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Benjamin L. Ebert, MD, PhD

Publications

  • Mullally A, Bruedigam C, Poveromo L, Heidel FH, Purdon A, Vu T, Austin R, Heckl D, Breyfogle LJ, Kuhn CP, Kalaitzidis D, Armstrong SA, Williams DA, Hill GR, Ebert BL, Lane SW.Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera.Blood. 2013 May 2;121(18):3692-702.
    23487027
  • Tothova Z, Steensma DP, Ebert BL.New strategies in myelodysplastic syndromes: application of molecular diagnostics to clinical practice.Clin Cancer Res. 2013 Apr 1;19(7):1637-43.
    23329810
  • Losman JA, Looper RE, Koivunen P, Lee S, Schneider RK, McMahon C, Cowley GS, Root DE, Ebert BL, Kaelin WG.(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.Science. 2013 Mar 29;339(6127):1621-5.
    23393090
  • Shah DI, Takahashi-Makise N, Cooney JD, Li L, Schultz IJ, Pierce EL, Narla A, Seguin A, Hattangadi SM, Medlock AE, Langer NB, Dailey TA, Hurst SN, Faccenda D, Wiwczar JM, Heggers SK, Vogin G, Chen W, Chen C, Campagna DR, Brugnara C, Zhou Y, Ebert BL, Danial NN, Fleming MD, Ward DM, Campanella M, Dailey HA, Kaplan J, Paw BH.Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts.Nature. 2012 Nov 7;491(7425):608-12.
    23135403
  • Mullally A, Ebert BL.Janus reveals another face: the biologic rationale for targeting janus kinase 2 in lymphoma.J Clin Oncol. 2012 Nov 20;30(33):4168-70.
    22965959
  • Lee J, Li M, Milwid J, Dunham J, Vinegoni C, Gorbatov R, Iwamoto Y, Wang F, Shen K, Hatfield K, Enger M, Shafiee S, McCormack E, Ebert BL, Weissleder R, Yarmush ML, Parekkadan B.Implantable microenvironments to attract hematopoietic stem/cancer cells.Proc Natl Acad Sci U S A. 2012 Nov 12.
    23150542
  • Mullally A, Lane SW, Brumme K, Ebert BL.Myeloproliferative neoplasm animal models.Hematol Oncol Clin North Am. 2012 Oct;26(5):1065-81.
    23009938
  • Bejar R, Stevenson KE, Caughey BA, Abdel-Wahab O, Steensma DP, Galili N, Raza A, Kantarjian H, Levine RL, Neuberg D, Garcia-Manero G, Ebert BL.Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes.J Clin Oncol. 2012 Sep 20;30(27):3376-82.
    22869879
  • Payne EM, Virgilio M, Narla A, Sun H, Levine M, Paw BH, Berliner N, Look AT, Ebert BL, Khanna-Gupta A.L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway.Blood. 2012 Sep 13;120(11):2214-24.
    22734070
  • Ashton JM, Balys M, Neering SJ, Hassane DC, Cowley G, Root DE, Miller PG, Ebert BL, McMurray HR, Land H, Jordan CT.Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells.Cell Stem Cell. 2012 Sep 7;11(3):359-72.
    22863534
  • Koppikar P, Bhagwat N, Kilpivaara O, Manshouri T, Adli M, Hricik T, Liu F, Saunders LM, Mullally A, Abdel-Wahab O, Leung L, Weinstein A, Marubayashi S, Goel A, Gönen M, Estrov Z, Ebert BL, Chiosis G, Nimer SD, Bernstein BE, Verstovsek S, Levine RL.Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy.Nature. 2012 Sep 6;489(7414):155-9.
    22820254
  • Lindsley RC, Ebert BL.Molecular Pathophysiology of Myelodysplastic Syndromes.Annu Rev Pathol. 2012 Aug 28.
    22934674
  • Mullally A, Poveromo L, Schneider RK, Al-Shahrour F, Lane SW, Ebert BL.Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera.Blood. 2012 Jul 5;120(1):166-72.
    22627765
  • Nelson EA, Walker SR, Weisberg E, Bar-Natan M, Barrett R, Gashin LB, Terrell S, Klitgaard JL, Santo L, Addorio MR, Ebert BL, Griffin JD, Frank DA.The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors.Blood. 2011 Mar 24;117(12):3421-9.
