan;48(1):39-45.
  21232657
• Roper N, Deangelo DJ, Kuo F, Cin PD, Ghobrial I, Aster JC.An asymptomatic 61-year-old man with BCR-ABL-positive bone marrow following autologous transplantation for multiple myeloma.Am J Hematol. 2010 Dec;85(12):944-6.
  20730794
• Sacco A, Issa GC, Zhang Y, Liu Y, Maiso P, Ghobrial IM, Roccaro AM.Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology.J Hematol Oncol. 2010;3(1):38.
  20929526
• Rourke M, Anderson KC, Ghobrial IM.Review of clinical trials conducted in Waldenstrom macroglobulinemia and recommendations for reporting clinical trial responses in these patients.Leuk Lymphoma. 2010 Oct;51(10):1779-92.
  20795787
• Ghobrial IM, Xie W, Padmanabhan S, Badros A, Rourke M, Leduc R, Chuma S, Kunsman J, Warren D, Poon T, Harris B, Sam A, Anderson KC, Richardson PG, Treon SP, Weller E, Matous J.Phase II trial of weekly bortezomib in combination with rituximab in untreated
  20652865
• Roccaro AM, Sacco A, Jia X, Azab AK, Maiso P, Ngo HT, Azab F, Runnels J, Quang P, Ghobrial IM.microRNA-dependent modulation of histone acetylation in Waldenstrom macroglobulinemia.Blood. 2010 Sep 2;116(9):1506-14.
  20519629
• Richardson PG, Weller E, Lonial S, Jakubowiak AJ, Jagannath S, Raje NS, Avigan DE, Xie W, Ghobrial IM, Schlossman RL, Mazumder A, Munshi NC, Vesole DH, Joyce R, Kaufman JL, Doss D, Warren DL, Lunde LE, Kaster S, Delaney C, Hideshima T, Mitsiades CS, Knigh
  20385792
• Prabhala RH, Pelluru D, Fulciniti M, Prabhala HK, Nanjappa P, Song W, Pai C, Amin S, Tai YT, Richardson PG, Ghobrial IM, Treon SP, Daley JF, Anderson KC, Kutok JL, Munshi NC.Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits i
  20395418
• Richardson PG, Laubach J, Mitsiades C, Schlossman RL, Doss D, Colson K, McKenney ML, Noonan K, Warren DL, Ghobrial IM, Munshi NC, Anderson K.Tailoring treatment for multiple myeloma patients with relapsed and refractory disease.Oncology (Huntingt). 2010 M
  20518367
• Roccaro AM, Sacco A, Aujay M, Ngo HT, Azab AK, Azab F, Quang P, Maiso P, Runnels J, Anderson KC, Demo S, Ghobrial IM.Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenstrom macroglobulinemia.Bl
  20110419
• Ghobrial IM, Gertz M, Laplant B, Camoriano J, Hayman S, Lacy M, Chuma S, Harris B, Leduc R, Rourke M, Ansell SM, Deangelo D, Dispenzieri A, Bergsagel L, Reeder C, Anderson KC, Richardson PG, Treon SP, Witzig TE.Phase II trial of the oral mammalian target
  20142598
• Ghobrial IM, Hong F, Padmanabhan S, Badros A, Rourke M, Leduc R, Chuma S, Kunsman J, Warren D, Harris B, Sam A, Anderson KC, Richardson PG, Treon SP, Weller E, Matous J.Phase II trial of weekly bortezomib in combination with rituximab in relapsed or relap
  20142586
• Ghobrial IM, Roccaro A, Hong F, Weller E, Rubin N, Leduc R, Rourke M, Chuma S, Sacco A, Jia X, Azab F, Azab AK, Rodig S, Warren D, Harris B, Varticovski L, Sportelli P, Leleu X, Anderson KC, Richardson PG.Clinical and translational studies of a phase II t
  20103671
• Fonseca R, Richardson P, Giralt S, Lonial S, Rajkumar SV, Stewart AK, Bensinger W, Somlo G, Vescio R, Mikhael J, Reeder C, Tiedemann R, Tricot G, Rifkin R, Shaughnessy J, Munshi N, Raje N, Ghobrial I, Laubach J, Schlossman R, Treon S, Mahindra A, Avigan D
  20118399
• Roccaro AM, Sacco A, Husu EN, Pitsillides C, Vesole S, Azab AK, Azab F, Melhem M, Ngo HT, Quang P, Maiso P, Runnels J, Liang MC, Wong KK, Lin C, Ghobrial IM.Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobuline
  19965685
• Laubach JP, Mahindra A, Mitsiades CS, Schlossman RL, Munshi NC, Ghobrial IM, Carreau N, Hideshima T, Anderson KC, Richardson PG.The use of novel agents in the treatment of relapsed and refractory multiple myeloma.Leukemia..
