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Michael J. Birrer, MD, PhD

Publications

  • Birrer MJ.Ovarian cancer: targeting the untargetable.Am Soc Clin Oncol Educ Book. 2014;34:13-5.
    24857054
  • Riester M, Wei W, Waldron L, Culhane AC, Trippa L, Oliva E, Kim SH, Michor F, Huttenhower C, Parmigiani G, Birrer MJ.Risk prediction for late-stage ovarian cancer by meta-analysis of 1525 patient samples.Journal of the National Cancer Institute. 2014 May(5).
    24700803
  • Waldron L, Haibe-Kains B, Culhane AC, Riester M, Ding J, Wang XV, Ahmadifar M, Tyekucheva S, Bernau C, Risch T, Ganzfried BF, Huttenhower C, Birrer M, Parmigiani G.Comparative meta-analysis of prognostic gene signatures for late-stage ovarian cancer.Journal of the National Cancer Institute. 2014 May(5).
    24700801
  • Bookman MA, Gilks CB, Kohn EC, Kaplan KO, Huntsman D, Aghajanian C, Birrer MJ, Ledermann JA, Oza AM, Swenerton KD.Better therapeutic trials in ovarian cancer.Journal of the National Cancer Institute. 2014 Apr 1;106(4):dju029.
    24627272
  • Tanwar PS, Mohapatra G, Chiang S, Engler DA, Zhang L, Kaneko-Tarui T, Ohguchi Y, Birrer MJ, Teixeira JM.Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer.Carcinogenesis. 2014 Mar;35(3):546-53.
    24170201
  • Peterson VM, Castro CM, Chung J, Miller NC, Ullal AV, Castano MD, Penson RT, Lee H, Birrer MJ, Weissleder R.Ascites analysis by a microfluidic chip allows tumor-cell profiling.Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4978-86.
    24297935
  • Creutzberg CL, Kitchener HC, Birrer MJ, Landoni F, Lu KH, Powell M, Aghajanian C, Edmondson R, Goodfellow PJ, Quinn M, Salvesen HB, Thomas G, .Gynecologic Cancer InterGroup (GCIG) endometrial cancer clinical trials planning meeting: taking endometrial cancer trials into the translational era.Int J Gynecol Cancer. 2013 Oct;23(8):1528-34.
    24257568
  • Wei W, Mok SC, Oliva E, Kim SH, Mohapatra G, Birrer MJ.FGF18 as a prognostic and therapeutic biomarker in ovarian cancer.J Clin Invest. 2013 Oct 1;123(10):4435-48.
    24018557
  • Rauh-Hain JA, Guseh SH, Esselen KM, Growdon WB, Schorge JO, Horowitz NS, Krasner CN, del Carmen MG, Birrer MJ, Dizon DS.Patterns of recurrence in patients treated with bevacizumab in the primary treatment of advanced epithelial ovarian cancer.Int J Gynecol Cancer. 2013 Sep;23(7):1219-25.
    23975042
  • Liu JF, Tolaney SM, Birrer M, Fleming GF, Buss MK, Dahlberg SE, Lee H, Whalen C, Tyburski K, Winer E, Ivy P, Matulonis UA.A Phase 1 trial of the poly(ADP-ribose) polymerase inhibitor olaparib (AZD2281) in combination with the anti-angiogenic cediranib (AZD2171) in recurrent epithelial ovarian or triple-negative breast cancer.Eur J Cancer. 2013 Sep;49(14):2972-8.
    23810467
  • Yeung TL, Leung CS, Wong KK, Samimi G, Thompson MS, Liu J, Zaid TM, Ghosh S, Birrer MJ, Mok SC.TGF-β modulates ovarian cancer invasion by upregulating CAF-derived versican in the tumor microenvironment.Cancer Res. 2013 Aug 15;73(16):5016-28.
    23824740
  • Holderness Parker N, Donninger H, Birrer MJ, Leaner VD.p21-activated kinase 3 (PAK3) is an AP-1 regulated gene contributing to actin organisation and migration of transformed fibroblasts.PLoS ONE. 2013;8(6):e66892.
    23818969
  • Bradford LS, Rauh-Hain JA, Schorge J, Birrer MJ, Dizon DS.Advances in the Management of Recurrent Endometrial Cancer.Am J Clin Oncol. 2013 Jun 11.
    23764681
  • Ganzfried BF, Riester M, Haibe-Kains B, Risch T, Tyekucheva S, Jazic I, Wang XV, Ahmadifar M, Birrer MJ, Parmigiani G, Huttenhower C, Waldron L.curatedOvarianData: clinically annotated data for the ovarian cancer transcriptome.Database (Oxford). 2013;2013:bat013.
    23550061
  • Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K, Buckley M, Fridley BL, Tyrer JP, Shen H, Weber R, Karevan R, Larson MC, Song H, Tessier DC, Bacot F, Vincent D, Cunningham JM, Dennis J, Dicks E, , , Aben KK, Anton-Culver H, Antonenkova N, Armasu SM, Baglietto L, Bandera EV, Beckmann MW, Birrer MJ, Bloom G, Bogdanova N, Brenton JD, Brinton LA, Brooks-Wilson A, Brown R, Butzow R, Campbell I, Carney ME, Carvalho RS, Chang-Claude J, Chen YA, Chen Z, Chow WH, Cicek MS, Coetzee G, Cook LS, Cramer DW, Cybulski C, Dansonka-Mieszkowska A, Despierre E, Doherty JA, Dörk T, du Bois A, Dürst M, Eccles D, Edwards R, Ekici AB, Fasching PA, Fenstermacher D, Flanagan J, Gao YT, Garcia-Closas M, Gentry-Maharaj A, Giles G, Gjyshi A, Gore M, Gronwald J, Guo Q, Halle MK, Harter P, Hein A, Heitz F, Hillemanns P, Hoatlin M, Høgdall E, Høgdall CK, Hosono S, Jakubowska A, Jensen A, Kalli KR, Karlan BY, Kelemen LE, Kiemeney LA, Kjaer SK, Konecny GE, Krakstad C, Kupryjanczyk J, Lambrechts D, Lambrechts S, Le ND, Lee N, Lee J, Leminen A, Lim BK, Lissowska J, Lubiński J, Lundvall L, Lurie G, Massuger LF, Matsuo K, McGuire V, McLaughlin JR, Menon U, Modugno F, Moysich KB, Nakanishi T, Narod SA, Ness RB, Nevanlinna H, Nickels S, Noushmehr H, Odunsi K, Olson S, Orlow I, Paul J, Pejovic T, Pelttari LM, Permuth-Wey J, Pike MC, Poole EM, Qu X, Risch HA, Rodriguez-Rodriguez L, Rossing MA, Rudolph A, Runnebaum I, Rzepecka IK, Salvesen HB, Schwaab I, Severi G, Shen H, Shridhar V, Shu XO, Sieh W, Southey MC, Spellman P, Tajima K, Teo SH, Terry KL, Thompson PJ, Timorek A, Tworoger SS, van Altena AM, van den Berg D, Vergote I, Vierkant RA, Vitonis AF, Wang-Gohrke S, Wentzensen N, Whittemore AS, Wik E, Winterhoff B, Woo YL, Wu AH, Yang HP, Zheng W, Ziogas A, Zulkifli F, Goodman MT, Hall P, Easton DF, Pearce CL, Berchuck A, Chenevix-Trench G, Iversen E, Monteiro AN, Gayther SA, Schildkraut JM, Sellers TA.GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.Nat Genet. 2013 Apr;45(4):362-70.
