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Augustine M. K. Choi, MD


  • Contreras AU, Mebratu Y, Delgado M, Montano G, Hu CA, Ryter SW, Choi AM, Lin Y, Xiang J, Chand H, Tesfaigzi Y.Deacetylation of p53 induces autophagy by suppressing Bmf expression.J Cell Biol. 2013 Apr 29;201(3):427-37.
  • Zhou X, Qiu W, Sathirapongsasuti JF, Cho MH, Mancini JD, Lao T, Thibault DM, Litonjua AA, Bakke PS, Gulsvik A, Lomas DA, Beaty TH, Hersh CP, Anderson C, Geigenmuller U, Raby BA, Rennard SI, Perrella MA, Choi AM, Quackenbush J, Silverman EK.Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells.Genomics. 2013 May;101(5):263-72.
  • An CH, Wang XM, Lam HC, Ifedigbo E, Washko GR, Ryter SW, Choi AM.TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema.Am J Physiol Lung Cell Mol Physiol. 2012 Nov;303(9):L748-57.
  • Ryter SW, Choi AM.Regulation of Autophagy in Oxygen-Dependent Cellular Stress.Curr Pharm Des. 2012 Oct 18.
  • Patel AS, Morse D, Choi AM.Regulation and Functional Significance of Autophagy in Respiratory Cell Biology and Disease.Am J Respir Cell Mol Biol. 2012 Sep 13.
  • Banerjee P, Basu A, Wegiel B, Otterbein LE, Mizumura K, Gasser M, Waaga-Gasser AM, Choi AM, Pal S.Heme oxygenase-1 promotes survival of renal cancer cells through modulation of apoptosis- and autophagy-regulating molecules.J Biol Chem. 2012 Sep 14;287(38):32113-23.
  • Shi Y, Cao J, Gao J, Zheng L, Goodwin A, An CH, Patel A, Lee JS, Duncan SR, Kaminski N, Pandit KV, Rosas IO, Choi AM, Morse D.Retinoic acid-related orphan receptor-α is induced in the setting of DNA damage and promotes pulmonary emphysema.Am J Respir Crit Care Med. 2012 Sep 1;186(5):412-9.
  • Li W, Liu H, Zhou JS, Cao JF, Zhou XB, Choi AM, Chen ZH, Shen HH.Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2).J Biol Chem. 2012 Jun 15;287(25):20922-30.
  • Lam HC, Choi AM, Ryter SW.Isolation of mouse respiratory epithelial cells and exposure to experimental cigarette smoke at air liquid interface.Journal Of Visualized Experiments : Jo Ve. 2011(48).
  • Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, Englert JA, Rabinovitch M, Cernadas M, Kim HP, Fitzgerald KA, Ryter SW, Choi AM.Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.Nat Immunol. 2011 Mar;12(3):222-30.
  • Ryter SW, Lam HC, Chen ZH, Choi AM.Deadly triplex: Smoke, autophagy, and apoptosis.Autophagy. 2011 Apr 1;7(4).
  • Chen ZH, Lam HC, Jin Y, Kim HP, Cao J, Lee SJ, Ifedigbo E, Parameswaran H, Ryter SW, Choi AM.Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema.Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18880-5.
  • Ryter SW, Lee SJ, Choi AM.Autophagy in cigarette smoke-induced chronic obstructive pulmonary disease.Expert Rev Respir Med. 2010 Oct;4(5):573-84.
  • Ryter SW, Lee SJ, Smith A, Choi AM.Autophagy in vascular disease.Proc Am Thorac Soc. 2010 Feb;7(1):40-7. Review.
  • Ryter SW, Choi AM.Autophagy in the lung.Proc Am Thorac Soc. 2010 Feb;7(1):13-21. Review.
  • Choi AM, Reynolds HY, Colombini-Hatch S, Rothgeb A, Blaisdell CJ, Gail DB.NHLBI workshop: respiratory medicine-related research training for adult and pediatric fellows.Lung.;187(6):347-66.
  • DeMeo DL, Mariani T, Bhattacharya S, Srisuma S, Lange C, Litonjua A, Bueno R, Pillai SG, Lomas DA, Sparrow D, Shapiro SD, Criner GJ, Kim HP, Chen Z, Choi AM, Reilly J, Silverman EK.Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene.Am J Hum Genet. 2009 Oct;85(4):493-502.
  • Wong SW, Kwon MJ, Choi AM, Kim HP, Nakahira K, Hwang DH.Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner.J Biol Chem. 2009 Oct 2;284(40):27384-92.