    21233313
  • Dutt S, Narla A, Lin K, Mullally A, Abayasekara N, Megerdichian C, Wilson FH, Currie T, Khanna-Gupta A, Berliner N, Kutok JL, Ebert BL.Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells.Blood. 2011 Mar 3;117(9):2567-76.
    21068437
  • Narla A, Hurst SN, Ebert BL.Ribosome defects in disorders of erythropoiesis.Int J Hematol. 2011 Feb;93(2):144-9.
    21279816
  • Bejar R, Levine R, Ebert BL.Unraveling the molecular pathophysiology of myelodysplastic syndromes.J Clin Oncol. 2011 Feb 10;29(5):504-15. Review.
    21220588
  • Elkabets M, Gifford AM, Scheel C, Nilsson B, Reinhardt F, Bray MA, Carpenter AE, Jirström K, Magnusson K, Ebert BL, Pontén F, Weinberg RA, McAllister SS.Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice.J Clin Invest. 2011 Feb 1;121(2):784-99.
    21266779
  • Novershtern N, Subramanian A, Lawton LN, Mak RH, Haining WN, McConkey ME, Habib N, Yosef N, Chang CY, Shay T, Frampton GM, Drake AC, Leskov I, Nilsson B, Preffer F, Dombkowski D, Evans JW, Liefeld T, Smutko JS, Chen J, Friedman N, Young RA, Golub TR, Regev A, Ebert BL.Densely interconnected transcriptional circuits control cell states in human hematopoiesis.Cell. 2011 Jan 21;144(2):296-309.
    21241896
  • Ebert BL.Genetic deletions in AML and MDS.Best Pract Res Clin Haematol. 2010 Dec;23(4):457-61. Review.
    21130407
  • Mullally A, Ebert BL.STATistical power of clonal analysis: differential STAT1 pathway activation downstream of the JAK2V617F mutation.Cancer Cell. 2010 Nov 16;18(5):405-6.
    21075304
  • Mullally A, Ebert BL.NF1 inactivation revs up Ras in adult acute myelogenous leukemia.Clin Cancer Res. 2010 Aug 15;16(16):4074-6.
    20587590
  • Kharas MG, Lengner CJ, Al-Shahrour F, Bullinger L, Ball B, Zaidi S, Morgan K, Tam W, Paktinat M, Okabe R, Gozo M, Einhorn W, Lane SW, Scholl C, Fröhling S, Fleming M, Ebert BL, Gilliland DG, Jaenisch R, Daley GQ.Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.Nat Med. 2010 Aug;16(8):903-8.
    20616797
  • Mullally A, Lane SW, Ball B, Megerdichian C, Okabe R, Al-Shahrour F, Paktinat M, Haydu JE, Housman E, Lord AM, Wernig G, Kharas MG, Mercher T, Kutok JL, Gilliland DG, Ebert BL.Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells.Cancer Cell. 2010 Jun 15;17(6):584-96.
    20541703
  • Lane SW, Sykes SM, Al-Shahrour F, Shterental S, Paktinat M, Lo Celso C, Jesneck JL, Ebert BL, Williams DA, Gilliland DG.The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS.Blood. 2010 Apr 29;115(17):3489-97.
    20197553
  • Narla A, Ebert BL.Ribosomopathies: human disorders of ribosome dysfunction.Blood. 2010 Apr 22;115(16):3196-205. Review.
    20194897
  • Zimmer M, Lamb J, Ebert BL, Lynch M, Neil C, Schmidt E, Golub TR, Iliopoulos O.The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.Cancer Res. 2010 Apr 15;70(8):3071-9.
    20354189
  • Raaijmakers MH, Mukherjee S, Guo S, Zhang S, Kobayashi T, Schoonmaker JA, Ebert BL, Al-Shahrour F, Hasserjian RP, Scadden EO, Aung Z, Matza M, Merkenschlager M, Lin C, Rommens JM, Scadden DT.Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.Nature. 2010 Apr 8;464(7290):852-7.
    20305640
  • Bejar R, Ebert BL.The genetic basis of myelodysplastic syndromes.Hematol Oncol Clin North Am. 2010 Apr;24(2):295-315. Review.
    20359627
  • Ebert BL.Preface. The biology and treatment of myelodysplastic syndrome.Hematol Oncol Clin North Am. 2010 Apr;24(2):xiii-xvi.