    23535730
  • Permuth-Wey J, Lawrenson K, Shen HC, Velkova A, Tyrer JP, Chen Z, Lin HY, Ann Chen Y, Tsai YY, Qu X, Ramus SJ, Karevan R, Lee J, Lee N, Larson MC, Aben KK, Anton-Culver H, Antonenkova N, Antoniou AC, Armasu SM, , , Bacot F, Baglietto L, Bandera EV, Barnholtz-Sloan J, Beckmann MW, Birrer MJ, Bloom G, Bogdanova N, Brinton LA, Brooks-Wilson A, Brown R, Butzow R, Cai Q, Campbell I, Chang-Claude J, Chanock S, Chenevix-Trench G, Cheng JQ, Cicek MS, Coetzee GA, , Cook LS, Couch FJ, Cramer DW, Cunningham JM, Dansonka-Mieszkowska A, Despierre E, Doherty JA, Dörk T, du Bois A, Dürst M, Easton DF, Eccles D, Edwards R, Ekici AB, Fasching PA, Fenstermacher DA, Flanagan JM, Garcia-Closas M, Gentry-Maharaj A, Giles GG, Glasspool RM, Gonzalez-Bosquet J, Goodman MT, Gore M, Górski B, Gronwald J, Hall P, Halle MK, Harter P, Heitz F, Hillemanns P, Hoatlin M, Høgdall CK, Høgdall E, Hosono S, Jakubowska A, Jensen A, Jim H, Kalli KR, Karlan BY, Kaye SB, Kelemen LE, Kiemeney LA, Kikkawa F, Konecny GE, Krakstad C, Krüger Kjaer S, Kupryjanczyk J, Lambrechts D, Lambrechts S, Lancaster JM, Le ND, Leminen A, Levine DA, Liang D, Kiong Lim B, Lin J, Lissowska J, Lu KH, Lubiński J, Lurie G, Massuger LF, Matsuo K, McGuire V, McLaughlin JR, Menon U, Modugno F, Moysich KB, Nakanishi T, Narod SA, Nedergaard L, Ness RB, Nevanlinna H, Nickels S, Noushmehr H, Odunsi K, Olson SH, Orlow I, Paul J, Pearce CL, Pejovic T, Pelttari LM, Pike MC, Poole EM, Raska P, Renner SP, Risch HA, Rodriguez-Rodriguez L, Anne Rossing M, Rudolph A, Runnebaum IB, Rzepecka IK, Salvesen HB, Schwaab I, Severi G, Shridhar V, Shu XO, Shvetsov YB, Sieh W, Song H, Southey MC, Spiewankiewicz B, Stram D, Sutphen R, Teo SH, Terry KL, Tessier DC, Thompson PJ, Tworoger SS, van Altena AM, Vergote I, Vierkant RA, Vincent D, Vitonis AF, Wang-Gohrke S, Palmieri Weber R, Wentzensen N, Whittemore AS, Wik E, Wilkens LR, Winterhoff B, Ling Woo Y, Wu AH, Xiang YB, Yang HP, Zheng W, Ziogas A, Zulkifli F, Phelan CM, Iversen E, Schildkraut JM, Berchuck A, Fridley BL, Goode EL, Pharoah PD, Monteiro AN, Sellers TA, Gayther SA.Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31.Nat Commun. 2013 Mar 27;4:1627.
    23535648
  • Zaid TM, Yeung TL, Thompson MS, Leung CS, Harding T, Co NN, Schmandt RS, Kwan SY, Rodriguez-Aguay C, Lopez-Berestein G, Sood AK, Wong KK, Birrer MJ, Mok SC.Identification of FGFR4 as a potential therapeutic target for advanced-stage, high-grade serous ovarian cancer.Clin Cancer Res. 2013 Feb 15;19(4):809-20.
    23344261
  • Goode EL, DeRycke M, Kalli KR, Oberg AL, Cunningham JM, Maurer MJ, Fridley BL, Armasu SM, Serie DJ, Ramar P, Goergen K, Vierkant RA, Rider DN, Sicotte H, Wang C, Winterhoff B, Phelan CM, Schildkraut JM, Weber RP, Iversen E, Berchuck A, Sutphen R, Birrer MJ, Hampras S, Preus L, Gayther SA, Ramus SJ, Wentzensen N, Yang HP, Garcia-Closas M, Song H, Tyrer J, Pharoah PP, Konecny G, Sellers TA, Ness RB, Sucheston LE, Odunsi K, Hartmann LC, Moysich KB, Knutson KL.Inherited variants in regulatory T cell genes and outcome of ovarian cancer.PLoS ONE. 2013;8(1):e53903.
    23382860
  • Verhaak RG, Tamayo P, Yang JY, Hubbard D, Zhang H, Creighton CJ, Fereday S, Lawrence M, Carter SL, Mermel CH, Kostic AD, Etemadmoghadam D, Saksena G, Cibulskis K, Duraisamy S, Levanon K, Sougnez C, Tsherniak A, Gomez S, Onofrio R, Gabriel S, Chin L, Zhang N, Spellman PT, Zhang Y, Akbani R, Hoadley KA, Kahn A, Köbel M, Huntsman D, Soslow RA, Defazio A, Birrer MJ, Gray JW, Weinstein JN, Bowtell DD, Drapkin R, Mesirov JP, Getz G, Levine DA, Meyerson M, .Prognostically relevant gene signatures of high-grade serous ovarian carcinoma.J Clin Invest. 2013 Jan 2;123(1):517-25.