• Richardson PG, Weller E, Jagannath S, Avigan DE, Alsina M, Schlossman RL, Mazumder A, Munshi NC, Ghobrial IM, Doss D, Warren DL, Lunde LE, McKenney M, Delaney C, Mitsiades CS, Hideshima T, Dalton W, Knight R, Esseltine DL, Anderson KC.Multicenter, phase I
  19786667
• Laubach JP, Mitsiades CS, Mahindra A, Schlossman RL, Hideshima T, Chauhan D, Carreau NA, Ghobrial IM, Raje N, Munshi NC, Anderson KC, Richardson PG.Novel therapies in the treatment of multiple myeloma.J Natl Compr Canc Netw. 2009 Oct;7(9):947-60. Review.
  19878638
• Laubach JP, Mitsiades CS, Mahindra A, Schlossman RL, Hideshima T, Chauhan D, Carreau NA, Ghobrial IM, Raje N, Munshi NC, Anderson KC, Richardson PG.Novel therapies in the treatment of multiple myeloma.J Natl Compr Canc Netw..
• Ngo HT, Azab AK, Farag M, Jia X, Melhem MM, Runnels J, Roccaro AM, Azab F, Sacco A, Leleu X, Anderson KC, Ghobrial IM.Src tyrosine kinase regulates adhesion and chemotaxis in Waldenstrom macroglobulinemia.Clin Cancer Res. 2009 Oct 1;15(19):6035-41.
  19755386
• Venon MD, Roccaro AM, Gay J, Moreau AS, Dulery R, Facon T, Ghobrial IM, Leleu X.Front line treatment of elderly multiple myeloma in the era of novel agents.Biologics. 2009;3:99-109.
  19707399
• Treon SP, Ioakimidis L, Soumerai JD, Patterson CJ, Sheehy P, Nelson M, Willen M, Matous J, Mattern J, Diener JG, Keogh GP, Myers TJ, Boral A, Birner A, Esseltine DL, Ghobrial IM.Primary therapy of Waldenström macroglobulinemia with bortezomib, dexamethas
  19506160
• Azab AK,Azab F,Blotta S,Pitsillides CM,Thompson B,Runnels JM,Roccaro AM,Ngo HT,Melhem MR,Sacco A,Jia X,Anderson KC,Lin CP,Rollins BJ,Ghobrial IM.Rho-A and Rac-1 GTPases play major and differential roles in SDF1-induced cell adhesion and chemotaxis in mult
  19443661
• Roccaro AM,Sacco A,Thompson B,Leleu X,Azab AK,Azab F,Runnels J,Jia X,Ngo HT,Melhem MR,Lin CP,Ribatti D,Rollins BJ,Witzig TE,Anderson KC,Ghobrial IM.microRNAs 15a and 16 regulate tumor proliferation in multiple myeloma.Blood. 2009 Jun 25;113(26):6669-80.
  19401561
• Laubach JP,Mitsiades CS,Roccaro AM,Ghobrial IM,Anderson KC,Richardson PG.Clinical challenges associated with bortezomib therapy in multiple myeloma and Waldenstroms Macroglobulinemia.Leuk Lymphoma. 2009 May;50(5):694-702. Review.
  19452315
• Roccaro AM,Sacco A,Leleu X,Azab AK,Azab F,Runnels J,Jia X,Ngo HT,Melhem M,Moreau AS,Ghobrial IM.Role of proteasome inhibition in Waldenstrom's macroglobulinemia.Clin Lymphoma Myeloma. 2009 Mar;9(1):94-6. Review.
  19362985
• Ghobrial IM,Leleu X,Azab AK,Runnels J,Jia X,Ngo H,Melhem M,Azab F,Sacco A,Quang P,Burwick N,Moreau AS,Husu E,Farag M,Roccaro A.Novel therapeutic agents in Waldenstrom's macroglobulinemia.Clin Lymphoma Myeloma. 2009 Mar;9(1):84-6. Review.
