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Alex Toker, PhD

Publications

  • Toker A, Marmiroli S.Signaling specificity in the Akt pathway in biology and disease.Adv Biol Regul. 2014 May;55C:28-38.
    24794538
  • Chin YM, Yuan X, Balk SP, Toker A.Pten-deficient tumors depend on akt2 for maintenance and survival.Cancer Discovery. 2014 May 16.
    24838891
  • Toker A, Chin YR.Akt-ing up on SRPK1: oncogene or tumor suppressor?.Mol Cell. 2014 May 8;54(3):329-30.
    24813709
  • Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W.Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.Nature. 2014 Apr 24;508(7497):541-5.
    24670654
  • Elloul S, Kedrin D, Knoblauch NW, Beck AH, Toker A.The adherens junction protein afadin is an AKT substrate that regulates breast cancer cell migration.Mol Cancer Res. 2014 Mar;12(3):464-76.
    24269953
  • Chin YR, Yoshida T, Marusyk A, Beck AH, Polyak K, Toker A.Targeting Akt3 signaling in triple-negative breast cancer.Cancer Res. 2014 Feb 1;74(3):964-73.
    24335962
  • White CD, Toker A.Using phospho-motif antibodies to determine kinase substrates.Curr Protoc Mol Biol. 2013 Jan;Chapter 18:Unit 18.20..
    23288461
  • Kazerounian S, Gerald D, Huang M, Chin YR, Udayakumar D, Zheng N, O'Donnell RK, Perruzzi C, Mangiante L, Pourat J, Phung TL, Bravo-Nuevo A, Shechter S, McNamara S, Duhadaway JB, Kocher ON, Brown LF, Toker A, Prendergast GC, Benjamin LE.RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis.Cancer Res. 2012 Nov 7.
    23135917
  • Christoforides C, Rainero E, Brown KK, Norman JC, Toker A.PKD controls αvβ3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5.Dev Cell. 2012 Sep 11;23(3):560-72.
    22975325
  • Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W.Acetylation-dependent regulation of Skp2 function.Cell. 2012 Jul 6;150(1):179-93.
    22770219
  • Banerji S, Cibulskis K, Rangel-Escareno C, Brown KK, Carter SL, Frederick AM, Lawrence MS, Sivachenko AY, Sougnez C, Zou L, Cortes ML, Fernandez-Lopez JC, Peng S, Ardlie KG, Auclair D, Bautista-Piña V, Duke F, Francis J, Jung J, Maffuz-Aziz A, Onofrio RC, Parkin M, Pho NH, Quintanar-Jurado V, Ramos AH, Rebollar-Vega R, Rodriguez-Cuevas S, Romero-Cordoba SL, Schumacher SE, Stransky N, Thompson KM, Uribe-Figueroa L, Baselga J, Beroukhim R, Polyak K, Sgroi DC, Richardson AL, Jimenez-Sanchez G, Lander ES, Gabriel SB, Garraway LA, Golub TR, Melendez-Zajgla J, Toker A, Getz G, Hidalgo-Miranda A, Meyerson M.Sequence analysis of mutations and translocations across breast cancer subtypes.Nature. 2012 Jun 21;486(7403):405-9.
    22722202
  • Chin YR, Toker A.Akt2 regulates expression of the actin-bundling protein palladin.FEBS Lett. 2010 Dec 1;584(23):4769-74.
    21050850
  • Fry JL, Toker A.Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration.Cancer Res. 2010 Oct 15;70(20):8187-98.
    20736367
  • Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W.Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.Mol Cell. 2010 Sep 10;39(5):797-808.
    20832730
  • Nhek S, Ngo M, Yang X, Ng MM, Field SJ, Asara JM, Ridgway ND, Toker A.Regulation of OSBP Golgi Localization through Protein Kinase D-mediated Phosphorylation.Mol Biol Cell. 2010 Jul;21(13):2327-37.
    20444975
  • Chin YR, Toker A.The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration.Mol Cell. 2010 May 14;38(3):333-44.
    20471940
  • Toker A.TTC3 ubiquitination terminates Akt-ivation.Dev Cell. 2009 Dec;17(6):752-4.
    20059946
  • Mancini M, Toker A.NFAT proteins: emerging roles in cancer progression.Nat Rev Cancer. 2009 Nov;9(11):810-20. Review.
    19851316
  • Storz P, Döppler H, Copland JA, Simpson KJ, Toker A.FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases.Mol Cell Biol. 2009 Sep;29(18):4906-17.
    19564415
  • Maurer M, Su T, Saal LH, Koujak S, Hopkins BD, Barkley CR, Wu J, Nandula S, Dutta B, Xie Y, Chin YR, Kim DI, Ferris JS, Gruvberger-Saal SK, Laakso M, Wang X, Memeo L, Rojtman A, Matos T, Yu JS, Cordon-Cardo C, Isola J, Terry MB, Toker A, Mills GB, Zhao JJ, Murty VV, Hibshoosh H, Parsons R.3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma.Cancer Res. 2009 Aug 1;69(15):6299-306.
    19602588
  • Gao D,Inuzuka H,Tseng A,Chin RY,Toker A,Wei W.Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.Nat Cell Biol. 2009 Apr;11(4):397-408.
