Wolfram Goessling, MD, PhD

Publications

• Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, Kühnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, Leach IM, O'Reilly PF, Peden JF,
  22001757
• Goessling W, North TE.Hematopoietic stem cell development: using the zebrafish to identify the signaling networks and physical forces regulating hematopoiesis.Methods Cell Biol. 2011;105:117-36.
  21951528
• Liu CT, Garnaas MK, Tin A, Kottgen A, Franceschini N, Peralta CA, de Boer IH, Lu X, Atkinson E, Ding J, Nalls M, Shriner D, Coresh J, Kutlar A, Bibbins-Domingo K, Siscovick D, Akylbekova E, Wyatt S, Astor B, Mychaleckjy J, Li M, Reilly MP, Townsend RR, Ad
  21931561
• Saadi I, Alkuraya FS, Gisselbrecht SS, Goessling W, Cavallesco R, Turbe-Doan A, Petrin AL, Harris J, Siddiqui U, Grix AW, Hove HD, Leboulch P, Glover TW, Morton CC, Richieri-Costa A, Murray JC, Erickson RP, Maas RL.Deficiency of the cytoskeletal protein S
  21703590
• North TE, Goessling W.Endoderm specification, liver development, and regeneration.Methods Cell Biol. 2011;101:205-23. Review.
  21550446
• Goessling W, Allen RS, Guan X, Jin P, Uchida N, Dovey M, Harris JM, Metzger ME, Bonifacino AC, Stroncek D, Stegner J, Armant M, Schlaeger T, Tisdale JF, Zon LI, Donahue RE, North TE.Prostaglandin e2 enhances human cord blood stem cell xenotransplants and
  21474107
• North TE, Babu IR, Vedder LM, Lord AM, Wishnok JS, Tannenbaum SR, Zon LI, Goessling W.PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury.Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):173
  20855591
• Wang Y, Krivtsov AV, Sinha AU, North TE, Goessling W, Feng Z, Zon LI, Armstrong SA.The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.Science. 2010 Mar 26;327(5973):1650-3.
  20339075
• Baba Y, Nosho K, Shima K, Goessling W, Chan AT, Ng K, Chan JA, Giovannucci EL, Fuchs CS, Ogino S.PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype.Cancer Epidemiol Biom
  20200425
• North TE, Goessling W.Previews. NOTCHing an arrow at cord blood: translating stem cell knowledge into clinical practice.Cell Stem Cell. 2010 Mar 5;6(3):186-7.
  20207217
• Goessling W.Deciphering hepatocellular carcinoma: from bench to bedside and back.Gastroenterology. 2009 Sep;137(3):786-8.
  19643190
• Dovey M,Patton EE,Bowman T,North T,Goessling W,Zhou Y,Zon LI.Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish.Mol Cell Biol. 2009 Jul;29(13):3746-53.
  19380487
• North TE,Goessling W,Peeters M,Li P,Ceol C,Lord AM,Weber GJ,Harris J,Cutting CC,Huang P,Dzierzak E,Zon LI.Hematopoietic stem cell development is dependent on blood flow.Cell. 2009 May 15;137(4):736-48.
  19450519
• Goessling W,North TE,Loewer S,Lord AM,Lee S,Stoick-Cooper CL,Weidinger G,Puder M,Daley GQ,Moon RT,Zon LI.Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration.Cell. 2009 Mar 20;136(6):1136-47.
  19303855
• Goessling W, Massaro JM, Vasan RS, D'Agostino RB, Ellison RC, Fox CS.Aminotransferase levels and 20-year risk of metabolic syndrome, diabetes, and cardiovascular disease.Gastroenterology. 2008 Dec;135(6):1935-44, 1944.e1.
  19010326
• Upadhyay G, Goessling W, North TE, Xavier R, Zon LI, Yajnik V.Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling.Oncogene. 2008 Oct 2;27(44):5845-55.