  19362982
• Braggio E,Keats JJ,Leleu X,Wier SV,Jimenez-Zepeda VH,Schop RF,Chesi M,Barrett M,Stewart AK,Dogan A,Bergsagel PL,Ghobrial IM,Fonseca R.High-resolution genomic analysis in Waldenstrom's macroglobulinemia identifies disease-specific and common abnormali
  19362969
• Leleu X,Tamburini J,Roccaro A,Morel P,Soumerai J,Levy V,Wemeau M,Balkaran S,Poulain S,Hunter ZR,Ghobrial IM,Treon SP,Leblond V.Balancing risk versus benefit in the treatment of Waldenstrom's Macroglobulinemia patients with nucleoside analogue-based t
  19362978
• Braggio E,Keats JJ,Leleu X,Van Wier S,Jimenez-Zepeda VH,Valdez R,Schop RF,Price-Troska T,Henderson K,Sacco A,Azab F,Greipp P,Gertz M,Hayman S,Rajkumar SV,Carpten J,Chesi M,Barrett M,Stewart AK,Dogan A,Bergsagel PL,Ghobrial IM,Fonseca R.Identification of c
  19351844
• Leleu X,Hunter ZR,Xu L,Roccaro AM,Moreau AS,Santos DD,Hatjiharissi E,Bakthavachalam V,Adamia S,Ho AW,Soumerai J,Patterson CJ,Manning RJ,Hamilton S,Verselis S,Fox E,Carrasco R,Ghobrial IM,Treon SP.Expression of regulatory genes for lymphoplasmacytic cell d
  19220283
• Azab AK,Runnels JM,Pitsillides C,Moreau AS,Azab F,Leleu X,Jia X,Wright R,Ospina B,Carlson AL,Alt C,Burwick N,Roccaro AM,Ngo HT,Farag M,Melhem MR,Sacco A,Munshi NC,Hideshima T,Rollins BJ,Anderson KC,Kung AL,Lin CP,Ghobrial IM.CXCR4 inhibitor AMD3100 disrup
  19139079
• Leleu X,Gay J,Roccaro AM,Moreau AS,Poulain S,Dulery R,Champs BB,Robu D,Ghobrial IM.Update on therapeutic options in Waldenstrom macroglobulinemia.Eur J Haematol. 2009 Jan;82(1):1-12. Review.
  19087134
• Roccaro AM,Sacco A,Chen C,Runnels J,Leleu X,Azab F,Azab AK,Jia X,Ngo HT,Melhem MR,Burwick N,Varticovski L,Novina CD,Rollins BJ,Anderson KC,Ghobrial IM.microRNA expression in the biology, prognosis, and therapy of Waldenstrom macroglobulinemia.Blood. 2009
  19074725
• Leleu X,Soumerai J,Roccaro A,Hatjiharissi E,Hunter ZR,Manning R,Ciccarelli BT,Sacco A,Ioakimidis L,Adamia S,Moreau AS,Patterson CJ,Ghobrial IM,Treon SP.Increased incidence of transformation and myelodysplasia/acute leukemia in patients with Waldenstrom ma
  19064987
• Dimopoulos MA,Gertz MA,Kastritis E,Garcia-Sanz R,Kimby EK,Leblond V,Fermand JP,Merlini G,Morel P,Morra E,Ocio EM,Owen R,Ghobrial IM,Seymour J,Kyle RA,Treon SP.Update on treatment recommendations from the Fourth International Workshop on Waldenstrom's
  19047284
• Leleu X,Xu L,Jia X,Sacco A,Farag M,Hunter ZR,Moreau AS,Ngo HT,Hatjiharissi E,Ho AW,Santos DD,Adamia S,O'Connor K,Ciccarelli B,Soumerai J,Manning RJ,Patterson CJ,Roccaro AM,Ghobrial IM,Treon SP.Endoplasmic reticulum stress is a target for therapy in W
  18981296
• Oton AB,Wang H,Leleu X,Melhem MF,George D,Lacasce A,Foon K,Ghobrial IM.Clinical and pathological prognostic markers for survival in adult patients with post-transplant lymphoproliferative disorders in solid transplant.Leuk Lymphoma. 2008 Sep;49(9):1738-44
  18798108
• Richardson PG,Mitsiades C,Schlossman R,Ghobrial I,Hideshima T,Munshi N,Anderson KC.Bortezomib in the front-line treatment of multiple myeloma.Expert Rev Anticancer Ther. 2008 Jul;8(7):1053-72. Review.