    23257362
  • Li H, Cai Q, Wu H, Vathipadiekal V, Dobbin ZC, Li T, Hua X, Landen CN, Birrer MJ, Sánchez-Beato M, Zhang R.SUZ12 Promotes Human Epithelial Ovarian Cancer by Suppressing Apoptosis via Silencing HRK.Mol Cancer Res. 2012 Nov;10(11):1462-72.
    22964433
  • Del Carmen MG, Birrer M, Schorge JO.Uterine papillary serous cancer: A review of the literature.Gynecol Oncol. 2012 Dec;127(3):651-61.
    23000148
  • Sethi G, Pathak HB, Zhang H, Zhou Y, Einarson MB, Vathipadiekal V, Gunewardena S, Birrer MJ, Godwin AK.An RNA interference lethality screen of the human druggable genome to identify molecular vulnerabilities in epithelial ovarian cancer.PLoS ONE. 2012;7(10):e47086.
    23056589
  • Alsop K, Fereday S, Meldrum C, deFazio A, Emmanuel C, George J, Dobrovic A, Birrer MJ, Webb PM, Stewart C, Friedlander M, Fox S, Bowtell D, Mitchell G.BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group.J Clin Oncol. 2012 Jul 20;30(21):2654-63.
    22711857
  • King ER, Tung CS, Tsang YT, Zu Z, Lok GT, Deavers MT, Malpica A, Wolf JK, Lu KH, Birrer MJ, Mok SC, Gershenson DM, Wong KK.The Anterior Gradient Homolog 3 (AGR3) Gene Is Associated With Differentiation and Survival in Ovarian Cancer.Am J Surg Pathol. 2011 Mar 25.
    21451362
  • Maritz MF, van der Watt PJ, Holderness N, Birrer MJ, Leaner VD.Inhibition of AP-1 suppresses cervical cancer cell proliferation and is associated with p21 expression.Biol Chem. 2011 Mar 22.
    21417953
  • Emmanuel C, Gava N, Kennedy C, Balleine RL, Sharma R, Wain G, Brand A, Hogg R, Etemadmoghadam D, George J, , Birrer MJ, Clarke CL, Chenevix-Trench G, Bowtell DD, Harnett PR, Defazio A.Comparison of expression profiles in ovarian epithelium in vivo and ovarian cancer identifies novel candidate genes involved in disease pathogenesis.PLoS ONE. 2011;6(3):e17617.
    21423607
  • Pharoah PD, Palmieri RT, Ramus SJ, Gayther SA, Andrulis IL, Anton-Culver HA, Antonenkova N, Antoniou AC, Bcfr Investigators SG, Beattie MS, Beckmann M, Birrer MJ, Bogdanova N, Bolton KL, Brewster W, Brooks-Wilson A, Brown R, Bützow R, Caldes T, Caligo MA, Campbell IG, Chang-Claude J, Chen A, Chenevix-Trench G, Cook LS, Couch FJ, Cramer DW, Cunningham JM, Despierre E, Doherty JA, Dork T, Durst M, Eccles D, Ekici AB, Embrace Investigators SG, Fasching PA, de Fazio A, Fenstermacher DA, Flanagan JM, Fridley BL, Friedman E, Gao B, Gemo Study Collaborators SG, Gentry-Maharaj A, Godwin AK, Goode E, Goodman MT, Gross J, Hansen TV, Harnett PR, Hebon Investigators SG, Heikkinen T, Hein R, Hogdall CK, Hogdall EV, Iversen E, Jakubowska A, Johnatty SE, Karlan BY, Kauff ND, Kaye SB, Kconfab Investigators SG, Kelemen LE, Kiemeney LA, Kjaer SK, Lambrechts D, Lapolla JP, Lazaro C, Le ND, Leminen A, Leunen K, Levine DA, Lu Y, Lundvall L, Macgregor S, Marees T, Massuger L, McLaughlin JR, Menon U, Montagna M, Moysich KB, Narod S, Nathanson KL, Nedergaard L, Ness RB, Nevanlinna HA, Nickels S, Osorio A, Paul J, Pearce CL, Phelan CM, Pike MC, Radice P, Rossing MA, Schildkraut J, Sellers TA, Singer CF, Song H, Stram DO, Sutphen R, Swe-Brca Investigators SG, Terry KL, Tsai YY, van Altena AM, Vergote I, Vierkant RA, Vitonis AF, Walsh C, Wang-Gohrke S, Wappenschmidt B, Wu AH, Ziogas A, Berchuck A, Risch HA.The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing.Clin Cancer Res. 2011 Mar 9.
    21385923
  • Anglesio MS, George J, Kulbe H, Friedlander ML, Rischin D, Lemech C, Power J, Coward J, Cowin PA, House CM, Chakravarty P, Gorringe KL, Campbell IG, Group AO, Okamoto A, Birrer MJ, Huntsman DG, Defazio A, Kalloger SE, Balkwill FR, Gilks B, Bowtell DD.IL6-STAT3-HIF SIGNALLING AND THERAPEUTIC RESPONSE TO THE ANGIOGENESIS INHIBITOR, SUNITINIB, IN OVARIAN CLEAR CELL CANCER.Clin Cancer Res. 2011 Feb 22.
    21343371
  • Farley J, Smith LM, Darcy KM, Brady MF, Bell J, McGuire W, Birrer MJ.Nuclear P27 expression in benign, borderline (LMP) and invasive tumors of the ovary and its association with prognosis: A gynecologic oncology group study.Gynecol Oncol. 2011 Feb 8.
    21310472
  • Matei D, Sill MW, Lankes HA, DeGeest K, Bristow RE, Mutch D, Yamada SD, Cohn D, Calvert V, Farley J, Petricoin EF, Birrer MJ.Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: a gynecologic oncology group trial.J Clin Oncol. 2011 Jan 1;29(1):69-75.
    21098323
  • Trimble EL, Birrer MJ, Hoskins WJ, Marth C, Petryshyn R, Quinn M, Thomas GM, Kitchener HC.Current academic clinical trials in ovarian cancer: Gynecologic Cancer Intergroup (GCIG) and United States National Cancer Institute (NCI) clinical trials planning meeting, May, 2009.Int J Gynecol Cancer. 2010 Oct;20(7):1290-1298.
    21151709
  • Birrer MJ.The origin of ovarian cancer—is it getting clearer?.N Engl J Med. 2010 Oct 14;363(16):1574-5.