    20359625
  • Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L, Greulich H, Reich M, Winckler W, Lawrence MS, Weir BA, Tanaka KE, Chiang DY, Bass AJ, Loo A, Hoffman C, Prensner J, Liefeld T, Gao Q, Yecies D, Signoretti S, Maher E, Kaye FJ, Sasaki H, Tepper JE, Fletcher JA, Tabernero J, Baselga J, Tsao MS, Demichelis F, Rubin MA, Janne PA, Daly MJ, Nucera C, Levine RL, Ebert BL, Gabriel S, Rustgi AK, Antonescu CR, Ladanyi M, Letai A, Garraway LA, Loda M, Beer DG, True LD, Okamoto A, Pomeroy SL, Singer S, Golub TR, Lander ES, Getz G, Sellers WR, Meyerson M.The landscape of somatic copy-number alteration across human cancers.Nature. 2010 Feb 18;463(7283):899-905.
    20164920
  • Abdel-Wahab O,Mullally A,Hedvat C,Garcia-Manero G,Patel J,Wadleigh M,Malinge S,Yao J,Kilpivaara O,Bhat R,Huberman K,Thomas S,Dolgalev I,Heguy A,Paietta E,Le Beau MM,Beran M,Tallman MS,Ebert BL,Kantarjian HM,Stone RM,Gilliland DG,Crispino JD,Levine RL.Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.Blood. 2009 Jul 2;114(1):144-7.
    19420352
  • Cheung KJ,Ebert BL.Therapeutic potential of targeting haploinsufficient genes in cancer.Pediatr Blood Cancer. 2009 Aug;53(2):131-2. Review.
    19343773
  • Kilpivaara O,Mukherjee S,Schram AM,Wadleigh M,Mullally A,Ebert BL,Bass A,Marubayashi S,Heguy A,Garcia-Manero G,Kantarjian H,Offit K,Stone RM,Gilliland DG,Klein RJ,Levine RL.A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms.Nat Genet. 2009 Apr;41(4):455-9.
    19287384
  • Zimmer M,Ebert BL,Neil C,Brenner K,Papaioannou I,Melas A,Tolliday N,Lamb J,Pantopoulos K,Golub T,Iliopoulos O.Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.Mol Cell. 2008 Dec 26;32(6):838-48.
    19111663
  • Haining WN, Ebert BL, Subrmanian A, Wherry EJ, Eichbaum Q, Evans JW, Mak R, Rivoli S, Pretz J, Angelosanto J, Smutko JS, Walker BD, Kaech SM, Ahmed R, Nadler LM, Golub TR.Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells.J Immunol. 2008 Aug 1;181(3):1859-68.
    18641323
  • Lu J, Guo S, Ebert BL, Zhang H, Peng X, Bosco J, Pretz J, Schlanger R, Wang JY, Mak RH, Dombkowski DM, Preffer FI, Scadden DT, Golub TR.MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors.Dev Cell. 2008 Jun;14(6):843-53.
    18539114
  • Ebert BL, Galili N, Tamayo P, Bosco J, Mak R, Pretz J, Tanguturi S, Ladd-Acosta C, Stone R, Golub TR, Raza A.An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome.PLoS Med. 2008 Feb;5(2):e35.
    18271621
  • Ebert BL, Pretz J, Bosco J, Chang CY, Tamayo P, Galili N, Raza A, Root DE, Attar E, Ellis SR, Golub TR.Identification of RPS14 as a 5q- syndrome gene by RNA interference screen.Nature. 2008 Jan 17;451(7176):335-9.
    18202658
  • Frohling S, Scholl C, Levine RL, Loriaux M, Boggon TJ, Bernard OA, Berger R, Dohner H, Dohner K, Ebert BL, Teckie S, Golub TR, Jiang J, Schittenhelm MM, Lee BH, Griffin JD, Stone RM, Heinrich MC, Deininger MW, Druker BJ, Gilliland DG.Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles.Cancer Cell. 2007 Dec;12(6):501-13.
    18068628
  • Yang H, Minamishima YA, Yan Q, Schlisio S, Ebert BL, Zhang X, Zhang L, Kim WY, Olumi AF, Kaelin WG.pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2.Mol Cell. 2007 Oct 12;28(1):15-27.
    17936701
  • Tamayo P, Scanfeld D, Ebert BL, Gillette MA, Roberts CW, Mesirov JP.Metagene projection for cross-platform, cross-species characterization of global transcriptional states.Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5959-64.
