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Elizabeth Henske, MD


  • El-Chemaly S, Henske EP.Towards personalised therapy for lymphangioleiomyomatosis: lessons from cancer.Eur Respir Rev. 2014 Mar 1;23(131):30-5.
  • Parkhitko AA, Priolo C, Coloff JL, Yun J, Wu JJ, Mizumura K, Xu W, Malinowska IA, Yu J, Kwiatkowski DJ, Locasale JW, Asara JM, Choi AM, Finkel T, Henske EP.Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.Mol Cancer Res. 2014 Jan;12(1):48-57.
  • Ma N, Liu Q, Zhang L, Henske EP, Ma Y.TORC1 signaling is governed by two negative regulators in fission yeast.Genetics. 2013 Oct;195(2):457-68.
  • Gu X, Yu JJ, Ilter D, Blenis N, Henske EP, Blenis J.Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis.Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14960-5.
  • Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, Blenis J.The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.Cell. 2013 May 9;153(4):840-54.
  • Li C, Zhou X, Sun Y, Zhang E, Mancini JD, Parkhitko A, Morrison TA, Silverman EK, Henske EP, Yu JJ.Faslodex Inhibits Estradiol-induced ECM Dynamics and Lung Metastasis in a Model of LAM.Am J Respir Cell Mol Biol. 2013 Mar 22.
  • Priolo C, Henske EP.Metabolic reprogramming in polycystic kidney disease.Nat Med. 2013 Apr;19(4):407-9.
  • Trindade AJ, Medvetz DA, Neuman NA, Myachina F, Yu J, Priolo C, Henske EP.MicroRNA-21 is induced by rapamycin in a model of tuberous sclerosis (TSC) and lymphangioleiomyomatosis (LAM).PLoS ONE. 2013;8(3):e60014.
  • McCormack FX, Travis WD, Colby TV, Henske EP, Moss J.Lymphangioleiomyomatosis: calling it what it is: a low-grade, destructive, metastasizing neoplasm.Am J Respir Crit Care Med. 2012 Dec 15;186(12):1210-2.
  • Medvetz DA, Khabibullin D, Hariharan V, Ongusaha PP, Goncharova EA, Schlechter T, Darling TN, Hofmann I, Krymskaya VP, Liao JK, Huang H, Henske EP.Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion.PLoS ONE. 2012;7(11):e47842.
  • Henske EP, McCormack FX.Lymphangioleiomyomatosis - a wolf in sheep's clothing.J Clin Invest. 2012 Nov 1;122(11):3807-16.
  • Liu F, Lunsford EP, Tong J, Ashitate Y, Gibbs SL, Yu J, Choi HS, Henske EP, Frangioni JV.Real-time monitoring of tumorigenesis, dissemination, & drug response in a preclinical model of lymphangioleiomyomatosis/tuberous sclerosis complex.PLoS ONE. 2012;7(6):e38589.
  • Neuman NA, Henske EP.Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis.EMBO Mol Med. 2011 Apr;3(4):189-200.
  • Nurok M, Eslick I, Carvalho CR, Costabel U, D'Armiento J, Glanville AR, Harari S, Henske EP, Inoue Y, Johnson SR, Lacronique J, Lazor R, Moss J, Ruoss SJ, Ryu JH, Seyama K, Watz H, Xu KF, Hohmann EL, Moss F.The International LAM Registry: A Component of an Innovative Web-Based Clinician, Researcher, and Patient-Driven Rare Disease Research Platform.Lymphat Res Biol. 2010 Mar;8(1):81-7.
  • Yu J, Henske EP.mTOR Activation, Lymphangiogenesis, and Estrogen-Mediated Cell Survival: The "Perfect Storm" of Pro-Metastatic Factors in LAM Pathogenesis.Lymphat Res Biol. 2010 Mar;8(1):43-9.
  • Yu J, Parkhitko AA, Henske EP.Mammalian target of rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapy.Proc Am Thorac Soc. 2010 Feb;7(1):48-53. Review.
  • Karbowniczek M, Zitserman D, Khabibullin D, Hartman T, Yu J, Morrison T, Nicolas E, Squillace R, Roegiers F, Henske EP.The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development.J Clin Invest. 2010 Jan;120(1):93-102.
  • Matthew EM, Hart LS, Astrinidis A, Navaraj A, Dolloff NG, Dicker DT, Henske EP, El-Deiry WS.The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions.Cell Cycle. 2009 Dec 15;8(24):4168-75.
  • Yu JJ,Robb VA,Morrison TA,Ariazi EA,Karbowniczek M,Astrinidis A,Wang C,Hernandez-Cuebas L,Seeholzer LF,Nicolas E,Hensley H,Jordan VC,Walker CL,Henske EP.Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells.Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2635-40.
  • Hartman TR,Liu D,Zilfou JT,Robb V,Morrison T,Watnick T,Henske EP.The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway.Hum Mol Genet. 2009 Jan 1;18(1):151-63.
  • Lee CH,Inoki K,Karbowniczek M,Petroulakis E,Sonenberg N,Henske EP,Guan KL.Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53.EMBO J. 2007 Nov 28;26(23):4812-23.
  • Karbowniczek M,Spittle CS,Morrison T,Wu H,Henske EP.mTOR is activated in the majority of malignant melanomas.J Invest Dermatol. 2008 Apr;128(4):980-7.
  • Pugacheva EN,Jablonski SA,Hartman TR,Henske EP,Golemis EA.HEF1-dependent Aurora A activation induces disassembly of the primary cilium.Cell. 2007 Jun 29;129(7):1351-63.