    20942676
  • Kikuchi J, Kinoshita I, Shimizu Y, Kikuchi E, Takeda K, Aburatani H, Oizumi S, Konishi J, Kaga K, Matsuno Y, Birrer MJ, Nishimura M, Dosaka-Akita H.Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer.Lung Cancer. 2010 Sep 28.
    20884074
  • Bolton KL, Tyrer J, Song H, Ramus SJ, Notaridou M, Jones C, Sher T, Gentry-Maharaj A, Wozniak E, Tsai YY, Weidhaas J, Paik D, Van Den Berg DJ, Stram DO, Pearce CL, Wu AH, Brewster W, Anton-Culver H, Ziogas A, Narod SA, Levine DA, Kaye SB, Brown R, Paul J, Flanagan J, Sieh W, McGuire V, Whittemore AS, Campbell I, Gore ME, Lissowska J, Yang HP, Medrek K, Gronwald J, Lubinski J, Jakubowska A, Le ND, Cook LS, Kelemen LE, Brook-Wilson A, Massuger LF, Kiemeney LA, Aben KK, van Altena AM, Houlston R, Tomlinson I, Palmieri RT, Moorman PG, Schildkraut J, Iversen ES, Phelan C, Vierkant RA, Cunningham JM, Goode EL, Fridley BL, Kruger-Kjaer S, Blaeker J, Hogdall E, Hogdall C, Gross J, Karlan BY, Ness RB, Edwards RP, Odunsi K, Moyisch KB, Baker JA, Modugno F, Heikkinenen T, Butzow R, Nevanlinna H, Leminen A, Bogdanova N, Antonenkova N, Doerk T, Hillemanns P, Dürst M, Runnebaum I, Thompson PJ, Carney ME, Goodman MT, Lurie G, Wang-Gohrke S, Hein R, Chang-Claude J, Rossing MA, Cushing-Haugen KL, Doherty J, Chen C, Rafnar T, Besenbacher S, Sulem P, Stefansson K, Birrer MJ, Terry KL, Hernandez D, Cramer DW, Vergote I, Amant F, Lambrechts D, Despierre E, Fasching PA, Beckmann MW, Thiel FC, Ekici AB, Chen X, , , , Johnatty SE, Webb PM, Beesley J, Chanock S, Garcia-Closas M, Sellers T, Easton DF, Berchuck A, Chenevix-Trench G, Pharoah PD, Gayther SA.Common variants at 19p13 are associated with susceptibility to ovarian cancer.Nat Genet. 2010 Oct;42(10):880-4.
    20852633
  • Goode EL, Chenevix-Trench G, Song H, Ramus SJ, Notaridou M, Lawrenson K, Widschwendter M, Vierkant RA, Larson MC, Kjaer SK, Birrer MJ, Berchuck A, Schildkraut J, Tomlinson I, Kiemeney LA, Cook LS, Gronwald J, Garcia-Closas M, Gore ME, Campbell I, Whittemore AS, Sutphen R, Phelan C, Anton-Culver H, Pearce CL, Lambrechts D, Rossing MA, Chang-Claude J, Moysich KB, Goodman MT, Dörk T, Nevanlinna H, Ness RB, Rafnar T, Hogdall C, Hogdall E, Fridley BL, Cunningham JM, Sieh W, McGuire V, Godwin AK, Cramer DW, Hernandez D, Levine D, Lu K, Iversen ES, Palmieri RT, Houlston R, van Altena AM, Aben KK, Massuger LF, Brooks-Wilson A, Kelemen LE, Le ND, Jakubowska A, Lubinski J, Medrek K, Stafford A, Easton DF, Tyrer J, Bolton KL, Harrington P, Eccles D, Chen A, Molina AN, Davila BN, Arango H, Tsai YY, Chen Z, Risch HA, McLaughlin J, Narod SA, Ziogas A, Brewster W, Gentry-Maharaj A, Menon U, Wu AH, Stram DO, Pike MC, , Beesley J, Webb PM, , , , Chen X, Ekici AB, Thiel FC, Beckmann MW, Yang H, Wentzensen N, Lissowska J, Fasching PA, Despierre E, Amant F, Vergote I, Doherty J, Hein R, Wang-Gohrke S, Lurie G, Carney ME, Thompson PJ, Runnebaum I, Hillemanns P, Dürst M, Antonenkova N, Bogdanova N, Leminen A, Butzow R, Heikkinen T, Stefansson K, Sulem P, Besenbacher S, Sellers TA, Gayther SA, Pharoah PD, .A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.Nat Genet. 2010 Oct;42(10):874-9.
    20852632
  • Ghosh S, Albitar L, LeBaron R, Welch WR, Samimi G, Birrer MJ, Berkowitz RS, Mok SC.Up-regulation of stromal versican expression in advanced stage serous ovarian cancer.Gynecol Oncol. 2010 Oct;119(1):114-20.
    20619446
  • Lu C, Han HD, Mangala LS, Ali-Fehmi R, Newton CS, Ozbun L, Armaiz-Pena GN, Hu W, Stone RL, Munkarah A, Ravoori MK, Shahzad MM, Lee JW, Mora E, Langley RR, Carroll AR, Matsuo K, Spannuth WA, Schmandt R, Jennings NB, Goodman BW, Jaffe RB, Nick AM, Kim HS, Guven EO, Chen YH, Li LY, Hsu MC, Coleman RL, Calin GA, Denkbas EB, Lim JY, Lee JS, Kundra V, Birrer MJ, Hung MC, Lopez-Berestein G, Sood AK.Regulation of tumor angiogenesis by EZH2.Cancer Cell. 2010 Aug 9;18(2):185-97.
    20708159
  • Annunziata CM, Birrer MJ.CD157 in ovarian carcinoma: how does it help us?.Journal of the National Cancer Institute. 2010 Aug 4;102(15):1104-5.
    20639477
  • Annunziata CM, Stavnes HT, Kleinberg L, Berner A, Hernandez LF, Birrer MJ, Steinberg SM, Davidson B, Kohn EC.Nuclear factor kappaB transcription factors are coexpressed and convey a poor outcome in ovarian cancer.Cancer. 2010 Jul 1;116(13):3276-84.
    20564628
  • Darcy KM, Birrer MJ.Translational research in the Gynecologic Oncology Group: Evaluation of ovarian cancer markers, profiles, and novel therapies.Gynecol Oncol. 2010 Jun;117(3):429-39. Review.
    20233625
  • Hernandez L, Hsu SC, Davidson B, Birrer MJ, Kohn EC, Annunziata CM.Activation of NF-kappaB signaling by inhibitor of NF-kappaB kinase beta increases aggressiveness of ovarian cancer.Cancer Res. 2010 May 15;70(10):4005-14.