    19270695
  • Yoeli-Lerner M,Chin YR,Hansen CK,Toker A.Akt/protein kinase b and glycogen synthase kinase-3beta signaling pathway regulates cell migration through the NFAT1 transcription factor.Mol Cancer Res. 2009 Mar;7(3):425-32.
    19258413
  • Chin YR,Toker A.Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer.Cell Signal. 2009 Apr;21(4):470-6.
    19110052
  • Watkins JL, Lewandowski KT, Meek SE, Storz P, Toker A, Piwnica-Worms H.Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association.Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18378-83.
    19011111
  • Toker A.mTOR and Akt signaling in cancer: SGK cycles in.Mol Cell. 2008 Jul 11;31(1):6-8.
    18614042
  • Toker A.Akt signaling: a damaging interaction makes good.Trends Biochem Sci. 2008 Aug;33(8):356-9.
    18585043
  • Kunkel MT, Toker A, Tsien RY, Newton AC.Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter.J Biol Chem. 2007 Mar 2;282(9):6733-42.
    17189263
  • Toker A, Yoeli-Lerner M.Akt signaling and cancer: surviving but not moving on.Cancer Res. 2006 Apr 15;66(8):3963-6. Review.
    16618711
  • Yoeli-Lerner M, Toker A.Akt/PKB signaling in cancer: a function in cell motility and invasion.Cell Cycle. 2006 Mar;5(6):603-5. Review.
    16582622
  • Yiu GK, Toker A.NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2.J Biol Chem. 2006 May 5;281(18):12210-7.
    16505480
  • Yoeli-Lerner M, Yiu GK, Rabinovitz I, Erhardt P, Jauliac S, Toker A.Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT.Mol Cell. 2005 Nov 23;20(4):539-50.
    16307918
  • Storz P, Dppler H, Toker A.Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species.Mol Cell Biol. 2005 Oct;25(19):8520-30.
    16166634
  • Hausser A, Storz P, Mrtens S, Link G, Toker A, Pfizenmaier K.Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex.Nat Cell Biol. 2005 Sep;7(9):880-6.
    16100512
  • Mazzocca A, Coppari R, De Franco R, Cho JY, Libermann TA, Pinzani M, Toker A.A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions.Cancer Res. 2005 Jun 1;65(11):4728-38.
    15930291
  • Toker A.The biology and biochemistry of diacylglycerol signalling. Meeting on molecular advances in diacylglycerol signalling.EMBO Rep. 2005 Apr;6(4):310-4.
    15791268
  • Hutti JE, Jarrell ET, Chang JD, Abbott DW, Storz P, Toker A, Cantley LC, Turk BE.A rapid method for determining protein kinase phosphorylation specificity.Nat Methods. 2004 Oct;1(1):27-9.
    15782149
  • Dppler H, Storz P, Li J, Comb MJ, Toker A.A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D.J Biol Chem. 2005 Apr 15;280(15):15013-9.
    15728188
  • Storz P, Dppler H, Ferran C, Grey ST, Toker A.Functional dichotomy of A20 in apoptotic and necrotic cell death.Biochem J. 2005 Apr 1;387(Pt 1):47-55.
    15527421
  • Hodges RR, Raddassi I, Zoukhri D, Toker A, Kazlauskas A, Dartt DA.Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion.Invest Ophthalmol Vis Sci. 2004 Nov;45(11):3974-81.
    15505044
  • Storz P, Dppler H, Toker A.Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB.Mol Pharmacol. 2004 Oct;66(4):870-9.
    15226414
  • Storz P, Dppler H, Toker A.Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling.Mol Cell Biol. 2004 Apr;24(7):2614-26.
    15024053
  • Toker A.Identifying protein kinase C substrates: an introduction.Methods Mol Biol. 2003;233:247-51.
    12840512
  • Toker A.PDK-1 and protein kinase C phosphorylation.Methods Mol Biol. 2003;233:171-89.
    12840507
  • Toker A.Genetic manipulation of protein kinase C in vivo.Methods Mol Biol. 2003;233:475-89.
    12840530
  • Storz P, Toker A.NF-kappaB signaling--an alternate pathway for oxidative stress responses.Cell Cycle. 2003 Jan-Feb;2(1):9-10.
    12695674
  • Storz P, Dppler H, Johannes FJ, Toker A.Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation.J Biol Chem. 2003 May 16;278(20):17969-76.
    12637538
  • Hodges RR, Kazlauskas A, Toker A, Dartt DA.Effect of overexpression of protein kinase C alpha on rat lacrimal gland protein secretion.Adv Exp Med Biol. 2002;506(Pt A):237-41.
    12613914
  • Storz P, Toker A.Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway.EMBO J. 2003 Jan 2;22(1):109-20.
    12505989
  • Jauliac S, Lpez-Rodriguez C, Shaw LM, Brown LF, Rao A, Toker A.The role of NFAT transcription factors in integrin-mediated carcinoma invasion.Nat Cell Biol. 2002 Jul;4(7):540-4.
    12080349
  • Cenni V, Dppler H, Sonnenburg ED, Maraldi N, Newton AC, Toker A.Regulation of novel protein kinase C epsilon by phosphorylation.Biochem J. 2002 May 1;363(Pt 3):537-45.
    11964154
  • Storz P, Toker A.3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling.Front Biosci. 2002 Apr 1;7:d886-902.
    11897568