  18588451
• Alsayed Y,Leleu X,Leontovich A,Oton AB,Melhem M,George D,Ghobrial IM.Proteomics analysis in post-transplant lymphoproliferative disorders.Eur J Haematol. 2008 Oct;81(4):298-303.
  18573174
• Ngo HT, Leleu X, Lee J, Jia X, Melhem M, Runnels J, Moreau AS, Burwick N, Azab AK, Roccaro A, Azab F, Sacco A, Farag M, Sackstein R, Ghobrial IM.SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom Macroglobulinemia.Blood. 2008 Jul 1;112(1):1
  18448868
• Leleu X,Roccaro AM,Moreau AS,Dupire S,Robu D,Gay J,Hatjiharissi E,Burwik N,Ghobrial IM.Waldenstrom macroglobulinemia.Cancer Lett. 2008 Oct 18;270(1):95-107.
  18555588
• Moreau AS,Jia X,Patterson CJ,Roccaro AM,Xu L,Sacco A,O'Connor K,Soumerai J,Ngo HT,Hatjiharissi E,Hunter ZR,Ciccarelli B,Manning R,Ghobrial IM,Leleu X,Treon SP.The HMG-CoA inhibitor, simvastatin, triggers in vitro anti-tumour effect and decreases IgM
  18537966
• Burwick N,Roccaro AM,Leleu X,Ghobrial IM.Targeted therapies in Waldenstrom macroglobulinemia.Curr Opin Investig Drugs. 2008 Jun;9(6):631-7. Review.
  18516762
• Moreau AS, Sebti Y, Duhamel A, Roccaro AM, Coiteux V, Gastinne T, Friec GL, Burwick N, Amiot L, Ho AW, Poulain S, Hennache B, Hunter ZR, Dessaint JP, Ghobrial IM, Treon SP, Facon T, Zorn E, Leleu X.Clinical relevance of soluble HLA class I molecules in Wa
  18331603
• Leleu X, Eeckhoute J, Jia X, Roccaro AM, Moreau AS, Farag M, Sacco A, Ngo HT, Runnels J, Melham MR, Burwick N, Azab A, Azab F, Hunter Z, Hatjiharissi E, Carrasco DR, Treon SP, Witzig TE, Hideshima T, Brown M, Anderson KC, Ghobrial IM.Targeting NF-{kappa}B
  18334673
• Leleu X, Moreau AS, Weller E, Roccaro AM, Coiteux V, Manning R, Nelson M, Leduc R, Robu D, Dupire S, Hatjiharissi E, Burwick N, Darre S, Hennache B, Treon SP, Facon T, Gertz MA, Ghobrial IM.Serum immunoglobulin free light chain correlates with tumor burde
  18452095
• Roccaro AM, Leleu X, Sacco A, Jia X, Melhem M, Moreau AS, Ngo HT, Runnels J, Azab A, Azab F, Burwick N, Farag M, Treon SP, Palladino MA, Hideshima T, Chauhan D, Anderson KC, Ghobrial IM.Dual targeting of the proteasome regulates survival and homing in Wal
  18316628
• Roccaro AM, Leleu X, Sacco A, Moreau AS, Hatjiharissi E, Jia X, Xu L, Ciccarelli B, Patterson CJ, Ngo HT, Russo D, Vacca A, Dammacco F, Anderson KC, Ghobrial IM, Treon SP.Resveratrol exerts antiproliferative activity and induces apoptosis in Waldenstrom&#
  18347188
• Krim S, Vivo R, Ghobrial I, Ergina F.Misplaced concern.Am J Med. 2008 Mar;121(3):196-8.
  18328301
• Huston A, Leleu X, Jia X, Moreau AS, Ngo HT, Runnels J, Anderson J, Alsayed Y, Roccaro A, Vallet S, Hatjiharissi E, Tai YT, Sportelli P, Munshi N, Richardson P, Hideshima T, Roodman DG, Anderson KC, Ghobrial IM.Targeting Akt and heat shock protein 90 prod
  18245550
• Richardson P, Mitsiades C, Schlossman R, Ghobrial I, Hideshima T, Chauhan D, Munshi N, Anderson K.The treatment of relapsed and refractory multiple myeloma.Hematology Am Soc Hematol Educ Program. 2007;2007:317-23. Review.