    20424119
  • Huh WK, Sill MW, Darcy KM, Elias KM, Hoffman JS, Boggess JF, Alvarez RD, Long HJ, O'Malley DM, Birrer MJ.Efficacy and safety of imatinib mesylate (Gleevec(R)) and immunohistochemical expression of c-Kit and PDGFR-beta in a Gynecologic Oncology Group Phase Il Trial in women with recurrent or persistent carcinosarcomas of the uterus.Gynecol Oncol. 2010 May;117(2):248-54.
    20189232
  • Byron SA, Gartside MG, Wellens CL, Goodfellow PJ, Birrer MJ, Campbell IG, Pollock PM.FGFR2 mutations are rare across histologic subtypes of ovarian cancer.Gynecol Oncol. 2010 Apr;117(1):125-129.
    20106510
  • Clauss A, Ng V, Liu J, Piao H, Russo M, Vena N, Sheng Q, Hirsch MS, Bonome T, Matulonis U, Ligon AH, Birrer MJ, Drapkin R.Overexpression of elafin in ovarian carcinoma is driven by genomic gains and activation of the nuclear factor kappaB pathway and is associated with poor overall survival.Neoplasia. 2010 Feb;12(2):161-72.
    20126474
  • Minig L, Trimble EL, Birrer MJ, Kim KY, Takebe N, Abrams JS.NIH and NCI support for development of novel therapeutics in gynecologic cancer: a user's guide.Gynecol Oncol. 2010 Feb;116(2):177-80. Review.
    19889449
  • Mok SC, Bonome T, Vathipadiekal V, Bell A, Johnson ME, Wong KK, Park DC, Hao K, Yip DK, Donninger H, Ozbun L, Samimi G, Brady J, Randonovich M, Pise-Masison CA, Barrett JC, Wong WH, Welch WR, Berkowitz RS, Birrer MJ.A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotein 2.Cancer Cell. 2009 Dec 8;16(6):521-32.
    19962670
  • Na YJ, Farley J, Zeh A, del Carmen M, Penson R, Birrer MJ.Ovarian cancer: markers of response.Int J Gynecol Cancer. 2009 Dec;19 Suppl 2:S21-9. Review.
    19955910
  • Darcy KM, Brady WE, Blancato JK, Dickson RB, Hoskins WJ, McGuire WP, Birrer MJ.Prognostic relevance of c-MYC gene amplification and polysomy for chromosome 8 in suboptimally-resected, advanced stage epithelial ovarian cancers: a Gynecologic Oncology Group study.Gynecol Oncol. 2009 Sep;114(3):472-9.
    19524285
  • Wang XY, Demelash A, Kim H, Jensen-Taubman S, Dakir el H, Ozbun L, Birrer MJ, Linnoila RI.Matrilysin-1 mediates bronchiolization of alveoli, a potential premalignant change in lung cancer.Am J Pathol. 2009 Aug;175(2):592-604.
    19608871
  • Kwong J,Chan FL,Wong KK,Birrer MJ,Archibald KM,Balkwill FR,Berkowitz RS,Mok SC.Inflammatory cytokine tumor necrosis factor alpha confers precancerous phenotype in an organoid model of normal human ovarian surface epithelial cells.Neoplasia. 2009 Jun;11(6):529-41.
    19484142
  • Nosov V,Su F,Amneus M,Birrer M,Robins T,Kotlerman J,Reddy S,Farias-Eisner R.Validation of serum biomarkers for detection of early-stage ovarian cancer.Am J Obstet Gynecol. 2009 Jun;200(6):639.e1-5.
    19285648
  • Calvisi DF,Donninger H,Vos MD,Birrer MJ,Gordon L,Leaner V,Clark GJ.NORE1A tumor suppressor candidate modulates p21CIP1 via p53.Cancer Res. 2009 Jun 1;69(11):4629-37.
    19435914
  • Farley J,Fuchiuji S,Darcy KM,Tian C,Hoskins WJ,McGuire WP,Hanjani P,Warshal D,Greer BE,Belinson J,Birrer MJ.Associations between ERBB2 amplification and progression-free survival and overall survival in advanced stage, suboptimally-resected epithelial ovarian cancers: A Gynecologic Oncology Group study.Gynecol Oncol. 2009 Jun;113(3):341-7.
    19272639
  • Singh S,Manda SM,Sikder D,Birrer MJ,Rothermel BA,Garry DJ,Mammen PP.Calcineurin activates cytoglobin transcription in hypoxic myocytes.J Biol Chem. 2009 Apr 17;284(16):10409-21.
    19203999
  • van der Watt PJ,Maske CP,Hendricks DT,Parker MI,Denny L,Govender D,Birrer MJ,Leaner VD.The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.Int J Cancer. 2009 Apr 15;124(8):1829-40.
    19117056
  • Merritt WM,Lin YG,Han LY,Kamat AA,Spannuth WA,Schmandt R,Urbauer D,Pennacchio LA,Cheng JF,Nick AM,Deavers MT,Mourad-Zeidan A,Wang H,Mueller P,Lenburg ME,Gray JW,Mok S,Birrer MJ,Lopez-Berestein G,Coleman RL,Bar-Eli M,Sood AK.Dicer, Drosha, and outcomes in patients with ovarian cancer.N Engl J Med. 2008 Dec 18;359(25):2641-50.
    19092150
  • Leaner VD,Chick JF,Donninger H,Linniola I,Mendoza A,Khanna C,Birrer MJ.Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcoma.Am J Pathol. 2009 Jan;174(1):265-75.
    19074613
  • Chung TK,Cheung TH,Huen NY,Wong KW,Lo KW,Yim SF,Siu NS,Wong YM,Tsang PT,Pang MW,Yu MY,To KF,Mok SC,Wang VW,Li C,Cheung AY,Doran G,Birrer MJ,Smith DI,Wong YF.Dysregulated microRNAs and their predicted targets associated with endometrioid endometrial adenocarcinoma in Hong Kong women.Int J Cancer. 2009 Mar 15;124(6):1358-65.
    19065659
  • Callahan MJ,Nagymanyoki Z,Bonome T,Johnson ME,Litkouhi B,Sullivan EH,Hirsch MS,Matulonis UA,Liu J,Birrer MJ,Berkowitz RS,Mok SC.Increased HLA-DMB expression in the tumor epithelium is associated with increased CTL infiltration and improved prognosis in advanced-stage serous ovarian cancer.Clin Cancer Res. 2008 Dec 1;14(23):7667-73.