  • Bon JM, Leader JK, Weissfeld JL, Coxson HO, Zheng B, Branch RA, Kondragunta V, Lee JS, Zhang Y, Choi AM, Lokshin AE, Kaminski N, Gur D, Sciurba FC.The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease.PLoS ONE. 2009;4(8):e6865.
  • Yasuoka H, Hsu E, Ruiz XD, Steinman RA, Choi AM, Feghali-Bostwick CA.The fibrotic phenotype induced by IGFBP-5 is regulated by MAPK activation and egr-1-dependent and -independent mechanisms.Am J Pathol. 2009 Aug;175(2):605-15.
  • van der Toorn M,Rezayat D,Kauffman HF,Bakker SJ,Gans RO,Koeter GH,Choi AM,van Oosterhout AJ,Slebos DJ.Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells.Am J Physiol Lung Cell Mol Physiol. 2009 Jul;297(1):L109-14.
  • Kim HP,Chen ZH,Choi AM,Ryter SW.Analyzing autophagy in clinical tissues of lung and vascular diseases.Methods Enzymol. 2009;453:197-216.
  • Ryter SW,Chen ZH,Kim HP,Choi AM.Autophagy in chronic obstructive pulmonary disease: homeostatic or pathogenic mechanism?.Autophagy. 2009 Feb;5(2):235-7.
  • Mangalmurti NS,Xiong Z,Hulver M,Ranganathan M,Liu XH,Oriss T,Fitzpatrick M,Rubin M,Triulzi D,Choi A,Lee JS.Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation.Blood. 2009 Jan 29;113(5):1158-66.
  • Szczepaniak WS,Zhang Y,Hagerty S,Crow MT,Kesari P,Garcia JG,Choi AM,Simon BA,McVerry BJ.Sphingosine 1-phosphate rescues canine LPS-induced acute lung injury and alters systemic inflammatory cytokine production in vivo.Transl Res. 2008 Nov;152(5):213-24.
  • Chen ZH,Kim HP,Sciurba FC,Lee SJ,Feghali-Bostwick C,Stolz DB,Dhir R,Landreneau RJ,Schuchert MJ,Yousem SA,Nakahira K,Pilewski JM,Lee JS,Zhang Y,Ryter SW,Choi AM.Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease.PLoS ONE. 2008;3(10):e3316.
  • Jin Y,Kim HP,Cao J,Zhang M,Ifedigbo E,Choi AM.Caveolin-1 regulates the secretion and cytoprotection of Cyr61 in hyperoxic cell death.FASEB J. 2009 Feb;23(2):341-50.
  • McComb JG,Ranganathan M,Liu XH,Pilewski JM,Ray P,Watkins SC,Choi AM,Lee JS.CX3CL1 up-regulation is associated with recruitment of CX3CR1+ mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema.Am J Pathol. 2008 Oct;173(4):949-61.
  • Kim HP,Wang X,Chen ZH,Lee SJ,Huang MH,Wang Y,Ryter SW,Choi AM.Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1.Autophagy. 2008 Oct 1;4(7):887-95.
  • Rodway GW,Hoffman LA,Tasota FJ,Sethi JM,Choi AM,Ryter SW,Sanders MH.Inducing hypoxemia in healthy humans: a method for intermittently lowering arterial blood oxygenation during physiological studies.Wilderness Environ Med. 2008 Fall;19(3):218-20.
  • Nakao A,Faleo G,Shimizu H,Nakahira K,Kohmoto J,Sugimoto R,Choi AM,McCurry KR,Takahashi T,Murase N.Ex vivo carbon monoxide prevents cytochrome P450 degradation and ischemia/reperfusion injury of kidney grafts.Kidney Int. 2008 Oct;74(8):1009-16.
  • Faleo G,Neto JS,Kohmoto J,Tomiyama K,Shimizu H,Takahashi T,Wang Y,Sugimoto R,Choi AM,Stolz DB,Carrieri G,McCurry KR,Murase N,Nakao A.Carbon monoxide ameliorates renal cold ischemia-reperfusion injury with an upregulation of vascular endothelial growth factor by activation of hypoxia-inducible factor.Transplantation. 2008 Jun 27;85(12):1833-40.
  • Sethi JM,Choi AM,Calhoun WJ,Ameredes BT.Non-invasive measurements of exhaled NO and CO associated with methacholine responses in mice.Respir Res. 2008;9:45.