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Jonathan L. Hecht, MD, PhD


  • Hecht JL, Konstantinopoulos PA, Awtrey CS, Soslow RA.Immunohistochemical Loss of BRCA1 Protein in Uterine Serous Carcinoma.Int J Gynecol Pathol. 2014 May;33(3):282-7.
  • Hu J, Lu J, Lian G, Zhang J, Hecht JL, Sheen VL.Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signaling.PLoS ONE. 2014;9(2):e89352.
  • Fadare O, Desouki MM, Gwin K, Hanley KZ, Jarboe EA, Liang SX, Quick CM, Zheng W, Parkash V, Hecht JL.Frequent expression of napsin A in clear cell carcinoma of the endometrium: potential diagnostic utility.Am J Surg Pathol. 2014 Feb;38(2):189-96.
  • Fadare O, Parkash V, Gwin K, Hanley KZ, Jarboe EA, Liang SX, Quick CM, Zheng W, Rawish KR, Hecht JL, Desouki MM.Utility of α-methylacyl-coenzyme-A racemase (p504s) immunohistochemistry in distinguishing endometrial clear cell carcinomas from serous and endometrioid carcinomas.Hum Pathol. 2013 Dec;44(12):2814-21.
  • Schmolze D, Awtrey CS, Hecht JL.Value of additional level sections in the evaluation of lymph nodes for endometrial carcinoma staging.Am J Clin Pathol. 2013 Oct;140(4):516-8.
  • Howitt BE, Herfs M, Brister K, Oliva E, Longtine J, Hecht JL, Nucci MR.Intestinal-type Endocervical Adenocarcinoma In Situ: An Immunophenotypically Distinct Subset of AIS Affecting Older Women.Am J Surg Pathol. 2013 May;37(5):625-33.
  • Fadare O, Gwin K, Desouki MM, Crispens MA, Jones HW, Khabele D, Liang SX, Zheng W, Mohammed K, Hecht JL, Parkash V.The clinicopathologic significance of p53 and BAF-250a (ARID1A) expression in clear cell carcinoma of the endometrium.Mod Pathol. 2013 Mar 22.
  • Kotsopoulos J, Terry KL, Poole EM, Rosner B, Murphy MA, Hecht JL, Crum CP, Missmer SA, Cramer DW, Tworoger SS.Ovarian cancer risk factors by tumor dominance, a surrogate for cell of origin.Int J Cancer. 2013 Jan 30.
  • Fadare O, Liang SX, Crispens MA, Jones HW, Khabele D, Gwin K, Zheng W, Mohammed K, Parkash V, Hecht JL, Desouki MM.Expression of the oncofetal protein IGF2BP3 in endometrial clear cell carcinoma: assessment of frequency and significance.Hum Pathol. 2013 Mar 1.
  • Fadare O, Zheng W, Crispens MA, Jones HW, Khabele D, Gwin K, Liang SX, Mohammed K, Desouki MM, Parkash V, Hecht JL.Morphologic and other clinicopathologic features of endometrial clear cell carcinoma: a comprehensive analysis of 50 rigorously classified cases.Am J Cancer Res. 2013;3(1):70-95.
  • Fadare O, Parkash V, Dupont WD, Acs G, Atkins KA, Irving JA, Pirog EC, Quade BJ, Quddus MR, Rabban JT, Vang R, Hecht JL.The diagnosis of endometrial carcinomas with clear cells by gynecologic pathologists: an assessment of interobserver variability and associated morphologic features.Am J Surg Pathol. 2012 Aug;36(8):1107-18.
  • Hecht JL.To count and how to count, that is the question.Am J Clin Pathol. 2011 Mar;135(3):480.
  • Levine D, Brown DL, Andreotti RF, Benacerraf B, Benson CB, Brewster WR, Coleman B, DePriest P, Doubilet PM, Goldstein SR, Hamper UM, Hecht JL, Horrow M, Hur HC, Marnach M, Patel MD, Platt LD, Puscheck E, Smith-Bindman R.Management of asymptomatic ovarian and other adnexal cysts imaged at US: Society of Radiologists in Ultrasound consensus conference statement.Ultrasound Q. 2010 Sep;26(3):121-31.
  • Levine D, Brown DL, Andreotti RF, Benacerraf B, Benson CB, Brewster WR, Coleman B, Depriest P, Doubilet PM, Goldstein SR, Hamper UM, Hecht JL, Horrow M, Hur HC, Marnach M, Patel MD, Platt LD, Puscheck E, Smith-Bindman R.Management of Asymptomatic Ovarian and Other Adnexal Cysts Imaged at US: Society of Radiologists in Ultrasound Consensus Conference Statement.Radiology. 2010 Sep;256(3):943-54. Review.
  • Kotsopoulos J, Hecht JL, Marotti JD, Kelemen LE, Tworoger SS.Relationship between dietary and supplemental intake of folate, methionine, vitamin B6 and folate receptor alpha expression in ovarian tumors.Int J Cancer. 2010 May 1;126(9):2191-8.