    19047092
  • Arora S,Wang Y,Jia Z,Vardar-Sengul S,Munawar A,Doctor KS,Birrer M,McClelland M,Adamson E,Mercola D.Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip.Genome Biol. 2008;9(11):R166.
    19032775
  • Anglesio MS,Arnold JM,George J,Tinker AV,Tothill R,Waddell N,Simms L,Locandro B,Fereday S,Traficante N,Russell P,Sharma R,Birrer MJ,deFazio A,Chenevix-Trench G,Bowtell DD.Mutation of ERBB2 provides a novel alternative mechanism for the ubiquitous activation of RAS-MAPK in ovarian serous low malignant potential tumors.Mol Cancer Res. 2008 Nov;6(11):1678-90.
    19010816
  • Lorenzi PL,Llamas J,Gunsior M,Ozbun L,Reinhold WC,Varma S,Ji H,Kim H,Hutchinson AA,Kohn EC,Goldsmith PK,Birrer MJ,Weinstein JN.Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines.Mol Cancer Ther. 2008 Oct;7(10):3123-8.
    18852115
  • Park DC,Yeo SG,Wilson MR,Yerbury JJ,Kwong J,Welch WR,Choi YK,Birrer MJ,Mok SC,Wong KK.Clusterin interacts with Paclitaxel and confer Paclitaxel resistance in ovarian cancer.Neoplasia. 2008 Sep;10(9):964-72.
    18714397
  • Sood AK,Birrer MJ.Highlights from the 2008 Annual Meeting of the American Association for Cancer Research.Gynecol Oncol. 2008 Jul;110(1):5-6.
    18595162
  • Bonome T,Levine DA,Shih J,Randonovich M,Pise-Masison CA,Bogomolniy F,Ozbun L,Brady J,Barrett JC,Boyd J,Birrer MJ.A gene signature predicting for survival in suboptimally debulked patients with ovarian cancer.Cancer Res. 2008 Jul 1;68(13):5478-86.
    18593951
  • Stany MP,Bonome T,Wamunyokoli F,Zorn K,Ozbun L,Park DC,Hao K,Boyd J,Sood AK,Gershenson DM,Berkowitz RS,Mok SC,Birrer MJ.Classification of ovarian cancer: a genomic analysis.Adv Exp Med Biol. 2008;622:23-33. Review.
    18546616
  • Zhang L,Volinia S,Bonome T,Calin GA,Greshock J,Yang N,Liu CG,Giannakakis A,Alexiou P,Hasegawa K,Johnstone CN,Megraw MS,Adams S,Lassus H,Huang J,Kaur S,Liang S,Sethupathy P,Leminen A,Simossis VA,Sandaltzopoulos R,Naomoto Y,Katsaros D,Gimotty PA,DeMichele A,Huang Q,Butzow R,Rustgi AK,Weber BL,Birrer MJ,Hatzigeorgiou AG,Croce CM,Coukos G.Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer.Proc Natl Acad Sci U S A. 2008 May 13;105(19):7004-9.
    18458333
  • Farley J,Ozbun LL,Birrer MJ.Genomic analysis of epithelial ovarian cancer.Cell Res. 2008 May;18(5):538-48. Review.
    18427574
  • Litkouhi B, Litkouhi B, Fleming E, Welch WR, Berkowitz RS, Birrer MJ, Mok SC.Overexpression of CEACAM6 in borderline and invasive mucinous ovarian neoplasms.Gynecol Oncol. 2008 May;109(2):234-9.
    18331757
  • Landen CN Jr,Birrer MJ,Sood AK.Early events in the pathogenesis of epithelial ovarian cancer.J Clin Oncol. 2008 Feb 20;26(6):995-1005. Review.
    18195328
  • Zudaire E,Cuesta N,Murty V,Woodson K,Adams L,Gonzalez N,Martinez A,Narayan G,Kirsch I,Franklin W,Hirsch F,Birrer M,Cuttitta F.The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers.J Clin Invest. 2008 Feb;118(2):640-50.
    18172554
  • Farley J,Ozbun L,Samimi G,Birrer MJ.Cell cycle and related protein.Dis Markers. 2007;23(5-6):433-43. Review.
    18057526
  • Samimi G,Ozbun L,Johnson ME,Mok SC,Birrer MJ.Biomarkers of mucinous tumors of the ovary.Dis Markers. 2007;23(5-6):389-96.
    18057522
  • Mok SC,Kwong J,Welch WR,Samimi G,Ozbun L,Bonome T,Birrer MJ,Berkowitz RS,Wong KK.Etiology and pathogenesis of epithelial ovarian cancer.Dis Markers. 2007;23(5-6):367-76. Review.
    18057520
  • Irarrazabal CE,Williams CK,Ely MA,Birrer MJ,Garcia-Perez A,Burg MB,Ferraris JD.Activator protein-1 contributes to high NaCl-induced increase in tonicity-responsive enhancer/osmotic response element-binding protein transactivating activity.J Biol Chem. 2008 Feb 1;283(5):2554-63.
    18056707
  • Whibley CE,McPhail KL,Keyzers RA,Maritz MF,Leaner VD,Birrer MJ,Davies-Coleman MT,Hendricks DT.Reactive oxygen species mediated apoptosis of esophageal cancer cells induced by marine triprenyl toluquinones and toluhydroquinones.Mol Cancer Ther. 2007 Sep;6(9):2535-43.
    17876050
  • Kelloff GJ,Sullivan DC,Baker H,Clarke LP,Nordstrom R,Tatum JL,Dorfman GS,Jacobs P,Berg CD,Pomper MG,Birrer MJ,Tempero M,Higley HR,Petty BG,Sigman CC,Maley C,Sharma P,Wax A,Ginsberg GG,Dannenberg AJ,Hawk ET,Messing EM,Grossman HB,Harisinghani M,Bigio IJ,Griebel D,Henson DE,Fabian CJ,Ferrara K,Fantini S,Schnall MD,Zujewski JA,Hayes W,Klein EA,DeMarzo A,Ocak I,Ketterling JA,Tempany C,Shtern F,Parnes HL,Gomez J,Srivastava S,Szabo E,Lam S,Seibel EJ,Massion P,McLennan G,Cleary K,Suh R,Burt RW,Pfeiffer RM,Hoffman JM,Roy HK,Wang T,Limburg PJ,El-Deiry WS,Papadimitrakopoulou V,Hittelman WN,MacAulay C,Veltri RW,Solomon D,Jeronimo J,Richards-Kortum R,Johnson KA,Viner JL,Stratton SP,Rajadhyaksha M,Dhawan A.Workshop on imaging science development for cancer prevention and preemption.Cancer Biomark. 2007;3(1):1-33.