  18641688
• Goessling W, North TE, Lord AM, Ceol C, Lee S, Weidinger G, Bourque C, Strijbosch R, Haramis AP, Puder M, Clevers H, Moon RT, Zon LI.APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development.Dev Biol. 2008 Aug 1;3
  18585699
• White RM, Sessa A, Burke C, Bowman T, LeBlanc J, Ceol C, Bourque C, Dovey M, Goessling W, Burns CE, Zon LI.Transparent adult zebrafish as a tool for in vivo transplantation analysis.Cell Stem Cell. 2008 Feb 7;2(2):183-9.
  18371439
• North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, Bowman TV, Jang IH, Grosser T, Fitzgerald GA, Daley GQ, Orkin SH, Zon LI.Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.Nature. 2007 Jun 21;447(7147):
  17581586
• Goessling W, North TE, Zon LI.Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors.Nat Methods. 2007 Jul;4(7):551-3.
  17572681
• Goessling W, North TE, Zon LI.New waves of discovery: modeling cancer in zebrafish.J Clin Oncol. 2007 Jun 10;25(17):2473-9. Review.
  17557959
• Langenau DM, Keefe MD, Storer NY, Guyon JR, Kutok JL, Le X, Goessling W, Neuberg DS, Kunkel LM, Zon LI.Effects of RAS on the genesis of embryonal rhabdomyosarcoma.Genes Dev. 2007 Jun 1;21(11):1382-1395.
  17510286
• Goessling W, Mayer RJ.Systemic treatment of patients who have colorectal cancer and inflammatory bowel disease.Gastroenterol Clin North Am. 2006 Sep;35(3):713-27. Review.
  16952747
• Goessling W, Friedman LS.Increased liver chemistry in an asymptomatic patient.Clin Gastroenterol Hepatol. 2005 Sep;3(9):852-8.
  16234021
• Goessling W, Chung RT.Amebic Liver Abscess.Curr Treat Options Gastroenterol. 2002 Dec;5(6):443-449.
  12408781
• Goessling W, McKee PH, Mayer RJ.Merkel cell carcinoma.J Clin Oncol. 2002 Jan 15;20(2):588-98.
  11786590
• Zucker SD, Goessling W, Bootle EJ, Sterritt C.Localization of bilirubin in phospholipid bilayers by parallax analysis of fluorescence quenching.J Lipid Res. 2001 Sep;42(9):1377-88.
  11518756
• Goessling W, Zucker SD.Role of apolipoprotein D in the transport of bilirubin in plasma.Am J Physiol Gastrointest Liver Physiol. 2000 Aug;279(2):G356-65.
  10915645
• Zucker SD, Goessling W.Mechanism of hepatocellular uptake of albumin-bound bilirubin.Biochim Biophys Acta. 2000 Feb 15;1463(2):197-208.
  10675499
• Zucker SD, Goessling W, Hoppin AG.Unconjugated bilirubin exhibits spontaneous diffusion through model lipid bilayers and native hepatocyte membranes.J Biol Chem. 1999 Apr 16;274(16):10852-62.
  10196162
• Zucker SD, Goessling W, Gollan JL.Intracellular transport of small hydrophobic compounds by the hepatocyte.Semin Liver Dis. 1996 May;16(2):159-67.
  8781021
• Zucker SD, Goessling W, Ransil BJ, Gollan JL.Influence of glutathione S-transferase B (ligandin) on the intermembrane transfer of bilirubin. Implications for the intracellular transport of nonsubstrate ligands in hepatocytes.J Clin Invest. 1995 Oct;96(4):
  7560084
• Zucker SD, Goessling W, Gollan JL.Kinetics of bilirubin transfer between serum albumin and membrane vesicles. Insight into the mechanism of organic anion delivery to the hepatocyte plasma membrane.J Biol Chem. 1995 Jan 20;270(3):1074-81.
  7836362
• Zucker SD, Goessling W, Zeidel ML, Gollan JL.Membrane lipid composition and vesicle size modulate bilirubin intermembrane transfer. Evidence for membrane-directed trafficking of bilirubin in the hepatocyte.J Biol Chem. 1994 Jul 29;269(30):19262-70.
  8034688