  • Gates MA, Rosner BA, Hecht JL, Tworoger SS.Risk factors for epithelial ovarian cancer by histologic subtype.Am J Epidemiol. 2010 Jan 1;171(1):45-53.
  • McElrath TF, Hecht JL.Invited commentary: Intrauterine epidemiology.Am J Epidemiol. 2009 Jul 15;170(2):159-61; discussion 162-3.
  • Asch E,Levine D,Pedrosa I,Hecht JL,Kruskal J.Patterns of Misinterpretation of Adnexal Masses on CT and MR in an Academic Radiology Department(1).Acad Radiol. 2009 Aug;16(8):969-80.
  • Hecht JL,Kotsopoulos J,Hankinson SE,Tworoger SS.Relationship between epidemiologic risk factors and hormone receptor expression in ovarian cancer: results from the Nurses' Health Study.Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1624-30.
  • Hecht JL, Kotsopoulos J, Gates MA, Hankinson SE, Tworoger SS.Validation of tissue microarray technology in ovarian cancer: results from the Nurses' Health Study.Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3043-50.
  • McElrath TF, Hecht JL, Dammann O, Boggess K, Onderdonk A, Markenson G, Harper M, Delpapa E, Allred EN, Leviton A,.Pregnancy disorders that lead to delivery before the 28th week of gestation: an epidemiologic approach to classification.Am J Epidemiol. 2008 Nov 1;168(9):980-9.
  • Fadare O, Orejudos MP, Jain R, Mariappan MR, Hecht JL, Renshaw IL, Hileeto D, Wang SA, Ghofrani M, Liang SX.A comparative analysis of lymphatic vessel density in ovarian serous tumors of low malignant potential (borderline tumors) with and without lymph node involvement.Int J Gynecol Pathol. 2008 Oct;27(4):483-90.
  • Hecht JL, Dolinski BM, Gardner HA, Violette SM, Weinreb PH.Overexpression of the alphavbeta6 integrin in endometrial cancer.Appl Immunohistochem Mol Morphol. 2008 Dec;16(6):543-7.
  • Hecht JL, Allred EN, Kliman HJ, Zambrano E, Doss BJ, Husain A, Pflueger SM, Chang CH, Livasy CA, Roberts D, Bhan I, Ross DW, Senagore PK, Leviton A,.Histological characteristics of singleton placentas delivered before the 28th week of gestation.Pathology. 2008 Jun;40(4):372-6.
  • Levine D, Asch E, Mehta TS, Broder J, O'Donnell C, Hecht JL.Assessment of factors that affect the quality of performance and interpretation of sonography of adnexal masses.J Ultrasound Med. 2008 May;27(5):721-8.
  • Asch E, Levine D, Kim Y, Hecht JL.Histologic, surgical, and imaging correlations of adnexal masses.J Ultrasound Med. 2008 Mar;27(3):327-42.
  • Onderdonk AB, Hecht JL, McElrath TF, Delaney ML, Allred EN, Leviton A,.Colonization of second-trimester placenta parenchyma.Am J Obstet Gynecol. 2008 Jul;199(1):52.e1-52.e10.
  • Hecht JL, Onderdonk A, Delaney M, Allred EN, Kliman HJ, Zambrano E, Pflueger SM, Livasy CA, Bhan I, Leviton A,.Characterization of chorioamnionitis in 2nd-trimester C-section placentas and correlation with microorganism recovery from subamniotic tissues.Pediatr Dev Pathol. 2008 Jan-Feb;11(1):15-22.
  • Tworoger SS, Gertig DM, Gates MA, Hecht JL, Hankinson SE.Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer.Cancer. 2008 Mar 1;112(5):1169-77.
  • Gates MA, Tworoger SS, Hecht JL, De Vivo I, Rosner B, Hankinson SE.A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer.Int J Cancer. 2007 Nov 15;121(10):2225-32.
  • Hecht JL, Kliman HJ, Allred EN, Pflueger SM, Chang CH, Doss BJ, Roberts D, Livasy CA, Bhan I, Zambrano E, Ross DW, Senagore P, Husain AN, Leviton A.Reference weights for placentas delivered before the 28th week of gestation.Placenta. 2007 Oct;28(10):987-90.
  • Danforth KN, Tworoger SS, Hecht JL, Rosner BA, Colditz GA, Hankinson SE.Breastfeeding and risk of ovarian cancer in two prospective cohorts.Cancer Causes Control. 2007 Jun;18(5):517-523.
  • Gilmore H, Fleischhacker D, Hecht JL.Diagnosis of chronic endometritis in biopsies with stromal breakdown.Hum Pathol. 2007 Apr;38(4):581-4.