    17655039
  • Gershenson DM,Birrer M.Time for action: a "sea change" in treatment strategies for rare types of epithelial ovarian cancer.Gynecol Oncol. 2007 Jul;106(1):1-3.
    17574071
  • Birrer MJ, Johnson ME, Hao K, Wong KK, Park DC, Bell A, Welch WR, Berkowitz RS, Mok SC.Whole genome oligonucleotide-based array comparative genomic hybridization analysis identified fibroblast growth factor 1 as a prognostic marker for advanced-stage serous ovarian adenocarcinomas.J Clin Oncol. 2007 Jun 1;25(16):2281-7.
    17538174
  • Kajanne R,Miettinen P,Mehlem A,Leivonen SK,Birrer M,Foschi M,Kahari VM,Leppa S.EGF-R regulates MMP function in fibroblasts through MAPK and AP-1 pathways.J Cell Physiol. 2007 Aug;212(2):489-97.
    17348021
  • Lu C,Bonome T,Li Y,Kamat AA,Han LY,Schmandt R,Coleman RL,Gershenson DM,Jaffe RB,Birrer MJ,Sood AK.Gene alterations identified by expression profiling in tumor-associated endothelial cells from invasive ovarian carcinoma.Cancer Res. 2007 Feb 15;67(4):1757-68.
    17308118
  • Mok SC, Elias KM, Wong KK, Ho K, Bonome T, Birrer MJ.Biomarker discovery in epithelial ovarian cancer by genomic approaches.Adv Cancer Res.;96:1-22.
  • Wu K,Liu M,Li A,Donninger H,Rao M,Jiao X,Lisanti MP,Cvekl A,Birrer M,Pestell RG.Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth.Mol Biol Cell. 2007 Mar;18(3):755-67.
    17182846
  • Mok SC, Elias KM, Wong KK, Ho K, Bonome T, Birrer MJ.Biomarker discovery in epithelial ovarian cancer by genomic approaches.Adv Cancer Res. 2007;96:1-22. Review.
    17161674
  • Farley J,Birrer MJ,Christian MC.The future of phase II trials.Gynecol Oncol. 2006 Nov;103(2 Suppl 1):S20-2.
    17027074
  • Farley J,Bast RC Jr,Birrer MJ.Biomarkers and clinical trial design.Gynecol Oncol. 2006 Nov;103(2 Suppl 1):S3-5.
    17027069
  • Fountain J,Trimble E,Birrer MJ.Summary and discussion of session recommendations.Gynecol Oncol. 2006 Nov;103(2 Suppl 1):S23-5.
    17027068
  • Sunde JS, Donninger H, Wu K, Johnson ME, Pestell RG, Rose GS, Mok SC, Brady J, Bonome T, Birrer MJ.Expression Profiling Identifies Altered Expression of Genes That Contribute to the Inhibition of Transforming Growth Factor-{beta} Signaling in Ovarian Cancer.Cancer Res. 2006 Sep 1;66(17):8404-12.
    16951150
  • Birrer MJ.Ovarian cancer: not a borderline issue!.Cancer Biol Ther. 2006 Jul;5(7):786-7.
    16921259
  • DiFeo A,Narla G,Hirshfeld J,Camacho-Vanegas O,Narla J,Rose SL,Kalir T,Yao S,Levine A,Birrer MJ,Bonome T,Friedman SL,Buller RE,Martignetti JA.Roles of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination.Clin Cancer Res. 2006 Jun 15;12(12):3730-9.
    16778100
  • Wamunyokoli FW, Bonome T, Lee JY, Feltmate CM, Welch WR, Radonovich M, Pise-Masison C, Brady J, Hao K, Berkowitz RS, Mok S, Birrer MJ.Expression profiling of mucinous tumors of the ovary identifies genes of clinicopathologic importance.Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):690-700.
    16467078
  • Nummela P,Yin M,Kielosto M,Leaner V,Birrer MJ,Holtta E.Thymosin beta4 is a determinant of the transformed phenotype and invasiveness of S-adenosylmethionine decarboxylase-transfected fibroblasts.Cancer Res. 2006 Jan 15;66(2):701-12.
    16423999
  • Tsuda H, Ito YM, Ohashi Y, Wong KK, Hashiguchi Y, Welch WR, Berkowitz RS, Birrer MJ, Mok SC.Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses.Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6880-8.
    16203778
  • Zorn KK,Bonome T,Gangi L,Chandramouli GV,Awtrey CS,Gardner GJ,Barrett JC,Boyd J,Birrer MJ.Gene expression profiles of serous, endometrioid, and clear cell subtypes of ovarian and endometrial cancer.Clin Cancer Res. 2005 Sep 15;11(18):6422-30.
    16166416
  • Jazaeri AA,Awtrey CS,Chandramouli GV,Chuang YE,Khan J,Sotiriou C,Aprelikova O,Yee CJ,Zorn KK,Birrer MJ,Barrett JC,Boyd J.Gene expression profiles associated with response to chemotherapy in epithelial ovarian cancers.Clin Cancer Res. 2005 Sep 1;11(17):6300-10.
    16144934
  • Elam C,Hesson L,Vos MD,Eckfeld K,Ellis CA,Bell A,Krex D,Birrer MJ,Latif F,Clark GJ.RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor suppressor potential.Cancer Res. 2005 Apr 15;65(8):3117-25.
    15833841
  • Leaner VD,Donninger H,Ellis CA,Clark GJ,Birrer MJ.p75-Ras-GRF1 is a c-Jun/AP-1 target protein: its up regulation results in increased Ras activity and is necessary for c-Jun-induced nonadherent growth of Rat1a cells.Mol Cell Biol. 2005 Apr;25(8):3324-37.
    15798216
  • Katabami M,Donninger H,Hommura F,Leaner VD,Kinoshita I,Chick JF,Birrer MJ.Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells.J Biol Chem. 2005 Apr 29;280(17):16728-38.
    15737994
  • Tsuda H, Birrer MJ, Ito YM, Ohashi Y, Lin M, Lee C, Wong WH, Rao PH, Lau CC, Berkowitz RS, Wong KK, Mok SC.Identification of DNA copy number changes in microdissected serous ovarian cancer tissue using a cDNA microarray platform.Cancer Genet Cytogenet. 2004 Dec;155(2):97-107.