  18024646
• Treon SP, Hatjiharissi E, Leleu X, Moreau AS, Roccaro A, Hunter ZR, Soumerai JD, Ciccarelli B, Xu L, Sacco A, Ngo HT, Jia X, Yang C, Adamia S, Branagan AR, Ho AW, Santos DD, Tournilhac O, Manning RJ, Leduc R, O'Connor K, Nelson M, Patterson CJ, Ghobr
  17877845
• Leleu X, Jia X, Runnels J, Ngo HT, Moreau AS, Farag M, Spencer JA, Pitsillides CM, Hatjiharissi E, Roccaro A, O'Sullivan G, McMillin DW, Moreno D, Kiziltepe T, Carrasco R, Treon SP, Hideshima T, Anderson KC, Lin CP, Ghobrial IM.The Akt pathway regula
  17761832
• Ghobrial J, Ghobrial IM, Mitsiades C, Leleu X, Hatjiharissi E, Moreau AS, Roccaro A, Schlossman R, Hideshima T, Anderson KC, Richardson P.Novel therapeutic avenues in myeloma: changing the treatment paradigm.Oncology (Huntingt). 2007 Jun;21(7):785-92; dis
  17722741
• Tai YT, Fulciniti M, Hideshima T, Song W, Leiba M, Li XF, Rumizen M, Burger P, Morrison A, Podar K, Chauhan D, Tassone P, Richardson P, Munshi NC, Ghobrial I, Anderson KC.Targeting MEK induces myeloma cell cytotoxicity and inhibits osteoclastogenesis.Bloo
  17510321
• Younes H, Leleu X, Hatjiharissi E, Moreau AS, Hideshima T, Richardson P, Anderson KC, Ghobrial IM.Targeting the phosphatidylinositol 3-kinase pathway in multiple myeloma.Clin Cancer Res. 2007 Jul 1;13(13):3771-5. Review.
  17606706
• Hatjiharissi E, Ngo H, Leontovich AA, Leleu X, Timm M, Melhem M, George D, Lu G, Ghobrial J, Alsayed Y, Zeismer S, Cabanela M, Nehme A, Jia X, Moreau AS, Treon SP, Fonseca R, Gertz MA, Anderson KC, Witzig TE, Ghobrial IM.Proteomic analysis of waldenstrom
  17440091
• Ghobrial IM, Leleu X, Hatjiharissi E, Hideshima T, Mitsiades C, Schlossman R, Anderson KC, Richardson P.Emerging drugs in multiple myeloma.Expert Opin Emerg Drugs. 2007 Mar;12(1):155-63. Review.
  17355220
• Moreau AS, Jia X, Ngo HT, Leleu X, O'sullivan G, Alsayed Y, Leontovich A, Podar K, Kutok J, Daley J, Lazo-Kallanian S, Hatjiharissi E, Raab MS, Xu L, Treon SP, Hideshima T, Anderson KC, Ghobrial IM.Protein kinase C inhibitor enzastaurin induces in vi
  17284528
• Hwang JJ, Ghobrial IM, Anderson KC.New frontiers in the treatment of multiple myeloma.ScientificWorldJournal. 2006;6:1475-503. Review.
  17160337
• Francis LK, Alsayed Y, Leleu X, Jia X, Singha UK, Anderson J, Timm M, Ngo H, Lu G, Huston A, Ehrlich LA, Dimmock E, Lentzsch S, Hideshima T, Roodman GD, Anderson KC, Ghobrial IM.Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhib
  17121904
• Alsayed Y, Ngo H, Runnels J, Leleu X, Singha UK, Pitsillides CM, Spencer JA, Kimlinger T, Ghobrial JM, Jia X, Lu G, Timm M, Kumar A, Côté D, Veilleux I, Hedin KE, Roodman GD, Witzig TE, Kung AL, Hideshima T, Anderson KC, Lin CP, Ghobrial IM.Mechanisms of
  17119115
• Chauhan D, Velankar M, Brahmandam M, Hideshima T, Podar K, Richardson P, Schlossman R, Ghobrial I, Raje N, Munshi N, Anderson KC.A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.Oncogene. 2007 Apr 5;26(16):2374-80.
  17016430
• Richardson PG, Mitsiades C, Ghobrial I, Anderson K.Beyond single-agent bortezomib: combination regimens in relapsed multiple myeloma.Curr Opin Oncol. 2006 Nov;18(6):598-608. Review.
  16988581