  • Danforth KN, Tworoger SS, Hecht JL, Rosner BA, Colditz GA, Hankinson SE.A prospective study of postmenopausal hormone use and ovarian cancer risk.Br J Cancer. 2007 Jan 15;96(1):151-6.
  • Galan M, Kim YB, Hecht JL.Does physiologic breakdown mask significant pathology in endometrial biopsies? A retrospective case-control study.Arch Pathol Lab Med. 2006 Dec;130(12):1847-9.
  • Hecht JL, Mutter GL.Molecular and pathologic aspects of endometrial carcinogenesis.J Clin Oncol. 2006 Oct 10;24(29):4783-91. Review.
  • Tworoger SS, Hecht JL, Giovannucci E, Hankinson SE.Intake of folate and related nutrients in relation to risk of epithelial ovarian cancer.Am J Epidemiol. 2006 Jun 15;163(12):1101-11.
  • Hecht JL, Pinkus JL, Pinkus GS.Monoclonal antibody MOC-31 reactivity as a marker for adenocarcinoma in cytologic preparations.Cancer. 2006 Feb 25;108(1):56-9.
  • Drapkin R, von Horsten HH, Lin Y, Mok SC, Crum CP, Welch WR, Hecht JL.Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas.Cancer Res. 2005 Mar 15;65(6):2162-9.
  • Witkiewicz AK, Hecht JL, Cviko A, McKeon FD, Ince TA, Crum CP.Microglandular hyperplasia: a model for the de novo emergence and evolution of endocervical reserve cells.Hum Pathol. 2005 Feb;36(2):154-61.
  • Hecht JL, Ince TA, Baak JP, Baker HE, Ogden MW, Mutter GL.Prediction of endometrial carcinoma by subjective endometrial intraepithelial neoplasia diagnosis.Mod Pathol. 2005 Mar;18(3):324-30.
  • Drapkin R, Crum CP, Hecht JL.Expression of candidate tumor markers in ovarian carcinoma and benign ovary: evidence for a link between epithelial phenotype and neoplasia.Hum Pathol. 2004 Aug;35(8):1014-21.
  • Hecht JL, Pinkus JL, Pinkus GS.Enhanced detection of atypical hyperplasia in endometrial polyps by PTEN expression.Appl Immunohistochem Mol Morphol. 2004 Mar;12(1):36-9.
  • Nascimento AF, Granter SR, Cviko A, Yuan L, Hecht JL, Crum CP.Vulvar acanthosis with altered differentiation: a precursor to verrucous carcinoma?.Am J Surg Pathol. 2004 May;28(5):638-43.
  • Qian X, Hecht JL.Pancreatic fine needle aspiration. A comparison of computed tomographic and endoscopic ultrasonographic guidance.Acta Cytol. 2003 Sep-Oct;47(5):723-6.
  • Hecht JL, Cibas ES, Kutok JL.Fine-needle aspiration cytology of lymphoproliferative disorders in the immunosuppressed patient: the diagnostic utility of in situ hybridization for Epstein-Barr virus.Diagn Cytopathol. 2002 Jun;26(6):360-5.
  • Lee BH, Hecht JL, Pinkus JL, Pinkus GS.WT1, estrogen receptor, and progesterone receptor as markers for breast or ovarian primary sites in metastatic adenocarcinoma to body fluids.Am J Clin Pathol. 2002 May;117(5):745-50.
  • Hecht JL, Lee BH, Pinkus JL, Pinkus GS.The value of Wilms tumor susceptibility gene 1 in cytologic preparations as a marker for malignant mesothelioma.Cancer. 2002 Apr 25;96(2):105-9.
  • Hecht JL, Sheets EE, Lee KR.Atypical glandular cells of undetermined significance in conventional cervical/vaginal smears and thin-layer preparations.Cancer. 2002 Feb 25;96(1):1-4.
  • Domchek SM, Hecht JL, Fleming MD, Pinkus GS, Canellos GP.Lymphomas of the breast: primary and secondary involvement.Cancer. 2002 Jan 1;94(1):6-13.
  • Hecht JL, Pinkus JL, Weinstein LJ, Pinkus GS.The value of thyroid transcription factor-1 in cytologic preparations as a marker for metastatic adenocarcinoma of lung origin.Am J Clin Pathol. 2001 Oct;116(4):483-8.
  • Thorner AR, Travis AC, Hecht JL, Conrow DS, Fisher DC.Unusual presentations of malignancy. Case 3. Mantle-cell lymphoma of soft tissue.J Clin Oncol. 2001 Jul 1;19(13):3291-3.
  • Hecht JL, Aster JC.Molecular biology of Burkitt's lymphoma.J Clin Oncol. 2000 Nov 1;18(21):3707-21.
  • Velasquez MM, Hecht J, Quinn VP, Emmons KM, DiClemente CC, Dolan-Mullen P.Application of motivational interviewing to prenatal smoking cessation: training and implementation issues.Tob Control. 2000;9 Suppl 3:III36-40.