    15571795
  • Tsuda H,Bandera CA,Birrer MJ,Hashiguchi Y,Berkowitz RS,Mok SC.Cyclin E amplification and overexpression in clear cell adenocarcinoma of the ovary.Oncology. 2004;67(3-4):291-9.
    15557791
  • Donninger H,Bonome T,Radonovich M,Pise-Masison CA,Brady J,Shih JH,Barrett JC,Birrer MJ.Whole genome expression profiling of advance stage papillary serous ovarian cancer reveals activated pathways.Oncogene. 2004 Oct 21;23(49):8065-77.
    15361855
  • Elagib KE,Xiao M,Hussaini IM,Delehanty LL,Palmer LA,Racke FK,Birrer MJ,Shanmugasundaram G,McDevitt MA,Goldfarb AN.Jun blockade of erythropoiesis: role for repression of GATA-1 by HERP2.Mol Cell Biol. 2004 Sep;24(17):7779-94.
    15314183
  • Sherman ME,Berman J,Birrer MJ,Cho KR,Ellenson LH,Gorstein F,Seidman JD.Current challenges and opportunities for research on borderline ovarian tumors.Hum Pathol. 2004 Aug;35(8):961-70.
    15297963
  • Hommura F,Katabami M,Leaner VD,Donninger H,Sumter TF,Resar LM,Birrer MJ.HMG-I/Y is a c-Jun/activator protein-1 target gene and is necessary for c-Jun-induced anchorage-independent growth in Rat1a cells.Mol Cancer Res. 2004 May;2(5):305-14.
    15192124
  • Kielosto M,Nummela P,Katainen R,Leaner V,Birrer MJ,Holtta E.Reversible regulation of the transformed phenotype of ornithine decarboxylase- and ras-overexpressing cells by dominant-negative mutants of c-Jun.Cancer Res. 2004 Jun 1;64(11):3772-9.
    15172983
  • Zhou X,Jordan RC,Mok S,Birrer MJ,Wong DT.DNA copy number abnormality of oral squamous cell carcinoma detected with cDNA array-based comparative genomic hybridization.Cancer Genet Cytogenet. 2004 May;151(1):90-2.
    15120918
  • Farley J,Uyehara C,Hashiro G,Belnap C,Birrer M,Salminen E.Cyclooxygenase-2 expression predicts recurrence of cervical dysplasia following loop electrosurgical excision procedure.Gynecol Oncol. 2004 Feb;92(2):596-602.
    14766253
  • Liu S,Brown CW,Berlin KD,Dhar A,Guruswamy S,Brown D,Gardner GJ,Birrer MJ,Benbrook DM.Synthesis of flexible sulfur-containing heteroarotinoids that induce apoptosis and reactive oxygen species with discrimination between malignant and benign cells.J Med Chem. 2004 Feb 12;47(4):999-1007.
    14761202
  • Zorn KK, Jazaeri AA, Awtrey CS, Gardner GJ, Mok SC, Boyd J, Birrer MJ.Choice of normal ovarian control influences determination of differentially expressed genes in ovarian cancer expression profiling studies.Clin Cancer Res. 2003 Oct 15;9(13):4811-8.
    14581352
  • Romashko J 3rd,Horowitz S,Franek WR,Palaia T,Miller EJ,Lin A,Birrer MJ,Scott W,Mantell LL.MAPK pathways mediate hyperoxia-induced oncotic cell death in lung epithelial cells.Free Radic Biol Med. 2003 Oct 15;35(8):978-93.
    14556862
  • Winter WE 3rd,Seidman JD,Krivak TC,Chauhan S,Carlson JW,Rose GS,Birrer MJ.Clinicopathological analysis of c-kit expression in carcinosarcomas and leiomyosarcomas of the uterine corpus.Gynecol Oncol. 2003 Oct;91(1):3-8.
    14529656
  • Farley JH,Birrer MJ.Biologic directed therapies in gynecologic oncology.Curr Oncol Rep. 2003 Nov;5(6):459-67.
    14521804
  • Trepel J,Birrer MJ.A link between histone deacetylase inhibitors and NF- kappaB signaling.Cell Cycle. 2003 Sep-Oct;2(5):452-3.
    12963841
  • Leaner VD,Kinoshita I,Birrer MJ.AP-1 complexes containing cJun and JunB cause cellular transformation of Rat1a fibroblasts and share transcriptional targets.Oncogene. 2003 Aug 28;22(36):5619-29.
    12944910
  • Kinoshita I,Leaner V,Katabami M,Manzano RG,Dent P,Sabichi A,Birrer MJ.Identification of cJun-responsive genes in Rat-1a cells using multiple techniques: increased expression of stathmin is necessary for cJun-mediated anchorage-independent growth.Oncogene. 2003 May 8;22(18):2710-22.
    12743595
  • Shen YH,Godlewski J,Zhu J,Sathyanarayana P,Leaner V,Birrer MJ,Rana A,Tzivion G.Cross-talk between JNK/SAPK and ERK/MAPK pathways: sustained activation of JNK blocks ERK activation by mitogenic factors.J Biol Chem. 2003 Jul 18;278(29):26715-21.
    12738796
  • Dent P,Qiao L,Gilfor D,Birrer M,Grant S,Fisher PB.The regulation of tumor suppressor genes by oncogenes.Methods Mol Biol. 2003;222:269-92.
    12710693
  • Farley J,Smith LM,Darcy KM,Sobel E,O'Connor D,Henderson B,Morrison LE,Birrer MJ.Cyclin E expression is a significant predictor of survival in advanced, suboptimally debulked ovarian epithelial cancers: a Gynecologic Oncology Group study.Cancer Res. 2003 Mar 15;63(6):1235-41.
    12649182
  • Quong J,Eppenberger-Castori S,Moore D 3rd,Scott GK,Birrer MJ,Kueng W,Eppenberger U,Benz CC.Age-dependent changes in breast cancer hormone receptors and oxidant stress markers.Breast Cancer Res Treat. 2002 Dec;76(3):221-36.
    12462383
  • Bowen C,Birrer M,Gelmann EP.Retinoblastoma protein-mediated apoptosis after gamma-irradiation.J Biol Chem. 2002 Nov 22;277(47):44969-79.
    12297496
  • Manzano RG,Montuenga LM,Dayton M,Dent P,Kinoshita I,Vicent S,Gardner GJ,Nguyen P,Choi YH,Trepel J,Auersperg N,Birrer MJ.CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential.Oncogene. 2002 Jun 27;21(28):4435-47.
    12080474