    17389406
  • Kim WY, Safran M, Buckley MR, Ebert BL, Glickman J, Bosenberg M, Regan M, Kaelin WG.Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo.EMBO J. 2006 Oct 4;25(19):4650-62.
    16977322
  • Pikman Y, Lee BH, Mercher T, McDowell E, Ebert BL, Gozo M, Cuker A, Wernig G, Moore S, Galinsky I, Deangelo DJ, Clark JJ, Lee SJ, Golub TR, Wadleigh M, Gilliland DG, Levine RL.MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia.PLoS Med. 2006 Jul 18;3(7):e270.
    16834459
  • Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP.Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50.
    16199517
  • Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR.MicroRNA expression profiles classify human cancers.Nature. 2005 Jun 9;435(7043):834-8.
    15944708
  • Ebert BL, Lee MM, Pretz JL, Subramanian A, Mak R, Golub TR, Sieff CA.An RNA interference model of RPS19 deficiency in Diamond Blackfan Anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone responsive genes by microarray.Blood. 2005 Jun 15;105(12):4620-6.
    15755903
  • Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, Huntly BJ, Boggon TJ, Wlodarska I, Clark JJ, Moore S, Adelsperger J, Koo S, Lee JC, Gabriel S, Mercher T, D'Andrea A, Frohling S, Dohner K, Marynen P, Vandenberghe P, Mesa RA, Tefferi A, Griffin JD, Eck MJ, Sellers WR, Meyerson M, Golub TR, Lee SJ, Gilliland DG.Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.Cancer Cell. 2005 Apr;7(4):387-97.
    15837627
  • Ebert BL, Golub TR.Genomic approaches to hematologic malignancies.Blood. 2004 Aug 15;104(4):923-32.
    15155462
  • Ebert BL, Niemierko E, Shaffer K, Salgia R.Use of temozolomide with other cytotoxic chemotherapy in the treatment of patients with recurrent brain metastases from lung cancer.Oncologist. 2003;8(1):69-75.
    12604733
  • Ebert BL, Bunn HF.Regulation of the erythropoietin gene.Blood. 1999 Sep 15;94(6):1864-77.
    10477715
  • Ebert BL, Bunn HF.Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein.Mol Cell Biol. 1998 Jul;18(7):4089-96.
    9632793
  • Ratcliffe PJ, Ebert BL, Firth JD, Gleadle JM, Maxwell PH, Nagao M, O'Rourke JF, Pugh CW, Wood SM.Oxygen regulated gene expression: erythropoietin as a model system.Kidney Int. 1997 Feb;51(2):514-26.
    9027732
  • Nagao M, Ebert BL, Ratcliffe PJ, Pugh CW.Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF-binding sites.FEBS Lett. 1996 Jun 3;387(2-3):161-6.
    8674541
  • Ebert BL, Gleadle JM, O'Rourke JF, Bartlett SM, Poulton J, Ratcliffe PJ.Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin.Biochem J. 1996 Feb 1;313 ( Pt 3):809-14.
    8611159
  • Ebert BL, Firth JD, Ratcliffe PJ.Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences.J Biol Chem. 1995 Dec 8;270(49):29083-9.
    7493931
  • Gleadle JM, Ebert BL, Ratcliffe PJ.Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing.Eur J Biochem. 1995 Nov 15;234(1):92-9.
    8529674
  • Firth JD, Ebert BL, Ratcliffe PJ.Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements.J Biol Chem. 1995 Sep 8;270(36):21021-7.
    7673128
  • Ratcliffe PJ, Ebert BL, Ferguson DJ, Firth JD, Gleadle JM, Maxwell PH, Pugh CW.Regulation of the erythropoietin gene.Nephrol Dial Transplant. 1995;10 Suppl 2:18-27.
    7644101
  • Firth JD, Ebert BL, Pugh CW, Ratcliffe PJ.Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6496-500.
    8022811
  • Pugh CW, Ebert BL, Ebrahim O, Maxwell PH, Ratcliffe PJ.Analysis of cis-acting sequences required for operation of the erythropoietin 3' enhancer in different cell lines.Ann N Y Acad Sci. 1994 Apr 15;718:31-9; discussion 39-40.
    8185238
  • Pugh CW, Ebert BL, Ebrahim O, Ratcliffe PJ.Characterisation of functional domains within the mouse erythropoietin 3' enhancer conveying oxygen-regulated responses in different cell lines.Biochim Biophys Acta. 1994 Apr 6;1217(3):297-306.
    8148375